Curcumin: A Review of Its Effects on Human Health

Foods, Journal Year: 2017, Volume and Issue: 6(10), P. 92 - 92

Published: Oct. 22, 2017

Turmeric, a spice that has long been recognized for its medicinal properties, received interest from both the medical/scientific world and culinary enthusiasts, as it is major source of polyphenol curcumin. It aids in management oxidative inflammatory conditions, metabolic syndrome, arthritis, anxiety, hyperlipidemia. may also help exercise-induced inflammation muscle soreness, thus enhancing recovery performance active people. In addition, relatively low dose complex can provide health benefits people do not have diagnosed conditions. Most these be attributed to antioxidant anti-inflammatory effects. Ingesting curcumin by itself does lead associated due poor bioavailability, which appears primarily absorption, rapid metabolism, elimination. There are several components increase bioavailability. For example, piperine component black pepper and, when combined with curcumin, shown bioavailability 2000%. Curcumin agents provides multiple benefits. The purpose this review brief overview plethora research regarding

Language: Английский

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Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases

British Journal of Pharmacology, Journal Year: 2016, Volume and Issue: 174(11), P. 1325 - 1348

Published: Sept. 17, 2016

Curcumin, a yellow pigment in the Indian spice Turmeric (Curcuma longa), which is chemically known as diferuloylmethane, was first isolated exactly two centuries ago 1815 by German Scientists, Vogel and Pelletier. However, according to pubmed database, study on its biological activity an antibacterial agent published 1949 Nature clinical trial reported The Lancet 1937. Although current database indicates almost 9000 publications curcumin, until 1990 there were less than 100 papers this nutraceutical. At molecular level, multitargeted has been shown exhibit anti-inflammatory through suppression of numerous cell signalling pathways including NF-κB, STAT3, Nrf2, ROS COX-2. Numerous studies have indicated that curcumin highly potent antimicrobial be active against various chronic diseases types cancers, diabetes, obesity, cardiovascular, pulmonary, neurological autoimmune diseases. Furthermore, compound also synergistic with other nutraceuticals such resveratrol, piperine, catechins, quercetin genistein. To date, over different trials completed clearly show safety, tolerability effectiveness humans. more populations are necessary prove potential This review's primary focus lessons learnt about from trials.

Language: Английский

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Innovative approaches for cancer treatment: current perspectives and new challenges

ecancermedicalscience, Journal Year: 2019, Volume and Issue: 13

Published: Sept. 10, 2019

Every year, cancer is responsible for millions of deaths worldwide and, even though much progress has been achieved in medicine, there are still many issues that must be addressed order to improve therapy. For this reason, oncological research putting a lot effort towards finding new and efficient therapies which can alleviate critical side effects caused by conventional treatments. Different technologies currently under evaluation clinical trials or have already introduced into practice. While nanomedicine contributing the development biocompatible materials both diagnostic therapeutic purposes, bioengineering extracellular vesicles cells derived from patients allowed designing ad hoc systems univocal targeting strategies. In review, we will provide an in-depth analysis most innovative advances basic applied research.

Language: Английский

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Turmeric and Its Major Compound Curcumin on Health: Bioactive Effects and Safety Profiles for Food, Pharmaceutical, Biotechnological and Medicinal Applications

Frontiers in Pharmacology, Journal Year: 2020, Volume and Issue: 11

Published: Sept. 15, 2020

Curcumin, a yellow polyphenolic pigment from the Curcuma longa L. (turmeric) rhizome, has been used for centuries culinary and food coloring purposes, besides to be an ingredient various medicinal preparations widely in Ayurveda or Chinese medicine. In last decades, their biological activities have extensively studied. Thus, focus of this review is offer in-depth revision curcumin applications biotechnological industries, on health promotion disease prevention, with emphasis its antioxidant, anti-inflammatory, neuroprotective, anticancer, hepatoprotective, cardioprotective effects. Bioavailability, bioefficacy, safety, side effects quality parameters are also focused. Finally, curcumin' multidimensional applications, attractiveness optimization, agroindustrial procedures offset instability low-bioavailability, concerns upcoming strategies clinical application were covered.

Language: Английский

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Polyphenols: A concise overview on the chemistry, occurrence, and human health

Phytotherapy Research, Journal Year: 2019, Volume and Issue: 33(9), P. 2221 - 2243

Published: July 29, 2019

This review gives an updated picture of each class phenolic compounds and their properties. The most common classification implies the subdivision phenolics in two main groups: flavonoids (e.g., anthocyanins, flavanols, flavanones, flavonols, flavonones, isoflavones) non‐flavonoids acids, xanthones, stilbens, lignans, tannins) polyphenols. great interest polyphenols is associated with high potential application for food preservation therapeutic beneficial use. relationship between polyphenol intake human health has been exploited special reference to cardiovascular diseases, hypertension, diabetes, metabolic syndrome, obesity, cancer. use current existing databases bioactive including described as key tools research.

Language: Английский

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Plant Secondary Metabolites as Anticancer Agents: Successes in Clinical Trials and Therapeutic Application

International Journal of Molecular Sciences, Journal Year: 2018, Volume and Issue: 19(1), P. 263 - 263

Published: Jan. 16, 2018

Cancer is a multistage process resulting in an uncontrolled and abrupt division of cells one the leading causes mortality. The cases reported predictions for near future are unthinkable. Food Drug Administration data showed that 40% approved molecules natural compounds or inspired by them, from which, 74% used anticancer therapy. In fact, products viewed as more biologically friendly, less toxic to normal cells. this review, most recent successful secondary metabolites, including alkaloid, diterpene, triterpene polyphenolic type compounds, with great potential discussed. Focusing on ones clinical trial development already therapy, therefore such paclitaxel homoharringtonine (in use), curcumin ingenol mebutate trials) will be addressed. Each compound’s source, important steps their discovery, therapeutic targets, well main structural modifications can improve properties discussed order show role plants source effective safe drugs.

Language: Английский

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Bioactivity of dietary polyphenols: The role of metabolites

Critical Reviews in Food Science and Nutrition, Journal Year: 2019, Volume and Issue: 60(4), P. 626 - 659

Published: Jan. 7, 2019

A polyphenol-rich diet protects against chronic pathologies by modulating numerous physiological processes, such as cellular redox potential, enzymatic activity, cell proliferation and signaling transduction pathways. However, polyphenols have a low oral bioavailability mainly due to an extensive biotransformation mediated phase I II reactions in enterocytes liver but also gut microbiota. Despite bioavailability, most proved significant biological effects which brought into attention the bioavailability/high bioactivity paradox. In recent years, polyphenol metabolites attracted great interest many of them showed similar or higher intrinsic comparison parent compounds. There is huge body literature reporting on functions generated metabolic microbiota-mediated biotransformation. this respect, review highlights pharmacokinetic fate major dietary (resveratrol, curcumin, quercetin, rutin, genistein, daidzein, ellagitannins, proanthocyanidins) order further address efficacy biometabolites compared molecules. The present work strongly supports contribution health benefits polyphenols, thus offering better perspective understanding role played human health.

Language: Английский

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Curcumin and Health

Molecules, Journal Year: 2016, Volume and Issue: 21(3), P. 264 - 264

Published: Feb. 25, 2016

Nowadays, there are some molecules that have shown over the years a high capacity to act against relevant pathologies such as cardiovascular disease, neurodegenerative disorders or cancer. This article provides brief review about origin, bioavailability and new research on curcumin synthetized derivatives. It examines beneficial effects health, delving into aspects cancer, effects, metabolic syndrome, antioxidant capacity, anti-inflammatory properties, neurological, liver respiratory disorders. Thanks all these activities, is positioned an interesting nutraceutical. reason why it has been subjected several modifications in its structure administration form permitted increase effectiveness different diseases, decreasing mortality morbidity associated pathologies.

Language: Английский

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Cellular and molecular mechanisms of curcumin in prevention and treatment of disease

Critical Reviews in Food Science and Nutrition, Journal Year: 2019, Volume and Issue: 60(6), P. 887 - 939

Published: Jan. 11, 2019

Curcumin is a naturally occurring polyphenolic compound present in rhizome of Curcuma longa belonging to the family zingiberaceae. Growing experimental evidence revealed that curcumin exhibit multitarget biological implications signifying its crucial role health and disease. The current review highlights recent progress mechanisms underlying wide range pharmacological effects against numerous diseases like neuronal, cardiovascular, metabolic, kidney, endocrine, skin, respiratory, infectious, gastrointestinal cancer. ability modulate functions multiple signal transductions are linked with attenuation acute chronic diseases. Numerous preclinical clinical studies have modulates several molecules cell transduction pathway including PI3K, Akt, mTOR, ERK5, AP-1, TGF-β, Wnt, β-catenin, Shh, PAK1, Rac1, STAT3, PPARγ, EBPα, NLRP3 inflammasome, p38MAPK, Nrf2, Notch-1, AMPK, TLR-4 MyD-88. has potential prevent and/or manage various due anti-inflammatory, anti-oxidant anti-apoptotic properties an excellent safety profile. In contrast, anti-cancer reflected induction growth arrest apoptosis premalignant malignant cells. This also carefully emphasized pharmacokinetics interaction other drugs. Clinical shown safe at doses 12 g/day but exhibits poor systemic bioavailability. use adjuvant piperine, liposomal curcumin, nanoparticles phospholipid complex enhanced bioavailability therapeutic potential. Further warranted prove ailments.

Language: Английский

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Therapeutic and Medicinal Uses of Terpenes

Springer eBooks, Journal Year: 2019, Volume and Issue: unknown, P. 333 - 359

Published: Jan. 1, 2019

Language: Английский

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