Molecular Biotechnology, Journal Year: 2023, Volume and Issue: 66(8), P. 1883 - 1893
Published: July 21, 2023
Language: Английский
Molecular Cancer, Journal Year: 2022, Volume and Issue: 21(1)
Published: Dec. 14, 2022
Abstract Cancer drug resistance represents the main obstacle in cancer treatment. Drug-resistant cancers exhibit complex molecular mechanisms to hit back therapy under pharmacological pressure. As a reversible epigenetic modification, N 6 -methyladenosine (m A) RNA modification was regarded be most common modification. methyltransferases (writers), demethylases (erasers), and m A-binding proteins (readers) are frequently disordered several tumors, thus regulating expression of oncoproteins, enhancing tumorigenesis, proliferation, development, metastasis. The review elucidated underlying role A resistance. Alteration affected efficacy by restructuring multidrug efflux transporters, drug-metabolizing enzymes, anticancer targets. Furthermore, variation resulted DNA damage repair, downstream adaptive response (apoptosis, autophagy, oncogenic bypass signaling), cell stemness, tumor immune microenvironment, exosomal non-coding RNA. It is highlighted that small molecules targeting regulators have shown significant potential for overcoming different categories. Further inhibitors activators A-modified expected provide novel drugs, delivering therapeutic addressing challenge clinical
Language: Английский
Citations
61
Drug Resistance Updates, Journal Year: 2022, Volume and Issue: 65, P. 100866 - 100866
Published: Sept. 20, 2022
Language: Английский
Citations
51
Experimental & Molecular Medicine, Journal Year: 2023, Volume and Issue: 55(3), P. 487 - 501
Published: March 1, 2023
Abstract N6-methyladenosine (m6A) is one of the epigenetic modifications RNA. The addition this chemical mark to RNA molecules regulates gene expression by affecting fate molecules. This posttranscriptional modification reversible and regulated methyltransferase “writers” demethylase “erasers”. m6A-modified RNAs depends on function different “readers” that recognize bind them. Research m6A methylation has recently increased due its important role in regulating cancer progression. Noncoding (ncRNAs) are a class transcribed from genome but whose roles have been overlooked their lack well-defined potential for translation into proteins or peptides. However, misconception now completely overturned. ncRNAs regulate various diseases, especially tumors, it confirmed they play either tumor-promoting tumor-suppressing almost all types tumors. In review, we discuss ncRNA summarize mechanisms involved. Finally, progress research clinical treatment significance
Language: Английский
Citations
42
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(9), P. 8095 - 8095
Published: April 30, 2023
(1) Although long noncoding RNAs (lncRNAs) are known to be precursors of microRNAs (miRNAs), they frequently act as competing endogoneous (ceRNAs), yet still their interplay with miRNA is not well known. However, interaction miRNAs may result in the modulation action. (2) To determine contribution these RNA molecules tumor resistance chemotherapeutic drugs, it essential consider only oncogenic and suppressive function but also impact lncRNAs on miRNAs. Therefore, we performed an extensive search different databases including PubMed. (3) The present study concerns between regulatory post-transcriptional network drugs used treatment breast cancer. (4) Consideration this improve for new circumvent chemoresistance.
Language: Английский
Citations
28
Cancer Gene Therapy, Journal Year: 2024, Volume and Issue: 31(6), P. 816 - 830
Published: Feb. 14, 2024
Abstract RNA modification, especially N6-methyladenosine, 5-methylcytosine, and N7-methylguanosine methylation, participates in the occurrence progression of cancer through multiple pathways. The function expression these epigenetic regulators have gradually become a hot topic research. Mutation regulation noncoding RNA, lncRNA, play major role cancer. Generally, lncRNAs exert tumor-suppressive or oncogenic functions its dysregulation can promote tumor metastasis. In this review, we summarize modifications lncRNAs. Furthermore, discuss relationship between modification lncRNA interaction various cancers. Therefore, review gives comprehensive understanding mechanisms by which affects cancers regulating lncRNAs, may shed new light on research provide insights into therapy.
Language: Английский
Citations
12
Biomolecules, Journal Year: 2022, Volume and Issue: 12(9), P. 1224 - 1224
Published: Sept. 2, 2022
Wilms’ tumor 1-associating protein (WTAP) is required for N6-methyladenosine (m6A) RNA methylation modifications, which regulate biological processes such as splicing, cell proliferation, cycle, and embryonic development. m6A the predominant form of mRNA modification in eukaryotes. WTAP exerts by binding to methyltransferase-like 3 (METTL3) nucleus METTL3-methyltransferase-like 14 (METTL14)-WTAP (MMW) complex, a core component methyltransferase complex (MTC), localizing nuclear patches. Studies have demonstrated that plays critical role various cancers, both dependent independent its methyltransferases. Here, we describe recent findings on structural features WTAP, mechanisms regulates functions, molecular functions cancers. By summarizing latest research, expect provide new directions insights oncology research discover targets cancer treatment.
Language: Английский
Citations
33
Experimental Hematology and Oncology, Journal Year: 2023, Volume and Issue: 12(1)
Published: Feb. 21, 2023
Abstract Marvelous advancements have been made in cancer therapies to improve clinical outcomes over the years. However, therapeutic resistance has always a major difficulty therapy, with extremely complicated mechanisms remain elusive. N6-methyladenosine (m6A) RNA modification, hotspot epigenetics, gained growing attention as potential determinant of resistance. As most prevalent m6A is involved every links metabolism, including splicing, nuclear export, translation and stability. Three kinds regulators, “writer” (methyltransferase), “eraser” (demethylase) “reader” (m6A binding proteins), together orchestrate dynamic reversible process modification. Herein, we primarily reviewed regulatory resistance, chemotherapy, targeted radiotherapy immunotherapy. Then discussed modification overcome optimize therapy. Additionally, proposed existing problems current research prospects for future research.
Language: Английский
Citations
20
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 174, P. 116559 - 116559
Published: April 10, 2024
Breast cancer comprises a substantial proportion of diagnoses in women and is primary cause cancer-related mortality. While hormone-responsive cases generally have favorable prognosis, the aggressive nature triple-negative breast presents challenges, with intrinsic resistance to established treatments being persistent issue. The complexity intensifies emergence acquired resistance, further complicating management cancer. Epigenetic changes, encompassing DNA methylation, histone RNA modifications, non-coding RNAs, are acknowledged as crucial contributors heterogeneity unique epigenetic landscape harbored by each cellular component within tumor microenvironment (TME) adds great diversity intricate regulations which influence therapeutic responses. TME, sophisticated ecosystem non-cellular elements interacting cells, establishes an immunosuppressive fuels processes such growth, angiogenesis, extracellular matrix remodeling. These factors contribute challenging conditions treatment fostering hypoxic environment, inducing metabolic stress, creating physical barriers drug delivery. This article delves into complex connections between response, underlying vital interactions TME. To restore sensitivity treatment, it emphasizes need for combination therapies considering changes specific individual members Recognizing pivotal role epigenetics comprehending specificities TME essential devising more effective strategies. development reliable biomarkers patient stratification will facilitate tailored precise approaches.
Language: Английский
Citations
7
Cancer Cell International, Journal Year: 2023, Volume and Issue: 23(1)
Published: June 26, 2023
Abstract N 6 -methyladenosine (m A), one of the most common RNA methylation modifications, has emerged in recent years as a new layer regulatory mechanism controlling gene expression eukaryotes. As reversible epigenetic modification, m A not only occurs on mRNAs but also Long non-coding RNAs (LncRNAs). we all known, despite LncRNAs cannot encode proteins, they affect proteins by interacting with or miRNAs, thus playing important roles occurrence and development variety tumors. Up to now, it been widely accepted that modification affects fate corresponding LncRNAs. Interestingly, levels functions modifications are mediated through affecting methyltransferases (METTL3, METTL14, WTAP, METTL16, etc.), demethylases (FTO, ALKBH5) methyl-binding (YTHDFs, YTHDCs, IGF2BPs, HNRNPs, which collectively referred “m regulators”. In this review, summarized mutual regulation mechanisms between cancer progression, metastasis, invasion drug resistance. detail, focus specific is demethylases, involves LncRNA first part. And section two intensively displays mediation via changing proteins. At last part, described interaction effects during various tumor development.
Language: Английский
Citations
14
Bioengineered, Journal Year: 2022, Volume and Issue: 13(5), P. 13462 - 13473
Published: May 2, 2022
Increasing evidence supports that N6-methyladenine (m6A) and long noncoding RNAs (lncRNAs) both act as master regulators involved in breast cancer (BC) tumorigenesis at epigenetic modification level. Here, our research tries to unveil the interaction of m6A lncRNAs on BC progression explore underlying regulatory mechanism. In current study, we found LINC00667 was m6A-modified lncRNA, which up-regulated upon overexpression KIAA1429. The high expression correlated with prognosis patients. Bio-functional assays indicated promoted proliferation migration cells. Mechanistic illustrated KIAA1429 targeted site enhanced its mRNA stability. Moreover, positively regulated via sponging miR-556-5p, forming a KIAA1429/m6A/LINC00667/miR-556-5p feedback loop. Collectively, central findings study suggest KIAA1429-induced exerted functions an oncogene through m6A-dependent
Language: Английский
Citations
22