The 16p11.2 microdeletion influences how early-life microbiota perturbations affect hippocampal development and behavior throughout the lifespan DOI Creative Commons
Courtney McDermott, Zhan Gao,

Anya S. Mirmajlesi

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Neurodevelopmental disorders result from interactions between genetic predisposition and environmental risk factors, with infancy being the most vulnerable period. We designed a longitudinal study to determine how short-term antibiotic exposure during early postnatal life impacts gut microbiome, neurodevelopment, behavior, whether these alterations were exacerbated by neurodevelopmental disorder-associated 16p11.2 microdeletion (16pDel) mutation. The cephalosporin antibiotic, cefdinir, broadly altered microbiome acutely, persistent reductions in several Lachnospiraceae genera despite overall recovery. These preceded long-term behavioral changes, including reduced juvenile sociability, compromised assessment, deficits associative learning. Remarkably, only cefdinir-exposed 16pDel mice had changes hippocampal stem cell proliferation, subsequent adolescent numbers, gene expression compared other groups, demonstrating that can modulate effects of early-life on neurodevelopment. may be mediated gastrointestinal disturbances, as males increased intestinal permeability shifted metabolite profiles arginine biosynthesis glycerophospholipid metabolism. Taken together, this highlights microbial affect behavior reveals influences antibiotic-induced development. Further, insights identify metabolic mechanisms potential targets for intervention raise concerns regarding use infancy.

Language: Английский

Sodium alginate and galactooligosaccharides ameliorate metabolic disorders and alter the composition of the gut microbiota in mice with high-fat diet-induced obesity DOI
Yao Li, Juan Huang, Silu Zhang

et al.

International Journal of Biological Macromolecules, Journal Year: 2022, Volume and Issue: 215, P. 113 - 122

Published: June 16, 2022

Language: Английский

Citations

19
Molecular structure, IgE binding capacity and gut microbiota of ovalbumin conjugated to fructose and galactose:A comparative study DOI

Ji‐hua Mao,

Kai Zhang,

Ying-fei He

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 234, P. 123640 - 123640

Published: Feb. 16, 2023

Language: Английский

Citations

12
Feeding the microbiota–gut–brain axis: Nucleotides and their role in early life DOI Creative Commons

Zhihao Qu,

Peijun Tian,

Jianxin Zhao

et al.

Food Frontiers, Journal Year: 2023, Volume and Issue: 4(3), P. 1164 - 1178

Published: June 1, 2023

Abstract Nucleotides ingested from breast milk and complementary foods during infancy play a vital role in the development of immune nervous system, as well maturation gut function, are considered “special dietary nutrient.” Based on existing research progress theoretical basis, this review takes distribution nucleotides (NTs) early life (after birth to age 3 years) diet vivo metabolism/absorption process starting point expounds its potential impact mechanism action gastrointestinal brain development. With understanding microbiota (GM), interaction between factors GM has become focus food research. It is great significance reexamine biological effects nucleotide intake infant gut–brain perspective GM–gut–brain axis. This paper reveals relationship NTs–GM–gut–brain axis provides new ideas theories for application NTs field nutrition.

Language: Английский

Citations

12
Early-life gut microbiota and neurodevelopment in preterm infants: a narrative review DOI Creative Commons
Isadora Beghetti, Monica Barone, Patrizia Brigidi

et al.

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10

Published: Aug. 8, 2023

Infants born preterm are at a high risk of both gut microbiota (GM) dysbiosis and neurodevelopmental impairment. While the link between early short-term clinical outcomes is well established, relationship with long-term infant health has only recently gained interest. Notably, there significant overlap in developmental windows GM nervous system life. The connection neurodevelopment was first described animal models, but over last decade growing body research also identified features as one potential mediators for human neuropsychiatric disorders. In this narrative review, we provide an overview developing life its prospective neurodevelopment, focus on infants. Animal models have provided evidence emerging pathways linking early-life brain development. Furthermore, dynamic patterns static during infants’ maturation, childhood, documented. Future studies larger cohorts, integrated may additional help to identify predictive biomarkers therapeutic targets healthy

Language: Английский

Citations

11
The social microbiome: gut microbiome diversity and abundance are negatively associated with sociality in a wild mammal DOI Creative Commons

Madison Pfau,

Sam Degregori,

Gina Johnson

et al.

Royal Society Open Science, Journal Year: 2023, Volume and Issue: 10(10)

Published: Oct. 1, 2023

The gut microbiome has a well-documented relationship with host fitness. Greater microbial diversity and abundance of specific microbes have been associated improved fitness outcomes. Intestinal also may be patterns social behaviour. However, these associations largely studied in captive animal models; we know less about composition as potential driver individual behaviour position the wild. We used linear mixed models to quantify between fecal composition, network traits wild population yellow-bellied marmots (

Language: Английский

Citations

11
Comprehensive analysis of the microbiome in Apis cerana honey highlights honey as a potential source for the isolation of beneficial bacterial strains DOI Creative Commons
Pham Thi Lanh,

Bùi Thị Thùy Dương,

Hà Thị Thu

et al.

PeerJ, Journal Year: 2024, Volume and Issue: 12, P. e17157 - e17157

Published: March 27, 2024

Background Honey is a nutritious food made by bees from nectar and sweet deposits of flowering plants has been used for centuries as natural remedy wound healing other bacterial infections due to its antibacterial properties. contains diverse community bacteria, especially probiotic that greatly affect the health their consumers. Therefore, understanding microorganisms in honey can help ensure quality lead identification potential bacteria. Methods Herein, bacteria produced Apis cerana was investigated applying next-generation sequencing (NGS) method V3–V4 hypervariable regions 16S rRNA gene. In addition, lactic acid (LAB) sample were also isolated screened vitro antimicrobial activity. Results The results showed microbiota A. consisted two major phyla, Firmicutes (50%; Clostridia , 48.2%) Proteobacteria (49%; Gammaproteobacteria 47.7%). Among 67 identified genera, three most predominant genera beneficial obligate anaerobic Lachnospiraceae (48.14%), followed Gilliamella (26.80%), Enterobacter (10.16%). Remarkably, among LAB, Lactobacillus kunkeei found be abundant species. Interestingly, L. strains exhibited activity against some pathogenic honeybees, including Klebsiella spp ., Escherichia coli Enterococcus faecalis Pseudomonas aeruginosa Staphylococcus aureus . This underscores candidacy developing probiotics medical use. Taken together, our provided new insights into Hanoi, Vietnam, highlighting evidence an unexplored source isolating with applications honeybees humans.

Language: Английский

Citations

4
A digital twin of the infant microbiome to predict neurodevelopmental deficits DOI Creative Commons
nicholas sizemore, Kaitlyn Oliphant, Ruolin Zheng

et al.

Science Advances, Journal Year: 2024, Volume and Issue: 10(15)

Published: April 10, 2024

Despite the recognized gut-brain axis link, natural variations in microbial profiles between patients hinder definition of normal abundance ranges, confounding impact dysbiosis on infant neurodevelopment. We infer a digital twin microbiome, forecasting ecosystem trajectories from few initial observations. Using 16 S ribosomal RNA 88 preterm infants (398 fecal samples and 32,942 estimates for 91 classes), model (Q-net) predicts dynamics with R 2 = 0.69. Contrasting fit to Q-nets typical versus suboptimal development, we can reliably estimate individual deficit risk ( M δ ) identify achieving poor future head circumference growth ≈76% area under receiver operator characteristic curve, 95% ± 1.8% positive predictive value at 98% specificity 30 weeks postmenstrual age. find that early transplantation might mitigate ≈45.2% cohort, potentially negative effects incorrect supplementation. are generative artificial intelligence models dynamics, broad potential applications.

Language: Английский

Citations

4
Pesticide butachlor exposure perturbs gut microbial homeostasis DOI
Jiakui Li, Fang Liu,

Wenyu Si

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 281, P. 116646 - 116646

Published: July 1, 2024

Agricultural production relies heavily on the use of pesticides, which may accumulate in soil and water, posing a significant threat to global ecological environment biological health. Butachlor is commonly used herbicide environmental pollutant, has been linked liver kidney damage, as well neurological abnormalities. However, potential impact butachlor exposure gut microbiota remains understudied. Thus, our aim was investigate negative effects host health microbiota. Our results demonstrated that significantly reduced antioxidant capacity, evidenced by decreased levels T-AOC, SOD, GSH-Px, increased MDA. Serum biochemical analysis also revealed increase AST ALT during exposure. Microbial showed abundance diversity Furthermore, altered microbial composition. In conclusion, findings indicate can have detrimental effects, including dysregulation enzymes, abnormalities transaminases, hepatointestinal damage. it disrupts homeostasis altering composition reducing abundance. context increasingly serious this study will help provide impetus for standardizing application pesticides pollution.

Language: Английский

Citations

4
Effects of Lactiplantibacillus-plantarum-ZG7-Fermented Feed on Laying-Hen Productivity and Intestinal Health DOI Creative Commons
Zhaolong Li, Wenjing Liu,

Huini Wu

et al.

Fermentation, Journal Year: 2025, Volume and Issue: 11(3), P. 123 - 123

Published: March 4, 2025

The improvement in poultry production performance varies with different microbial strains used fermented feed. This study investigates the efficacy of Lactiplantibacillus-plantarum-ZG7-fermented feed (ZG7-FF) on productivity laying hens. Results indicated that ZG7-FF significantly reduced daily intake while increasing egg weight and decreasing feed-to-egg ratio during peak (p < 0.05), addition to enhancing late-phase rate 0.05). Further intestinal morphological results showed increased length villi each segment, most duodenum jejunum 0.01). also abundance phylum Desulfobacterota, showing a notable increase Cyanobacteria. Conversely, there was significant reduction Firmicutes specifically Limosilactobacillus Ligilactobacillus. LEfSe (LDA Effect Size) analysis differential species associated are primarily Bifidobacteriales Aeriscardovia. In contrast, is predominantly composed Cyanobacteria, colon mainly characterized by Enterococcus. Non-targeted metabolomics revealed drives suppression key metabolites, including 3-hydroxybutyric acid, ethylnitronate, 6-chlorocoumarin-3-carboxylic lotaustralin, oleoylcarnitine, enriching pathways related amino acid metabolism. downregulated metabolites were functionally linked ABC transporters neuroactive ligand–receptor interactions. Correlation analyses demonstrated positive associations between Limosilactobacillus/Ligilactobacillus suppressed whereas Enterococcus chloroplast-related taxa exhibited negative correlations. summary, administration enhances morphology, reduces intake, increases weight, decreases ingredient usage, elevates Enterococcus, diminishes overall load.

Language: Английский

Citations

0
Preventive effect of quinoa polysaccharides on lipopolysaccharide-induced inflammation in mice through gut microbiota regulation DOI

Hitache Zeyneb,

Ya Song,

Lin Wang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141899 - 141899

Published: March 1, 2025

Language: Английский

Citations

0