Phytotherapy of Vulvovaginal Candidiasis: A Narrative Review

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3796 - 3796

Published: March 28, 2024

Vulvovaginal candidiasis (VVC) is a real gynecological problem among women of reproductive age from 15 to 49. A recent analysis showed that 75% will have an occurrence at least once per year, while 5% are observed recurrent vaginal mycosis-these patients may become unwell four or more times year. This pathology caused in 85-90% cases by fungi the Candida albicans species. It represents intractable medical for female due pain and pruritus. Due observation increasing number strains resistant standard preparations increase recurrence this when using local oral preferential therapy, such as fluconazole, was launched develop alternative methods treating VVC herbs dill, turmeric, berberine. An in-depth databases include scientific articles years made it possible draw satisfactory conclusions supporting validity herbal therapy question. Although phytotherapy has not yet been approved Food Drug Administration, appears be promising therapeutic solution existing treatments. There research currently undergoing aimed comparing classical pharmacotherapy treatment purpose competence knowledge care health long-term comfort patients.

Language: Английский

---

Composition and antibacterial, anti-inflammatory, antioxidant, and anticancer activities of Rosmarinus officinalis L. essential oil

South African Journal of Botany, Journal Year: 2023, Volume and Issue: 160, P. 437 - 445

Published: July 22, 2023

Language: Английский

---

Dietary Chinese herbal mixture supplementation improves production performance by regulating reproductive hormones, antioxidant capacity, immunity, and intestinal health of broiler breeders

Poultry Science, Journal Year: 2023, Volume and Issue: 103(1), P. 103201 - 103201

Published: Oct. 21, 2023

Chinese herbs have been used as feed additives and are commonly utilized in domestic intensive livestock farming. However, their impact on the production performance intestinal health of broiler breeders has yet to be thoroughly explored. This study aimed evaluate effects a herbal mixture (CHM) terms reproductive hormones, antioxidant capacity, immunity, breeders. A total 336 thirty-wk-old hens were randomly allotted 4 groups with 6 replicates fourteen each, which fed basal diet supplemented 0 (CON), 500 (CHM500), 1,000 (CHM1000), 1,500 (CHM1500) mg/kg CHM for 56 days, respectively. Our results showed that dietary supplementation CHM1000 increased laying rate number SYF decreased conversion ratio (P < 0.05). All oviduct ovarian indexes, serum E2 T-AOC levels, TG MDA levels compared CON In comparison group, CHM1500 ALB, IgM, IL-10 whereas group also TP SOD P TNF-α The addition FSHR expressions ovary, Claudin-1 jejunum, SOD1 liver but mRNA INH ovary well IL-2 IL-6 jejunum Moreover, CHM500 CAT, GPx, HO-1 expression GPx while decreasing IL-17A addition, villus height, VCR, Nrf2, HO-1, Occludin, MUC2 increasing NQO1, Supplementation ESR-α, ESR-β, GnRH, NQO1 IFN-γ crypt depth Supplementing ZO-1 high-throughput sequencing altered composition microbiota, evidenced by regulation genera Lactobacillus, Faecalibacterium, Phascolarctobacterium. PICRUSt analysis revealed metabolic pathways bacterial chemotaxis, butanoate metabolism, synthesis degradation ketone bodies enriched group. Spearman's correlation indicated differentiated significantly associated performance, hormone, gut barrier-related genes. Taken together, CHM, especially at mg/kg, could improve regulating breeders, maybe provide insights into its application potential additive promote

Language: Английский

---

Manuka honey as a non-antibiotic alternative against Staphylococcus spp. and their small colony variant (SCVs) phenotypes

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: May 28, 2024

The antibiotic resistance (ABR) crisis is an urgent global health priority. Staphylococci are among the problematic bacteria contributing to this emergency owing their recalcitrance many clinically important antibiotics. Staphylococcal pathogenesis further complicated by presence of small colony variants (SCVs), a bacterial subpopulation displaying atypical characteristics including retarded growth, prolific biofilm formation, heightened tolerance, and enhanced intracellular persistence. These capabilities severely impede current chemotherapeutics, resulting in chronic infections, poor patient outcomes, significant economic burden. Tackling ABR requires alternative measures beyond conventional options that have dominated treatment regimens over past 8 decades. Non-antibiotic therapies gaining interest arena, use honey, which despite having ancient therapeutic roots has now been reimagined as just traditional topical use, include array difficult-to-treat staphylococcal infections. This literature review focused on Manuka honey (MH) its efficacy anti-staphylococcal treatment. We summarized studies used product technologies employed study antibacterial mechanisms render MH suitable agent for management those involving SCVs. also discussed status development other factors may impact therapy help combat ABR.

Language: Английский

---

Phytochemical and ethnomedicinal evidences of the use of Alternanthera brasiliana (L.) Kuntze against infectious diseases

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 331, P. 118304 - 118304

Published: May 8, 2024

Language: Английский

---

Antifungal properties of Cymbopogon citratus (DC.) Stapf—A scoping review

South African Journal of Botany, Journal Year: 2024, Volume and Issue: 170, P. 425 - 442

Published: June 5, 2024

Language: Английский

---

An Update on the Application of Nano Phytomedicine as an Emerging Therapeutic Tool for Neurodegenerative Diseases

Current Bioactive Compounds, Journal Year: 2023, Volume and Issue: 20(5)

Published: Oct. 25, 2023

Abstract: The existence of the blood-brain barrier (BBB), a densely woven network blood vessels and endothelial cells designed to prevent infiltration foreign substances into brain, methods employed in developing treatments for neurodegenerative disorders (NDs) such as Alzheimer's disease, Parkinson's Huntington's Multiple sclerosis, Amyotrophic lateral others, pose significant challenges complexities. These illnesses have had terrible impact on human population's health. Because early detection these problems is poor no good therapy has been established, they emerged biggest lifethreatening healthcare burden worldwide compared other illnesses. Traditional drug delivery techniques do not offer efficient treatment NDs due constraints BBB design, efflux pumps, metabolic enzyme expression. Nanotechnology potential significantly enhance ND by utilizing systems that bioengineered engage with living organisms at cellular range. Compared traditional techniques, nanotechnological technologies several ways crossing increasing therapeutic efficacy brain. introduction growth nanotechnology indicate promising overcoming this issue. Engineered nanoparticles coupled moieties imaging agents dimensions ranging from 1-100 nm can improve effectiveness, uptake, selective transport, brain their changed physicochemical properties. Conjugates medicinal plants, or constituents known nano phytomedicine, recently gained importance cutting-edge neuro-therapeutics abundant natural supply, targeted lower adverse effects. This study summarizes common NDs, prevalence pathogenesis, herbal nanoformulation treating NDs.

Language: Английский

---

Rosmarinus officinalis essential oils’ eradication of beta-lactamase and multidrug resistant clinical bacterial pathogens from hospital settings

Natural Product Research, Journal Year: 2023, Volume and Issue: 38(5), P. 796 - 806

Published: April 19, 2023

Antibiotics have become increasingly ineffective in the face of bacterial resistance, particularly hospitals. Interestingly, there is high demand for bioprospecting secondary metabolites, treating multidrug-resistant clinical diseases. In fact, Rosemary has been used its antiseptic properties dating back to antiquity. The aim this research evaluate effectiveness Rosmarinus officinalis essential oil against pathogens. Results showed promising antibacterial activity seven bacteria: Escherichia coli, Enterobacter cloacae, Staphylococcus aureus, Serratia odorifera, Klebsiella pneumoniae, oxytoca, Aeromonas hydrophila with MIC values 35.7, 17.85, 71.4, 8.9, 17.8, 285.7, 35.7 µg/ml respectively and MBC 142.8, 571.5,71.4 respectively. This study suggests that can be as a therapeutic agent fight wide range multi-resistant bacteria.

Language: Английский

---

Traditional uses and phytopharmacology of Cirsium arvense: Bioprospecting potential of a weed from temperate biome

Journal of Applied Pharmaceutical Science, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Cirsium arvense, a noxious weed of the Asteraceae family, has potential medicinal benefits. Traditionally, it been used to cure ulcers, mouth infections, leukemia, dentalgia, canker sores, pharyngitis, and other ailments. Alkaloids, flavonoids, tannins, diverse phytoconstituents are associated with its therapeutic potential. This review article sheds light on C. arvense’s taxonomy, geographical distribution, ethnomedicinal uses, phytopharmacology. Despite weedy nature, rich source phytoconstituents, which is evident from antimicrobial (against Gram-positive negative strains), antioxidant (2,2-diphenyl-1-picrylhydrazyl others), antiproliferative (HeLa, A43, MCF7 cell lines) Hispidulin, luteolin, tracin, isolated arvense were reported be antibacterial Based bioactive components, proposed mechanism for action also highlighted. A toxicity study revealed that aerial parts toxic (LC50 51 μg/ml). Bioprospecting this after detailed follow-up studies will help manage in future.

Language: Английский

---

Phytochemical strategies for combating Spodoptera litura (Fab.): a review of botanicals and their metabolites

Toxin Reviews, Journal Year: 2024, Volume and Issue: 43(4), P. 591 - 633

Published: Aug. 2, 2024

The adverse effects of the lepidopteran pest, Spodoptera litura (Fab.) on crops, result in significant economic losses due to decreased crop productivity and cost pest control measures. Using synthetic chemicals manage this polyphagous can adversely impact environment contribute development pesticide resistance other insects. Integrated management strategies, including biological agents, are often recommended S. infestations a more sustainable environmentally friendly manner. Compared with chemicals, herbal pesticides generally considered nontoxic for environment. They have lower toxicity toward non-target organisms, thus reducing risk harming beneficial animals wildlife. Botanicals include variety phytocompounds that potentially help managing pests, such as litura. Improving herbal-based nano-pesticides (Hb-Np) serve carriers bioactive compounds would enable their controlled targeted release. Therefore, present review aims highlight different mechanisms employed by larvae against efficacy extracts, essential oils, nano-formulations targeting litura, key challenges associated agriculture sector.

Language: Английский

---