Advances on carbon nanomaterials and their applications in medical diagnosis and drug delivery

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 241, P. 114032 - 114032

Published: June 13, 2024

Language: Английский

---

Advancements in Cancer Treatment: Harnessing the Synergistic Potential of Graphene-Based Nanomaterials in Combination Therapy

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Combination therapy, which involves using multiple therapeutic modalities simultaneously or sequentially, has become a cornerstone of modern cancer treatment. Graphene-based nanomaterials (GBNs) have emerged as versatile platforms for drug delivery, gene and photothermal therapy. These materials enable synergistic approach, improving the efficacy treatments while reducing side effects. This review explores roles graphene, graphene oxide (GO), quantum dots (GQDs) in combination therapies highlights their potential to enhance immunotherapy targeted therapies. The large surface area high drug-loading capacity facilitate codelivery agents, promoting sustained release. GQDs, with unique optical properties, offer real-time imaging capabilities, adding another layer precision However, challenges such biocompatibility, long-term toxicity, scalability need be addressed ensure clinical safety. Preclinical studies show promising results GBNs, suggesting revolutionize treatment through innovative

Language: Английский

---

Current Strategies in Photodynamic Therapy (PDT) and Photodynamic Diagnostics (PDD) and the Future Potential of Nanotechnology in Cancer Treatment

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(6), P. 1712 - 1712

Published: June 12, 2023

Photodynamic diagnostics (PDD) and photodynamic therapy (PDT) are well-established medical technologies used for the diagnosis treatment of malignant neoplasms. They rely on use photosensitizers, light oxygen to visualize or eliminate cancer cells. This review demonstrates recent advancements in these modalities with nanotechnology, including quantum dots as innovative photosensitizers energy donors, liposomes micelles. Additionally, this literature explores combination PDT radiotherapy, chemotherapy, immunotherapy, surgery treating various The article also focuses latest achievements PDD enhancements, which seem be very promising field oncology.

Language: Английский

---

Microfluidic Synthesis of Ultrasmall Chitosan/Graphene Quantum Dots Particles for Intranasal Delivery in Alzheimer's Disease Treatment

Small, Journal Year: 2023, Volume and Issue: 19(40)

Published: June 12, 2023

Nanoparticles (NPs) based therapies for Alzheimer's disease (AD) attract interest due to their ability pass across or bypass the blood-brain barrier. Chitosan (CS) NPs graphene quantum dots (GQDs) are promising drug carriers with excellent physicochemical and electrical properties. The current study proposes combination of CS GQDs in ultrasmall NP form not as but theranostic agents AD. microfluidic-based synthesis CS/GQD optimized characteristics makes them ideal transcellular transfer brain targeting after intranasal (IN) delivery. have enter cytoplasm C6 glioma cells vitro show dose time-dependent effects on viability cells. IN administration streptozotocin (STZ) induced AD-like models lead a significant number entrances treated rats target arm radial water maze (RAWM) test. It shows positive effect memory recovery rats. detectable via vivo bioimaging diagnostic markers. noncytotoxic localize myelinated axons hippocampal neurons. They do affect clearance amyloid β (Aβ) plaques at intercellular space. Moreover, they showed no impact enhancement MAP2 NeuN expression markers neural regeneration. improvement AD may be neuroprotection anti-inflammation regulation tissue microenvironment that needs studied.

Language: Английский

---

Recent Advances in Collagen Antimicrobial Biomaterials for Tissue Engineering Applications: A Review

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(9), P. 7808 - 7808

Published: April 25, 2023

Biomaterial-based therapies have been receiving attention for treating microbial infections mainly to overcome the increasing number of drug-resistant bacterial strains and off-target impacts therapeutic agents by conventional strategies. A fibrous, non-soluble protein, collagen, is one most studied biopolymers development antimicrobial biomaterials owing its superior physicochemical, biomechanical, biological properties. In this study, we reviewed different approaches used develop collagen-based devices, such as non-pharmacological, antibiotic, metal oxide, peptide, herbal extract-based, combination approaches, with a particular focus on preclinical studies that published in last decade.

Language: Английский

---

Biogenic carbon nanostructured materials for detection of cancer and medical applications: A mini review

Hybrid Advances, Journal Year: 2024, Volume and Issue: 5, P. 100166 - 100166

Published: March 1, 2024

In this new era, the cutting-edge progress of numerous technologies for modern and better lifestyles as well a wide range aquatic global habitats by increasing anthropogenic activities is directly responsible contaminated potable water edible things, which are hazardous to living entities. recent decades, there has been lot interest in several research groups biomass renewable energy source or biogenic carbon-based devices medical applications. Biomass such wheat straw ash (WSA), rice husk (RHA), sugarcane bagasse (SBA), coconut peal (CPA), sunflower (SHA), peanut peel (PPA), walnut (WPA) waste coffee beans contain an enormous quantity carbon, ashes can be utilized generating high-quality nanomaterials graphene (Gr), oxide (GO) CNTs that excellent purity from combustion by-products total process practically environmentally beneficial terms CO2 emissions warming. The unique properties nanostructures play vital role enhancing performance detection tools cancer its therapy overcome diseases. Thus, significance carbon allotropes underlined, with particular emphasis on nanostructured healthcare products high-surface-area adsorbents, mechanically stable devices, tailored instinctive micro-based assist avoiding health problem. This review summarizes affordable, modern, sophisticated applications using high-valued materials, particularly production CNTs, used make biomarkers, biosensors, bio-imaging, gene drug delivery systems, initial stage treatment.

Language: Английский

---

Multifunctional GQDs for receptor targeting, drug delivery, and bioimaging in pancreatic cancer

Nanoscale, Journal Year: 2023, Volume and Issue: 15(36), P. 14698 - 14716

Published: Jan. 1, 2023

Pancreatic cancer is a devastating disease with low survival rate and limited treatment options in this context, multifunctional graphene quantum dot-based receptor targeting, drug delivery, bioimaging possess immense potential to cure pancreatic cancer.

Language: Английский

---

Carbon materials and their metal composites for biomedical applications: A short review

Nanoscale, Journal Year: 2024, Volume and Issue: 16(35), P. 16313 - 16328

Published: Jan. 1, 2024

Carbon materials and their hybrid metal composites have garnered significant attention in biomedical applications due to exceptional biocompatibility.

Language: Английский

---

Recent Advances in Biomacromolecule‐Reinforced 2D Material (2DM) Hydrogels: From Interactions, Synthesis, and Functionalization to Biomedical Applications

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: July 27, 2024

Abstract Regenerative biomedicine has emerged as a forefront area in medical research, heralding new era of therapeutic strategies. This review delineates the integration 2D materials (2DMs) within biomedical engineering, leveraging their superior physicochemical attributes for enhance outcomes. The synergistic interaction between biomacromolecules and 2DMs is explored, demonstrating potential to mitigate limitations inherent each while simultaneously augmenting beneficial properties. In particular, incorporating into hydrogels highlights capability mechanical strength hydrogels, providing biomimetic scaffold tissue engineering regeneration cancer diagnosis therapy. An overview synthetic methodologies are provided 2DMs, elucidating dynamics with biomacromolecules. primarily concentrates on applications biomacromolecule‐reinforced 2DM across various fields, including bone wound healing, neural cardiac well delivery drugs genes, therapy, biosensing technologies. Finally, discusses existing challenges future outlook developing using underlining transformative regenerative medicine.

Language: Английский

---

Machine learning integrated graphene oxide‐based diagnostics, drug delivery, analytical approaches to empower cancer diagnosis

BMEMat, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 28, 2024

Abstract Machine learning (ML) and nanotechnology interfacing are exploring opportunities for cancer treatment strategies. To improve therapy, this article investigates the synergistic combination of Graphene Oxide (GO)‐based devices with ML techniques. The production techniques functionalization tactics used to modify physicochemical characteristics GO specific drug delivery explained at outset investigation. is a great option treating because its natural biocompatibility capacity absorb medicinal chemicals. Then, complicated biological data analyzed using algorithms, which make it possible identify best medicine formulations individualized plans depending on each patient's particular characteristics. study also looks optimizing predicting interactions between carriers cells ML. Predictive modeling helps ensure effective payload release therapeutic efficacy in design customized systems. Furthermore, tracking outcomes real time made by permit adaptive modifications therapy regimens. By medication doses settings, not only decreases adverse effects but enhances accuracy.

Language: Английский

---