Microbial community-scale metabolic modelling predicts personalized short-chain fatty acid production profiles in the human gut

Nature Microbiology, Journal Year: 2024, Volume and Issue: 9(7), P. 1700 - 1712

Published: June 24, 2024

Language: Английский

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Probiotics and Food Bioactives: Unraveling Their Impact on Gut Microbiome, Inflammation, and Metabolic Health

Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Language: Английский

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A review on probiotics and dietary bioactives: Insights on metabolic well-being, gut microbiota, and inflammatory responses

Food Chemistry Advances, Journal Year: 2025, Volume and Issue: 6, P. 100919 - 100919

Published: Feb. 11, 2025

Language: Английский

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Metagenomic estimation of dietary intake from human stool

Nature Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Language: Английский

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Biotics vs food systems: Challenges and perspectives

Food Research International, Journal Year: 2025, Volume and Issue: unknown, P. 115806 - 115806

Published: Jan. 1, 2025

Language: Английский

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Synergizing Artificial Intelligence and Probiotics: A Comprehensive Review of Emerging Applications in Health Promotion and Industrial Innovation

Trends in Food Science & Technology, Journal Year: 2025, Volume and Issue: unknown, P. 104938 - 104938

Published: Feb. 1, 2025

Language: Английский

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Exploring the gut microbiota: lifestyle choices, disease associations, and personal genomics

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10

Published: Oct. 5, 2023

The gut microbiota is a rich and dynamic ecosystem that actively interacts with the human body, playing significant role in state of health disease host. Diet, exercise, mental health, other factors have exhibited ability to influence bacterial composition, leading changes can prevent improve, or favor worsen, both intestinal extra-intestinal conditions. Altered microbial states, ‘dysbiosis’, associated conditions diseases are often characterized by shifts abundance diversity, including an impaired Firmicutes Bacteroidetes ratio. By understanding effect lifestyle on microbiota, personalized advice be generated suit each individual profile foster adoption ameliorate dysbiosis. delivery effective reliable advice, however, depends not only available research current topic, but also methods used assess individuals discover associations, which introduce bias at multiple stages. aim this review summarize how variability defined what choices shown association composition. Furthermore, popular investigate outlined, focus possible caused lack use standardized methods. Finally, overview based testing presented, underlining its power limitations.

Language: Английский

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The effect of microbiome-modulating probiotics, prebiotics and synbiotics on glucose homeostasis in type 2 diabetes: A systematic review, meta-analysis, and meta-regression of clinical trials

Pharmacological Research, Journal Year: 2022, Volume and Issue: 185, P. 106520 - 106520

Published: Oct. 20, 2022

The globally escalating diabetes epidemic is responsible for significant morbidity and mortality. Microbiome-modulating nutraceuticals have been investigated their potential to restore metabolic floral homeostasis in type 2 diabetic patients METHODS: A systematic review, meta-analyses meta-regressions were conducted investigate the effect of probiotics, prebiotics, synbiotics on various biomarkers glucose based a multi-database search clinical trials published through April 10, 2022. Data was pooled using random effects reported as mean differences with 95% confidence intervals (CIs), followed by univariate linear model meta-regression.Data from 68 trial comparisons across 58 studies (n = 3835) revealed that, compared placebo/control group, administration pro/pre/synbiotics associated statistically changes fasting plasma (-12.41 mg/dl [95% CI: -15.94; -8.88], p 0.0001), glycated hemoglobin (-0.38% -0.47; -0.30], insulin (-1.49 µU/mL -2.12; -0.86], HOMA-IR (-0.69 -1.16; -0.23], 0.0031) QUICKI (0.0148 0.0052; 0.0244], 0.0025), but not C-peptide (-0.0144 ng/mL -0.2564; -0.2275], 0.9069). Age, baseline BMI, biomarker value, pro/prebiotic dosage, duration, nutraceutical type, recruitment region significantly affected use personalized adjunct therapy. Lastly, we discuss unexplained observations directives future trials, aim maximizing our understanding how microbiome-modulating can treat diseases CONCLUSIONS: Pro/pre/synbiotic supplementation improved patients. Our results support therapy improving glycemia insulinemia alongside pharmacological therapeutics.

Language: Английский

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Roles of Diet-Associated Gut Microbial Metabolites on Brain Health: Cell-to-Cell Interactions between Gut Bacteria and the Central Nervous System

Advances in Nutrition, Journal Year: 2023, Volume and Issue: 15(1), P. 100136 - 100136

Published: Oct. 29, 2023

Gut microbiota have crucial effects on brain function via the gut-brain axis. Growing evidence suggests that this interaction is mediated by signaling molecules derived from dietary components metabolized intestinal microbiota. Although recent studies provided a substantial understanding of cell-specific gut microbial in microbiome-brain research, further validation needed. This review presents findings microbiota-derived metabolites enter systemic circulation and influence cell-to-cell interactions between microbes cells central nervous system (CNS), particularly microglia, astrocytes, neuronal cells, ultimately affecting cognitive function, mood, behavior. Specifically, highlights roles produced component transformation, including short-chain fatty acids, tryptophan metabolites, bile acid promoting maturation suppressing inflammatory signals CNS. We also discuss future directions for focusing diet-induced metabolite-based therapies as possible novel approaches to mental health treatment.

Language: Английский

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Unraveling the Gut Microbiota: Implications for Precision Nutrition and Personalized Medicine

Nutrients, Journal Year: 2024, Volume and Issue: 16(22), P. 3806 - 3806

Published: Nov. 6, 2024

Recent studies have shown a growing interest in the complex relationship between human gut microbiota, metabolism, and overall health. This review aims to explore microbiota-host association, focusing on its implications for precision nutrition personalized medicine. The objective is highlight how microbiota modulate metabolic immune functions, contributing disease susceptibility wellbeing. synthesizes recent research findings, analyzing key influence of lipid carbohydrate intestinal health, neurobehavioral regulation, endocrine signaling. Data were drawn from both experimental clinical trials examining interactions relevant nutrition. Our findings essential role microbiota-derived metabolites regulating host including glucose pathways. These been found responses barrier integrity. Additionally, impacts broader physiological processes, neuroendocrine which could be crucial dietary interventions. Therefore, understanding molecular mechanisms dietary-microbiota-host pivotal advancing strategies. Tailored recommendations based individual compositions hold promise improving health outcomes, potentially revolutionizing future healthcare approaches across diverse populations.

Language: Английский

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