Exosomes derived from bone marrow mesenchymal stromal cells promote remyelination and reduce neuroinflammation in the demyelinating central nervous system

Experimental Neurology, Journal Year: 2021, Volume and Issue: 347, P. 113895 - 113895

Published: Oct. 13, 2021

Language: Английский

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Hyaluronan-based hydrogel integrating exosomes for traumatic brain injury repair by promoting angiogenesis and neurogenesis

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 306, P. 120578 - 120578

Published: Jan. 18, 2023

Language: Английский

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A New Strategy for the Regulation of Neuroinflammation: Exosomes Derived from Mesenchymal Stem Cells

Cellular and Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 44(1)

Published: Feb. 19, 2024

Abstract Neuroinflammation is an important pathogenesis of neurological diseases and causes a series physiopathological changes, such as abnormal activation glial cells, neuronal degeneration death, disruption the blood‒brain barrier. Therefore, modulating inflammation may be therapeutic tool for treating diseases. Mesenchymal stem cells (MSCs), pluripotent have great potential due to their regenerative ability, immunity, ability regulate inflammation. However, recent studies shown that MSC-derived exosomes (MSC-Exos) play major role in this process key neuroprotection by regulating neuroglia. This review summarizes progress made neuroinflammation focusing on mechanisms which MSC-Exos are involved regulation through signaling pathways TLR, NF-κB, MAPK, STAT, NLRP3 provide some references subsequent research therapy. Graphical Exosomes derived from MSCs exhibit neuroprotective effects mitigating triggered cells.

Language: Английский

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Nanozymes: Potential Therapies for Reactive Oxygen Species Overproduction and Inflammation in Ischemic Stroke and Traumatic Brain Injury

ACS Nano, Journal Year: 2024, Volume and Issue: 18(26), P. 16450 - 16467

Published: June 19, 2024

Nanozymes, which can selectively scavenge reactive oxygen species (ROS), have recently emerged as promising candidates for treating ischemic stroke and traumatic brain injury (TBI) in preclinical models. ROS overproduction during the early phase of these diseases leads to oxidative damage, has been a major cause mortality worldwide. However, clinical application ROS-scavenging enzymes is limited by their short vivo half-life inability cross blood-brain barrier. mimic catalytic function natural enzymes, several advantages, including cost-effectiveness, high stability, easy storage. These advantages render them superior disease diagnosis therapeutic interventions. This review highlights recent advancements nanozyme applications TBI, emphasizing potential mitigate detrimental effect overproduction, inflammation, barrier compromise. Therefore, nanozymes represent treatment modality conditions future medical practices.

Language: Английский

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Extracellular Vesicles as Mediators of Neuroinflammation in Intercellular and Inter-Organ Crosstalk

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7041 - 7041

Published: June 27, 2024

Neuroinflammation, crucial in neurological disorders like Alzheimer's disease, multiple sclerosis, and hepatic encephalopathy, involves complex immune responses. Extracellular vesicles (EVs) play a pivotal role intercellular inter-organ communication, influencing disease progression. EVs serve as key mediators the system, containing molecules capable of activating molecular pathways that exacerbate neuroinflammatory processes disorders. However, from mesenchymal stem cells show promise reducing neuroinflammation cognitive deficits. can cross CNS barriers, peripheral signals influence brain function via EV-mediated impacting barrier Understanding EV interactions within other organs could unveil novel therapeutic targets for

Language: Английский

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Mesenchymal stem cells and their extracellular vesicle therapy for neurological disorders: traumatic brain injury and beyond

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 5, 2025

Traumatic brain injury (TBI) is a complex condition involving mechanisms that lead to dysfunction and nerve damage, resulting in significant morbidity mortality globally. Affecting ~50 million people annually, TBI's impact includes high death rate, exceeding of heart disease cancer. Complications arising from TBI encompass concussion, cerebral hemorrhage, tumors, encephalitis, delayed apoptosis, necrosis. Current treatment methods, such as pharmacotherapy with dihydropyridines, high-pressure oxygen therapy, behavioral non-invasive stimulation, have shown limited efficacy. A comprehensive understanding vascular components essential for developing new treatments improve blood vessel-related damage. Recently, mesenchymal stem cells (MSCs) promising results repairing mitigating Studies indicate MSCs can promote neurogenesis angiogenesis through various mechanisms, including releasing bioactive molecules extracellular vesicles (EVs), which help reduce neuroinflammation. In research, the distinctive characteristics positioned them highly desirable cell sources. Extensive investigations been conducted on regulatory properties their manipulation, tagging, transportation techniques brain-related applications. This review explores progress prospects MSC therapy TBI, focusing action, therapeutic benefits, challenges potential limitations using treating neurological disorders.

Language: Английский

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Mesenchymal stromal cell secretome for traumatic brain injury: Focus on immunomodulatory action

Experimental Neurology, Journal Year: 2022, Volume and Issue: 357, P. 114199 - 114199

Published: Aug. 8, 2022

The severity and long-term consequences of brain damage in traumatic injured (TBI) patients urgently calls for better neuroprotective/neuroreparative strategies this devastating disorder. Mesenchymal stromal cells (MSCs) hold great promise have been shown to confer neuroprotection experimental TBI, mainly through paracrine mechanisms via secreted bioactive factors (i.e. secretome), which indicates significant potential a cell-free neuroprotective approach. secretome is composed cytokines, chemokines, growth factors, proteins, lipids, nucleic acids, metabolites, extracellular vesicles; it may offer advantages over MSCs terms delivery, safety, variability therapeutic response injury. Immunomodulation by molecular considered be key mechanism involved their multi-potential effects. Regulated neuroinflammation required healthy remodeling central nervous system during development adulthood. Moreover, immune can also contribute tissue repair neurological recovery following acute However, chronic maladaptive neuroinflammatory exacerbate TBI progressive neurodegeneration impairments. Here, we review the evidence MSC-derived as therapy TBI. Our framework incorporates detailed analysis vitro vivo studies investigating effects on clinically relevant histopathological outcomes. We describe activation after immunomodulatory properties exerted mediators released secretome. then how ageing modifies systemic responses discuss challenges opportunities developing based therapies elderly populations. Finally, aimed at modulating order boost its efficacy will discussed.

Language: Английский

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Mesenchymal stem cell-derived extracellular vesicles as a cell-free therapy for traumatic brain injury via neuroprotection and neurorestoration

Neural Regeneration Research, Journal Year: 2023, Volume and Issue: 19(1), P. 49 - 54

Published: April 13, 2023

Traumatic brain injury is a serious and complex neurological condition that affects millions of people worldwide. Despite significant advancements in the field medicine, effective treatments for traumatic remain limited. Recently, extracellular vesicles released from mesenchymal stem/stromal cells have emerged as promising novel therapy injury. Extracellular are small membrane-bound naturally by cells, including those brain, can be engineered to contain therapeutic cargo, such anti-inflammatory molecules, growth factors, microRNAs. When administered intravenously, cross blood-brain barrier deliver their cargos site injury, where they taken up recipient modulate inflammatory response, promote neuroregeneration, improve functional outcomes. In preclinical studies, vesicle-based therapies shown results promoting recovery after reducing neuronal damage, improving cognitive function, enhancing motor recovery. While further research needed establish safety efficacy humans, represent approach treatment this review, we summarize cell-derived cell-free via neuroprotection neurorestoration brain-derived potential biofluid biomarkers large animal models

Language: Английский

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Bidirectional Communication Between the Brain and Other Organs: The Role of Extracellular Vesicles

Cellular and Molecular Neurobiology, Journal Year: 2023, Volume and Issue: 43(6), P. 2675 - 2696

Published: April 17, 2023

Language: Английский

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Human umbilical cord mesenchymal stem cell-derived exosomes promote neurological function recovery in rat after traumatic brain injury by inhibiting the activation of microglia and astrocyte

Regenerative Therapy, Journal Year: 2022, Volume and Issue: 21, P. 282 - 287

Published: Aug. 28, 2022

Traumatic brain injury (TBI) is a serious neurological disorder with increasing worldwide incidence. Emerging evidence has shown significant therapeutic role of mesenchymal stem cells (MSCs) derived exosomes on traumatic broad application prospects as cell-free therapy. However, comprehensive understanding its underlying mechanism remained elusive. In this study, umbilical cord (UCMSCs)-derived (UC-MSCs-Exo) were isolated by ultracentrifugation and injected intraventricularly in rat model TBI. Our results showed that UC-MSCs-Exo promoted functional recovery reduced neuronal apoptosis TBI rats. Moreover, inhibited the activation microglia astrocytes during injury, thereby promoting recovery. effect content plasma inflammatory factors rats was not significant. Collectively our study suggested promotes function inhibiting astrocytes, providing theoretical basis for new strategies central nervous system diseases.

Language: Английский

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