Associations between circadian disruption and cardiometabolic disease risk: A review DOI Creative Commons
Velarie Ansu, Kristen L. Knutson

Obesity, Journal Year: 2023, Volume and Issue: 31(3), P. 615 - 624

Published: Feb. 7, 2023

Abstract The human circadian system plays a vital role in many physiological processes, and rhythms are found virtually all tissues organs. disruption of may lead to adverse health outcomes. Evidence from recent population‐based studies was reviewed because they represent real‐world behavior can be useful developing future reduce the risk conditions, including cardiovascular diseases, obesity, diabetes mellitus, which occur disruption. An electronic search PubMed Web Science (2012–2022) performed. Selected articles were based on specific inclusion exclusion criteria. Five factors that disrupt rhythm alignment discussed: shift work, late chronotype, sleep timing, irregularity, meal timing. observational these disruptors suggests potential detrimental effects cardiometabolic health, higher BMI/obesity, blood pressure, greater dyslipidemia, inflammation, diabetes. Future research should identify underlying pathways order mitigate consequences work. Furthermore, optimal mealtimes for metabolic explored intervention studies. Lastly, it is important timing external environmental cues (such as light) behaviors influence managed.

Language: Английский

Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice DOI
Victoria A. Acosta-Rodríguez, Filipa Rijo‐Ferreira,

Mariko Izumo

et al.

Science, Journal Year: 2022, Volume and Issue: 376(6598), P. 1192 - 1202

Published: May 5, 2022

Caloric restriction (CR) prolongs life span, yet the mechanisms by which it does so remain poorly understood. Under CR, mice self-impose chronic cycles of 2-hour feeding and 22-hour fasting, raising question if is calories, or time day that cause this increased span. We show here 30% CR was sufficient to extend span 10%; however, a daily fasting interval circadian alignment acted together 35% in male C57BL/6J mice. These effects were independent body weight. Aging induced widespread increases gene expression associated with inflammation decreases genes encoding components metabolic pathways liver from ad libitum-fed at night ameliorated these aging-related changes. Our results interventions promote longevity provide perspective further explore aging.

Language: Английский

Citations

260
Circadian disruption and human health DOI Open Access
Anna Fishbein, Kristen L. Knutson, Phyllis C. Zee

et al.

Journal of Clinical Investigation, Journal Year: 2021, Volume and Issue: 131(19)

Published: Sept. 30, 2021

Circadian disruption is pervasive and can occur at multiple organizational levels, contributing to poor health outcomes individual population levels. Evidence points a bidirectional relationship, in that circadian increases disease severity many diseases disrupt rhythms. Importantly, increase the risk for expression development of neurologic, psychiatric, cardiometabolic, immune disorders. Thus, harnessing rich findings from preclinical translational research biology enhance via circadian-based approaches represents unique opportunity personalized/precision medicine overall societal well-being. In this Review, we discuss implications human using bench-to-bedside approach. science applied clinical population-based Given broad regulation health, Review focuses its discussion on selected examples metabolic, cardiovascular, allergic, immunologic disorders highlight interrelatedness between potential interventions, such as bright light therapy exogenous melatonin, well chronotherapy improve and/or modify outcomes.

Language: Английский

Citations

247
Circadian rhythms and disorders of the timing of sleep DOI
Nicholas Meyer, Allison G. Harvey, Steven W. Lockley

et al.

The Lancet, Journal Year: 2022, Volume and Issue: 400(10357), P. 1061 - 1078

Published: Sept. 1, 2022

Language: Английский

Citations

182
The translational neuroscience of sleep: A contextual framework DOI
Michael A. Grandner, Fabian‐Xosé Fernandez

Science, Journal Year: 2021, Volume and Issue: 374(6567), P. 568 - 573

Published: Oct. 28, 2021

Sleep is entwined across many physiologic processes in the brain and periphery, thereby exerting tremendous influence on our well-being. Yet sleep exists a social-environmental context. Contextualizing health with respect to its determinants—from individual- societal-level factors—would enable neuroscientists more effectively translate into clinical practice. Key challenges opportunities pertain (i) recognizing exploring sleep’s functional roles, (ii) clarifying causal mechanisms relation key outcomes, (iii) developing richer model systems, (iv) linking models known contextual factors, (v) leveraging advances multisensory technology. Meeting these would help transcend disciplinary boundaries such that considerations related become an ever-greater presence clinic.

Language: Английский

Citations

117
Time spent in outdoor light is associated with mood, sleep, and circadian rhythm-related outcomes: A cross-sectional and longitudinal study in over 400,000 UK Biobank participants DOI
A Burns, Richa Saxena, Céline Vetter

et al.

Journal of Affective Disorders, Journal Year: 2021, Volume and Issue: 295, P. 347 - 352

Published: Aug. 26, 2021

Language: Английский

Citations

114
Hypoxia-induced signaling in the cardiovascular system: pathogenesis and therapeutic targets DOI Creative Commons
Yongchao Zhao, Weidong Xiong,

Chaofu Li

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Nov. 20, 2023

Hypoxia, characterized by reduced oxygen concentration, is a significant stressor that affects the survival of aerobic species and plays prominent role in cardiovascular diseases. From research history milestone events related to hypoxia development diseases, The "hypoxia-inducible factors (HIFs) switch" can be observed from both temporal spatial perspectives, encompassing occurrence progression (gradual decline concentration), acute chronic manifestations hypoxia, geographical characteristics (natural selection at high altitudes). Furthermore, signaling pathways are associated with natural rhythms, such as diurnal hibernation processes. In addition innate selection, it has been found epigenetics, postnatal factor, profoundly influences hypoxic response within system. Within this intricate process, interactions between different tissues organs system other systems context have established. Thus, time summarize construct multi-level regulatory framework mechanisms diseases for developing more therapeutic targets make reasonable advancements clinical research, including FDA-approved drugs ongoing trials, guide future practice field

Language: Английский

Citations

106
Circadian rhythms and cancers: the intrinsic links and therapeutic potentials DOI Creative Commons
Li Zhou, Zhe Zhang, Edouard C. Nice

et al.

Journal of Hematology & Oncology, Journal Year: 2022, Volume and Issue: 15(1)

Published: March 4, 2022

The circadian rhythm is an evolutionarily conserved time-keeping system that comprises a wide variety of processes including sleep-wake cycles, eating-fasting and activity-rest coordinating the behavior physiology all organs for whole-body homeostasis. Acute disruption may lead to transient discomfort, whereas long-term irregular will result in dysfunction organism, therefore increasing risks numerous diseases especially cancers. Indeed, both epidemiological experimental evidence has demonstrated intrinsic link between dysregulated cancer. Accordingly, rapidly understanding molecular mechanisms rhythms opening new options cancer therapy, possibly by modulating clock. In this review, we first describe general regulators their functions on addition, provide insights into underlying how several types (including sleep-wake, eating-fasting, activity-rest) can drive progression, which expand our development from clock perspective. Moreover, also summarize potential applications treatment, optional therapeutic strategy patients.

Language: Английский

Citations

93
Disruption of Circadian Rhythms by Shift Work Exacerbates Reperfusion Injury in Myocardial Infarction DOI Creative Commons
Yichao Zhao, Xiyuan Lu, Fang Wan

et al.

Journal of the American College of Cardiology, Journal Year: 2022, Volume and Issue: 79(21), P. 2097 - 2115

Published: May 1, 2022

Shift work is associated with increased risk of acute myocardial infarction (AMI) and worsened prognosis. However, the mechanisms linking shift prognosis in AMI remain unclear. This study sought to investigate impact on reperfusion injury, a major determinant clinical outcomes AMI. Study patient data were obtained from database EARLY-MYO-CMR (Early Assessment Myocardial Tissue Characteristics by CMR STEMI) registry, which was prospective, multicenter registry patients ST-segment elevation (STEMI) undergoing cardiac magnetic resonance (CMR) imaging after therapy. The primary endpoint CMR-defined post-reperfusion infarct size. A secondary composite adverse events (MACE) during follow-up. Potential explored use preclinical animal models. Of 706 enrolled 412 STEMI ultimately included. size (β = 5.94%; 95% CI: 2.94-8.94; P < 0.0001). During median follow-up 5.0 years, risks MACE (adjusted HR: 1.92; 1.12-3.29; 0.017). Consistent findings, simulation mice sheep significantly augmented injury Mechanism studies identified novel nuclear receptor subfamily 1 group D member 1/cardiotrophin-like cytokine factor axis heart that played crucial role mediating detrimental effects injury. current provided findings increases It might play this process. [EARLY-MYO-CMR] registry; NCT03768453)

Language: Английский

Citations

74
Personalized nutrition therapy in critical care: 10 expert recommendations DOI Creative Commons
Paul E. Wischmeyer, Danielle E. Bear, Mette M. Berger

et al.

Critical Care, Journal Year: 2023, Volume and Issue: 27(1)

Published: July 4, 2023

Abstract Personalization of ICU nutrition is essential to future critical care. Recommendations from American/European guidelines and practice suggestions incorporating recent literature are presented. Low-dose enteral (EN) or parenteral (PN) can be started within 48 h admission. While EN preferred route delivery, new data highlight PN given safely without increased risk; thus, when early not feasible, provision isocaloric effective results in similar outcomes. Indirect calorimetry (IC) measurement energy expenditure (EE) recommended by both European/American after stabilization post-ICU Below-measured EE (~ 70%) targets should used during phase match later stay. protein delivery D1-2) (< 0.8 g/kg/d) progressed ≥ 1.2 g/kg/d as patients stabilize, with consideration avoiding higher unstable acute kidney injury on CRRT. Intermittent-feeding schedules hold promise for further research. Clinicians must aware delivered energy/protein what percentage represents. Computerized monitoring systems/platforms have become widely available. In at risk micronutrient/vitamin losses (i.e., CRRT), evaluation micronutrient levels considered days 5–7 repletion deficiencies where indicated. future, we hope use muscle monitors such ultrasound, CT scan, and/or BIA will utilized assess monitor response nutrition. Use specialized anabolic nutrients HMB, creatine, leucine improve strength/muscle mass promising other populations deserves study. setting, continued IC measures guide Research using rehabilitation interventions cardiopulmonary exercise testing (CPET) exercise/rehabilitation prescription agents testosterone/oxandrolone promote recovery needed.

Language: Английский

Citations

57
Effect of immunotherapy-infusion time of day on survival of patients with advanced cancers: a study-level meta-analysis DOI Creative Commons
Thierry Landre, Abdoulaye Karaboué, Zachary S. Buchwald

et al.

ESMO Open, Journal Year: 2024, Volume and Issue: 9(2), P. 102220 - 102220

Published: Jan. 21, 2024

Background

Immune checkpoint inhibitors (ICIs) have become the standard of care for numerous malignancies. Emerging evidence suggests that time day (ToD) ICI administration could impact outcomes patients with cancer. The consistency ToD effects on efficacy awaits initial evaluation.

Materials and methods

This meta-analysis integrates progression-free survival (PFS) overall (OS) data from studies a defined ‘cut-off' ToD. Hazard ratios (HRs) [95% confidence interval (CI)] an earlier progression or death according to ‘early' ‘late' ICIs were collected each report pooled.

Results

Thirteen involved 1663 (Eastern Cooperative Oncology Group performance status 0-1, 83%; males/females, 67%/33%) non-small-cell lung cancer (47%), renal cell carcinoma (24%), melanoma (20%), urothelial (5%), esophageal (4%). Most received anti-programmed protein 1 death-ligand (98%), small proportion also anti-cytotoxic T-lymphocyte-associated 4 (anti-CTLA-4) (18%). cut-offs 13:00 14:00 (i.e. median infusion time), six studies, 16:00 16:30 reported threshold weaker vaccination responses) seven studies. Pooled analyses revealed early groups had longer OS (HR 0.50, 95% CI 0.42-0.58; P < 0.00001) PFS 0.51, 0.42-0.61; compared late groups.

Conclusions

Patients selected metastatic cancers seemed largely benefit infusions, which is consistent circadian mechanisms in immune-cell functions trafficking. Prospective randomized trials are needed establish recommendations optimal timing ICI-based therapies.

Language: Английский

Citations

27