Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 20, 2025
The
severe
Asiatic
form
of
huanglongbing
(HLB),
caused
by
"Candidatus
Liberibacter
asiaticus"
(CLas),
threatens
global
citrus
production
via
the
psyllid,
Diaphorina
citri.
Culturing
challenges
CLas
necessitate
reducing
D.
citri
populations
for
disease
management.
boosts
fecundity
CLas-positive
(CLas+)
and
fosters
its
own
proliferation
modulating
insect
host's
juvenile
hormone
(JH),
but
intricate
endocrine
regulatory
mechanisms
remain
elusive.
Here,
it
is
reported
that
ecdysis-triggering
(DcETH)
receptor
DcETHR
play
pivotal
roles
in
reciprocal
benefits
between
within
ovaries,
influencing
energy
metabolism
reproductive
development
host
insects;
miR-210,
negatively
regulates
expression,
contributing
to
this
symbiotic
interaction.
infection
reduces
20-hydroxyecdysone
(20E)
levels
stimulates
DcETH
release,
elevating
JH
DcETHR,
enhancing
proliferation.
Furthermore,
circulating
suppress
20E
CLas+
ovaries.
Collectively,
orchestrated
functional
interplay
involving
20E,
ETH,
increases
promotes
These
insights
not
only
broaden
knowledge
how
plant
pathogens
manipulate
behavior
hosts
also
offer
novel
targets
strategies
combatting
HLB
Cell and Tissue Research,
Journal Year:
2020,
Volume and Issue:
382(2), P. 233 - 266
Published: Aug. 22, 2020
Hormones
regulate
development,
as
well
many
vital
processes
in
the
daily
life
of
an
animal.
Many
these
hormones
are
peptides
that
act
at
a
higher
hierarchical
level
animal
with
roles
organizers
globally
orchestrate
metabolism,
physiology
and
behavior.
Peptide
can
on
multiple
peripheral
targets
simultaneously
convey
basal
states,
such
metabolic
status
sleep-awake
or
arousal
across
central
neuronal
circuits.
Thereby,
they
coordinate
responses
to
changing
internal
external
environments.
The
activity
neurosecretory
cells
is
controlled
either
by
(1)
cell
autonomous
sensors,
(2)
other
neurons
relay
signals
from
sensors
tissues
(3)
feedback
target
cells.
Thus,
hormonal
signaling
axis
commonly
comprises
several
components.
In
mammals
vertebrates,
axes
known,
hypothalamic-pituitary-gonad
hypothalamic-pituitary-thyroid
reproduction
respectively.
It
has
been
proposed
basic
organization
evolutionarily
old
cellular
homologs
hypothalamic-pituitary
system
be
found
for
instance
insects.
To
obtain
appreciation
similarities
between
insect
vertebrate
axes,
we
review
systems
Drosophila.
Our
outlines
major
peptidergic
pathways
known
Drosophila
presents
set
schemes
orchestrating
systems.
detailed
larval
adult
displays
only
very
those
arthropods
vertebrates.
PLoS Genetics,
Journal Year:
2021,
Volume and Issue:
17(2), P. e1009352 - e1009352
Published: Feb. 2, 2021
Diapause,
a
programmed
developmental
arrest
primarily
induced
by
seasonal
environmental
changes,
is
very
common
in
the
animal
kingdom,
and
found
vertebrates
invertebrates
alike.
Diapause
provides
an
adaptive
advantage
to
animals,
as
it
increases
odds
of
surviving
adverse
conditions.
In
insects,
individuals
perceive
photoperiodic
cues
modify
endocrine
signaling
direct
reproductive
diapause
traits,
such
ovary
increased
fat
accumulation.
However,
remains
unclear
which
factors
are
involved
this
process
how
they
regulate
onset
diapause.
Here,
we
that
long
day-mediated
drop
concentration
steroid
hormone
ecdysone
essential
for
preparation
Colaphellus
bowringi
,
economically
important
cabbage
beetle.
The
diapause-inducing
long-day
condition
reduced
expression
biosynthetic
genes,
explaining
titer
20-hydroxyecdysone
(20E,
active
form
ecdysone)
female
adults.
Application
exogenous
20E
vitellogenesis
ovarian
development
but
accumulation
diapause-destined
females.
Knocking
down
receptor
(
EcR
)
females
destined
reproduction
blocked
traits.
RNA-seq
measurements
indicated
stimulates
production
juvenile
(JH),
key
factor
To
verify
this,
depleted
three
enzymes
via
RNAi,
confirmed
critical
JH
biosynthesis
Importantly,
impairing
Met
function,
component
intracellular
receptor,
partially
20E-regulated
preparation,
indicating
regulates
both
JH-dependent
-independent
manners.
Finally,
deficiency
decreased
ecdysis-triggering
production,
thereby
inducing
Together,
these
results
suggest
pivotal
regulator
coordinates
plasticity
response
inputs.
Proceedings of the National Academy of Sciences,
Journal Year:
2021,
Volume and Issue:
118(4)
Published: Jan. 21, 2021
Significance
Metazoan
species
optimize
the
timing
of
reproduction
to
maximize
fitness.
To
understand
how
biological
clocks
direct
reproduction,
we
investigated
neural
substrates
that
produce
oogenesis
rhythms
in
genetically
amenable
model
organism
Drosophila
melanogaster
.
The
neuropeptide
allatostatin
C
(AstC)
is
an
insect
counterpart
vertebrate
somatostatin,
which
suppresses
gonadotropin
production.
A
subset
brain
circadian
pacemaker
neurons
produces
AstC.
We
have
uncovered
these
clock-associated
AstC
generate
rhythm
via
insulin-producing
cells
and
juvenile
hormone.
Identification
a
conserved
pathway
links
female
clock
offers
insight
into
molecular
mechanisms
reproductive
timing.
Proceedings of the National Academy of Sciences,
Journal Year:
2021,
Volume and Issue:
118(39)
Published: Sept. 20, 2021
It
is
well
documented
that
the
juvenile
hormone
(JH)
can
function
as
a
gonadotropic
stimulates
vitellogenesis
by
activating
production
and
uptake
of
vitellogenin
in
insects.
Here,
we
describe
phenotype
associated
with
mutations
Frontiers in Physiology,
Journal Year:
2022,
Volume and Issue:
12
Published: Feb. 10, 2022
In
the
field
of
insect
endocrinology,
juvenile
hormone
(JH)
is
one
most
wondrous
entomological
terms.
As
a
unique
sesquiterpenoid
produced
and
released
by
endocrine
gland,
corpus
allatum
(CA),
JH
critical
regulator
in
multiple
developmental
physiological
processes,
such
as
metamorphosis,
reproduction,
behavior.
Benefited
from
precise
genetic
interventions
simplicity,
fruit
fly,
Development,
Journal Year:
2023,
Volume and Issue:
150(10)
Published: May 15, 2023
ABSTRACT
Female
insects
can
enter
reproductive
diapause,
a
state
of
suspended
egg
development,
to
conserve
energy
under
adverse
environments.
In
many
insects,
including
the
fruit
fly,
Drosophila
melanogaster,
also
frequently
called
dormancy,
is
induced
low-temperature
and
short-day
conditions
by
downregulation
juvenile
hormone
(JH)
biosynthesis
in
corpus
allatum
(CA).
this
study,
we
demonstrate
that
neuropeptide
Diuretic
31
(DH31)
produced
brain
neurons
project
into
CA
plays
an
essential
role
regulating
dormancy
suppressing
JH
adult
D.
melanogaster.
The
expresses
gene
encoding
DH31
receptor,
which
required
for
DH31-triggered
elevation
intracellular
cAMP
CA.
Knocking
down
Dh31
these
CA-projecting
or
receptor
suppresses
decrease
titer,
normally
observed
dormancy-inducing
conditions,
leading
abnormal
yolk
accumulation
ovaries.
Our
findings
provide
first
molecular
genetic
evidence
demonstrating
peptidergic
play
biosynthesis.
