Pervasive sublethal effects of agrochemicals on insects at environmentally relevant concentrations

Science, Journal Year: 2024, Volume and Issue: 386(6720), P. 446 - 453

Published: Oct. 24, 2024

Insect biomass is declining globally, likely driven by climate change and pesticide use, yet systematic studies on the effects of various chemicals remain limited. In this work, we used a chemical library 1024 molecules-covering insecticides, herbicides, fungicides, plant growth inhibitors-to assess impact sublethal doses insects.

Language: Английский

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Neonicotinoids: mechanisms of systemic toxicity based on oxidative stress-mitochondrial damage

Archives of Toxicology, Journal Year: 2022, Volume and Issue: 96(6), P. 1493 - 1520

Published: March 28, 2022

Language: Английский

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Toxic temperatures: Bee behaviours exhibit divergent pesticide toxicity relationships with warming

Global Change Biology, Journal Year: 2023, Volume and Issue: 29(11), P. 2981 - 2998

Published: March 21, 2023

Climate change and agricultural intensification are exposing insect pollinators to temperature extremes increasing pesticide usage. Yet, we lack good quantification of how modulates the sublethal effects pesticides on behaviours vital for fitness pollination performance. Consequently, uncertain if warming decreases or increases severity different impacts, whether separate vary in direction response. Quantifying these interactive is forecasting risk across climate regions informing application strategies pollinator conservation. This multi-stressor study investigated responses six functional bumblebees when exposed either a neonicotinoid (imidacloprid) sulfoximine (sulfoxaflor) standardised low, mid, high temperature. We found had significant effect five behaviours, with greater at lower temperature(s) measuring responsiveness, likelihood movement, walking rate, food consumption rate. In contrast, impact flight distance higher Our findings show that organismal functions can exhibit divergent thermal responses, some pesticide-affected showing as temperatures dropped, others rose. must therefore account environmental context determining risk. Moreover, evidence synergistic effects, just 3°C increase causing sudden drop performance, despite seeing no two temperatures. highlight importance studies quantify threats insects, which will help improve dynamic evaluations population tipping points spatiotemporal risks biodiversity regions.

Language: Английский

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Imidacloprid disrupts larval molting regulation and nutrient energy metabolism, causing developmental delay in honey bee Apis mellifera

eLife, Journal Year: 2024, Volume and Issue: 12

Published: March 11, 2024

Imidacloprid is a global health threat that severely poisons the economically and ecologically important honeybee pollinator, Apis mellifera . However, its effects on developing bee larvae remain largely unexplored. Our pilot study showed imidacloprid causes developmental delay in larvae, but underlying toxicological mechanisms incompletely understood. In this study, we exposed to at environmentally relevant concentrations of 0.7, 1.2, 3.1, 377 ppb. There was marked dose-dependent larval development, characterized by reductions body mass, width, growth index. did not affect survival food consumption. The primary induced elevated (377 ppb) included inhibition neural transmission gene expression, induction oxidative stress, gut structural damage, apoptosis, regulatory hormones genes, suppression expression levels involved proteolysis, amino acid transport, protein synthesis, carbohydrate catabolism, phosphorylation, glycolysis energy production. addition, found may use antioxidant defenses P450 detoxification mitigate imidacloprid. Ultimately, provides first evidence can development disrupting molting regulation limiting metabolism utilization dietary nutrients energy. These findings have broader implications for studies assessing pesticide hazards other juvenile animals.

Language: Английский

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Acute exposure to glufosinate-ammonium induces hepatopancreas toxicity in juvenile Chinese mitten crab (Eriocheir sinensis)

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 488, P. 137487 - 137487

Published: Feb. 4, 2025

Language: Английский

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Pollen protein and lipid content influence resilience to insecticides in honey bees (Apis mellifera)

Journal of Experimental Biology, Journal Year: 2021, Volume and Issue: 224(9)

Published: March 23, 2021

ABSTRACT In honey bees (Apis mellifera), there is growing evidence that the impacts of multiple stressors can be mitigated by quality nutrition. Pollen, which primary source protein and lipids in bee diets, particularly critical for generating more resilient phenotypes. Here, we evaluated relationship between pollen to lipid (P:L) ratio insecticide resilience. We hypothesized diets richer would lead increased survival exposed insecticides, as pollen-derived have previously been shown improve resilience pathogens parasites. Furthermore, metabolic processes are altered insecticides. fed age-matched different P:L ratios altering a base either adding (casein powder) or (canola oil) simulating chronic exposure feeding an organophosphate (chlorpyrifos). also tested naturally determine whether results were consistent. Linear regression analysis revealed mean time was best explained concentration (P=0.04, adjusted R2=0.92), natural (P=0.008, R2=0.93). Our indicate higher dietary negative effect on physiology when combined with exposure, while lower positive effect. These suggest intake differentially influence response bees, laying groundwork future studies development improved diets.

Language: Английский

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Neonicotinoids disrupt memory, circadian behaviour and sleep

Scientific Reports, Journal Year: 2021, Volume and Issue: 11(1)

Published: Jan. 21, 2021

Abstract Globally, neonicotinoids are the most used insecticides, despite their well-documented sub-lethal effects on beneficial insects. Neonicotinoids nicotinic acetylcholine receptor agonists. Memory, circadian rhythmicity and sleep essential for efficient foraging pollination require signalling. The effect of field-relevant concentrations European Union-banned neonicotinoids: imidacloprid, clothianidin, thiamethoxam thiacloprid were tested Drosophila memory, rhythms sleep. Field-relevant clothianidin disrupted learning, behavioural whilst exposure only affected Exposure to imidacloprid prevented day/night remodelling accumulation pigment dispersing factor (PDF) neuropeptide in dorsal terminals clock neurons. Knockdown neonicotinoid susceptible Dα1 Dβ2 subunits mushroom bodies or neurons recapitulated like deficits memory sleep/circadian behaviour respectively. Disruption likely have far-reaching detrimental insects field.

Language: Английский

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Low doses of the organic insecticide spinosad trigger lysosomal defects, elevated ROS, lipid dysregulation, and neurodegeneration in flies

eLife, Journal Year: 2022, Volume and Issue: 11

Published: Feb. 22, 2022

Large-scale insecticide application is a primary weapon in the control of insect pests agriculture. However, growing body evidence indicates that it contributing to global decline population sizes many beneficial species. Spinosad emerged as an organic alternative synthetic insecticides and considered less harmful insects, yet its mode action remains unclear. Using

Language: Английский

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Insect cuticle and insecticide development

Archives of Insect Biochemistry and Physiology, Journal Year: 2023, Volume and Issue: 114(4)

Published: Oct. 15, 2023

Abstract Insecticide resistance poses a significant challenge, diminishing the effectiveness of chemical insecticides. To address this global concern, development novel and efficient pest management technologies based on insecticides is an ongoing necessity. The insect cuticle, highly complex continuously renewing organ, plays crucial role in context. On one hand, as most vital structure, it serves suitable target for other acts outermost barrier, isolating insect's inner organs from environment, thus offering to contact with insecticides, preventing their entry into bodies. Our work focuses key targets concerning cuticle formation interaction between Deeper studying cuticles understanding structure–function relationship, process, regulatory mechanisms during development, well investigating insecticide related barrier properties cuticles, are promising strategies not only developing but also discovering general synergists With comprehensive review, we hope contribute valuable insights effective solutions mitigation resistance.

Language: Английский

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Host-pathogen interaction in arthropod vectors: Lessons from viral infections

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Jan. 31, 2023

Haematophagous arthropods can harbor various pathogens including viruses, bacteria, protozoa, and nematodes. Insects possess an innate immune system comprising of both cellular humoral components to fight against infections. Haemocytes, the haemolymph, are central insect as their primary functions include phagocytosis, encapsulation, coagulation, detoxification, storage distribution nutritive materials. Plasmatocytes granulocytes also involved in defense responses. Blood-feeding arthropods, such mosquitoes ticks, harbour a variety viral that cause infectious diseases human animal hosts. Therefore, it is imperative study virus-vector-host relationships since arthropod vectors important constituents ecosystem. Regardless complex response these vectors, viruses usually manage survive transmitted eventual host. A multidisciplinary approach utilizing novel strategic interventions required control ectoparasite infestations block vector-borne transmission humans animals. In this review, we discuss infections with focus on responses ticks mosquitoes. We aim summarize critically vector infection strategies mammalian hosts foster debate could help developing new therapeutic protect arthropod-borne

Language: Английский

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