Recent Applications and Evaluation of Metal Nanoparticle–Polymer Hybrids as Chronic Wound Dressings DOI Open Access
Mohammad Tahir Aminzai, Abubaker Patan

Journal of Nanomaterials, Journal Year: 2024, Volume and Issue: 2024, P. 1 - 23

Published: Jan. 8, 2024

Chronic wounds, which include venous leg ulcers, diabetic foot and pressure are a global health issue that affects between 1% 2% of the developed world’s population. wound healing necessitates extensive medical intervention at costly healthcare expenses. Wound care management is mainly dependent on discovery new appropriate chronic dressing materials, it remains focus research in care. Biocompatible metallic nanoparticle-loaded offers novel opportunity for effectively overcoming inherent drawbacks traditional particularly nonhealing wounds due to their clinical complexity, example, infections, irritation, trauma, persistence foreign body or bacterial proteins, ischemia. In this review, we will primarily advancements nanoparticle-based antibacterial antioxidant materials (e.g., hydrogels, electrospun scaffolds, sponges, films) treatment overcome limitations dressings.

Language: Английский

Innovative Treatment Strategies to Accelerate Wound Healing: Trajectory and Recent Advancements DOI Creative Commons
Praveen Kolimi, Sagar Narala, Dinesh Nyavanandi

et al.

Cells, Journal Year: 2022, Volume and Issue: 11(15), P. 2439 - 2439

Published: Aug. 6, 2022

Wound healing is highly specialized dynamic multiple phase process for the repair of damaged/injured tissues through an intricate mechanism. Any failure in normal wound results abnormal scar formation, and chronic state which more susceptible to infections. Chronic wounds affect patients' quality life along with increased morbidity mortality are huge financial burden healthcare systems worldwide, thus requires biomedical intensive treatment its management. The clinical assessment management remains challenging despite development various therapeutic regimens owing painstakingly long-term requirement complex Various conventional approaches such as cell therapy, gene growth factor delivery, dressings, skin grafts etc., being utilized promoting different types wounds. However, all these abovementioned therapies not satisfactory types, therefore, there urgent demand competitive therapies. Therefore, a pertinent develop newer innovative modalities multipart Recent developments advanced care technology includes nanotherapeutics, stem cells bioengineered grafts, 3D bioprinting-based strategies improving outcomes focus on regeneration minimal side effects. main objective this review provide updated overview progress options over years using next generation approaches. Herein, we have discussed function anatomy, processes, followed by regeneration. Furthermore, emerging bioprinted skin, extracellular matrix-based approaches, platelet-rich plasma-based cold plasma therapy been their benefits shortcomings. Finally, challenges reviewed note future prospects.

Language: Английский

Citations

262
Nanomaterials for wound healing: Current status and futuristic frontier DOI Creative Commons

J. Nandhini,

Karthikeyan Elumalai, S. Rajeshkumar

et al.

Biomedical Technology, Journal Year: 2023, Volume and Issue: 6, P. 26 - 45

Published: Nov. 8, 2023

Wound healing is a complex process that involves variety of physical, chemical, and biological processes. Because their remarkable characteristics capabilities, nanomaterials have recently emerged as potential therapeutic agents for wound healing. Many different nanomaterial-based wound-healing treatments been created put into widespread use. In this review, we compile the most recent research on cutting-edge healing, including both organic inorganic nanomaterials. We highlight prospective approaches developing therapy procedures talk about benefits limitations these treatments. Future prospects therapies based are discussed, need to address toxicity concerns, scalability production, long-term stability The safety effectiveness depend further investigation design, interactions with systems, results rigorous preclinical clinical trials. There great dramatic improvement in patient outcomes introduction therapies.

Language: Английский

Citations

86
Wound healing strategies based on nanoparticles incorporated in hydrogel wound patches DOI Creative Commons
Paulami Dam, Merve Celik, Merve Ustun

et al.

RSC Advances, Journal Year: 2023, Volume and Issue: 13(31), P. 21345 - 21364

Published: Jan. 1, 2023

Nanoparticle-modified hydrogels exhibit substantial promise in the realm of wound healing, with their ability to expedite tissue regeneration, mitigate infection risks, and facilitate enhanced therapeutic outcomes.

Language: Английский

Citations

51
Bi-functional quercetin/copper nanoparticles integrating bactericidal and anti-quorum sensing properties for preventing the formation of biofilms DOI
Jingjing Cheng, Haixin Zhang,

Kunyan Lu

et al.

Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(7), P. 1788 - 1800

Published: Jan. 1, 2024

A bi-functional antibiofilm nanoplatform was developed based on a complex of quercetin and copper integrating bactericidal anti-quorum sensing properties.

Language: Английский

Citations

29
MOF/MXene-loaded PVA/chitosan hydrogel with antimicrobial effect and wound healing promotion under electrical stimulation and improved mechanical properties DOI
Nan Zhang, Xiuwen Zhang,

Yueyuan Zhu

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 264, P. 130625 - 130625

Published: March 6, 2024

Language: Английский

Citations

17
Nanoparticle-Containing Wound Dressing: Antimicrobial and Healing Effects DOI Creative Commons
Pavel Yudaev, Yaroslav Mezhuev, Evgeniy M. Chistyakov

et al.

Gels, Journal Year: 2022, Volume and Issue: 8(6), P. 329 - 329

Published: May 24, 2022

The dressings containing nanoparticles of metals and metal oxides are promising types materials for wound repair. In such dressings, biocompatible nontoxic hydrophilic polymers used as a matrix. the present review, we take look at anti-microbial effect nanoparticle-modified against various microorganisms evaluate their healing action. A detailed analysis 31 sources published in 2021 2022 was performed. Furthermore, trend development modern antibacterial wound-healing nanomaterials shown exemplified publications starting from 2018. review may be helpful researchers working areas biotechnology, medicine, epidemiology, material science other fields aimed improvement quality life.

Language: Английский

Citations

48
Effectiveness of Copper Nanoparticles in Wound Healing Process Using In Vivo and In Vitro Studies: A Systematic Review DOI Creative Commons
Cristian Sandoval,

Gemima Ríos,

Natalia Sepúlveda

et al.

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(9), P. 1838 - 1838

Published: Aug. 31, 2022

Chronic wounds are defined as that do not heal in an orderly and timely manner through the various stages of healing process. Copper nanoparticles essential dressings for wound because they promote angiogenesis skin regeneration, which hasten This systematic investigation sought to explain how copper affect chronic vivo vitro. We realized a review original articles studying effectiveness process wounds. The protocol was registered PROSPERO database. Several databases were searched between 2012 January 2022 English-language papers using MeSH terms text related wounds, nanoparticles, healing. Quality evaluated National Institute Health Care Excellence methodology PRISMA guidelines. looked at total 12 primary studies. Quantitative data gathered presented all Our results suggest could have excellent property, facilitating liberation growth factors help anti-inflammatory significantly improving antibacterial antioxidant activities. In addition, presents higher biocompatibility than other metallic ions, promoting regeneration increasing quality.

Language: Английский

Citations

46
The application of green synthesis nanoparticles in wound healing: a review DOI
Hamide Ehtesabi, Muhammad Fayaz,

F. Hosseini-Doabi

et al.

Materials Today Sustainability, Journal Year: 2022, Volume and Issue: 21, P. 100272 - 100272

Published: Nov. 16, 2022

Language: Английский

Citations

43
Sustainable Nanomaterials for Biomedical Applications DOI Creative Commons
Yuhang Zhang, Kingsley Poon,

Gweneth Sofia P. Masonsong

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(3), P. 922 - 922

Published: March 12, 2023

Significant progress in nanotechnology has enormously contributed to the design and development of innovative products that have transformed societal challenges related energy, information technology, environment, health. A large portion nanomaterials developed for such applications is currently highly dependent on energy-intensive manufacturing processes non-renewable resources. In addition, there a considerable lag between rapid growth innovation/discovery unsustainable their effects human health, climate long term. Therefore, an urgent need sustainably using renewable natural resources with minimal impact society. Integrating sustainability can support sustainable optimized performance. This short review discusses framework designing high-performance nanomaterials. We briefly summarize recent advances producing from use various biomedical as biosensing, bioimaging, drug delivery, tissue engineering. Additionally, we provide future perspectives into guidelines fabricating medical applications.

Language: Английский

Citations

41
Preparation of Ultra-Small Copper Nanoparticles-Loaded Self-Healing Hydrogels with Antibacterial, Inflammation-Suppressing and Angiogenesis-Enhancing Properties for Promoting Diabetic Wound Healing DOI Creative Commons

Xinrong Geng,

Kang Liu, Jinlei Wang

et al.

International Journal of Nanomedicine, Journal Year: 2023, Volume and Issue: Volume 18, P. 3339 - 3358

Published: June 1, 2023

Bacterial invasion, protracted inflammation, and angiogenesis inhibition are hallmarks of chronic diabetic wounds, bringing about patient morbidity rising healthcare costs. For such there currently few efficient therapies available.We reported the development carboxymethyl chitosan (CMCS)-based self-healing hydrogel loaded with ultra-small copper nanoparticles (Cunps) for local treatment wound healing. The structure Cunps was identified by XRD, TEM, XPS other methods, characterization synthesized Cunps-loaded (CMCS)-protocatechualdehyde (PCA) (Cunps@CMCS-PCA hydrogel) further investigated. therapeutic effect Cunps@CMCS-PCA in healing explored vitro vivo.The findings showed that a kind size excellent biocompatibility prepared. CMCS chemically conjugated to PCA form hydrogels via formation an amide bond followed loading nanoparticles. obtained typical three-dimensional interlinked network ability porosity. It exhibited good wounds. Furthermore, group significantly prevented bacterial growth skin rats as compared model CMCS-PCA hydrogel-treated group. After 3 days, no visible proliferation observed. also increased through mediated activation ATP7A prevent induction autophagy. mainly depended on PCA-induced inflammation macrophage JAK2/STAT3 signaling pathway. As result, delayed process lower rate valued at 68.6% within 7 days group, accelerated recovery 86.5%, suggesting effectively healing.Cunps@CMCS-PCA offered new approach quickening

Language: Английский

Citations

30