The Influence of Intestinal Microbiota on BDNF Levels DOI Open Access
Marta Molska, Kinga Mruczyk, Angelika Cisek-Woźniak

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(17), P. 2891 - 2891

Published: Aug. 29, 2024

The regulation of neurogenesis, the complex process producing and differentiating new brain tissue cells, is influenced by a interaction internal external factors. Over past decade, extensive research has been conducted on neurotrophins their key role in adult as well impact diseases such depression. Among neurotrophins, brain-derived neurotrophic factor (BDNF) subject comprehensive studies scientific evidence supports its necessity for neurogenesis subventricular zone hippocampus. A novel area emerging gut microbiota significant contributor to neurotrophin production. Studies have shown that reduced BDNF levels can lead mood disorders, which are observed intestinal dysbiosis, characterized an imbalance composition quantity microbiota. There literature there link between function Physical activity, especially regularity intensity exercise, important relation level Probiotics, prebiotics physical activity may positive effect microbiota, therefore also factor.

Language: Английский

Exercise induces tissue-specific adaptations to enhance cardiometabolic health DOI Creative Commons
Stephen P. Ashcroft, Ben Stocks, Brendan Egan

et al.

Cell Metabolism, Journal Year: 2024, Volume and Issue: 36(2), P. 278 - 300

Published: Jan. 5, 2024

The risk associated with multiple cancers, cardiovascular disease, diabetes, and all-cause mortality is decreased in individuals who meet the current recommendations for physical activity. Therefore, regular exercise remains a cornerstone prevention treatment of non-communicable diseases. An acute bout results coordinated interaction between tissues to increased energy demand exercise. Over time, metabolic stress each individual provides basis long-term adaptations across tissues, including system, skeletal muscle, adipose tissue, liver, pancreas, gut, brain. plethora benefits throughout whole body, improved cardiorespiratory fitness, function, glycemic control. Overall, we summarize exercise-induced that occur within how they converge ultimately improve cardiometabolic health.

Language: Английский

Citations

30
Physical Exercise and Diet: Regulation of Gut Microbiota to Prevent and Treat Metabolic Disorders to Maintain Health DOI Open Access
Li Zhang, Yuan Liu, Wang Xinzhou

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(6), P. 1539 - 1539

Published: March 22, 2023

Each person’s body is host to a large number and variety of gut microbiota, which has been described as the second genome plays an important role in body’s metabolic process closely related health. It common knowledge that proper physical activity right diet structure can keep us healthy, recent years, researchers have found this boost health may be microbiota. Past studies reported modulate compositional microbiota further influence production key metabolites effective way improve metabolism prevent treat diseases. In review, we outline regulating improving disorders. addition, highlight regulation through appropriate exercise diseases, aiming promote public provide new approach treating such

Language: Английский

Citations

24
Effects of Exercise on Gut Microbiota of Adults: A Systematic Review and Meta-Analysis DOI Open Access
Leizi Min, Alimjan Ablitip, Rui Wang

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(7), P. 1070 - 1070

Published: April 5, 2024

Background: The equilibrium between gut microbiota (GM) and the host plays a pivotal role in maintaining overall health, influencing various physiological metabolic functions. Emerging research suggests that exercise modulates abundance functionality of bacteria, yet comprehensive effects on GM diversity remain to be synthesized. Objectives Design: study aims quantitatively examine effect adults using systemic review meta-analysis approach. Methods: PubMed, Ebsco, Embase, Web Science, Cochrane Central Register Controlled Trials, China National Knowledge Infrastructure, Wanfang Data were searched from their inception September 2023. Exercise intervention studies with control group describe compare composition adults, 16S rRNA gene sequencing, included this meta-analysis. Results: A total 25 1044 participants. Based fixed-effects model [Chi2 = 29.40, df 20 (p 0.08); I2 32%], pooled analysis showed compared group, can significantly increase alpha adult GM, Shannon index as an example [WMD 0.05, 95% CI (0.00, 0.09); Z 1.99 0.05)]. In addition, interventions found alter notably decreasing Bacteroidetes increasing Firmicutes, indicating shift Firmicutes/Bacteroidetes ratio. subgroup indicates females older appear exhibit more significant changes Index observed OTUs. Conclusions: may promising way improve adults. particular, was increased after exercise. Distinct responses based gender age implicated needed.

Language: Английский

Citations

15
Physical activity, sedentary behavior and microbiome: A systematic review and meta-analysis DOI Creative Commons
Inmaculada Pérez‐Prieto, Abel Plaza‐Florido, Esther Ubago‐Guisado

et al.

Journal of science and medicine in sport, Journal Year: 2024, Volume and Issue: 27(11), P. 793 - 804

Published: July 9, 2024

The effects of physical activity and sedentary behavior on human health are well known, however, the molecular mechanisms poorly understood. Growing evidence points to as an important modulator composition function microbial communities, while is scarce. We aimed synthesize meta-analyze current about microbiome across different body sites in populations.

Language: Английский

Citations

9
The Microbiota–Gut–Brain Axis and Neurological Disorders: A Comprehensive Review DOI Creative Commons

Mohammed M. Nakhal,

Lidya K. Yassin,

Rana Alyaqoubi

et al.

Life, Journal Year: 2024, Volume and Issue: 14(10), P. 1234 - 1234

Published: Sept. 26, 2024

Microbes have inhabited the earth for hundreds of millions years longer than humans. The microbiota-gut-brain axis (MGBA) represents a bidirectional communication pathway. These communications occur between central nervous system (CNS), enteric (ENS), and emotional cognitive centres brain. field research on gut-brain has grown significantly during past two decades. Signalling occurs gut microbiota brain through neural, endocrine, immune, humoral pathways. A substantial body evidence indicates that MGBA plays pivotal role in various neurological diseases. include Alzheimer's disease (AD), autism spectrum disorder (ASD), Rett syndrome, attention deficit hyperactivity (ADHD), non-Alzheimer's neurodegeneration dementias, fronto-temporal lobe dementia (FTLD), Wilson-Konovalov (WD), multisystem atrophy (MSA), Huntington's chorea (HC), Parkinson's (PD), multiple sclerosis (MS), amyotrophic lateral (ALS), temporal epilepsy (TLE), depression, schizophrenia (SCZ). Furthermore, correlation therapeutics will be discussed. Conversely, mood delivery, exercise, psychotropic agents, stress, neurologic drugs can influence MGBA. By understanding MGBA, it may possible to facilitate into microbial-based interventions therapeutic strategies

Language: Английский

Citations

8
Gut microbiota: a novel target for exercise-mediated regulation of NLRP3 inflammasome activation DOI Creative Commons
Jun Chen,

Shaohui Jia,

Xiaoguang Xue

et al.

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 6, 2025

The NOD-like receptor family pyrin domain-containing 3 (NLRP3) is a key pattern recognition in the innate immune system. Its overactivation leads to production of pro-inflammatory cytokines, such as IL-1β and IL-18, which contribute development progression various diseases. In recent years, evidence has shown that gut microbiota plays an important role regulating activation NLRP3 inflammasome. Variations function composition can directly or indirectly influence inflammasome by influencing bacterial components metabolites. Additionally, exercise been effectively reduce while promoting beneficial changes microbiota. This suggests may play mediating effects on regulation. review explores impact activation, examines mechanisms through mediates anti-inflammatory exercise, providing new avenues for research.

Language: Английский

Citations

1
Gut Microecological Prescription: A Novel Approach to Regulating Intestinal Micro-Ecological Balance DOI Creative Commons
Lingping Zhu, Xuefeng Yang

International Journal of General Medicine, Journal Year: 2025, Volume and Issue: Volume 18, P. 603 - 626

Published: Feb. 1, 2025

Abstract: The intestinal microecology is comprises microorganisms and other components constituting the entire ecosystem, presenting characteristics of stability dynamic balance. Current research reveals microecological imbalances are related to various diseases. However, fundamental clinical applications have not been effectively integrated. Considering importance complexity regulating balance, this study provides an overview high-risk factors affecting detection methods. Moreover, it proposes definition imbalance definition, formulation, outcomes gut prescription facilitate its application in practice, thus promoting on improving quality life population. Keywords: microecology, risk, prescription, faecal microbiota transplantation

Language: Английский

Citations

1
Effect of Hesperidin Supplementation on Liver Metabolomics and Gut Microbiota in a High-Fat Diet-Induced NAFLD Mice Model DOI
Xiaoping Li,

Yexuan Yao,

Yu Wang

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2022, Volume and Issue: 70(36), P. 11224 - 11235

Published: Sept. 1, 2022

The present study investigated the mechanism underlying impact of hesperidin (HES) on nonalcoholic fatty liver (NAFLD). C57BL/6J male mice were administered a low-fat diet, high-fat diet (HFD), or HFD plus 0.2% (wt/wt) HES (HFD + HES) diet. After 16 weeks intervention, in HFD+HES group showed lower final body weight and improved serum lipid profiles when compared with group. Alleviation dysfunction induced by was observed HES-fed mice, expression genes involved metabolism also altered. Moreover, changed composition intestinal microbiota enriched specific genera such as Bacteroidota. Liver metabolomics analysis indicated that enhanced abundance metabolites arginine-related well mitochondrial oxidation-related pathways, these predicted to be positively correlated gut HES. Together, results indicate HFD-fed supplemented markedly regulated hepatic concurrent shifts bacteria.

Language: Английский

Citations

34
The Effects of Diet Intervention on the Gut Microbiota in Type 2 Diabetes Mellitus: A Systematic Review DOI Open Access

Kiana Farahbod,

Ethan Slouha,

Andrew Gerts

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: March 22, 2024

The GI tract hosts a dynamic community known as the gut microbiota, which encompasses thriving bacteria that actively contribute to physiological functions of human body. intricacies its composition are profoundly influenced by dietary preferences, where quality, quantity, and frequency food consumption play pivotal role in either fostering or impeding specific bacterial strains. Type 2 diabetes mellitus (T2DM) is prevalent deleterious condition originates from excessive hyperglycemia. Do lifestyle interventions targeting adjustments, nutritional supplements, physical activity, weight management programs exhibit significant relationship altering microbiome managing T2DM? This paper aims evaluate effects on patients with T2DM implications these changes disease outcomes progression. Lifestyle can significantly impact T2DM, especially those programs. adoption high-fiber diet increased fruit have shown positive impacts both insulin sensitivity microbiota. Additionally, promising emerge supplementing Omega-3 fatty acids, Vitamin K2 (MK-7), transglucosidase, influence levels, glycemic control, microbiota composition. Personalized transformative Mediterranean present metabolic control. intensity exercise plays shaping moderate-intensity continuous displaying anti-inflammatory microbes. Chronic showcases favorable control systemic inflammation. Emphasizing intricate between habits, risk underscores potential universal biomarker for assessing risk. Nutritional supplements provide avenues emphasizing necessity tailored strategies. Further research encouraged delve into long-term interplay factors microbiome, enhancing our understanding pathophysiology targeted therapeutic approaches.

Language: Английский

Citations

7
A systematic review on the effects of exercise on gut microbial diversity, taxonomic composition, and microbial metabolites: identifying research gaps and future directions DOI Creative Commons

John M. A. Cullen,

Shahim Shahzad,

Jaapna Dhillon

et al.

Frontiers in Physiology, Journal Year: 2023, Volume and Issue: 14

Published: Dec. 19, 2023

The gut microbiome, hosting a diverse microbial community, plays pivotal role in metabolism, immunity, and digestion. While the potential of exercise to influence this microbiome has been increasingly recognized, findings remain incongruous. This systematic review examined effects on human animal models. Databases (i.e., PubMed, Cochrane Library, Scopus, Web Science) were searched up June 2022. Thirty-two studies, i.e., 19 13 studies with minimum two groups that discussed outcomes, such as diversity, taxonomic composition, or metabolites, over intervention period, included (PROSPERO registration numbers for review: CRD42023394223). Results indicated 50% found no significant effect diversity. When evident, often augmented Shannon index, reflecting enhanced richness evenness, irrespective disease status. Changes beta-diversity metrics also documented but without clear directionality. A larger percentage demonstrated shifts diversity compared any distinct patterns, mainly due varied predominantly aerobic metrics. In terms humans, usually led decrease Firmicutes/Bacteroidetes ratio, consistent increases Bacteroides Roseburia genera. models, Coprococcus , another short chain fatty acid (SCFA) producer, consistently rose exercise. Generally, SCFA producers increase With regard SCFAs emerged most frequently measured metabolite. However, limited examining microbial-produced including SCFAs, patterns did not emerge. overall risk bias was deemed neutral. conclusion, comprehensive underscores can potentially impact indications changes composition. variability study designs protocols demands more standardized methodologies robust statistical nuanced understanding exercise-microbiome relationship could guide individualized programs optimize health. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=394223 identifier CRD42023394223.

Language: Английский

Citations

13