Hybrid Photoiniferter and Ring‐Opening Polymerization Yields One‐Pot Anisotropic Nanorods DOI
Paul J. Hurst, Junsik Yoon,

Riya Singh

et al.

Macromolecular Rapid Communications, Journal Year: 2024, Volume and Issue: 45(12)

Published: March 23, 2024

Polymerization-induced self-assembly (PISA) has emerged as a scalable one-pot technique to prepare block copolymer (BCP) nanoparticles. Recently, PISA process, that results in poly(l-lactide)-b-poly(ethylene glycol) BCP nanoparticles coined ring-opening polymerization (ROP)-induced crystallization-driven (ROPI-CDSA), was developed. The resulting nanorods demonstrate strong propensity for aggregation, the formation of 2D sheets and 3D networks. This article reports synthesis poly(N,N-dimethyl acrylamide)-b-poly(l)-lactide by ROPI-CDSA, utilizing two-step, approach. A dual-functionalized photoiniferter is first used controlled radical acrylamido-based monomer, polymer serves macroinitiator organocatalyzed ROP form solvophobic polyester block. are highly stable display anisotropy at higher molecular weights (>12k Da) concentrations (>20% solids) than previous report. development expands chemical scope ROPI-CDSA BCPs provides readily accessible made with biocompatible materials.

Language: Английский

Injectable biocompatible RAFT mediated nitroxide nanogels: A robust ROS-reduction antioxidant approach DOI
Suman Basak, Ishita Mukherjee, Tushar Kanti Das

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 236, P. 113790 - 113790

Published: Feb. 7, 2024

Language: Английский

Citations

29
Recent Advances and Future Developments in the Preparation of Polypeptides via N-Carboxyanhydride (NCA) Ring-Opening Polymerization DOI
Yueming Wu, Kang Chen, Jiangzhou Wang

et al.

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(35), P. 24189 - 24208

Published: Aug. 22, 2024

Polypeptides have the same or similar backbone structures as proteins and peptides, rendering them suitable important biomaterials. Amino acid N-carboxyanhydrides (NCA) ring-opening polymerization has been most efficient strategy for polypeptide preparation, with continuous advance in design of initiators, catalysts reaction conditions. This Perspective first summarizes recent progress NCA synthesis purification. Subsequently, we focus on various initiators polymerization, accelerating enhancing controllability advances approach polymerization. Finally, discuss future research directions open challenges.

Language: Английский

Citations

18
Polypeptide-Based Systems: From Synthesis to Application in Drug Delivery DOI Creative Commons
Maria Stepanova, Alexey A. Nikiforov, Tatiana Tennikova

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(11), P. 2641 - 2641

Published: Nov. 20, 2023

Synthetic polypeptides are biocompatible and biodegradable macromolecules whose composition architecture can vary over a wide range. Their unique ability to form secondary structures, as well different pathways of modification biofunctionalization due the diversity amino acids, provide variation in physicochemical biological properties polypeptide-containing materials. In this review article, we summarize advances synthesis their copolymers application these systems for drug delivery (nano)particles or hydrogels. The issues, such (nano)particle types, methods preparation loading, influence characteristics on stability, degradability, cellular uptake, cytotoxicity, hemolysis, immunogenicity nanoparticles formulations, comprehensively discussed. Finally, recent development certain nanoformulations peptides, proteins, gene delivery, cancer therapy, antimicrobial anti-inflammatory summarized.

Language: Английский

Citations

12
The Production of Polysarcosine‐Containing Nanoparticles by Ring‐Opening Polymerization‐Induced Self‐Assembly DOI Creative Commons

Anna H. Morrell,

Nicholas J. Warren, Paul D. Thornton

et al.

Macromolecular Rapid Communications, Journal Year: 2024, Volume and Issue: 45(15)

Published: April 10, 2024

N-carboxyanhydride ring-opening polymerization-induced self-assembly (NCA ROPISA) offers a convenient route for generating poly(amino acid)-based nanoparticles in single step, crucially avoiding the need post-polymerization self-assembly. Most examples of NCA ROPISA make use poly(ethylene glycol) (PEG) hydrophilic stabilizing block, however this non-biodegradable, oil-derived polymer may cause an immunological response some individuals. Alternative water-soluble polymers are therefore highly sought. This work reports synthesis wholly nanoparticles, through chain-extension polysarcosine macroinitiator with L-Phenylalanine-NCA (L-Phe-NCA) and Alanine-NCA (Ala-NCA), via aqueous ROPISA. The resulting polymeric structures comprise predominantly anisotropic, rod-like morphologies primarily influenced by secondary structure hydrophobic acid) that enables their formation.

Language: Английский

Citations

4
In Situ Formation of Nanoparticles from Graft Copolypeptides Under Dispersion Polymerization Conditions DOI
Ernesto Tinajero‐Díaz, Robert Murphy, Bo Li

et al.

Macromolecular Rapid Communications, Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

Abstract A simple method is presented for preparing polypeptide nanoparticles using hydrophilic biosynthetic ε‐poly(lysine) (εPL) as a reactive surfactant under dispersion polymerization conditions. In situ graft of benzyl‐L‐glutamic acid N ‐carboxyanhydride (BLG‐NCA) triggers the self‐assembly amphiphilic copolymers into nanoparticles, which are colloidally stabilized by remaining εPL amino groups at particle surface. The average nanoparticle diameter can be controlled in range 40–120 nm varying initiator‐to‐NCA ratio, demonstrated correlation between copolymer molecular weight (measured size exclusion chromatography) and z‐average dynamic light scattering). Secondary structure analysis indicates that α‐helical conformation poly(benzyl‐L‐glutamate) (PBLG) grafts plays role both accelerating NCA stabilizing nanostructures. This approach readily scalable to high concentrations offers straightforward route peptidomimetic entirely composed acids, with promising potential nanomedicine applications.

Language: Английский

Citations

0
Rational design and engineering of polypeptide/protein vesicles for advanced biological applications DOI

Jooyong Shin,

Yeongseon Jang

Journal of Materials Chemistry B, Journal Year: 2023, Volume and Issue: 11(37), P. 8834 - 8847

Published: Jan. 1, 2023

The rational design and engineering strategies, employed in polypeptide/protein vesicles, from synthesis to assembly, for advanced biological medical applications.

Language: Английский

Citations

8
高分子囊泡领域面临的挑战和未来研究方向 DOI Creative Commons
Junqiu Shi, Qingmei Sun, Wenli Wang

et al.

Science China Materials, Journal Year: 2023, Volume and Issue: 67(1), P. 18 - 30

Published: Dec. 11, 2023

As a major transport system in cells, naturally occurring vesicles play an important role to ensure that the right cargo is shipped destination at time. Similarly, artificial vesicles, such as polymersomes with similar structures and functions, have been developed for various biological applications due advantages of excellent membrane colloidal stability, high loading efficiency hydrophobic drugs, low permeability, functional modifiability, long circulation However, relatively complicated synthesis preparation methods, unpredictable biocompatibility limited functions delivery routes, largely hindered clinic translation polymersomes. In this review, we propose five key scientific questions next-generation polymersomes, aspects building blocks, self-assembly techniques, potential biomedical applications, emphasize on future challenges directions, simplifying design synthetic process, streamlining standardizing procedure, broadening horizon applications.

Language: Английский

Citations

8
Drug catalyzed polymerization yields one pot nanomedicines DOI Creative Commons
Paul J. Hurst, Kyle J. Gassaway,

Mohammed Faris Abouchaleh

et al.

RSC Applied Polymers, Journal Year: 2024, Volume and Issue: 2(2), P. 238 - 247

Published: Jan. 1, 2024

In this work, by using drugs as a catalyst coupled with polymerization-induced self-assembly process, we synthesise drug-polymer particles in one pot compared to standard stepwise process.

Language: Английский

Citations

2
Efficient Catalyst-Free One-Pot Synthesis of Polysaccharide-Polypeptide Hydrogels in Aqueous Solution DOI
Xiao-Yu Guo,

Bin Yang,

Junyi Chen

et al.

Biomacromolecules, Journal Year: 2024, Volume and Issue: 25(6), P. 3642 - 3650

Published: May 22, 2024

The preparation of polysaccharide-peptide hydrogels usually involves multiple synthetic steps, thus reducing the effectiveness and practicality these approaches. Inspired by recent discoveries in aqueous N-carboxyanhydride (NCA) ring-opening polymerization (ROP) polymerization-induced nanogelation, we present an one-pot strategy to prepare polysaccharide-polypeptide hydrogels. In this study, water-soluble polysaccharide carboxymethyl chitosan is used as macromolecular initiator copolymers through ROP NCA. catalyst-free approach afforded with properties that could be controlled adjusting type amount NCA used, elastic modulus ranging from 50 Pa 18000 Pa. hydrogen bond-cross-linked hydrogel exhibited self-healing injectable properties. Morphology characterization revealed micelles were formed early stage reaction, suggesting follows self-assembly (ROPISA) mechanism aggregation during reaction caused gelation. Moreover, displayed high swelling ratios (>95% water content), hemolysis cytotoxicity experiments demonstrated had excellent biocompatibility, indicating their potential medical applications.

Language: Английский

Citations

1
Hybrid Photoiniferter and Ring‐Opening Polymerization Yields One‐Pot Anisotropic Nanorods DOI
Paul J. Hurst, Junsik Yoon,

Riya Singh

et al.

Macromolecular Rapid Communications, Journal Year: 2024, Volume and Issue: 45(12)

Published: March 23, 2024

Polymerization-induced self-assembly (PISA) has emerged as a scalable one-pot technique to prepare block copolymer (BCP) nanoparticles. Recently, PISA process, that results in poly(l-lactide)-b-poly(ethylene glycol) BCP nanoparticles coined ring-opening polymerization (ROP)-induced crystallization-driven (ROPI-CDSA), was developed. The resulting nanorods demonstrate strong propensity for aggregation, the formation of 2D sheets and 3D networks. This article reports synthesis poly(N,N-dimethyl acrylamide)-b-poly(l)-lactide by ROPI-CDSA, utilizing two-step, approach. A dual-functionalized photoiniferter is first used controlled radical acrylamido-based monomer, polymer serves macroinitiator organocatalyzed ROP form solvophobic polyester block. are highly stable display anisotropy at higher molecular weights (>12k Da) concentrations (>20% solids) than previous report. development expands chemical scope ROPI-CDSA BCPs provides readily accessible made with biocompatible materials.

Language: Английский

Citations

0