Gut microbiota in obesity

World Journal of Gastroenterology, Journal Year: 2021, Volume and Issue: 27(25), P. 3837 - 3850

Published: July 5, 2021

Obesity is a major global health problem determined by heredity and environment, its incidence increasing yearly. In recent years, evidence linking obesity to the gut microbiota has been reported. Gut management become new method of treatment. However, complex interactions among genetics, microbiota, remain poorly understood. this review, we summarize characteristics in obesity, mechanism induced influence genetic environmental factors on provide support for understanding relationship between microbiota. At same time, prospect research related proposed.

Language: Английский

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Immunosenescence and inflammaging in the aging process: age-related diseases or longevity?

Ageing Research Reviews, Journal Year: 2021, Volume and Issue: 71, P. 101422 - 101422

Published: Aug. 13, 2021

Language: Английский

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Ageing of the gut microbiome: Potential influences on immune senescence and inflammageing

Ageing Research Reviews, Journal Year: 2021, Volume and Issue: 68, P. 101323 - 101323

Published: March 23, 2021

Language: Английский

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Excess body weight: Novel insights into its roles in obesity comorbidities

Seminars in Cancer Biology, Journal Year: 2023, Volume and Issue: 92, P. 16 - 27

Published: March 24, 2023

Excess body weight is a global health problem due to sedentary lifestyle and unhealthy diet, affecting 2 billion population worldwide. Obesity major risk factor for metabolic diseases. Notably, the of obesity largely depends on distribution, which visceral adipose tissues but not subcutaneous fats are closely associated with comorbidities, including type diabetes, non-alcoholic fatty liver disease, cardiovascular disease certain types cancer. Latest multi-omics mechanistical studies reported crucial involvement genetic epigenetic alterations, adipokines dysregulation, immunity changes, imbalance white brown tissues, gut microbial dysbiosis in mediating pathogenic association between comorbidities. In this review, we explore epidemiology excess up-to-date mechanism how lead chronic complications. We also examine utilization fat measurement as an accurate clinical parameter assessment healthy individuals outcome prediction obese subjects. addition, current approaches prevention treatment its related comorbidities further discussed.

Language: Английский

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Longevity of centenarians is reflected by the gut microbiome with youth-associated signatures

Nature Aging, Journal Year: 2023, Volume and Issue: 3(4), P. 436 - 449

Published: April 6, 2023

Language: Английский

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Gut commensal Christensenella minuta modulates host metabolism via acylated secondary bile acids

Nature Microbiology, Journal Year: 2024, Volume and Issue: 9(2), P. 434 - 450

Published: Jan. 17, 2024

Language: Английский

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Curcumin Mitigates the High-Fat High-Sugar Diet-Induced Impairment of Spatial Memory, Hepatic Metabolism, and the Alteration of the Gut Microbiome in Alzheimer’s Disease-Induced (3xTg-AD) Mice

Nutrients, Journal Year: 2024, Volume and Issue: 16(2), P. 240 - 240

Published: Jan. 12, 2024

The escalating prevalence of metabolic diseases and an aging demographic has been correlated with a concerning rise in Alzheimer's disease (AD) incidence. This study aimed to access the protective effects curcumin, bioactive flavonoid from turmeric, on spatial memory, functions, regulation gut microbiome AD-induced (3xTg-AD) mice fed either normal chow diet (NCD) or high-fat high-sugar (HFHSD). Our findings revealed augmented susceptibility HFHSD-fed 3xTg-AD for weight gain memory impairment, while curcumin supplementation demonstrated effect against these changes. was evidenced by significantly reduced body improved behavioral cognitive function curcumin-treated group. These improvements were substantiated diminished fatty acid synthesis, altered cholesterol metabolism, suppressed adipogenesis-related pathways liver, along modified synaptic plasticity-related brain. Moreover, enriched beneficial microbiota, including

Language: Английский

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The human gut microbiome and aging

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: June 3, 2024

The composition of the human gut microbiome has been observed to change over course an individual's life. From birth, it is shaped by mode delivery, diet, environmental exposures, geographic location, exposures medications, and aging itself. Here, we present a narrative review across lifespan with focus on its impacts age-related diseases in humans. We will describe how shaped, features that have associated at different phases life this can adversely affect healthy aging. Across lifespan, especially old age, diverse includes organisms suspected produce anti-inflammatory metabolites such as short-chain fatty acids, reported be These findings remarkably consistent regions world suggesting they could universal all cultures genetic backgrounds. Exactly these biologic processes thus promoting crucial targeting for interventions support health longevity.

Language: Английский

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Achieving healthy aging through gut microbiota-directed dietary intervention: Focusing on microbial biomarkers and host mechanisms

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown

Published: March 1, 2024

Population aging has become a primary global public health issue, and the prevention of age-associated diseases prolonging healthy life expectancies are particular importance. Gut microbiota emerged as novel target in various host physiological disorders including aging. Comprehensive understanding on changes gut during aging, characteristics centenarians, can provide us possibility to achieving or intervene pathological through microbiota-directed strategies. This review aims summarize associated with explore potential biomarkers address microbiota-associated mechanisms focusing intestinal barrier immune status. By summarizing existing effective dietary strategies interventions, probability developing diet targeting future is provided. focused three key notions: Firstly, new for regulating status lifespan, its closely related age. Thus, we summarized aging-associated features at levels genus/species important metabolites comparing differences among elderly people younger people. Secondly, exploring discussing using regime/components targeted aging-related promote human lifespan. Thirdly, intervention effectively improve imbalance such probiotics, prebiotics, postbiotics, but their effects vary among.

Language: Английский

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The Role of the Gut Microbiota in the Development and Progression of Major Depressive and Bipolar Disorder

Nutrients, Journal Year: 2021, Volume and Issue: 14(1), P. 37 - 37

Published: Dec. 23, 2021

A growing number of studies in rodents indicate a connection between the intestinal microbiota and brain, but comprehensive human data is scarce. Here, we systematically reviewed examining major depressive bipolar disorder. In this review discuss various changes bacterial abundance, particularly on low taxonomic levels, terms with pathophysiology disorder, their use as diagnostic treatment response parameter, health-promoting potential, well novel adjunctive options. The diversity mostly decreased depressed subjects. consistent elevation phylum Actinobacteria, family Bifidobacteriaceae, genus Bacteroides, reduction Ruminococcaceae, Faecalibacterium, Roseburia was reported. Probiotics containing Bifidobacterium and/or Lactobacillus spp. seemed to improve symptoms, approaches different probiotics synbiotics showed promising results. Comparing twin studies, report here that already an elevated risk developing depression, microbial towards “depression-like” were found. Overall, these findings highlight importance necessity for better understanding its contributing potentially leading new alleviate symptoms via alterations gut microbiota.

Language: Английский

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