Long-COVID Syndrome and the Cardiovascular System: A Review of Neurocardiologic Effects on Multiple Systems

Current Cardiology Reports, Journal Year: 2022, Volume and Issue: 24(11), P. 1711 - 1726

Published: Sept. 30, 2022

Language: Английский

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The relevance of pacing strategies in managing symptoms of post-COVID-19 syndrome

Journal of Translational Medicine, Journal Year: 2023, Volume and Issue: 21(1)

Published: June 8, 2023

Post-COVID-19 syndrome (PCS) shares many features with myalgic encephalomyelitis/chronic fatigue (ME/CFS). PCS represents a major health issue worldwide because it severely impacts patients' work activities and their quality of life. In the absence treatment for both conditions given beneficial effect pacing strategies in ME/CFS, we conducted this study to assess effectiveness patients.We retrospectively included patients meeting World Health Organization definition who attended Internal Medicine Department Angers University Hospital, France between June 2020 2022, were followed up until December 2022. Pacing systematically proposed all patients. Their medical records reviewed data related baseline follow-up assessments collected. This epidemiological characteristics, COVID-19 symptoms associated conditions, features, perceived status, employment activity, degree adherence assessed by engagement subscale (EPS). Recovery was defined as ability return work, improvement regarded reduction number severity symptoms.A total 86 followed-up median time 10 [6-13] months. rates 33.7% 23.3%, respectively. The EPS score only variable significantly recovery on multivariate analysis (OR 40.43 [95% CI 6.22-262.6], p < 0.001). Patients better adhered (high scores) experienced higher (60-33.3% respectively) than those low (5.5-5.5% respectively), or moderate (4.3-17.4% scores.Our findings demonstrated that is effective management PCS, high levels are outcomes.

Language: Английский

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Metabolic alterations upon SARS-CoV-2 infection and potential therapeutic targets against coronavirus infection

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: June 7, 2023

Abstract The coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection has become a global pandemic due to the high viral transmissibility and pathogenesis, bringing enormous burden our society. Most patients infected are asymptomatic or have mild symptoms. Although only small proportion of progressed severe COVID-19 with symptoms including acute respiratory distress syndrome (ARDS), disseminated coagulopathy, cardiovascular disorders, is accompanied mortality rates near 7 million deaths. Nowadays, effective therapeutic patterns for still lacking. It been extensively reported that host metabolism plays essential roles in various physiological processes during virus infection. Many viruses manipulate avoid immunity, facilitate their own replication, initiate pathological response. Targeting interaction between holds promise developing strategies. In this review, we summarize discuss recent studies dedicated uncovering role life cycle aspects entry, assembly, pathogenesis an emphasis on glucose lipid metabolism. Microbiota long also discussed. Ultimately, recapitulate metabolism-modulating drugs repurposed statins, ASM inhibitors, NSAIDs, Montelukast, omega-3 fatty acids, 2-DG, metformin.

Language: Английский

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Laboratory Findings and Biomarkers in Long COVID: What Do We Know So Far? Insights into Epidemiology, Pathogenesis, Therapeutic Perspectives and Challenges

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(13), P. 10458 - 10458

Published: June 21, 2023

Long COVID (LC) encompasses a constellation of long-term symptoms experienced by at least 10% people after the initial SARS-CoV-2 infection, and so far it has affected about 65 million people. The etiology LC remains unclear; however, many pathophysiological pathways may be involved, including viral persistence; chronic, low-grade inflammatory response; immune dysregulation defective reactivation latent viruses; autoimmunity; persistent endothelial dysfunction coagulopathy; gut dysbiosis; hormonal metabolic dysregulation; mitochondrial dysfunction; autonomic nervous system dysfunction. There are no specific tests for diagnosis LC, clinical features laboratory findings biomarkers not specifically relate to LC. Therefore, is paramount importance develop validate that can employed prediction, prognosis its therapeutic response, although this effort hampered challenges pertaining non-specific nature majority manifestations in spectrum, small sample sizes relevant studies other methodological issues. Promising candidate found some patients markers systemic inflammation, acute phase proteins, cytokines chemokines; reflecting persistence, herpesviruses endotheliopathy, coagulation fibrinolysis; microbiota alterations; diverse proteins metabolites; biomarkers; cerebrospinal fluid biomarkers. At present, there only two reviews summarizing they do cover entire umbrella current biomarkers, their link etiopathogenetic mechanisms or diagnostic work-up comprehensive manner. Herein, we aim appraise synopsize available evidence on typical classification based pathogenetic main symptomatology frame epidemiological aspects syndrome furthermore assess limitations as well potential implications interventions.

Language: Английский

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Oxidative Damage and Post-COVID Syndrome: A Cross-Sectional Study in a Cohort of Italian Workers

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(8), P. 7445 - 7445

Published: April 18, 2023

In addition to the acute symptoms after infection, patients and society are also being challenged by long-term effects of COVID-19, known as long COVID. Oxidative stress, a pivotal point in pathophysiology could potentially be involved development post-COVID syndrome. The aim present study was evaluate relationship between changes oxidative status persistence long-COVID workers with previous mild COVID-19 infection. A cross-sectional conducted among 127 employees an Italian university (80 47 healthy subjects). TBARS assay used detect malondialdehyde serum levels (MDA), while total hydroperoxide (TH) production measured d-ROMs kit. significant difference mean MDA values found previously infected subjects controls (4.9 µm vs. 2.8 µm, respectively). Receiver–operating characteristic (ROC) curves showed high specificity good sensibility (78.7% 67.5%, respectively) for levels. random forest classifier identified hematocrit value, levels, IgG titer against SARS-CoV-2 features highest predictive value distinguishing 34 from 46 asymptomatic subjects. damage persists suggesting possible role stress mediators pathogenesis

Language: Английский

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