LncRNA ADAMTS9-AS2 inhibits cell proliferation and decreases chemoresistance in clear cell renal cell carcinoma via the miR-27a-3p/FOXO1 axis

Aging, Journal Year: 2019, Volume and Issue: 11(15), P. 5705 - 5725

Published: Aug. 10, 2019

Accumulating evidence reveals the principal role of long noncoding RNAs in progression clear cell renal carcinoma (ccRCC).However, little is known about underlying mechanism ADAM metallopeptidase with thrombospondin type 1 motif, 9 antisense RNA 2 (ADAMTS9-AS2) ccRCC.Here, bioinformatics analyses verified ADAMTS9-AS2 a and its high expression was associated better prognosis ccRCC.ADAMTS9-AS2 clearly downregulated ccRCC clinical samples lines.Clinical data showed lowexpressed correlated worse overall survival patients.Next, miR-27a-3p identified as an inhibitory target by dual-luciferase reporter immunoprecipitation assays.Both overexpressed underexpressed lines led to inhibition proliferation reduction chemoresistance.Additionally, Forkhead Box Protein O1 (FOXO1) confirmed miR-27a-3p.Induced overexpression, chemoresistance exhibited obvious reduction, FOXO1 evident increase, but all were reversed after simultaneously overexpressed.Collectively, these results suggest inhibits impairs via miR-27a-3p-mediated regulation may serve prognostic biomarker therapeutic for ccRCC.

Language: Английский

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Noncoding RNAs as therapeutic targets in early stage diabetic kidney disease

Kidney Research and Clinical Practice, Journal Year: 2018, Volume and Issue: 37(3), P. 197 - 209

Published: Sept. 18, 2018

Diabetic kidney disease (DKD) is a major renal complication of diabetes that leads to dysfunction and end-stage (ESRD). Major features DKD include accumulation extracellular matrix proteins glomerular hypertrophy, especially in early stage. Transforming growth factor-β plays key roles regulation profibrotic genes signal transducers such as Akt kinase MAPK well endoplasmic reticulum stress, oxidant autophagy related hypertrophy diabetes. Many drugs targeting the pathogenic signaling (mostly through protein-coding genes) are under development. However, because limited number genes, noncoding RNAs (ncRNAs) including microRNAs (miRNAs) long (lncRNAs) attracting more attention potential new drug targets for human diseases. Some miRNAs lncRNAs regulate each other (by hosting, enhancing transcription from neighbor, hybridizing other, changing chromatin modifications) create circuits cascades DKD. In this short focused review, functional significance ncRNAs (miRNAs lncRNAs) stages their therapeutic discussed.

Language: Английский

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Roles of Identified Long Noncoding RNA in Diabetic Nephropathy

Journal of Diabetes Research, Journal Year: 2019, Volume and Issue: 2019, P. 1 - 8

Published: Feb. 12, 2019

Diabetes mellitus is the leading chronic disease in world, and diabetic nephropathy (DN) as one of its complications could increase mortality. The development DN associated to abnormal hemodynamic factors like cytokine networks intervention metabolic risk blood pressure, glucose, lipid. However, pathogenesis still poorly understood. Although glucose-lowering drugs insulins have significant effects on fluctuation glucose or other continuously damage kidney. Recent studies reported that progression closely related expression long noncoding RNA (lncRNA), which important for early diagnosis targeted DN. In this review, we briefly summarize published functions potential mechanism lncRNA regulation

Language: Английский

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Interactions Among Non-Coding RNAs in Diabetic Nephropathy

Frontiers in Pharmacology, Journal Year: 2020, Volume and Issue: 11

Published: March 3, 2020

Diabetic Nephropathy (DN) is the most common cause of End-stage renal disease (ESRD). Although various treatments and diagnosis applications are available, DN remains a clinical economic burden. Recent findings showed that noncoding RNAs (ncRNAs) play an important role in progression, potentially can be used as biomarkers therapeutic targets. NcRNAs refers to RNA species do not encode for any protein, known ncRNAs microRNAs (miRNAs), long (lncRNAs) circular (circRNAs). Dysregulation these was reported before patients animal models DN. Importantly, there some interactions between regulate crucial steps progression. Here, we aimed discuss their with critical genes Elucidating regulatory network will allow better understanding molecular mechanisms how they act new also potential targets treatment.

Language: Английский

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Role of long non‐coding RNAs in adipogenesis: State of the art and implications in obesity and obesity‐associated diseases

Obesity Reviews, Journal Year: 2021, Volume and Issue: 22(7)

Published: Jan. 14, 2021

Summary Obesity is an evolutionary, chronic, and relapsing disease that consists of a pathological accumulation adipose tissue able to increase morbidity for high blood pressure, type 2 diabetes, metabolic syndrome, obstructive sleep apnea in adults, children, adolescents. Despite intense research over the last 20 years, obesity remains today with complex multifactorial etiology. Recently, long non‐coding RNAs (lncRNAs) are emerging as interesting new regulators different lncRNAs have been found play role early late phases adipogenesis be implicated obesity‐associated complications onset. In this review, we discuss most recent advances on adipocyte biology complications. Indeed, more researchers focusing investigating underlying roles these molecular modulators could play. Even if significant number evidence correlation‐based, being differentially expressed specific disease, works now focused deeply analyzing how can effectively modulate pathogenesis onset progression. LncRNAs possibly represent markers useful future both diagnosis prompt clinical management patients obesity.

Language: Английский

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