Materials Today Bio,
Journal Year:
2023,
Volume and Issue:
23, P. 100810 - 100810
Published: Sept. 22, 2023
Diabetic
wounds
(DWs)
pose
a
major
challenge
for
the
public
health
system
owing
to
their
high
incidence,
complex
pathogenesis,
and
long
recovery
time;
thus,
there
is
an
urgent
need
develop
innovative
therapies
accelerate
healing
process
of
diabetic
wounds.
As
natural
nanovesicles,
extracellular
vesicles
(EVs)
are
rich
in
sources
with
low
immunogenicity
abundant
nutritive
molecules
exert
potent
therapeutic
effects
on
wound
healing.
To
avoid
rapid
removal
EVs,
suitable
delivery
required
controlled
release.
Owing
advantages
porosity,
good
biocompatibility,
adjustable
physical
chemical
properties
hydrogels,
EV
biopotentiated
hydrogels
can
aid
achieving
precise
favorable
therapy
against
This
review
highlights
different
design
strategies,
effects,
mechanisms
hydrogels.
We
also
discussed
future
challenges
opportunities
using
Small,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 3, 2024
Abstract
Oxidative
stress,
chronic
inflammation,
and
immune
senescence
are
important
pathologic
factors
in
diabetic
wound
nonhealing.
This
study
loads
taurine
(Tau)
into
cerium
dioxide
(CeO
2
)
to
develop
CeO
@Tau
nanoparticles
with
excellent
antioxidant,
anti‐inflammatory,
anti‐aging
properties.
To
enhance
the
drug
penetration
efficiency
wounds,
is
encapsulated
gelatin
methacryloyl
(GelMA)
hydrogel
prepare
@Tau@Hydrogel@Microneedle
(CTH@MN)
patch
system.
Microneedle
technology
achieves
precise
efficient
delivery
of
@Tau,
ensuring
their
deep
tissue
for
optimal
efficacy.
Rigorous
vitro
vivo
tests
have
confirmed
satisfactory
therapeutic
effect
CTH@MN
on
healing.
Mechanistically,
attenuates
oxidative
damage
inflammatory
responses
macrophages
by
inhibiting
ROS/NF‐κB
signaling
pathway.
Meanwhile,
activated
autophagy‐mediated
activity,
creating
a
favorable
microenvironment
repair.
Notably,
mouse
model,
multifunctional
significantly
promotes
healing
systematically
regulating
oxidation‐inflammation‐aging
(oxi‐inflamm‐aging)
pathological
axis.
In
conclusion,
in‐depth
exploration
system
this
provides
new
strategies
perspectives
treating
non‐healing
wounds.
Advanced NanoBiomed Research,
Journal Year:
2022,
Volume and Issue:
3(2)
Published: Dec. 23, 2022
Diabetic
wound,
also
known
as
diabetic
foot
ulcer
(DFU),
is
a
form
of
chronic
lesion
that
disrupts
the
patient's
lifestyle
and,
in
severe
cases,
may
be
fatal.
Recent
endeavors
utilizing
enzymes,
particularly
nanozymes
conjunction
with
other
materials,
have
revealed
potential
to
treat
wounds.
Herein,
rational
structural
design
enzyme‐based
biomaterials
summarized
after
presenting
types
and
processes
enzymes
employed
wound
healing,
goal
better
understanding
interaction
between
biological
materials.
The
importance
enzyme
catalytic
activity,
coupled
new
therapeutic
treatment
strategies,
emphasized
use
for
healing.
This
review
represents
most
recent
development
innovation
healing
applications,
it
can
used
reference
guide
regenerative
biomedicines
from
nanoenzyme
biomaterials.
Materials Today Bio,
Journal Year:
2023,
Volume and Issue:
23, P. 100810 - 100810
Published: Sept. 22, 2023
Diabetic
wounds
(DWs)
pose
a
major
challenge
for
the
public
health
system
owing
to
their
high
incidence,
complex
pathogenesis,
and
long
recovery
time;
thus,
there
is
an
urgent
need
develop
innovative
therapies
accelerate
healing
process
of
diabetic
wounds.
As
natural
nanovesicles,
extracellular
vesicles
(EVs)
are
rich
in
sources
with
low
immunogenicity
abundant
nutritive
molecules
exert
potent
therapeutic
effects
on
wound
healing.
To
avoid
rapid
removal
EVs,
suitable
delivery
required
controlled
release.
Owing
advantages
porosity,
good
biocompatibility,
adjustable
physical
chemical
properties
hydrogels,
EV
biopotentiated
hydrogels
can
aid
achieving
precise
favorable
therapy
against
This
review
highlights
different
design
strategies,
effects,
mechanisms
hydrogels.
We
also
discussed
future
challenges
opportunities
using
