The role of short-chain fatty acid in metabolic syndrome and its complications: focusing on immunity and inflammation

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 7, 2025

Metabolic syndrome (Mets) is an important contributor to morbidity and mortality in cardiovascular, liver, neurological, reproductive diseases. Short-chain fatty acid (SCFA), organismal energy donor, has recently been demonstrated increasing number of studies be molecule ameliorating immuno-inflammation, causative factor Mets, improve lipid distribution, blood glucose, body weight levels animal models Mets. This study reviews recent research advances on SCFA Mets from immune-inflammatory perspective, including complications dominated by chronic inflammation, as well the fact that these findings also contribute understanding specific mechanisms which gut flora metabolites metabolic processes humans. review proposes emerging role for inflammatory followed identification major ambiguities further understand anti-inflammatory potential this substance In addition, novel strategies modulate treatment may help mitigate prognosis its complications.

Language: Английский

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Tangshen formula targets the gut microbiota to treat non-alcoholic fatty liver disease in HFD mice: A 16S rRNA and non-targeted metabolomics analyses

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 173, P. 116405 - 116405

Published: March 14, 2024

Tangshen formula (TSF) has an ameliorative effect on hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD), but the role played by gut microbiota this process is unknown.

Language: Английский

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Macroalgae-Derived Sugars and Polysaccharides: Innovations in Natural Sweeteners and Food Applications

IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

This chapter explores the potential of macroalgae-derived sugars and polysaccharides as sustainable, functional alternatives to traditional sugars. Focusing on innovative extraction technologies, highlights unique properties macroalgal (such agar, alginate, carrageenan) natural sweeteners thickeners. Emphasis is placed nutritional benefits macroalgae, including their low-glycemic impact high content bioactive compounds that promote health. It will also mention integration derivatives into food products, enhancing both flavor texture while contributing reduced sugar dependence. aligns with modern trends in sustainable innovation enhancement, presenting macroalgae a promising resource for industry.

Language: Английский

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Extraction, Characterisation and Evaluation of Antioxidant and Probiotic Growth Potential of Water-Soluble Polysaccharides from Ulva rigida Macroalgae

Foods, Journal Year: 2024, Volume and Issue: 13(11), P. 1630 - 1630

Published: May 23, 2024

Ulva rigida green macroalgae contain a variety of polysaccharides. A recent study investigated the optimum concentration and yield polysaccharide extraction from oven-dried U. biomass using water-soluble method that adhered to safety standards. This utilised complete factorial experiments examine effects varying factors on extraction. Results showed positive correlation between increased levels all higher yield. also found main their interaction had significant impact extracted polysaccharides rigida. The highest content were 9.5 mg/mL 189 mg/g, respectively. Water-soluble demonstrated presence reducing sugar (8 mg/g), phenolics (0.69 mg/g) flavonoids (1.42 exhibited antioxidant properties. revealed freeze-dried powders primarily composed monosaccharide rhamnose. Preliminary results effect these probiotics supplementation promoted viable Lactobacillus rhamnosus ATCC 53103 growth during cultivation. discovery has potential revolutionise human food industry promote development functional ingredients for novel future products, with numerous applications in nutraceutical pharmaceutical industries.

Language: Английский

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Effects of seaweed on blood plasma immunoglobulin concentration, mucosal immunity, small intestine histomorphology, cecal microbial population, and volatile fatty acid profile in broiler chickens

Veterinary World, Journal Year: 2025, Volume and Issue: unknown, P. 508 - 518

Published: Feb. 1, 2025

Background and Aim: Seaweeds, particularly brown seaweed (BS) green (GS), are rich in bioactive compounds that may enhance poultry health productivity. This study evaluates the effects of dietary BS GS on blood plasma immunoglobulin concentrations, mucosal immunity, small intestine histomorphology, cecal microbial populations, volatile fatty acid (VFA) profiles broiler chickens. Materials Methods: A total 504 one-day-old male broilers were randomly assigned to 12 treatments: negative control (basal diet), a positive diet + 100 mg/kg Vitamin E), diets supplemented with at 0.25%, 0.50%, 0.75%, 1.00%, 1.25%. The followed completely randomized design, data analyzed using one-way analysis variance Duncan’s multiple range test (p < 0.05). Results: Broilers fed 1.25% exhibited significantly higher 0.05) (IgA) G (IgG) concentrations. Dietary inclusion upregulated messenger RNA expression interleukin-6, interleukin-10, interferon-gamma, indicating immunomodulatory effects. Jejunal villus height was increased birds during starter period. Birds receiving 0.50% BS, 0.25% GS, Lactobacillus counts, whereas 0.75% reduced Escherichia coli populations. Furthermore, VFA propionic concentrations observed 1.00% as well BS. Conclusion: (0.75%, 1.25%) enhances immune response by increasing IgA IgG levels. Both positively modulate cytokine expression, intestinal morphology, balance, leading improved gut health. results suggest supplementation serve sustainable feed additives performance while reducing reliance synthetic supplements. Future studies should focus identifying responsible for these their broader implications production. Keywords: chickens, health, immunoglobulin, supplementation, nutrition, acids.

Language: Английский

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Roles of Probiotics, Prebiotics, and Postbiotics in B-cell mediated Immune Regulation

Journal of Nutrition, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

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