JAMA Network Open, Journal Year: 2022, Volume and Issue: 5(5), P. e2210450 - e2210450
Published: May 4, 2022
Rotating night shift work is associated with higher mortality. Whether it also overall health among those who survive to older ages remains unclear.
Language: Английский
Trends in Endocrinology and Metabolism, Journal Year: 2022, Volume and Issue: 33(4), P. 247 - 265
Published: Feb. 9, 2022
Language: Английский
Citations
299
Nature Reviews Endocrinology, Journal Year: 2020, Volume and Issue: 16(12), P. 731 - 739
Published: Oct. 26, 2020
Language: Английский
Citations
243
Journal of Biological Rhythms, Journal Year: 2021, Volume and Issue: 37(1), P. 3 - 28
Published: Dec. 30, 2021
The various non-standard schedules required of shift workers force abrupt changes in the timing sleep and light-dark exposure. These result disturbances endogenous circadian system its misalignment with environment. Simulated night-shift experiments field-based studies both indicate that is resistant to adaptation from a day- night-oriented schedule, as determined by lack substantial phase shifts over multiple days centrally controlled rhythms, such those melatonin cortisol. There evidence disruption caused work results not only between external cycle, but also state internal desynchronization levels system. This case rhythms central pacemaker clock genes expression tissues peripheral blood mononuclear cells, hair follicle oral mucosa cells. disruptive effects atypical extend beyond profile canonical affects other transcripts human genome. In general, after several living at night, most rhythmic genome remain adjusted day-oriented dampened group amplitudes. contrast transcripts, metabolomics revealed metabolites hours when working nights, thus leading their Altogether, these sleep-wake emphasize all-encompassing impact work, can contribute increased risk medical conditions. Here, we review latest scientific regarding on system, alertness shift-working populations, discuss potential clinical impacts.
Language: Английский
Citations
218
Frontiers in Nutrition, Journal Year: 2020, Volume and Issue: 7
Published: April 17, 2020
The molecular circadian clock regulates metabolic processes within the cell, and alignment of these clocks between tissues is essential for maintenance homeostasis. possibility misalignment arises from differential responsiveness to environmental cues that synchronize (zeitgebers). Although light dominant cue master suprachiasmatic nucleus, many other are sensitive feeding fasting. When rhythms behaviour altered, example by shift work or constant availability highly palatable foods, strong feedback sent peripheral clocks. Varying degrees phase can cause systemic processes. Moreover, when there a endogenous in physiology inputs, such as during inactive phase, body's ability maintain homeostasis impaired. loss coordination organism environment, well internal tissues, produce cardiometabolic disease consequence. aim this review synthesize on mechanisms effects misalignment. timing food intake highlighted powerful with potential destroy restore synchrony metabolism.
Language: Английский
Citations
180
The Lancet, Journal Year: 2022, Volume and Issue: 400(10357), P. 1061 - 1078
Published: Sept. 1, 2022
Language: Английский
Citations
172
Cell Metabolism, Journal Year: 2022, Volume and Issue: 34(10), P. 1442 - 1456.e7
Published: Oct. 1, 2022
Over a quarter of the workforce in industrialized countries does shift work, which increases risk for cardiometabolic disease. Yet workers are often excluded from lifestyle intervention studies to reduce this risk. In randomized control trial with 137 firefighters who work 24-h shifts (23-59 years old, 9% female), 12 weeks 10-h time-restricted eating (TRE) was feasible, TRE participants decreasing their window (baseline, mean 14.13 h, 95% CI 13.78-14.47 h; intervention, 11.13 10.73-11.54 p = 3.29E-17) no adverse effects, and improved quality life assessed via SF-36 (ClinicalTrials.gov: NCT03533023). Compared standard care (SOC) arm, significantly decreased VLDL particle size. elevated risks at baseline, there were significant reductions compared SOC glycated hemoglobin A1C diastolic blood pressure. For individuals working schedule, is feasible can improve health, especially increased VIDEO ABSTRACT.
Language: Английский
Citations
111
Clocks & Sleep, Journal Year: 2020, Volume and Issue: 2(1), P. 61 - 85
Published: Feb. 28, 2020
Daylight stems solely from direct, scattered and reflected sunlight, undergoes dynamic changes in irradiance spectral power composition due to latitude, time of day, year the nature physical environment (reflections, buildings vegetation). Humans their ancestors evolved under these natural day/night cycles over millions years. Electric light, a relatively recent invention, interacts competes with light–dark cycle impact human biology. What are consequences living industrialised urban areas much less daylight more use electric throughout day (and at night), on general health quality life? In this workshop report, we have classified key gaps knowledge research into three main groups: (I) uncertainty as quantity needed for “optimal” physiological psychological functioning, (II) lack consensus practical measurement assessment methods tools monitoring real (day) light exposure across multiple scales, (III) insufficient integration exchange bases different disciplines. Crucial short long-term objectives fill proposed.
Language: Английский
Citations
132
Nature Reviews Gastroenterology & Hepatology, Journal Year: 2021, Volume and Issue: 18(4), P. 239 - 251
Published: Feb. 2, 2021
Language: Английский
Citations
98
Current Opinion in Biotechnology, Journal Year: 2020, Volume and Issue: 70, P. 1 - 6
Published: Sept. 29, 2020
Language: Английский
Citations
93
Sleep Health, Journal Year: 2019, Volume and Issue: 6(3), P. 314 - 320
Published: Dec. 12, 2019
Language: Английский
Citations
91