Limosilactobacillus-related 3-OMDP as a potential therapeutic target for depression DOI Creative Commons
Qi Zhong, Wentao Wu,

Jing Xie

et al.

Annals of Medicine, Journal Year: 2024, Volume and Issue: 56(1)

Published: Oct. 18, 2024

Objective Gut microbiota was closely involved in the pathogenesis of depression, but underlying molecular mechanisms depression remained unclear. This study conducted to investigate relationship between neurotransmitters/inflammatory factors and gut depressed mice.

Language: Английский

Exploring Phytochemicals and Their Pharmacological Applications from Ethnomedicinal Plants: A Focus on Lycium barbarum, Solanacea DOI Creative Commons
B.B. BAIMAKHANOVA, А.К. САДАНОВ, Andrey Bogoyavlenskiy

et al.

Heliyon, Journal Year: 2025, Volume and Issue: 11(2), P. e41782 - e41782

Published: Jan. 1, 2025

Lycium barbarum is a species commonly utilized in dietary supplements and natural healthcare products. also referred to as wolfberry or goji berry, are predominantly found China, Japan, Korea, North America. has lengthy history medicinal functional food. Recent studies showcasing their exceptional bioac-tive properties have led an increase cultivation popularity worldwide. been recognized valuable source of ingredients with promising applications the food medical sectors. rich phytochemical compounds such polysaccharides, carotenoids, organic acids, carbohydrates (fructose glucose), phenolic (such acids flavonoids), vitamins (ascorbic acid). Various biological activities, including antimicrobial, anti-inflammatory, prebiotic, neuroprotective, antidiabetic, gastroprotective effects, linked consumption. The purpose this review provide comprehensive overview components well active barbarum.

Language: Английский

Citations

1
Multi-effects of natural plant bioactive components on intestinal health in pigs: promising feed-antibiotic alternatives? DOI

Zhuan Song,

Peng Li, Mengjun Wu

et al.

Journal of Nutrition, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

1
Turtle peptide and its derivative peptide ameliorated DSS-induced ulcerative colitis by inhibiting inflammation and modulating the composition of the gut microbiota DOI
Hai‐Xiang Guo, Bingbing Wang, Hongyu Wu

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 132, P. 112024 - 112024

Published: April 11, 2024

Language: Английский

Citations

7
The combination of HSI and NMR techniques with deep learning for identification of geographical origin and GI markers of Lycium barbarum L. DOI
Chengcheng He, Xin Shi,

Lin Haifeng

et al.

Food Chemistry, Journal Year: 2024, Volume and Issue: 461, P. 140903 - 140903

Published: Aug. 22, 2024

Language: Английский

Citations

6
Kombucha polysaccharide alleviates DSS-induced colitis in mice by modulating the gut microbiota and remodeling metabolism pathways DOI Creative Commons
Zhong‐Hao Ji,

Wen‐Yin Xie,

Pei‐Sen Zhao

et al.

Frontiers in Microbiomes, Journal Year: 2024, Volume and Issue: 3

Published: Feb. 7, 2024

Ulcerative colitis (UC) is incurable, and rational dietary interventions are important in preventing UC. Kombucha a fermented beverage that originated China has variety of activities, including antioxidant, antibacterial hypoglycemic activities. The aim this study was to analyze the protective effect polysaccharide (KP) against UC determine its mechanism action. results showed KP intervention effective alleviating dextran sulfate sodium salt (DSS)-induced symptoms inhibiting DSS-induced inflammation oxidative stress. Moreover, able reduce intestinal permeability, promote expression tight junction proteins, help maintain thrush cell numbers mucus secretion. 16S rDNA indicated increased abundance Rikenellaceae_RC9_gut_group Clostridiales_unclassified . Untargeted metabolomics techniques revealed can reverse disorders metabolism. This demonstrated alleviated by helping barrier integrity, regulating gut microbiota remodeling metabolism pathways. findings provide theoretical basis for application as supplement prevention

Language: Английский

Citations

4
Polysaccharides from Lycium barbarum, yam, and sunflower ameliorate colitis in a structure and intrinsic flora-dependent manner DOI
Shanshan Zhang,

Ruchen Zhou,

Xiaoran Xie

et al.

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 349, P. 122905 - 122905

Published: Oct. 30, 2024

Language: Английский

Citations

4
Huanglian Ejiao Decoction Alleviates Ulcerative Colitis in Mice Through Regulating the Gut Microbiota and Inhibiting the Ratio of Th1 and Th2 Cells DOI Creative Commons
Jingyi Tang,

Yingnan Hu,

Jintao Fang

et al.

Drug Design Development and Therapy, Journal Year: 2025, Volume and Issue: Volume 19, P. 303 - 324

Published: Jan. 1, 2025

Huanglian-ejiao decoction (HED) is a Chinese traditional medicinal formula evolved from the Shanghan Lun (Treatise on Febrile Diseases). However, HED ultimate mechanism of action remained indistinct. Therefore, this study aimed to investigate whether could exert anti-inflammatory effects 2,4,6-Trinitrobenzenesulfonic acid (TNBS)-induced colitis (UC) model through regulation CD4+T subsets and gut microbiota. Fifty-eight major compounds in were identified by UPLC-Q-TOF/MS. The therapeutic efficacy UC was assessed evaluating survival rate so on. Flow cytometry employed assay percentages cell. RT-PCR Western blot took advantage detecting transcription factors, inflammatory tight junction proteins. Transcriptome sequencing performed colon tissue 16S rRNA gene enforced intestinal contents. administration enhanced mice, significantly restored body weight, DAI score, weight index, spleen index. effectively reshaped barrier dysfunction, inhibited ratio Th1 Th2 cells, preserved Th2/Th1 Tregs/Th17 balance. Moreover, notably decreased secretion factors related cytokines. Interestingly, also exerts regulatory dysbiosis cumulative plenteous beneficial probiotics like Lactobacillus Bacteroides, while inhibiting overgrowth opportunistic pathogens such as Helicobacter. cell balance, well modulation microbiota HED, provides further experimental evidence for feasibility its treatment UC.

Language: Английский

Citations

0
Dental problems and oral microbiome alterations in ulcerative colitis DOI Creative Commons
Robert Kucharski, Bartosz Kamil Sobocki, Ewa Stachowska

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 5, 2025

Ulcerative colitis is a chronic disease that has not well-established etiology. The role of microbial dysregulation in its pathogenesis been recently highlighted. Overall, microbiome alterations concern the reduction bacterial abundance and diversity, resulting gut imbalance negatively affecting immunological aspects. There link between ulcerative oral microbiome. changes are found at many levels, from gently dysbiotic composition to presence main periodontal microbes. analysis can be part personalized medicine due fact it potential biomarker. Patients with may manifest dental symptoms/problems, such as periodontitis (strongly related red-complex pathogens— Porphyromonas gingivalis , Tannerella forsythia Treponema denticola bacteria belonging other complexes, Fusobacterium nucleatum Aggregatibacter actinomycetecomitans ), caries, ulcerations, leukoplakia, halitosis, others. Notably, DMFT (Decayed, Missing, Filled Teeth) index higher these patients compared healthy subjects. According some data, lichen planus (which an background) also observed patients. It seems deep understanding association microbiome, immunology, manifestations crucial provide complex treatment point view.

Language: Английский

Citations

0
Sodium butyrate alleviates DSS-induced inflammatory bowel disease by inhibiting ferroptosis and modulating ERK/STAT3 signaling and intestinal flora DOI Creative Commons

Yingyin Liu,

Nan Chen, Han He

et al.

Annals of Medicine, Journal Year: 2025, Volume and Issue: 57(1)

Published: March 3, 2025

Background Inflammatory bowel disease (IBD), encompassing Crohn's (CD) and ulcerative colitis (UC), can seriously impact patients' quality of life. Sodium butyrate (NaB), a product dietary fiber fermentation, has been shown to alleviate IBD symptoms. Some studies have that it is related ferroptosis. However, the precise mechanism linking NaB, IBD, ferroptosis not clear.

Language: Английский

Citations

0
Angelica gigas Nakai hot water extracts alleviate IL-6-induced ulcerative colitis by restoring intestinal barrier function DOI
Ye Yang,

Min Jung Kim,

Ji Woong Heo

et al.

Molecular & Cellular Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Language: Английский

Citations

0