Poly(methyl methacrylate) in Orthopedics: Strategies, Challenges, and Prospects in Bone Tissue Engineering

Polymers, Journal Year: 2024, Volume and Issue: 16(3), P. 367 - 367

Published: Jan. 29, 2024

Poly(methyl methacrylate) (PMMA) is widely used in orthopedic applications, including bone cement total joint replacement surgery, fillers, and substitutes due to its affordability, biocompatibility, processability. However, the regeneration efficiency of PMMA limited because lack bioactivity, poor osseointegration, non-degradability. The use also has disadvantages such as methyl methacrylate (MMA) release high exothermic temperature during polymerization PMMA, which can cause thermal necrosis. To address these problems, various strategies have been adopted, surface modification techniques incorporation bioactive agents biopolymers into PMMA. In this review, physicochemical properties synthesis methods are discussed, with a special focus on utilization composites tissue engineering. Additionally, challenges involved incorporating regenerative medicine discussed suitable research findings intention providing insightful advice support successful clinical applications.

Language: Английский

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A Review of Advanced Hydrogel Applications for Tissue Engineering and Drug Delivery Systems as Biomaterials

Gels, Journal Year: 2024, Volume and Issue: 10(11), P. 693 - 693

Published: Oct. 25, 2024

Hydrogels are known for their high water retention capacity and biocompatibility have become essential materials in tissue engineering drug delivery systems. This review explores recent advancements hydrogel technology, focusing on innovative types such as self-healing, tough, smart, hybrid hydrogels, each engineered to overcome the limitations of conventional hydrogels. Self-healing hydrogels can autonomously repair structural damage, making them well-suited applications dynamic biomedical environments. Tough designed with enhanced mechanical properties, enabling use load-bearing cartilage regeneration. Smart respond external stimuli, including changes pH, temperature, electromagnetic fields, ideal controlled release tailored specific medical needs. Hybrid made from both natural synthetic polymers, combine bioactivity resilience, which is particularly valuable complex tissues. Despite these innovations, challenges optimizing biocompatibility, adjusting degradation rates, scaling up production remain. provides an in-depth analysis emerging technologies, highlighting transformative potential while outlining future directions development applications.

Language: Английский

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Multifunctional hydrogel scaffolds based on polysaccharides and polymer matrices promote bone repair: A review

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 294, P. 139418 - 139418

Published: Jan. 5, 2025

Language: Английский

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Polylactic Acid/Calcium Silicate Composite Scaffold Fabricated by Selective Laser Sintering with Coordinated Regulation of Bioactivity Induction, Degradation, and Mechanical Enhancement

Journal of Polymers and the Environment, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Language: Английский

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Toward Intelligent Materials with the Promise of Self-Healing Hydrogels in Flexible Devices

Polymers, Journal Year: 2025, Volume and Issue: 17(4), P. 542 - 542

Published: Feb. 19, 2025

Flexible sensors are revolutionizing wearable and implantable devices, with conductive hydrogels emerging as key materials due to their biomimetic structure, biocompatibility, tunable transparency, stimuli-responsive electrical properties. However, fragility limited durability pose significant challenges for broader applications. Drawing inspiration from the self-healing capabilities of natural organisms like mussels, researchers embedding self-repair mechanisms into improve reliability lifespan. This review highlights recent advances in (SH) hydrogels, focusing on synthesis methods, healing mechanisms, strategies enhance multifunctionality. It also explores wide-ranging applications, including vivo signal monitoring, biochemical sensors, supercapacitors, flexible displays, triboelectric nanogenerators, bioelectronics. While progress has been made, remain balancing efficiency, mechanical strength, sensing performance. offers insights overcoming these obstacles discusses future research directions advancing SH hydrogel-based bioelectronics, aiming pave way durable, high-performance devices next-generation technologies.

Language: Английский

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Enhancing regenerative medicine with self-healing hydrogels: A solution for tissue repair and advanced cyborganic healthcare devices

Biomaterials Advances, Journal Year: 2024, Volume and Issue: 161, P. 213869 - 213869

Published: April 22, 2024

Considering the global burden related to tissue and organ injuries or failures, self-healing hydrogels may be an attractive therapeutic alternative for future. Self-healing are highly hydrated 3D structures with ability self-heal after breaking, this property is attributable a variety of dynamic non-covalent covalent bonds that able re-linking within matrix. specially benefits minimal invasive medical treatments cell-delivery support. Moreover, those tissue-engineered network have demonstrated effectiveness myriad purposes; instance, they could act as delivery-platforms different cargos (drugs, growth factors, cells, among others) in tissues such bone, cartilage, nerve skin. Besides, currently found their way into new novel applications; example, development adhesive hydrogels, by merely aiding surgical closing processes providing biomaterial-tissue adhesion. Furthermore, conductive permit stimuli monitoring natural electrical signals, which facilitated better fitting native diagnosis various health diseases. Lastly, part cyborganics – merge between biology machinery can pave finer healthcare devices diagnostics precision therapies.

Language: Английский

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Innovations in 3D printed individualized bone prosthesis materials: revolutionizing orthopedic surgery: a review

International Journal of Surgery, Journal Year: 2024, Volume and Issue: 110(10), P. 6748 - 6762

Published: June 21, 2024

The advent of personalized bone prosthesis materials and their integration into orthopedic surgery has made a profound impact, primarily as result the incorporation three-dimensional (3D) printing technology. By leveraging digital models additive manufacturing techniques, 3D enables creation customized, high-precision implants tailored to address complex anatomical variabilities challenging defects. In this review, we highlight significant progress in utilizing printed prostheses across wide range procedures, including pelvis, hip, knee, foot, ankle, spine surgeries, tumor resections. preoperative planning, surgical navigation, postoperative rehabilitation not only enhances treatment outcomes but also reduces risks, accelerates recovery, optimizes cost-effectiveness. Emphasizing potential for care improved patient outcomes, review underscores pivotal role advancing practice towards precision, efficiency, patient-centric solutions. evolving landscape holds promise revolutionizing approaches, enhancing ultimately improving quality patients.

Language: Английский

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Genistein-Loaded, Quaternized Dextran/ Κ-Carrageenan Gels for Bone Regeneration in Osteoporotic Conditions

Published: Jan. 1, 2025

Language: Английский

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Addressing the challenges of infectious bone defects: a review of recent advances in bifunctional biomaterials

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 29, 2025

Infectious bone defects present a substantial clinical challenge due to the complex interplay between infection control and regeneration. These often result from trauma, autoimmune diseases, infections, or tumors, requiring nuanced approach that simultaneously addresses promotes tissue repair. Recent advances in engineering materials science, particularly nanomaterials nano-drug formulations, have led development of bifunctional biomaterials with combined osteogenic antibacterial properties. offer an alternative traditional grafts, minimizing complications such as multiple surgeries, high antibiotic dosages, lengthy recovery periods. This review examines repair mechanisms infectious microenvironment highlights various foster both anti-infective processes. Emerging design strategies are also discussed provide forward-looking perspective on treating clinically significant outcomes.

Language: Английский

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Revolutionizing Bone Repair and Regeneration: The Role of Machine Learning in Designing Advanced Nanocomposite Hydrogels

Polymers for Advanced Technologies, Journal Year: 2025, Volume and Issue: 36(4)

Published: March 28, 2025

ABSTRACT Bone repair is a complex biological process requiring dynamic interplay between cellular mechanisms, molecular signaling, and environmental factors. The intricate stages of bone healing, including hematoma formation, inflammation, soft callus development, hard remodeling, are driven by coordinated responses pathways. Proinflammatory cytokines, growth factors, the extracellular matrix play critical roles in promoting osteogenesis angiogenesis. Factors such as age, systemic health, mechanical stability significantly influence efficiency. To address limitations natural advancements regenerative medicine have introduced innovative materials like nanocomposite hydrogels, which mimic microenvironment enhance function. Semi‐interpenetrating network (semi‐IPN) hydrogels emerged promising tool for tissue engineering. Combining crosslinked non‐crosslinked polymers, these offer balance stability, functionality, controlled degradation. Semi‐IPN provide structural support, facilitate cell attachment, enable sustained release bioactive molecules. Their flexibility adaptability make them suitable encapsulating stem cells targeted regeneration. Moreover, nonsurgical surgical scaffold delivery methods, ranging from injectable to 3D‐printed magnetically guided scaffolds, expanded horizons strategies, reduced invasiveness, improved patient outcomes. This review explores dynamics role regeneration, advanced construction strategies semi‐IPN repair. By integrating polymer science, nanotechnology, bioengineering, represent transformative shift addressing defects, paving way therapeutic approaches medicine. With ongoing advancements, technologies hold significant potential improve effectiveness accessibility solutions.

Language: Английский

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