Journal of Biological Rhythms,
Journal Year:
2017,
Volume and Issue:
32(2), P. 154 - 164
Published: March 27, 2017
Shift
work
is
a
risk
factor
for
inflammation,
hypertension,
and
cardiovascular
disease.
This
increased
cannot
be
fully
explained
by
classical
factors.
workers’
behavioral
environmental
cycles
are
typically
misaligned
relative
to
their
endogenous
circadian
system.
However,
there
little
information
on
the
impact
of
acute
misalignment
disease
in
shift
workers,
independent
differences
stress,
food
quality,
other
factors
that
likely
differ
between
night
day
shifts.
Thus,
our
objectives
were
determine
effect
24-h
high-sensitivity
C-reactive
protein
(hs-CRP;
marker
systemic
inflammation)
blood
pressure
levels—cardiovascular
factors—in
chronic
workers.
Chronic
workers
undertook
two
3-day
laboratory
protocols
simulated
work,
comprising
12-hour
inverted
(circadian
misalignment)
or
alignment),
using
randomized,
crossover
design.
Circadian
hs-CRP
11%
(
p
<
0.0001).
systolic
(SBP)
diastolic
(DBP)
1.4
mmHg
0.8
mmHg,
respectively
(both
≤
0.038).
The
misalignment-mediated
increase
SBP
was
primarily
an
during
wake
period
(+1.7
mmHg;
=
0.017),
whereas
DBP
sleep
opportunity
(+1.8
0.005).
per
se
increases
may
help
explain
Nature Communications,
Journal Year:
2021,
Volume and Issue:
12(1)
Published: May 17, 2021
Dietary
restriction
(DR)
decreases
body
weight,
improves
health,
and
extends
lifespan.
DR
can
be
achieved
by
controlling
how
much
and/or
when
food
is
provided,
as
well
adjusting
nutritional
composition.
Because
these
factors
are
often
combined
during
DR,
it
unclear
which
necessary
for
beneficial
effects.
Several
drugs
have
been
utilized
that
target
nutrient-sensing
gene
pathways,
many
of
change
expression
throughout
the
day,
suggesting
timing
drug
administration
critical.
Here,
we
discuss
dietary
pharmacological
interventions
promote
a
healthy
lifespan
influencing
energy
intake
circadian
rhythms.
Environmental Epidemiology,
Journal Year:
2017,
Volume and Issue:
1(2), P. e005 - e005
Published: Dec. 1, 2017
High
ambient
temperatures
are
associated
with
an
acute
increase
in
mortality
risk.
Although
heat
exposure
during
the
night
is
anecdotally
cited
as
being
important,
this
has
not
been
rigorously
demonstrated
epidemiological
literature.We
quantified
contribution
of
nighttime
using
time-series
quasi-Poisson
regression
on
cause
and
age-specific
daily
London
between
1993
2015.
Daytime
exposures
were
characterized
by
average
9
am
pm
4
8
am,
respectively,
lagged
7
days.
We
also
examined
differential
impacts
hot
cool
nights
preceded
very
All
models
adjusted
for
air
quality,
season,
day
week.
Nighttime
additionally
daytime
exposure.Effects
from
persisted
after
adjusting
exposure.
This
was
highest
stroke,
RR
(relative
risk)
=
1.65
(95%
confidence
interval
(CI)
1.27
to
2.14)
estimated
comparing
risk
at
80th
99th
temperature
percentiles.
Compared
exposure,
had
a
higher
chronic
ischemic
stroke
younger
age
groups.
Respiratory
most
sensitive
temperatures.
Hot
days
followed
greater
than
nights.Nighttime
make
additional
important
heat-related
mortality.
impact
warm
that
day,
which
justifies
alert
criteria
heat-health
warning
system
based
nights.
The
stroke;
targeted
interventions
would
benefit
patients
susceptible
stroke.
European Journal of Neuroscience,
Journal Year:
2018,
Volume and Issue:
51(1), P. 396 - 412
Published: Oct. 25, 2018
Abstract
Shift
work,
defined
as
work
occurring
outside
typical
daytime
working
hours,
is
associated
with
an
increased
risk
of
various
non‐communicable
diseases,
including
diabetes
and
cardiovascular
disease.
Disruption
the
internal
circadian
timing
system
concomitant
sleep
disturbances
thought
to
play
a
critical
role
in
development
these
health
problems.
Indeed,
controlled
laboratory
studies
have
shown
that
short‐term
misalignment
restriction
independently
impair
physiological
processes,
insulin
sensitivity,
energy
expenditure,
immune
function,
blood
pressure
cardiac
modulation
by
autonomous
nervous
system.
If
allowed
persist,
acute
effects
may
lead
cardiometabolic
diseases
long
term.
Here,
we
discuss
evidence
for
contributions
disruption
metabolic
problems
shift
workers.
Improving
understanding
mechanisms
affected
disturbance
will
contribute
implementation
strategies
prevent
or
mitigate
impact
work.
Journal of Biological Rhythms,
Journal Year:
2017,
Volume and Issue:
32(2), P. 154 - 164
Published: March 27, 2017
Shift
work
is
a
risk
factor
for
inflammation,
hypertension,
and
cardiovascular
disease.
This
increased
cannot
be
fully
explained
by
classical
factors.
workers’
behavioral
environmental
cycles
are
typically
misaligned
relative
to
their
endogenous
circadian
system.
However,
there
little
information
on
the
impact
of
acute
misalignment
disease
in
shift
workers,
independent
differences
stress,
food
quality,
other
factors
that
likely
differ
between
night
day
shifts.
Thus,
our
objectives
were
determine
effect
24-h
high-sensitivity
C-reactive
protein
(hs-CRP;
marker
systemic
inflammation)
blood
pressure
levels—cardiovascular
factors—in
chronic
workers.
Chronic
workers
undertook
two
3-day
laboratory
protocols
simulated
work,
comprising
12-hour
inverted
(circadian
misalignment)
or
alignment),
using
randomized,
crossover
design.
Circadian
hs-CRP
11%
(
p
<
0.0001).
systolic
(SBP)
diastolic
(DBP)
1.4
mmHg
0.8
mmHg,
respectively
(both
≤
0.038).
The
misalignment-mediated
increase
SBP
was
primarily
an
during
wake
period
(+1.7
mmHg;
=
0.017),
whereas
DBP
sleep
opportunity
(+1.8
0.005).
per
se
increases
may
help
explain
