ACS Materials Letters,
Journal Year:
2023,
Volume and Issue:
5(4), P. 1153 - 1163
Published: March 13, 2023
Liver
fibrosis,
an
early
stage
of
cirrhosis,
with
large
number
patients
and
seriously
endangering
health,
has
no
viable
treatment
available
currently.
In
this
study,
we
choose
tetrahedral
framework
nucleic
acid
nanoparticles
as
carriers
to
deliver
the
polyphenolic
monomer
chlorogenic
injured
liver
for
first
time.
This
delivery
system
enhanced
bioavailability
stability
acid,
laying
foundation
its
antifibrotic
antioxidant
effects.
Our
findings
show
that
approach
can
reduce
fibrosis
by
down-regulating
Smad2/3
phosphorylation,
limiting
extracellular
matrix
synthesis,
substantially
improving
performance
mouse
livers
restoring
normal
function;
besides,
promote
reactive
oxygen
species
consumption
upregulating
Nrf2,
regulating
oxidative
stress
alleviating
multiorgan
damage
in
mice.
general,
created
a
nanodelivery
associated
providing
more
possibilities
clinical
application
small
molecule
drugs.
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
172, P. 116266 - 116266
Published: Feb. 13, 2024
β-Elemene
(IUPAC
name:
(1
S,2
S,4
R)-1-ethenyl-1-methyl-2,4-bis(prop-1-en-2-yl)
cyclohexane),
is
a
natural
compound
found
in
turmeric
root.
Studies
have
demonstrated
its
diverse
biological
functions,
including
anti-tumor
properties,
which
been
extensively
investigated.
However,
these
not
yet
reviewed.
The
aim
of
this
review
was
to
provide
comprehensive
summary
β-elemene
research,
with
respect
disease
treatment.
Stem Cell Research & Therapy,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: May 31, 2024
Abstract
Mesenchymal
stem
cells
(MSCs)
are
multipotent
that
can
differentiate
into
of
different
lineages
to
form
mesenchymal
tissues,
which
promising
in
regard
treatment
for
bone
diseases.
Their
osteogenic
differentiation
is
under
the
tight
regulation
intrinsic
and
extrinsic
factors.
Transforming
growth
factor
β
(TGF-β)
an
essential
metabolism,
regulates
MSCs.
However,
published
studies
differ
their
views
on
whether
TGF-β
signaling
MSCs
positively
or
negatively.
The
controversial
results
have
not
been
summarized
systematically
related
explanations
required.
Therefore,
we
reviewed
basics
how
each
three
isoforms
differentiation.
Three
(TGF-β1/β2/β3)
play
distinct
roles
regulating
Additionally,
other
possible
sources
conflicts
here.
Further
understanding
may
lead
new
applications
promote
regeneration
improve
therapies
Journal of Hepatology,
Journal Year:
2022,
Volume and Issue:
77(1), P. 219 - 236
Published: Feb. 12, 2022
HCV
hijacks
many
host
metabolic
processes
in
an
effort
to
aid
viral
replication.
The
resulting
hepatic
dysfunction
underpins
of
the
and
extrahepatic
manifestations
chronic
hepatitis
C
(CHC).
However,
natural
history
CHC
is
also
substantially
influenced
by
status:
obesity,
insulin
resistance
steatosis
are
major
determinants
progression
toward
hepatocellular
carcinoma
(HCC).
Direct-acting
antivirals
(DAAs)
have
transformed
treatment
CHC.
While
DAA
therapy
effectively
eradicates
virus,
long-lasting
overlapping
disease
can
persist,
especially
presence
increasing
risk
liver
progression.
This
review
covers
mechanisms
which
tunes
systemic
metabolism,
highlighting
how
disturbance,
lipotoxicity
inflammation
favour
a
precancerous
niche.
We
highlight
therapeutic
implications
sustained
following
virologic
response
as
well
considerations
for
patients
who
develop
HCC
on
background
dysfunction.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(6), P. 5600 - 5600
Published: March 15, 2023
The
study
of
the
tumor
microenvironment
(TME)
has
become
an
important
part
colorectal
cancer
(CRC)
research.
Indeed,
it
is
now
accepted
that
invasive
character
a
primary
CRC
determined
not
only
by
genotype
cells,
but
also
their
interactions
with
extracellular
environment,
which
thereby
orchestrates
development
tumor.
In
fact,
TME
cells
are
double-edged
sword
as
they
play
both
pro-
and
anti-tumor
roles.
interaction
tumor-infiltrating
(TIC)
induces
polarization
TIC,
exhibiting
antagonist
phenotype.
This
controlled
plethora
interconnected
anti-oncogenic
signaling
pathways.
complexity
this
dual
function
these
different
actors
contribute
to
failure
control.
Thus,
better
understanding
such
mechanisms
great
interest
provides
new
opportunities
for
personalized
efficient
therapies
CRC.
review,
we
summarize
pathways
linked
implication
in
or
inhibition
initiation
progression.
second
part,
enlist
major
components
discuss
functions.
Genes & Cancer,
Journal Year:
2023,
Volume and Issue:
14, P. 12 - 29
Published: Feb. 1, 2023
The
CEA
family
comprises
18
genes
and
11
pseudogenes
located
at
chromosome
19q13.2and
is
divided
into
two
main
groups:
cell
surface
anchored
CEA-related
adhesion
molecules
(CEACAMs)
the
secreted
pregnancy-specific
glycoproteins
(PSGs).CEACAMs
are
highly
glycosylated
anchored,
intracellular,
intercellular
signaling
with
diverse
functions,
from
differentiation
transformation
to
modulating
immune
responses
associated
infection,
inflammation,
cancer.In
this
review,
we
explore
current
knowledge
surrounding
CEACAM1,
CEACAM5,
CEACAM6,
highlight
their
pathological
significance
in
areas
of
cancer
biology,
immunology,
inflammatory
disease,
describe
utility
murine
models
exploring
questions
related
these
proteins.
Toxicology,
Journal Year:
2023,
Volume and Issue:
495, P. 153596 - 153596
Published: July 20, 2023
Aryl
hydrocarbon
receptor
(AHR)
is
a
ligand-dependent
that
belongs
to
the
superfamily
of
basic
helix-loop-helix
(bHLH)
transcription
factors.
The
activation
canonical
AHR
signaling
pathway
known
induce
expression
cytochrome
P450
enzymes,
facilitating
detoxification
metabolism
in
human
body.
Additionally,
could
interact
with
various
pathways
such
as
epidermal
growth
factor
(EGFR),
signal
transducer
and
activator
3
(STAT3),
hypoxia-inducible
factor-1α
(HIF-1α),
nuclear
kappa
B
(NF-κβ),
estrogen
(ER),
androgen
(AR)
pathways.
Over
past
30
years,
several
studies
have
reported
chemical,
physical,
or
biological
agents,
tobacco,
compounds,
industrial
agricultural
chemical
wastes,
drugs,
UV,
viruses,
other
toxins,
affect
activity,
promoting
cancer
development.
Thus,
it
valuable
overview
how
these
factors
regulate
AHR-mediated
carcinogenesis.
Current
findings
many
compounds
act
ligands
drive
expressions
AHR-target
genes,
CYP1A1,
CYP1B1,
MMPs,
AXL,
targets
exert
pro-proliferation
anti-apoptotic
effect,
like
XIAP.
Furthermore,
some
physical
UV
3-methylcholanthrene,
promote
activities,
increasing
activities
few
oncogenic
pathways,
phosphatidylinositol
3-kinase/protein
kinase
(PI3K/AKT)
mitogen-activated
protein
kinase/extracellular
signal-regulated
(MAPK/ERK)
Understanding
carcinogenesis
processes
helps
clinicians
scientists
plan
personalized
therapeutic
strategies
improve
anti-cancer
treatment
efficacy.
As
roles
regulating
are
preclinical
observational
clinical
did
not
explore
detailed
mechanisms
different
agents
processes,
future
should
focus
on
conducting
large-scale
functional
unravel
underlying
mechanism
interacts
processes.
Cells,
Journal Year:
2023,
Volume and Issue:
12(8), P. 1139 - 1139
Published: April 12, 2023
Growing
evidence
supports
an
important
role
of
the
tumor
microenvironment
(TME)
in
pathogenesis
colorectal
cancer
(CRC).
Resident
cells
such
as
fibroblasts
or
immune
infiltrating
into
TME
maintain
continuous
crosstalk
with
and
thereby
regulate
CRC
progression.
One
most
molecules
involved
is
immunoregulatory
cytokine
transforming
growth
factor-β
(TGFβ).
TGFβ
released
by
various
TME,
including
macrophages
fibroblasts,
it
modulates
cell
growth,
differentiation,
death.
Mutations
components
TGF
pathway,
receptor
type
2
SMAD4,
are
among
frequently
detected
mutations
have
been
associated
clinical
course
disease.
Within
this
review,
we
will
discuss
our
current
understanding
about
CRC.
This
includes
novel
data
on
molecular
mechanisms
signaling
well
possible
strategies
for
therapy
targeting
potential
combinations
checkpoint
inhibitors.
