Designed Monomers & Polymers,
Journal Year:
2024,
Volume and Issue:
28(1), P. 1 - 34
Published: Dec. 31, 2024
This
review
paper
analyzes
recent
advancements
in
bio-polymer
coatings
for
probiotic
microencapsulation,
with
a
particular
emphasis
on
chitosan
and
its
synergistic
combinations
other
materials.
Probiotic
microencapsulation
is
essential
protecting
probiotics
from
environmental
stresses,
enhancing
their
stability,
ensuring
effective
delivery
to
the
gut.
The
begins
an
overview
of
highlighting
significance
safeguarding
through
processing,
storage,
gastrointestinal
transit.
Advances
chitosan-based
encapsulation
are
explored,
including
integration
bio-polymers
such
as
alginate,
gelatin,
pectin,
well
application
nanotechnology
innovative
techniques
like
spray
drying
layer-by-layer
assembly.
Detailed
mechanistic
insights
integrated,
illustrating
how
influences
gut
microbiota
by
promoting
beneficial
bacteria
suppressing
pathogens,
thus
role
prebiotic
or
synbiotic.
Furthermore,
delves
into
chitosan's
immunomodulatory
effects,
particularly
context
inflammatory
bowel
disease
(IBD)
autoimmune
diseases,
describing
immune
signaling
pathways
influenced
linking
changes
improvements
systemic
immunity.
Recent
clinical
trials
human
studies
assessing
efficacy
chitosan-coated
presented,
alongside
discussion
practical
applications
comparison
vitro
vivo
findings
highlight
real-world
relevance.
sustainability
sources
impact
addressed,
along
novel
concept
gut-brain
axis.
Finally,
emphasizes
future
research
needs,
development
personalized
therapies
exploration
techniques.
Pathogens,
Journal Year:
2025,
Volume and Issue:
14(2), P. 126 - 126
Published: Feb. 1, 2025
Fungal
infections
are
a
significant
global
health
challenge,
causing
approximately
3.8
million
deaths
annually,
with
immunocompromised
populations
particularly
at
risk.
Traditional
antifungal
therapies,
including
azoles,
echinocandins,
and
polyenes,
face
limitations
due
to
rising
resistance,
toxicity,
inadequate
treatment
options.
This
review
explores
innovative
strategies
for
preventing
managing
fungal
infections,
such
as
vaccines,
peptides,
nanotechnology,
probiotics,
immunotherapy.
Vaccines
offer
promising
avenues
long-term
protection,
despite
difficulties
in
their
development
complexity
immune
evasion
mechanisms.
Antifungal
peptides
provide
novel
class
of
agents
broad-spectrum
activity
reduced
resistance
risk,
whilst
nanotechnology
enables
targeted,
effective
drug
delivery
systems.
Probiotics
show
potential
vulvovaginal
candidiasis,
by
maintaining
microbial
balance.
Immunotherapy
leverages
system
modulation
enhance
defenses,
omics
technologies
deliver
comprehensive
insights
into
biology,
paving
the
way
therapeutic
vaccine
targets.
While
these
approaches
hold
immense
promise,
challenges
cost,
accessibility,
translational
barriers
remain.
A
coordinated
effort
among
researchers,
clinicians,
policymakers
is
critical
advancing
addressing
burden
effectively.
Foods,
Journal Year:
2025,
Volume and Issue:
14(3), P. 495 - 495
Published: Feb. 4, 2025
Lactic
acid
bacteria
(LAB)
constitute
a
heterogeneous
group
of
isolated
from
fermented
foods,
animals,
plants,
and
mammalian
guts,
with
many
health-promoting
properties.
Probiotics
antagonistic
properties
against
human
pathogens
foodborne
have
garnered
significant
attention
the
scientific
fraternity.
A
dedicated
review
focusing
on
plant-derived
probiotic
their
has
not
been
comprehensively
reviewed.
Thus,
this
aimed
at
providing
an
overview
LAB
isolates
derived
several
unconventional
sources
such
as
fruits,
seeds,
fruit
pulp,
leaves,
roots,
vegetables,
grasses,
flowers
antibacterial,
antifungal,
antiviral
This
paper
reviewed
antimicrobial
different
genera,
Lactobacillus,
Leuconostoc,
Weissella,
Enterococcus,
Pediococcus,
Bacillus,
Fructobacillus,
postbiotics,
paraprobiotics.
Several
important
mechanisms,
including
secretion
bacteriocins,
bacteriocin-like
substances,
reuterin,
organic
acids
(lactic
acetic),
peptides,
exopolysaccharides,
hydrogen
peroxide,
attributed
to
actions
pathogens.
However,
precise
mode
action
is
poorly
understood;
hence,
further
research
should
be
conducted
reveal
detailed
mechanisms.
Finally,
discusses
summary
future
implications.
Given
significance,
compounds
can
potentially
exploited
in
food
preservation
safety
or
for
medicinal
applications
after
evaluating
safety.
Polymers,
Journal Year:
2025,
Volume and Issue:
17(2), P. 144 - 144
Published: Jan. 8, 2025
Probiotics
are
an
essential
dietary
supplement
for
intestinal
flora
balance,
inhibition
of
pathogenic
bacteria
and
immune
regulation.
However,
probiotic
inactivation
during
gastrointestinal
transportation
remains
a
big
challenge
oral
administration.
Hence,
delivery
systems
(ODSs)
based
on
polysaccharides
have
been
constructed
to
protect
probiotics
from
harsh
environments.
Cellulose,
chitosan,
alginate
their
derivates
used
form
protective
layer
probiotics.
This
review
summarizes
the
superiority
application
in
forming
layers
Meanwhile,
ODS
processes
including
extrusion,
emulsion
spray
drying
also
summarized.
The
preparation
technique
mechanism,
microparticle
formation
process
especially
role
serve
overviewed.
Lastly,
need
cell
viability
retention
dehydration
construction
core-shell
microparticles
is
emphasized
this
review.
Fermentation,
Journal Year:
2024,
Volume and Issue:
10(4), P. 222 - 222
Published: April 20, 2024
The
ongoing
occurrence
of
foodborne
diseases
and
the
imperative
need
for
efficient
spoilage
pathogen
control
in
food
products
constitute
a
critical
challenge
industry.
rising
demands
consumers
safe,
healthy,
clean-label
have
led
to
an
increased
interest
natural
antimicrobial
alternatives.
Lactic
acid
bacteria
(LAB)
proven
their
value
industry
recent
years,
also
reason
antagonistic
properties
against
undesired
microbes
significant
related
protechnological
attributes.
compounds
produced
by
LAB
exhibit
inhibitory
effects
on
pathogens
effectively
inhibit
activities
spoilage-related
organisms.
Applying
secondary
metabolites
LAB,
notably
bacteriocins,
organic
acids,
others,
has
found
commercial
utility
across
multiple
sectors,
preventing
proliferation
undesirable
microorganisms
simultaneously
enhancing
sensory
overall
quality
various
products.
This
review
comprehensively
explores
microbial
specifically
focusing
action
supporting
effective
sustainable
management.
Additionally,
it
highlights
strategic
application
technological
contexts
within
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(10), P. 5561 - 5561
Published: May 20, 2024
This
review
scrutinizes
the
intricate
interplay
between
microbiome
and
human
body,
exploring
its
multifaceted
dimensions
far-reaching
implications.
The
microbiome,
comprising
diverse
microbial
communities
inhabiting
various
anatomical
niches,
is
increasingly
recognized
as
a
critical
determinant
of
health
disease.
Through
an
extensive
examination
current
research,
this
elucidates
dynamic
interactions
host
physiology
across
multiple
organ
systems.
Key
topics
include
establishment
maintenance
microbiota
diversity,
influence
factors
on
composition,
bidirectional
communication
pathways
cells.
Furthermore,
we
delve
into
functional
implications
dysbiosis
in
disease
states,
emphasizing
role
shaping
immune
responses,
metabolic
processes,
neurological
functions.
Additionally,
discusses
emerging
therapeutic
strategies
aimed
at
modulating
to
restore
host–microbe
homeostasis
promote
health.
Microbiota
fecal
transplantation
represents
groundbreaking
approach
management
dysbiosis-related
diseases,
offering
promising
avenue
for
restoring
balance
within
gut
ecosystem.
innovative
therapy
involves
transfer
from
healthy
donor
individual
suffering
dysbiosis,
aiming
replenish
beneficial
populations
mitigate
pathological
imbalances.
By
synthesizing
findings
fields,
offers
valuable
insights
complex
relationship
highlighting
avenues
future
research
clinical
interventions.
