Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Feb. 22, 2024
There
exists
a
bidirectional
relationship
between
oral
health
and
general
well-being,
with
an
imbalance
in
symbiotic
flora
posing
threat
to
overall
human
health.
Disruptions
the
commensal
can
lead
diseases,
while
systemic
illnesses
also
impact
cavity,
resulting
development
of
diseases
disorders.
Porphyromonas
gingivalis
Fusobacterium
nucleatum
,
known
as
pathogenic
bacteria
associated
periodontitis,
play
crucial
role
linking
periodontitis
accompanying
diseases.
In
periodontal
tissues,
these
bacteria,
along
their
virulence
factors,
excessively
activate
host
immune
system
through
local
diffusion,
lymphatic
circulation,
blood
transmission.
This
response
disruption
contributes
osteoimmune
mechanisms,
alveolar
bone
resorption,
potential
inflammation.
To
restore
homeostasis,
deeper
understanding
microbiota–host
interactions
network
phenotype
tissues
is
imperative.
Defining
offers
promising
avenue
for
investigating
complex
characteristics
plaque
biofilms
exploring
review
aims
provide
overview
mechanisms
underlying
-
-induced
well
immunophenotypes
observed
during
pathological
conditions.
International Immunopharmacology,
Journal Year:
2024,
Volume and Issue:
136, P. 112341 - 112341
Published: May 28, 2024
Osteoporosis
(OP)
is
a
common
systemic
skeletal
disorder
characterized
by
an
imbalance
in
bone
homeostasis,
involving
increased
osteoclastic
formation
and
decreased
osteoblastic
resorption.
Quercetin
plant
polyphenol
that
has
been
found
to
exhibit
various
biological
activities,
including
antioxidant,
anti-inflammatory,
antimicrobial
effects.
Previous
studies
have
demonstrated
its
potential
improve
postmenopausal
OP,
although
the
exact
mechanism
remains
unclear.
This
study
aims
investigate
anti-osteoporotic
of
quercetin
based
on
"intestinal
flora
−
short-chain
fatty
acids
(SCFAs)
inflammatory"
signaling
axis.
In
this
study,
we
established
ovariectomized
(OVX)-induced
rat
model,
intervention
evaluated
effects
rats
following
antibiotic
(ABX)
treatment
fecal
microbiota
transplantation
(FMT).
After
6
weeks
intervention,
were
euthanized,
samples
from
their
femur,
tibia,
lumbar
spine,
serum,
colon
feces
collected,
strength,
intestinal
structure,
SCFAs
levels
cytokine
assessed.
modulates
increasing
potentially
probiotic
bacteria
(i.e.,
Lactobacillales,
Prevotellaceae,
Blautia)
decreasing
pathogenic
(Desulfobacterota,
Erysipelotrichales,
Romboutsia,
Butyricoccaceae).
It
also
increases
content
reduces
colonic
permeability
enhancing
tight
junction
proteins
(ZO-1,
Occludin).
Furthermore,
lowers
proinflammatory
(LPS,
IL-1β,
TNF-α),
which
enhances
strength
prevents
OVX-induced
loss.
may
effectively
reduce
loss
OVX
via
pathway.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 8, 2024
Abstract
Melatonin
(
N
‐acetyl‐5‐methoxytryptamine)
is
reported
to
improve
mood
disorders
in
perimenopausal
women
and
gut
microbiome
composition
altered
during
menopausal
period.
The
possible
role
of
the
treatment
effect
melatonin
on
depression
remains
unknown.
Here,
it
shown
that
reverses
microbiota
dysbiosis
depressive‐like
behaviors
ovariectomy
(OVX)
operated
mice.
This
prevented
by
antibiotic
cocktails
(ABX)
treatment.
Transferring
harvested
from
adolescent
female
mice
OVX‐operated
sufficient
ameliorate
behaviors.
Conversely,
transplantation
or
melatonin‐treated
naïve
recipient
exhibits
similar
phenotypes
donors.
colonization
Alistipes
Inops
,
which
abundant
mice,
confers
with
Further
investigation
indicates
expansion
induced
OVX
leads
degradation
intestinal
tryptophan,
destroys
systemic
tryptophan
availability.
supplementation
restores
metabolic
suppressing
growth
ameliorates
These
results
highlight
previously
unrecognized
modulation
OVX‐induced
behavioral
suggest
application
inhibit
may
serve
as
a
potential
strategy
for
preventing
depressive
symptoms.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Sept. 19, 2024
Osteoarthritis
(OA)
is
a
prevalent
clinical
condition
affecting
the
entire
joint,
characterized
by
its
multifactorial
etiology
and
complex
pathophysiology.
The
onset
of
OA
linked
to
inflammatory
mediators
produced
synovium,
cartilage,
subchondral
bone,
all
which
are
closely
tied
cartilage
degradation.
Consequently,
may
also
be
viewed
as
systemic
disorder.
Emerging
studies
have
underscored
significance
T
cells
in
development
OA.
Notably,
imbalances
Th1/Th2
Th17/Treg
immune
play
crucial
role
pathogenesis
This
review
aims
compile
recent
advancements
understanding
their
Th/Treg
subsets
OA,
examines
alterations
contributions
progression,
proposes
novel
directions
for
future
research,
including
potential
therapeutic
strategies
Dermatology and Therapy,
Journal Year:
2023,
Volume and Issue:
13(10), P. 2331 - 2343
Published: Aug. 31, 2023
Previous
studies
have
proposed
a
possible
gut–skin
axis,
and
linked
gut
microbiota
to
psoriasis
risks.
However,
there
is
heterogeneity
in
existing
evidence.
Observational
research
prone
bias,
it
hard
determine
causality.
Therefore,
this
study
aims
evaluate
causal
associations
between
(GM)
psoriasis.
With
published
large-scale
GWAS
(genome-wide
association
study)
summary
datasets,
two-sample
Mendelian
randomization
(MR)
was
performed
sort
out
roles
of
GM
arthropathic
(PsA).
The
inverse
variance
weighted
(IVW)
method
taken
as
the
primary
evaluation
association.
As
complements
IVW
method,
we
also
applied
MR-Egger,
median.
Sensitivity
analyses
were
conducted
using
Cochrane's
Q
test,
MR-Egger
intercept
MR-PRESSO
(Mendelian
Randomization
Pleiotropy
RESidual
Sum
Outlier)
global
leave-one-out
analysis.
By
analysis,
identified
nominal
protective
Bacteroidetes
(odds
ratio,
OR
0.81,
P
=
0.033)
Prevotella9
(OR
0.87,
0.045)
Bacteroidia
0.65,
0.03),
Bacteroidales
Ruminococcaceae
UCG002
0.038)
are
nominally
associated
with
lower
risks
for
PsA.
On
other
hand,
Pasteurellales
1.22,
0.033),
Pasteurellaceae
Blautia
1.46,
0.014),
Methanobrevibacter
1.27,
0.026),
Eubacterium
fissicatena
group
1.21,
0.028)
risk
factors
Additionally,
E.
factor
0.00018).
After
false
discovery
rate
(FDR)
correction,
remains
(PFDR
0.03798).
We
comprehensively
evaluated
psoriasis,
several
associations.
after
FDR
correction.
Our
results
offer
promising
therapeutic
targets
clinical
management.
Frontiers in Microbiology,
Journal Year:
2023,
Volume and Issue:
14
Published: Nov. 27, 2023
Introduction
The
intricate
interplay
between
gut
microbiota
and
hyperuricemia
remains
a
subject
of
growing
interest.
However,
existing
studies
only
provided
snapshots
the
microbiome
at
single
time
points,
temporal
dynamics
alterations
during
progression
barrier
remain
underexplored.
Our
investigation
revealed
compelling
insights
into
dynamic
changes
in
both
intestinal
function
throughout
course
hyperuricemia.
Methods
mice
(HY)
were
given
intragastric
administration
adenine
potassium
oxalate.
Gut
was
analyzed
by
16S
rRNA
sequencing
3,
7,
14,
21
days
after
start
modeling
process.
Intestinal
permeability
as
well
LPS,
TNF-α,
IL-1β
levels
measured
days.
Results
We
discovered
that
shifts
microbial
community
composition
occur
prior
to
onset
hyperuricemia,
key
bacterial
Bacteroidaceae
,
Bacteroides
Blautia
exhibited
reduced
levels,
potentially
fueling
dysbiosis
disease
progresses.
During
fluctuations
uric
acid
accompanied
with
depletion
beneficial
bacteria,
including
Prevotellaceae
Muribaculum
Parabacteroides
Akkermansia
coincided
an
increase
pathogenic
bacteria
such
Oscillibacter
Ruminiclostridium
.
This
shift
likely
contributed
elevated
lipopolysaccharide
(LPS)
pro-inflammatory
cytokine
ultimately
promoting
metabolic
inflammation.
decline
Burkholderiaceae
Parasutterella
inversely
related
Conversely,
families
Ruminococcaceae
Family_XIII
genera
Anaeroplasma
positive
correlations
levels.
Akkermansiaceae
demonstrating
negative
correlations,
while
LPS-containing
Desulfovibrio
Enterorhabdus
permeability.
Conclusion
In
summary,
this
study
offers
perspective
on
complex
microbiota,
progression.
suggested
Ruminiclostridium,
Bacteroides,
Akkermansiaceae,
Bilophila,
play
vital
rols
progress
compromised
barrier,
which
provide
potential
avenue
for
therapeutic
interventions
