Fecal Microbiota Transplantation from Methionine-Restricted Diet Mouse Donors Improves Alzheimer’s Learning and Memory Abilities Through Short-Chain Fatty Acids

Foods, Journal Year: 2025, Volume and Issue: 14(1), P. 101 - 101

Published: Jan. 2, 2025

Alzheimer’s disease (AD) is marked by impaired cognitive functions, particularly in learning and memory, owing to complex diverse mechanisms. Methionine restriction (MR) has been found exert a mitigating effect on brain oxidative stress improve AD. However, the bidirectional crosstalk between gut through which MR enhances memory AD, as well effects of fecal microbiota transplantation (FMT) from mice AD mice, remains underexplored. In this study, APP/PS1 double transgenic were used an FMT experiment was conducted. 16S rRNA gene sequencing, targeted metabolomics, microbial metabolite short-chain fatty acids (SCFAs) feces samples analyzed. The results showed that reversed reduction SCFAs induced further activated free acid receptors, FFAR2 FFAR3, transport protein MCT1, thereby signaling mitigate inflammation enhance capabilities. Furthermore, methionine-restricted diet mouse donors receiving ameliorated ability SCFAs. This study offers novel non-pharmaceutical intervention strategies for prevention.

Language: Английский

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Pathogenesis, Diagnostics, and Therapeutics for Alzheimer's Disease: Breaking the Memory Barrier

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 101, P. 102481 - 102481

Published: Sept. 3, 2024

Alzheimer's disease (AD) is the most common cause of dementia and accounts for 60-70 % all cases. It affects millions people worldwide. AD poses a substantial economic burden on societies healthcare systems. progressive neurodegenerative disorder characterized by cognitive decline, memory loss, impaired daily functioning. As prevalence continues to increase, understanding its pathogenesis, improving diagnostic methods, developing effective therapeutics have become paramount. This comprehensive review delves into intricate mechanisms underlying AD, explores current state techniques, examines emerging therapeutic strategies. By revealing complexities this aims contribute growing body knowledge surrounding devastating disease.

Language: Английский

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Alzheimer’s Disease as Type 3 Diabetes: Understanding the Link and Implications

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 11955 - 11955

Published: Nov. 7, 2024

Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM) are two prevalent conditions that present considerable public health issue in aging populations worldwide. Recent research has proposed a novel conceptualization of AD as "type 3 diabetes", highlighting the critical roles insulin resistance impaired glucose metabolism pathogenesis disease. This article examines implications this association, exploring potential new avenues for treatment preventive strategies AD. Key evidence linking to emphasizes metabolic processes contribute neurodegeneration, including inflammation, oxidative stress, alterations signaling pathways. By framing within context, we can enhance our understanding its etiology, which turn may influence early diagnosis, plans, measures. Understanding manifestation opens up possibility employing therapeutic incorporate lifestyle modifications use antidiabetic medications mitigate cognitive decline. integrated approach improve patient outcomes deepen comprehension intricate relationship between neurodegenerative diseases disorders.

Language: Английский

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The Kynurenine Pathway, Aryl Hydrocarbon Receptor, and Alzheimer’s Disease

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(9), P. 950 - 950

Published: Sept. 23, 2024

Alzheimer’s disease (AD) is the leading cause of dementia, mainly affecting elderly individuals. AD characterized by β-amyloid plaques, abnormal tau tangles, neuronal loss, and metabolic disruptions. Recent studies have revealed involvement kynurenine (KP) pathway aryl hydrocarbon receptor (AhR) in development. The KP metabolizes tryptophan to produce neuroactive substances like kynurenine, kynurenic acid, quinolinic acid. In AD, high levels neurotoxic acid are associated with increased neuroinflammation excitotoxicity; conversely, reduced which acts as a glutamate antagonist, compromise neuroprotection. Research has indicated elevated metabolites enzymes hippocampus patients other tissues such blood, cerebrospinal fluid, urine. However, finding that biomarkers urine been controversial. This controversy, stemming from lack consideration specific stage details patient’s treatment, cognitive deficits, psychiatric comorbidities, underscores need for more comprehensive research. AhR, ligand-activated transcription factor, regulates immune response, oxidative stress, xenobiotic metabolism. Various ligands, including metabolites, can activate it. Some suggest AhR activation contributes while others propose it provides discrepancy may be explained ligands highlighting complex relationship between pathway, activation, where same both neuroprotective harmful effects.

Language: Английский

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Modulatory effects of traditional Chinese medicines on gut microbiota and the microbiota-gut-x axis

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 9, 2024

The gut microbiota offers numerous benefits to the human body, including promotion of nutrient absorption, participation in metabolic processes, and enhancement immune function. Recent studies have introduced concept gut-organ axis, which encompasses interactions such as gut-brain gut-liver gut-lung axis. This underscores complex interplay between various organs tissues, brain, heart, lungs, liver, kidneys, muscles, bones. Growing evidence indicates that can influence onset progression multi-organ system diseases through their effects on Traditional Chinese medicine has demonstrated significant efficacy regulating gastrointestinal system, leveraging its unique advantages. Considerable advancements been made understanding role axis within mechanisms action traditional medicine. review aims elucidate roles health, explore potential connections microbiota, examine therapeutic microbiota-gut-organ Furthermore, addresses limitations challenges present current research while proposing directions for future investigations this area.

Language: Английский

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Sex-specific associations between estimated glucose disposal rate and cognitive decline in middle-aged and older adults in China: a longitudinal cohort study

Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 17

Published: Feb. 5, 2025

Background Insulin resistance (IR) is recognized as a potential modifiable risk factor for cognitive decline, but findings within Asian populations have been inconsistent. Given the high prevalence of dementia and its substantial economic burden in China, large-scale longitudinal studies are essential to elucidate complex relationship between IR function. Methods This cohort study included 8,734 middle-aged older adults (median age: 58 years; 53.6% females) from China Health Retirement Longitudinal Study (CHARLS), followed 2011 2018. Estimated glucose disposal rate (eGDR) was used assess calculated using waist circumference, hypertension status, HbA1c levels. Participants were categorized into tertiles based on eGDR levels (Tertile 1: lowest; Tertile 3: highest). Cognitive function sum episodic memory executive scores, which then standardized Z -score. Linear mixed-effects models dose-response analyses performed evaluate association baseline changes total population stratified by sex. Results Higher significantly associated with slower global decline 3 vs. β = 0.007; 95% CI: 0.000–0.014; P 0.047). stronger females 0.011; 0.002–0.021; 0.021), while no significant observed males. Dose-response indicated linear positive females, not Similar patterns found function, associations predominantly females. Conclusion particularly among women. These underscore marker identifying mitigating highlight importance sex-specific strategies address insulin promote health.

Language: Английский

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Association of dietary diversity, genetic susceptibility, and the risk of incident dementia: A prospective cohort study

The Journal of Prevention of Alzheimer s Disease, Journal Year: 2025, Volume and Issue: unknown, P. 100078 - 100078

Published: Feb. 1, 2025

Previous studies have revealed how single foods or nutrients affect dementia, but the evidence for a potential link between dietary diversity and dementia is inconsistent. This study aimed to evaluate association risk of incident dementia. prospective included 104,572 white participants without at baseline recruited 2006 2010 from UK Biobank. Dietary Diversity Score (DDS) was acquired through Oxford WebQ's 24-hour recall survey spanning 2009 2012. Cox proportional hazards models were used estimate associations DDS, scores food groups Stratified analyses subsequently conducted assess variations across different demographic, socioeconomic, genetic groups. Over median follow-up period 10.44 years, 725 developed A higher DDS associated with lower (HR: 0.95; 95 % CI: 0.93-0.97). statistical significance in this individuals under 65 years old 0.92-0.98), those polygenic (PRS; HR: 0.92; 0.89-0.95). Among five groups, score meat protein alternatives 0.86-0.99). Enhancing reduces risk, potentially influenced by predisposition. Consuming diverse range may be an effective strategy against

Language: Английский

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Gegen Qinlian Decoction improves Alzheimer’s disease through TLR4/NF-κB/NLRP3 pathway

Tissue and Cell, Journal Year: 2025, Volume and Issue: 95, P. 102818 - 102818

Published: March 1, 2025

Language: Английский

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Bibliometric analysis of the intestinal microbiota and demyelinating diseases, particularly multiple sclerosis, since 2014

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: March 5, 2025

The gut-brain axis (GBA) represents a complex, bidirectional communication network that connects the central nervous system (CNS) and gastrointestinal system. Our study aimed to explore correlation between intestinal microbiota demyelinating diseases from bibliometric perspective, focusing on research since 2014. A comprehensive search was carried out Web of Science Core Collection (WoSCC) locate studies diseases, with focus publications 1 January 2014 29 March 2024. We visualized analyzed data using VOSviewer, CiteSpace, Charticulator. gathered 429 scholarly articles disorders published in past 10 years. Research concerning has demonstrated consistent increase frequency over time. USA highest number publications, while Canada average citations, reaching as high 3,429, which is greater than USA. Moreover, journal Frontiers Immunology, 33 1,494 citations. majority scholars focused "multiple sclerosis" "gut microbiota," are primary keywords field diseases. This conducted analysis existing investigating Using advanced tools such VOSviewer this intricate relationship pathogenesis conditions. In addition, used literature statistical identify hotspots future directions field.

Language: Английский

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A retrospective study on blood microbiota as a marker for cognitive decline: implications for detecting Alzheimer’s disease and amnestic mild cognitive impairment in Republic of Korea

Osong Public Health and Research Perspectives, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

This study aimed to investigate the relationship between blood microbiota, specifically bacterial DNA, and cognitive decline in individuals with subjective (SCD) amnestic mild impairment (aMCI). The objective was identify potential microbial signatures that could serve as biomarkers for deterioration. Forty-seven participants were recruited, including 13 aMCI, 20 SCD, 14 normal cognition (NC). Blood samples collected, DNA analyzed using 16S rRNA sequencing on Illumina MiSeq platform. Bioinformatics analyses-including α- β-diversity measures differential abundance testing (using edgeR)-were employed assess diversity differences composition among groups. Logistic regression models used evaluate predictive impact of microbiota decline. Microbial differed significantly groups, NC exhibiting highest α-diversity. Both aMCI SCD groups showed reduced diversity. Taxa such Bacteroidia, Alphaproteobacteria, Clostridia decreased group compared (p<0.05). In contrast, Gammaproteobacteria increased both indicating progressive changes from aMCI. No significant found Distinct taxa-particularly increase along decreases Clostridia-are associated progression These findings suggest early detection However, small sample size lack control confounding factors diet medication limit findings. Larger studies are needed validate these results further explore role neurodegeneration.

Language: Английский

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