Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 21, 2024
Language: Английский
Heliyon, Journal Year: 2025, Volume and Issue: 11(2), P. e41782 - e41782
Published: Jan. 1, 2025
Lycium barbarum is a species commonly utilized in dietary supplements and natural healthcare products. also referred to as wolfberry or goji berry, are predominantly found China, Japan, Korea, North America. has lengthy history medicinal functional food. Recent studies showcasing their exceptional bioac-tive properties have led an increase cultivation popularity worldwide. been recognized valuable source of ingredients with promising applications the food medical sectors. rich phytochemical compounds such polysaccharides, carotenoids, organic acids, carbohydrates (fructose glucose), phenolic (such acids flavonoids), vitamins (ascorbic acid). Various biological activities, including antimicrobial, anti-inflammatory, prebiotic, neuroprotective, antidiabetic, gastroprotective effects, linked consumption. The purpose this review provide comprehensive overview components well active barbarum.
Language: Английский
Citations
1
Journal of Nutrition, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 1, 2025
Language: Английский
Citations
1
Annals of Medicine, Journal Year: 2025, Volume and Issue: 57(1)
Published: March 3, 2025
Background Inflammatory bowel disease (IBD), encompassing Crohn's (CD) and ulcerative colitis (UC), can seriously impact patients' quality of life. Sodium butyrate (NaB), a product dietary fiber fermentation, has been shown to alleviate IBD symptoms. Some studies have that it is related ferroptosis. However, the precise mechanism linking NaB, IBD, ferroptosis not clear.
Language: Английский
Citations
1
International Immunopharmacology, Journal Year: 2024, Volume and Issue: 132, P. 112024 - 112024
Published: April 11, 2024
Language: Английский
Citations
7
Food Chemistry, Journal Year: 2024, Volume and Issue: 461, P. 140903 - 140903
Published: Aug. 22, 2024
Language: Английский
Citations
6
Frontiers in Microbiomes, Journal Year: 2024, Volume and Issue: 3
Published: Feb. 7, 2024
Ulcerative colitis (UC) is incurable, and rational dietary interventions are important in preventing UC. Kombucha a fermented beverage that originated China has variety of activities, including antioxidant, antibacterial hypoglycemic activities. The aim this study was to analyze the protective effect polysaccharide (KP) against UC determine its mechanism action. results showed KP intervention effective alleviating dextran sulfate sodium salt (DSS)-induced symptoms inhibiting DSS-induced inflammation oxidative stress. Moreover, able reduce intestinal permeability, promote expression tight junction proteins, help maintain thrush cell numbers mucus secretion. 16S rDNA indicated increased abundance Rikenellaceae_RC9_gut_group Clostridiales_unclassified . Untargeted metabolomics techniques revealed can reverse disorders metabolism. This demonstrated alleviated by helping barrier integrity, regulating gut microbiota remodeling metabolism pathways. findings provide theoretical basis for application as supplement prevention
Language: Английский
Citations
4
Critical Reviews in Food Science and Nutrition, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 18
Published: Oct. 16, 2024
Akkermansia muciniphila (A. muciniphila) has gained recognition as a pioneering probiotic, exhibiting considerable potential to enhance immune conditions across both humans and animals. The health benefits of A. are attributed its various components, including outer membrane proteins (PilQ Amuc_1100), secreted (P9 AmTARS), extracellular vesicles, metabolites such SCFAs, ornithine lipids, γ-aminobutyric acid, cobalamin, inosine. dynamic control the mucus layer by plays crucial role in regulating intestinal mucosal immunity. Furthermore, modulates function interacting with macrophages, dendritic cells, T lymphocytes, Paneth cells. Increasing abundance gut through nutritional strategies represents safe effective means augment function. Various polyphenols, oligosaccharides, polysaccharides have been shown elevate levels this bacterium, thereby contributing favorable immunoregulatory outcomes. This paper delves into latest research advancements related probiotic mechanisms provides an overview current understanding how responds nutrients. These insights offer theoretical foundation for utilization immunoregulation.
Language: Английский
Citations
4
Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 349, P. 122905 - 122905
Published: Oct. 30, 2024
Language: Английский
Citations
4
Drug Design Development and Therapy, Journal Year: 2025, Volume and Issue: Volume 19, P. 303 - 324
Published: Jan. 1, 2025
Huanglian-ejiao decoction (HED) is a Chinese traditional medicinal formula evolved from the Shanghan Lun (Treatise on Febrile Diseases). However, HED ultimate mechanism of action remained indistinct. Therefore, this study aimed to investigate whether could exert anti-inflammatory effects 2,4,6-Trinitrobenzenesulfonic acid (TNBS)-induced colitis (UC) model through regulation CD4+T subsets and gut microbiota. Fifty-eight major compounds in were identified by UPLC-Q-TOF/MS. The therapeutic efficacy UC was assessed evaluating survival rate so on. Flow cytometry employed assay percentages cell. RT-PCR Western blot took advantage detecting transcription factors, inflammatory tight junction proteins. Transcriptome sequencing performed colon tissue 16S rRNA gene enforced intestinal contents. administration enhanced mice, significantly restored body weight, DAI score, weight index, spleen index. effectively reshaped barrier dysfunction, inhibited ratio Th1 Th2 cells, preserved Th2/Th1 Tregs/Th17 balance. Moreover, notably decreased secretion factors related cytokines. Interestingly, also exerts regulatory dysbiosis cumulative plenteous beneficial probiotics like Lactobacillus Bacteroides, while inhibiting overgrowth opportunistic pathogens such as Helicobacter. cell balance, well modulation microbiota HED, provides further experimental evidence for feasibility its treatment UC.
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: Feb. 5, 2025
Ulcerative colitis is a chronic disease that has not well-established etiology. The role of microbial dysregulation in its pathogenesis been recently highlighted. Overall, microbiome alterations concern the reduction bacterial abundance and diversity, resulting gut imbalance negatively affecting immunological aspects. There link between ulcerative oral microbiome. changes are found at many levels, from gently dysbiotic composition to presence main periodontal microbes. analysis can be part personalized medicine due fact it potential biomarker. Patients with may manifest dental symptoms/problems, such as periodontitis (strongly related red-complex pathogens— Porphyromonas gingivalis , Tannerella forsythia Treponema denticola bacteria belonging other complexes, Fusobacterium nucleatum Aggregatibacter actinomycetecomitans ), caries, ulcerations, leukoplakia, halitosis, others. Notably, DMFT (Decayed, Missing, Filled Teeth) index higher these patients compared healthy subjects. According some data, lichen planus (which an background) also observed patients. It seems deep understanding association microbiome, immunology, manifestations crucial provide complex treatment point view.
Language: Английский
Citations
0