Development of Gut Microbiota in the First 1000 Days after Birth and Potential Interventions

Nutrients, Journal Year: 2023, Volume and Issue: 15(16), P. 3647 - 3647

Published: Aug. 20, 2023

The first 1000 days after birth represent a critical window for gut microbiome development, which is essential immune system maturation and overall health. undergoes major changes during this period due to shifts in diet environment. Disruptions the microbiota early life can have lasting health effects, including increased risks of inflammatory disorders, autoimmune diseases, neurological obesity. Maternal environmental factors pregnancy infancy shape infant microbiota. In article, we will review how maintaining healthy important long-term Furthermore, briefly include fungal colonization its effects on host function, are discussed as part ecosystem. Additionally, describe potential approaches such hydrogels enriched with prebiotics probiotics, transplantation (GMT) pregnancy, age-specific microbial ecosystem therapeutics, CRISPR therapies targeting hold advancing research development. Nevertheless, thorough evaluation their safety, effectiveness, impacts crucial prior application clinical approach. article emphasizes need continued optimize development through targeted early-life interventions.

Language: Английский

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Effects of Probiotics on Gut Microbiota: An Overview

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 6022 - 6022

Published: May 30, 2024

The role of probiotics in regulating intestinal flora to enhance host immunity has recently received widespread attention. Altering the human gut microbiota may increase predisposition several disease phenotypes such as inflammation and metabolic disorders. converts dietary nutrients into metabolites that serve biologically active molecules modulating regulatory functions host. Probiotics, which are microorganisms, play a versatile restoring composition microbiota, helping improve prevent phenotypes. This comprehensive review provides firsthand information on their influence health, effects diet how alter function along with corresponding building healthy intestine. We also discuss implications some most important diseases. In summary, significant boosting overall immunity, increasing abundance beneficial bacteria, ameliorate symptoms multiple

Language: Английский

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Sugar-Sweetened Beverages and Metabolic Risk in Children and Adolescents with Obesity: A Narrative Review

Nutrients, Journal Year: 2023, Volume and Issue: 15(3), P. 702 - 702

Published: Jan. 30, 2023

Sugar-sweetened beverages (SSBs) are major contributors of free sugars to the diet. A strong relationship between SSB intake and weight gain is described. Methods: we performed a narrative review present an overview role SSBs as pivotal contributor in development obesity metabolism-related complications. Results: different factors influence consumption children, including economic variables, individual attributes behaviors environmental factors, parent features parents’ behaviors. Data suggest that has negative effect on obesity-related diseases. The leading mechanism linking risk gaining decreased satiety incomplete compensatory reduction energy at meals following ingestion liquid calories. Additionally, effects gut microbiota eating were also reported. An association intake, cardiometabolic risks evident. Consumption had significant impact prevalence related metabolic risks, insulin resistance, type 2 diabetes, hypertension syndrome. Conclusions: Limiting increasing knowledge early cardiovascular disorders will be useful developing strategies counteract problem prevent complications.Key future research areas for which further studies needed include investigating long-term health outcomes well analyzing sugar consumed solid compared forms elucidating biological mechanisms addiction compensation.

Language: Английский

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The Implication of the Gut Microbiome in Heart Failure

Cells, Journal Year: 2023, Volume and Issue: 12(8), P. 1158 - 1158

Published: April 14, 2023

Heart failure is a worldwide health problem with important consequences for the overall wellbeing of affected individuals as well healthcare system. Over recent decades, numerous pieces evidence have demonstrated that associated gut microbiota represent an component human physiology and metabolic homeostasis, can affect one’s state or disease directly, through their derived metabolites. The advances in microbiome studies shed light on relationship between cardiovascular system, revealing its contribution to development heart failure-associated dysbiosis. HF has been linked dysbiosis, low bacterial diversity, intestinal overgrowth potentially pathogenic bacteria decrease short chain fatty acids-producing bacteria. An increased permeability allowing microbial translocation passage bacterial-derived metabolites into bloodstream progression. A more insightful understanding interactions microbiome, risk factors mandatory optimizing therapeutic strategies based modulation offering individualized treatment. purpose this review summarize available data regarding influence communities HF, order obtain better multi-layered complex relationship.

Language: Английский

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Next-generation probiotics: the upcoming biotherapeutics

Molecular Biology Reports, Journal Year: 2024, Volume and Issue: 51(1)

Published: April 15, 2024

Abstract Recent and continuing advances in gut microbiome research have pointed out the role of microbiota as an unexplored source potentially beneficial probiotic microbes. Along lines these advances, both public awareness acceptance probiotics are increasing. That’s why; academic industrial is dedicated to identifying investigating new microbial strains for development next-generation (NGPs). At this time, there a growing interest NGPs biotherapeutics that alter affect various diseases development. In work, we focused on some emergent promising NGPs, specifically Eubacterium hallii, Faecalibacterium prausnitzii, Roseburia spp., Akkermansia muciniphila , Bacteroides fragilis their presence can impact diseases. Emerging studies point roles open up novel therapeutic options. Interestingly, were found enhance gastrointestinal immunity, immunotherapy efficacy cancer patients, retain intestinal barrier integrity, generate valuable metabolites, especially short-chain fatty acids, decrease complications chemotherapy radiotherapy. Although many considered prevention treatment several chronic diseases, humans still lacking. Therefore, approval microbes from regulatory agencies rare. Besides, issues limit wide use market, such suitable methods culture storage oxygen-sensitive The present review goes over main points related gives viewpoint key hinder application. Furthermore, advancement human healthiness investigations by clarifying limitations traditional microorganisms, discussing characteristics emerging defining management certain ailments. Future should emphasize isolation, mechanisms action probiotics, safety, clinical humans.

Language: Английский

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Dietary polyphenols regulate appetite mechanism via gut-brain axis and gut homeostasis

Food Chemistry, Journal Year: 2024, Volume and Issue: 446, P. 138739 - 138739

Published: Feb. 16, 2024

Language: Английский

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The Profound Influence of Gut Microbiome and Extracellular Vesicles on Animal Health and Disease

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 4024 - 4024

Published: April 4, 2024

The animal gut microbiota, comprising a diverse array of microorganisms, plays pivotal role in shaping host health and physiology. This review explores the intricate dynamics microbiome animals, focusing on its composition, function, impact host–microbe interactions. composition intestinal microbiota animals is influenced by ecology, including factors such as temperature, pH, oxygen levels, nutrient availability, well genetic makeup, diet, habitat, stressors, husbandry practices. Dysbiosis can lead to various gastrointestinal immune-related issues impacting overall productivity. Extracellular vesicles (EVs), particularly exosomes derived from play crucial intercellular communication, influencing transporting bioactive molecules across barriers like brain barriers. Dysregulation gut–brain axis has implications for disorders highlighting potential microbiota-derived EVs disease progression. Therapeutic approaches modulate probiotics, prebiotics, microbial transplants, phage therapy, offer promising strategies enhancing performance. Studies investigating effects therapy have shown results, with improving food safety poultry production systems. Understanding complex interactions between provides valuable insights into mechanisms underlying their Further research this field essential developing effective therapeutic interventions management promote well-being animals.

Language: Английский

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The gut microbiome associates with phenotypic manifestations of post-acute COVID-19 syndrome

Cell Host & Microbe, Journal Year: 2024, Volume and Issue: 32(5), P. 651 - 660.e4

Published: April 23, 2024

Language: Английский

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Gut‐liver axis: Potential mechanisms of action of food‐derived extracellular vesicles

Journal of Extracellular Vesicles, Journal Year: 2024, Volume and Issue: 13(6)

Published: June 1, 2024

Abstract Food‐derived extracellular vesicles (FEVs) are nanoscale membrane obtained from dietary materials such as breast milk, plants and probiotics. Distinct other EVs, FEVs can survive the harsh degrading conditions in gastrointestinal tract reach intestines. This unique feature allows to be promising prebiotics health oral nanomedicine for gut disorders, inflammatory bowel disease. Interestingly, therapeutic effects of have recently also been observed non‐gastrointestinal diseases. However, mechanisms remain unclear or even mysterious. It is speculated that orally administered could enter bloodstream, remote organs, thus exert therein. emerging evidence suggests amount reaching organs beyond marginal may insufficient account significant achieved regarding diseases involving liver. Thus, we herein propose primarily act locally intestine by modulating intestinal microenvironments barrier integrity microbiota, thereby eliciting impact remotely on liver via gut‐liver axis. Likewise, drugs delivered system through As main metabolic hub, microenvironment implicated In fact, many patients with non‐alcoholic fatty disease, obesity, diabetes cardiovascular disease suffer a leaky dysbiosis. this review, provide an overview recent progress discuss their biomedical applications agents drug delivery systems, highlighting pivotal role axis action treatment disorders

Language: Английский

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Exploring the Gut Microbiota: Key Insights into Its Role in Obesity, Metabolic Syndrome, and Type 2 Diabetes

The Journal of Clinical Endocrinology & Metabolism, Journal Year: 2024, Volume and Issue: 109(11), P. 2709 - 2719

Published: July 23, 2024

Abstract The gut microbiota (GM), comprising trillions of microorganisms in the gastrointestinal tract, is a key player development obesity and related metabolic disorders, such as type 2 diabetes (T2D), syndrome (MS), cardiovascular diseases. This mini-review delves into intricate roles mechanisms GM these conditions, offering insights potential therapeutic strategies targeting microbiota. review elucidates diversity human GM, highlighting its pivotal functions host physiology, including nutrient absorption, immune regulation, energy metabolism. Studies show that dysbiosis linked to increased extraction, altered pathways, inflammation, contributing obesity, MS, T2D. interplay between dietary habits composition explored, underscoring influence diet on microbial functions. Additionally, addresses impact common medications interventions like fecal transplantation composition. evidence so far advocates for further research delineate modulation mitigating diseases, emphasizing necessity clinical trials establish effective sustainable treatment protocols.

Language: Английский

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