Ectopic expression of a mechanosensitive channel confers spatiotemporal resolution to ultrasound stimulations of neurons for visual restoration DOI Creative Commons

Sara Cadoni,

Charlie Demené, Ignacio Alcala

et al.

Nature Nanotechnology, Journal Year: 2023, Volume and Issue: 18(6), P. 667 - 676

Published: April 3, 2023

Abstract Remote and precisely controlled activation of the brain is a fundamental challenge in development brain–machine interfaces for neurological treatments. Low-frequency ultrasound stimulation can be used to modulate neuronal activity deep brain, especially after expressing ultrasound-sensitive proteins. But so far, no study has described an ultrasound-mediated strategy whose spatiotemporal resolution acoustic intensity are compatible with mandatory needs interfaces, particularly visual restoration. Here we combined expression large-conductance mechanosensitive ion channels uncustomary high-frequency ultrasonic activate retinal or cortical neurons over millisecond durations at energy deposit vision The vivo sonogenetic cortex generated behaviour associated light perception. Our findings demonstrate that sonogenetics deliver pattern presentations via approach less invasive than current

Language: Английский

Applications of focused ultrasound in the brain: from thermoablation to drug delivery DOI
Ying Meng, Kullervo Hynynen, Nir Lipsman

et al.

Nature Reviews Neurology, Journal Year: 2020, Volume and Issue: 17(1), P. 7 - 22

Published: Oct. 26, 2020

Language: Английский

Citations

329
Mechanoluminescence Rebrightening the Prospects of Stress Sensing: A Review DOI
Yixi Zhuang, Rong‐Jun Xie

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(50)

Published: March 30, 2021

Abstract The emergence of new applications, such as in artificial intelligence, the internet things, and biotechnology, has driven evolution stress sensing technology. For these emerging stretchability, remoteness, distribution, a multimodal nature, biocompatibility are important performance characteristics sensors. Mechanoluminescence (ML)‐based attracted widespread attention because its remoteness having distributed response to mechanical stimuli well great potential for biocompatibility, self‐powering. In past few decades, progress been made discovery ML materials, analysis mechanisms, design devices, exploration applications. One can find that with this progress, focus research shifted from phenomenon earliest stage materials recently toward devices. At present stage, while showing prospects advanced ML‐based still faces major challenges material optimization, device design, system integration.

Language: Английский

Citations

311
Emerging Modalities and Implantable Technologies for Neuromodulation DOI Creative Commons
Sang Min Won, Enming Song, Jonathan T. Reeder

et al.

Cell, Journal Year: 2020, Volume and Issue: 181(1), P. 115 - 135

Published: March 26, 2020

Language: Английский

Citations

215
Ultrasound Technologies for Imaging and Modulating Neural Activity DOI Creative Commons
Claire Rabut, Sangjin Yoo, Robert C. Hurt

et al.

Neuron, Journal Year: 2020, Volume and Issue: 108(1), P. 93 - 110

Published: Oct. 1, 2020

Language: Английский

Citations

189
Recent advances in neurotechnologies with broad potential for neuroscience research DOI
Abraham Vázquez‐Guardado, Yiyuan Yang, Amay J. Bandodkar

et al.

Nature Neuroscience, Journal Year: 2020, Volume and Issue: 23(12), P. 1522 - 1536

Published: Nov. 16, 2020

Language: Английский

Citations

170
Tether-free photothermal deep-brain stimulation in freely behaving mice via wide-field illumination in the near-infrared-II window DOI
Xiang Wu, Yuyan Jiang, Nicholas J. Rommelfanger

et al.

Nature Biomedical Engineering, Journal Year: 2022, Volume and Issue: 6(6), P. 754 - 770

Published: March 21, 2022

Language: Английский

Citations

167
Nanoparticles with ultrasound-induced afterglow luminescence for tumour-specific theranostics DOI
Cheng Xu, Jingsheng Huang, Yuyan Jiang

et al.

Nature Biomedical Engineering, Journal Year: 2022, Volume and Issue: 7(3), P. 298 - 312

Published: Dec. 22, 2022

Language: Английский

Citations

154
A ZnS/CaZnOS Heterojunction for Efficient Mechanical‐to‐Optical Energy Conversion by Conduction Band Offset DOI
Dengfeng Peng, Yue Jiang, Bolong Huang

et al.

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(16)

Published: March 4, 2020

Actively collecting the mechanical energy by efficient conversion to other forms of such as light opens a new possibility energy-saving, which is pivotal significance for supplying potential solutions present crisis. Such has shown promising applications in modern sensors, actuators, and harvesting. However, implementation technologies being hindered because most luminescent materials show weak non-recoverable emissions under excitation. Herein, class heterojunctioned ZnS/CaZnOS piezophotonic systems presented, displays highly reproducible mechanoluminescence (ML) with an unprecedented intensity over two times higher than that widely used commercial ZnS (the state-of-the-art ML material). Density functional theory calculations reveal high-performance originates from charge transfer recombination through offset valence conduction bands heterojunction interface region. By controlling ZnS-to-CaZnOS ratio conjunction manganese (Mn2+ ) lanthanide (Ln3+ doping, tunable across full spectrum activated small stimulus 1 N (10 kPa). The findings demonstrate novel strategy constructing leveraging effects ultimately promoting practical ML.

Language: Английский

Citations

149
Smart Mechanoluminescent Phosphors: A Review of Strontium‐Aluminate‐Based Materials, Properties, and Their Advanced Application Technologies DOI Creative Commons
Zefeng Huang, Bing Chen,

Biyun Ren

et al.

Advanced Science, Journal Year: 2022, Volume and Issue: 10(3)

Published: Nov. 13, 2022

Mechanoluminescence, a smart luminescence phenomenon in which light energy is directly produced by mechanical force, has recently received significant attention because of its important applications fields such as visible strain sensing and structural health monitoring. Up to present, hundreds inorganic organic mechanoluminescent materials have been discovered studied. Among them, strontium-aluminate-based are an class for fundamental research practical attributed their extremely low force/pressure threshold mechanoluminescence, efficient photoluminescence, persistent afterglow, relatively synthesis cost. This paper presents systematic comprehensive review luminescent materials' mechanoluminescence phenomena, mechanisms, material techniques, related applications. Besides summarizing the early latest on this system, outlook provided environmental, issue future wearable devices, advanced energy-saving lighting displays.

Language: Английский

Citations

122
Expanding the Toolbox of Inorganic Mechanoluminescence Materials DOI
Bing Chen, Xin Zhang, Feng Wang

et al.

Accounts of Materials Research, Journal Year: 2021, Volume and Issue: 2(5), P. 364 - 373

Published: April 2, 2021

ConspectusMechanoluminescence is a process of light emission from materials in response to external mechanical actions. As energy ubiquitously available nature, mechanoluminescence can provide sustainable solutions challenging problems the fields biology and optoelectronics as well environmental sciences. In particular, remote delivery through also be achieved by noncontact forces ultrasonic waves magnetic fields, which enables noninvasive diagnosis therapy biomedical applications. Owing well-recognized merits, research has evolved into highly interdisciplinary field, turn inspired considerable interest development novel devices for boosting performances such brightness, repeatability, spectral tunability.Mechanoluminescence was originally observed processes associated with fracture plastic deformation materials, are characterized inefficient nonreproducible emissions. Therefore, current mainly directed repeatable elastic continuous generation light. Such elastico-mechanoluminescence primarily host piezoelectricity doped activator ions manganese lanthanide. Upon application stress, piezoelectric hosts establish internal electric that trigger electronic transitions between dopant-associated levels, eventually giving rise emissions dopant ions. On basis learned knowledge, various host/dopant combinations have been synthesized tested past few years. Meanwhile, composite structures incorporated designed an efficient under different forms actions, compressing, stretching, rubbing.The significant progress study generated new opportunities fundamental technological To inspire guide further investigations this we systematically review emerging systems their frontier We focus on identified render bright deliberately controlled characteristics, along analysis structure–property relationship these materials. discuss innovative methodologies translating cutting-edge device applications precisely controlling interaction surrounding environments. attempt rationale behind developments, simultaneously highlight future challenges mechanoluminescence.

Language: Английский

Citations

116