Journal of Functional Foods,
Journal Year:
2024,
Volume and Issue:
115, P. 106120 - 106120
Published: March 7, 2024
Population
aging
has
led
to
an
increased
interest
in
various
dietary
supplements
order
preserve
cognitive
function.
The
aim
of
our
study
was
examine
the
effects
Hericium
erinaceus
supplementation
(HE)
on
function
and
serum
levels
Brain-Derived
Neurotrophic
Factor
(BDNF)
Neuropeptide
Y
(NPY).
An
8-week
double-blind
comparative
involved
33
subjects,
randomly
assigned
a
HE
group
placebo
(P)
group.
Anthropometric
measurements
analyses
selected
biochemical
parameters
were
performed
before
after
intervention.
Simultaneously,
faecal
samples
collected
determine
gut
microbiota
chitinase
3-like-1
(CHI3L1)
levels.
Cognitive
assessed
using
two
non-verbal
speed
tests.
In
group,
significant
improvement
ability
observed
when
corresponding
scores
at
baseline,
CHI3L1
level,
age,
gender
considered.
Moreover,
there
increase
diversity
that
positively
correlated
NPY
mechanism
could
help
explain
results
relationship
between
active
ingredients
H.
point
activity
may
enhance
bioavailability
bioactive
ingredients.
Supplementing
diet
with
recognised
as
safe
well-tolerated
intervention
neurocognitive
benefit.
Zeitschrift für Neuropsychologie,
Journal Year:
2023,
Volume and Issue:
34(2), P. 57 - 70
Published: May 24, 2023
Abstract:
Cognitive
sequelae
after
recovery
from
an
initial
COVID-19
disease
are
present
in
a
subset
of
affected
individuals,
coalescing
around
several
important
issues
such
as
effects
age,
severity,
comorbidities,
and
other
factors.
Some
neuropsychological
symptoms
appear
more
common
among
certain
patient
populations.
Comorbidities
may
complicate
assessment
well.
Hence,
we
need
guideline-based
evaluation
to
guide
rehabilitation.
Drawing
the
recent
revision
German
National
Guideline
for
Long-
Post-COVID
Syndrome
current
advances
international
guidance
on
assessment,
this
article
provides
practical
scientifically
informed
recommendations
individuals
recovering
coronavirus-related
diseases.
Food & Function,
Journal Year:
2024,
Volume and Issue:
15(12), P. 6523 - 6535
Published: Jan. 1, 2024
PS23
supplementation
raises
ghrelin
levels
and
optimizes
the
gut
microbiota,
linked
to
improved
exercise
outcomes
reduced
inflammation,
promoting
muscle
recovery.
Biomedicines,
Journal Year:
2025,
Volume and Issue:
13(3), P. 697 - 697
Published: March 12, 2025
Background/Objectives:
Cortisol
levels
are
increased
in
stressful
situations
but
can
also
result
from
a
history
of
COVID-19
infection.
Long-term
exposure
to
high
cortisol
has
destructive
effect
on
the
CNS
(Central
Nervous
System)
and
lead
depression,
among
other
things.
The
most
commonly
used
psychotropic
drugs
reduce
concentrations.
Methods:
aim
our
study
was
develop
an
analytical
method
determine
level
hormone
small
volume
saliva
(200
µL)
patients
using
CNS-active
drugs.
Solid-phase
extraction
isolate
analyte,
determination
performed
by
liquid
chromatography
with
diode
array
detector
(LC
DAD).
Results:
developed
validated.
Its
linearity
determined
be
range
4–500
ng/mL
(R2
>
0.9986)
intra-
inter-day
precision
expressed
as
coefficient
variation
(CV%)
did
not
exceed
12%.
then
applied
post-COVID-19-recovered
healthy
volunteers.
were
12.24
±
7.33
recovered
4.11
1.46
subjects,
respectively.
A
comparison
results
showed
that
volunteers
significantly
different
statistically.
Conclusions:
allowed
for
saliva.
Comparison
concentration
individuals
recoveries
indicates
both
groups
differed
statistically,
patients.
obtained
indicate
concentrations
Neuropsychiatric Disease and Treatment,
Journal Year:
2023,
Volume and Issue:
Volume 19, P. 811 - 828
Published: April 1, 2023
Abstract:
A
healthy
stress
response
is
critical
for
good
mental
and
overall
health
promotes
neuronal
growth
adaptation,
but
the
intricately
balanced
biological
mechanisms
that
facilitate
a
can
also
result
in
predisposition
to
disease
when
equilibrium
disrupted.
The
hypothalamic-pituitary-adrenal
(HPA)
axis
neuroendocrine
system
plays
role
body's
adaptation
stress,
vasopressinergic
regulation
of
HPA
maintaining
responsiveness
during
chronic
stress.
However,
exposure
repeated
or
excessive
physical
emotional
trauma
shift
"new
normal"
underpinned
by
enduring
changes
function.
Exposure
early
life
due
adverse
childhood
experiences
lead
lasting
neurobiological
changes,
including
impairment
patients
with
depression
considered
among
most
reliable
findings
psychiatry,
has
been
shown
play
major
pathogenesis
onset
other
neuropsychiatric
disorders.
Modulating
activity,
example
via
targeted
antagonism
vasopressin
V
1b
receptor,
promising
approach
disorders
associated
impairment.
Despite
favorable
preclinical
indications
animal
models,
demonstration
clinical
efficacy
treatment
depressive
targeting
dysfunction
challenging,
possibly
heterogeneity
syndromal
nature
Measures
function,
such
as
elevated
cortisol
levels,
may
be
useful
biomarkers
identifying
who
benefit
from
treatments
modulate
activity.
Utilizing
identify
subsets
impaired
function
next
step
fine-tuning
activity
receptor.
Keywords:
allostatic
overload,
cortisol,
axis,
disorder,
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(9), P. 2196 - 2196
Published: May 5, 2023
Despite
the
known
effects
of
diet
on
gut
microbiota
composition,
not
many
studies
have
evaluated
relationship
between
distinct
dietary
patterns
and
microbiota.
The
aim
our
study
was
to
determine
whether
composition
could
be
a
useful
indicator
long-term
pattern.
We
collected
data
from
89
subjects
adhering
omnivorous,
vegetarian,
vegan,
low-carbohydrate,
high-fat
that
were
equally
distributed
groups
homogenous
by
age,
gender,
BMI.
Gut
analyzed
with
metabarcoding
approach
using
V4
hypervariable
region
16S
rRNA
gene.
K-means
clustering
at
genus
level
performed
nearest
neighbor
classifier
applied
predict
classes.
Our
results
suggest
is
subject’s
pattern,
exception
vegan
represented
high
abundance
Prevotella
9.
Based
model,
combination
26
variables
(anthropometric
measurements,
serum
biomarkers,
lifestyle
factors,
gastrointestinal
symptoms,
psychological
specific
nutrients
intake)
more
important
an
individual’s
cluster,
91%
accuracy,
than
intake
alone.
findings
serve
develop
strategies
educate
individuals
about
changes
some
modifiable
aiming
classify
them
into
clusters
favorable
health
markers,
independent
their
Food & Function,
Journal Year:
2022,
Volume and Issue:
13(17), P. 8907 - 8919
Published: Jan. 1, 2022
Nurses
often
experience
adverse
health
effects
associated
with
increasing
levels
of
work-related
stress.
Stress
may
induce
systemic
through
the
HPA
axis,
glucocorticoid
responses,
and
inflammatory
cascades.
Psychobiotics
help
alleviate
stress
associations
microbiota,
anti-inflammation
factors,
gut-brain
axis.
We
aimed
to
investigate
whether
interventions
a
psychobiotic,
heat-killed
(HK)-PS23
cells,
improve
perceived
stress,
anxiety,
related
biological
markers
among
highly
stressed
clinical
nurses.
This
double-blind,
randomized,
placebo-controlled
study
included
seventy
nurses
from
medical
center
in
Northern
Taiwan
who
scored
27
or
higher
on
10-item
version
Perceived
Scale
(PSS),
participants
were
randomized
into
either
taking
HK-PS23
placebo
for
8
weeks.
Baseline
endpoint
results
PSS,
Job
Scale,
State
Trait
Anxiety
Index
(STAI),
emotional
questionnaires,
gastrointestinal
severity
Trails
Marking
Tests,
blood
markers,
sleep
data
analyzed.
While
both
groups
demonstrated
improvements
most
measures
over
time,
only
cortisol
measure
significant
group
differences
after
8-week
trial.
Further
analyses
subgroup
anxiety
(nurses
STAI
≥
103)
revealed
that
states
had
improved
significantly
but
not
group.
In
summary,
this
trial
found
reduction
level
weeks
use.
The
distinctive
anxiolytic
be
beneficial
improving
hormone
female
under
pressure.
Clinical
registration:
https://clinicaltrials.gov/,
identifier:
NCT04452253-sub-project
1.
Bulletin of the Chemical Society of Ethiopia,
Journal Year:
2023,
Volume and Issue:
37(4), P. 845 - 857
Published: May 12, 2023
ABSTRACT.
This
work
explicates
a
simple,
rapid,
and
sensitive
method
for
the
electrochemical
detection
of
dopamine
(DOP)
utilising
1-phenyl-3-methyl-4-orthofluorobenzoyl-5-pyrazolone
(HPMoFBP)/multiwalled
carbon
nanotube
(MWCNT)
paste
electrode
(CPE).
The
behaviour
DOP
was
performed
through
cyclic
voltammetry
square
wave
voltammetry.
HPMoFBP/MWCNT
showed
higher
current
at
lower
potential
oxidation
compared
to
bare
MWCNT.
sensor's
improved
electrocatalytic
activity
observed
detect
in
1.0
x
10-1
M
phosphate
buffer
saline
(PBS)
solution
pH
8.0.
A
good
linear
regression
analysis
between
electrical
response
concentration
range
1
1000
µM.
Under
optimized
experimental
conditions,
10-7
has
been
determined
as
limit
(LOD).
sensor
expressed
considerable
sensitivity
towards
without
interference
is
successfully
used
determine
hydrochloride
injection.
KEY
WORDS:
Electrochemical
sensor,
Dopamine,
Pyrazolone,
MWCNT,
Voltammetry
Bull.
Chem.
Soc.
Ethiop.
2023,
37(4),
845-857.
DOI:
https://dx.doi.org/10.4314/bcse.v37i4.4
Biomarkers,
Journal Year:
2024,
Volume and Issue:
29(1), P. 18 - 29
Published: Jan. 2, 2024
Biomarkers
can
be
used
to
identify
determinants
of
response
various
treatments
mental
disorders.
Evidence
date
demonstrates
that
markers
inflammatory,
neurotransmitter,
neurotrophic,
neuroendocrine,
and
metabolic
function
predict
the
psychological
physical
consequences
depression
in
individuals,
allowing
for
development
new
therapeutic
targets
with
fewer
side
effects.
Extensive
research
has
included
hundreds
potential
biomarkers
depression,
but
their
roles
abnormal
patients,
how
bioinformatics
improve
diagnosis,
treatment,
prognosis
have
not
been
determined
or
defined.
To
determine
which
cannot
treatment
response,
classify
patients
specific
treatments,
develop
interventions,
proprietary
strategies,
current
projects
need
tailored.
