Unraveling the secrets: Evolution of resistance mediated by membrane proteins

Drug Resistance Updates, Journal Year: 2024, Volume and Issue: 77, P. 101140 - 101140

Published: Aug. 16, 2024

Membrane protein-mediated resistance is a multidisciplinary challenge that spans fields such as medicine, agriculture, and environmental science. Understanding its complexity devising innovative strategies are crucial for treating diseases like cancer managing resistant pests in agriculture. This paper explores the dual nature of mechanisms across different organisms: On one hand, animals, bacteria, fungi, plants, insects exhibit convergent evolution, leading to development similar mechanisms. other influenced by diverse pressures structural differences among organisms, they also demonstrate divergent characteristics. prevalent insects, reflecting their shared survival evolved through evolution address challenges. However, variations ecological environments biological characteristics result differing responses resistance. Therefore, examining these not only enhances our understanding adaptive but provides theoretical support insights addressing drug advancing pharmaceutical development.

Language: Английский

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Exploring the adaptation mechanism of Spodoptera litura to xanthotoxin: Insights from transcriptional responses and CncC signaling pathway-mediated UGT detoxification

Insect Biochemistry and Molecular Biology, Journal Year: 2025, Volume and Issue: unknown, P. 104259 - 104259

Published: Jan. 1, 2025

Language: Английский

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Identification of inducible CYP3 and CYP4 genes associated with abamectin tolerance in the fat body and Malpighian tubules of Spodoptera litura

Pesticide Biochemistry and Physiology, Journal Year: 2023, Volume and Issue: 198, P. 105751 - 105751

Published: Dec. 21, 2023

Language: Английский

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Expression reduction and a variant of a P450 gene mediate chlorpyrifos resistance in Tetranychus urticae Koch

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

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Intercropping-induced leaf metabolic changes increase plant resistance to herbivory

Plant and Soil, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 11, 2024

Language: Английский

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Molecular insights into the functional analysis of P450 CYP321A7 gene in the involvement of detoxification of lambda-cyhalothrin in Spodoptera frugiperda

Pesticide Biochemistry and Physiology, Journal Year: 2024, Volume and Issue: 203, P. 106009 - 106009

Published: July 2, 2024

Language: Английский

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Identification of the CYPome associated with acetamiprid resistance based on the chromosome‐level genome of Megalurothrips usitatus (Bagnall) (Thysanoptera: Thripidae)

Pest Management Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Abstract BACKGROUND The bean flower thrips, Megalurothrips usitatus , poses a great threat to cowpea and other legume cultivars. Chemical insecticides have been applied control M. but resulted in little profit because of the rapid evolution insecticide resistance. To characterize potential resistance mechanisms we sequenced assembled chromosome‐level genome by combining PacBio sequencing Hi‐C technology using susceptible population. RESULTS size was 248.60 Mb contained 14 128 protein‐coding genes. expansion genes were enriched functional categories heme binding monooxygenase activity. We further identified 103 cytochrome P450 from genome, 33 which belonged CYP6 family. Ten significantly overexpressed an acetamiprid‐resistant population . An RNA interference bioassay showed that knockdown CYP6FW1 CYP6GM5 CYP6GM6 CYP6GM7 reduced acetamiprid resistant In addition, expression all four could be induced exposure. AlphaFold2‐based homology modeling molecular docking analysis proteins with relevance had relatively lower free energy molecule. CONCLUSION This study provides reference gene resources for future studies on related pest species, highlights importance P450s this insect. © 2025 Society Industry.

Language: Английский

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Transcriptome Analysis of Insecticide Resistance Mechanisms in Field Populations of the Bean Flower Thrips, Megalurothrips Usitatus (Bagnall)

Published: Jan. 1, 2025

Language: Английский

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Monitoring insecticide resistance and target-site mutations in field populations of Spodoptera frugiperda (Lepidoptera: Noctuidae) in China

Journal of Economic Entomology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

The fall armyworm Spodoptera frugiperda (J. E. Smith) (Lepidoptera: Noctuidae), a notorious invasive pest, has been widely monitored for insecticide resistance. Since its invasion of China in late 2018, early to mid-stage monitoring resistance is particularly crucial inform effective control strategies. Resistance ratios (RRs) derived from bioassays offer valuable insights into the overall levels field populations, while detection allele frequencies helps uncover potential causes variation. In this study, we established baseline susceptibility third-instar larvae 7 insecticides using laboratory strain Xinzheng2019 and assessed 9 populations collected central southern between 2022 2023. Compared susceptible strain, 2 showed low-level (RR = 5-10) indoxacarb, one exhibited chlorantraniliprole. Minor 3-5) was observed lambda-cyhalothrin, 5 All remained < 3) spinetoram, emamectin benzoate, chlorfenapyr, lufenuron. Molecular analysis 11 mutation sites across 3 key resistance-related genes (Ace-1, GluCl, voltage-gated sodium channel [VGSC]) revealed that 52.1% all tested samples carried either homozygous or heterozygous alleles at F290V locus Ace-1 gene, no mutations were detected other sites. Our findings status S. provide guidance chemical use.

Language: Английский

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Functional analysis of the epsilon glutathione S-transferases in the adaptation of Spodoptera litura to xanthotoxin

Insect Biochemistry and Molecular Biology, Journal Year: 2025, Volume and Issue: 180, P. 104299 - 104299

Published: March 10, 2025

Language: Английский

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