Nano TransMed, Journal Year: 2025, Volume and Issue: unknown, P. 100086 - 100086
Published: May 1, 2025
Language: Английский
Biomass Conversion and Biorefinery, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 6, 2024
Language: Английский
Citations
63
Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(3), P. 91 - 91
Published: March 5, 2025
Chronic wound infections present a persistent medical challenge; however, advancements in dressings and antimicrobial nanomaterials offer promising solutions for improving healing outcomes. This study introduces hydrothermal synthesis approach producing zinc oxide (ZnO) copper (CuO) nanoparticles, subsequently incorporated into PLGA microspheres embedded within collagen hydrogels. The nanoparticles’ physicochemical properties were characterized using X-ray diffraction (XRD) to confirm crystalline structure, scanning electron microscopy (SEM) surface morphology, Fourier-transform infrared spectroscopy (FT-IR) verify functional groups successful hydrogel integration. hydrogels tested activity against Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans, which are key pathogens chronic wounds. Biocompatibility was assessed the human HaCat keratinocyte cell line. Both ZnO- CuO-loaded exhibited broad-spectrum efficacy. Cytocompatibility tests demonstrated that both sustain viability proliferation, highlighting their biocompatibility suitability applications, with superior biological performance of ZnO-loaded Furthermore, distinct profiles ZnO CuO suggest tailored use based on microbial composition, excelling antibacterial applications showing potential antifungal treatments. These results underscore nanoparticle-based as innovative therapeutic tools managing
Language: Английский
Citations
5
Biomolecules, Journal Year: 2022, Volume and Issue: 12(12), P. 1727 - 1727
Published: Nov. 22, 2022
Chronic diabetic wounds are one of the main complications diabetes, manifested by persistent inflammation, decreased epithelialization motility, and impaired wound healing. This will not only lead to repeated hospitalization patients, but also bear expensive costs. In severe cases, it can amputation, sepsis or death. Electrospun nanofibers membranes have characteristics high porosity, specific surface area, easy functionalization structure, so they be used as a safe effective platform in treatment great application potential. article briefly reviewed pathogenesis chronic types dressings commonly used, then development electrospinning technology recent years advantages electrospun wounds. Finally, reports different nanofiber on summarized, method using multi-drug combination therapy is emphasized, which provides new ideas for
Language: Английский
Citations
65
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(3), P. 874 - 874
Published: March 8, 2023
Wounds are alterations in skin integrity resulting from any type of trauma. The healing process is complex, involving inflammation and reactive oxygen species formation. Therapeutic approaches for the wound diverse, associating dressings topical pharmacological agents with antiseptics, anti-inflammatory, antibacterial actions. Effective treatment must maintain occlusion moisture site, suitable capacity absorption exudates, gas exchange, release bioactives, thus stimulating healing. However, conventional treatments have some limitations regarding technological properties formulations, such as sensory characteristics, ease application, residence time, low active penetration skin. Particularly, available may efficacy, unsatisfactory hemostatic performance, prolonged duration, adverse effects. In this sense, there significant growth research focusing on improving wounds. Thus, soft nanoparticles-based hydrogels emerge promising alternatives to accelerate due their improved rheological increased bioadhesiveness, greater permeation, controlled drug release, a more pleasant aspect comparison forms. Soft nanoparticles based organic material natural or synthetic source include liposomes, micelles, nanoemulsions, polymeric nanoparticles. This scoping review describes discusses main advantages nanoparticle-based process. Herein, state-of-the-art presented by addressing general aspects process, current status non-encapsulated drug-based hydrogels, formed different polymers containing nanostructures Collectively, presence performance bioactive compounds employed healing, demonstrating scientific advances obtained so far.
Language: Английский
Citations
30
International Wound Journal, Journal Year: 2024, Volume and Issue: 21(7)
Published: July 1, 2024
Abstract Wound healing is a complex process that orchestrates the coordinated action of various cells, cytokines and growth factors. Nanotechnology offers exciting new possibilities for enhancing by providing novel materials approaches to deliver bioactive molecules wound site. This article elucidates recent advancements in utilizing nanoparticles, nanofibres nanosheets healing. It comprehensively discusses advantages limitations each these materials, as well their potential applications types wounds. Each despite sharing common properties, can exhibit distinct practical characteristics render them particularly valuable In this review, our primary focus provide comprehensive overview current state‐of‐the‐art applying nanofibres, combinations healing, serving resource guide researchers appropriate utilization nanomaterials wound‐healing research. Further studies are necessary gain insight into application type clinical settings.
Language: Английский
Citations
9
Applied Biochemistry and Biotechnology, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 26, 2025
Language: Английский
Citations
1
Sustainability, Journal Year: 2025, Volume and Issue: 17(5), P. 2100 - 2100
Published: Feb. 28, 2025
The extraction of metallic nanoparticles (MNPs) from waste electrical and electronic equipment (WEEE) has gained extensive attention researchers for eco-friendly, reliable, sustainable alternative protocol over the traditional linear economic approach (make-use-dispose) boosting circular economy. A plethora MNPs including metals/metal oxide having a size dimension ranging 1–100 nanometers (nm) have been extracted these WEEE by using different chemical, physical, biological methods. Recovery certain precious can be achieved dismantling recycling items in form gold (Au), platinum (Pt), zinc (ZnO), silver (Ag), copper (CuO). These provide huge range applications such as antibacterial, therapeutic, target drug delivery, biotechnological applications. This comprehensive review provides in-depth knowledge synthesis techniques delves into their potential biomedical fields with mechanisms. article also discussed global challenges opportunities this area adopting concept economy to conserve natural resources future generations hence create greener environment protect our planet.
Language: Английский
Citations
1
Advanced Science, Journal Year: 2023, Volume and Issue: 10(27)
Published: Aug. 2, 2023
Nanofibers are long, wire-like materials with nanoscale diameters and specific length diameter ratios. have porous reticular networks remarkably high surface areas significant interconnectivity between pores, allowing for the chemical modification loading of drugs. Metallized nanofibers novel that enhance performance attributes conventional by combining metals through electrostatic spinning doping, modification, approaches. Due to their unique physical properties, metallized diverse, rapidly developed in fields chemistry, science, battery preparation. To date, improvement advanced preparation techniques biocompatibility levels materials, nanofiber applications gradually expanding into biomedical field due excellent thermal electrical conductivities metal properties. In this review, biomedicine summarized. It is suggested prepare multifunctional tissue engineering, drug delivery, tumor treatment, wound healing, biosensing taking safety stability as main material selection guidelines. Finally, development summarized discussed.
Language: Английский
Citations
23
Macromolecular Bioscience, Journal Year: 2023, Volume and Issue: 24(2)
Published: Sept. 26, 2023
In recent years, the development of new type wound dressings has gradually attracted more attention. Bacterial cellulose (BC) is a natural polymer material with various unique properties, such as ultrafine 3D nanonetwork structure, high water retention capacity, and biocompatibility. These properties allow BC to be used independently or in combination different components (such biopolymers nanoparticles) achieve diverse effects. This means that great potential dressing. However, systematic summaries for production commercial application BC-based are still lacking. Therefore, this review provides detailed introduction fermentation process BC, including strains their biosynthetic mechanisms. Subsequently, regard functional deficiencies bacterial dressing, research progress area enumerated. Finally, prospects discussed low-cost high-value-added product dressings.
Language: Английский
Citations
19
Polymers, Journal Year: 2023, Volume and Issue: 15(6), P. 1370 - 1370
Published: March 9, 2023
Bacterial infection associated with bone grafts is one of the major challenges that can lead to implant failure. Treatment these infections a costly endeavor; therefore, an ideal scaffold should merge both biocompatibility and antibacterial activity. Antibiotic-impregnated scaffolds may prevent bacterial colonization but exacerbate global antibiotic resistance problem. Recent approaches combined metal ions have antimicrobial properties. In our study, unique strontium/zinc (Sr/Zn) co-doped nanohydroxyapatite (nHAp) Poly (lactic-co-glycolic acid) -(PLGA) composite was fabricated using chemical precipitation method different ratios Sr/Zn (1%, 2.5%, 4%). The scaffolds’ activity against Staphylococcus aureus were evaluated by counting colony-forming unit (CFU) numbers after direct contact scaffolds. results showed dose-dependent reduction in CFU as Zn concentration increased, 4% showing best properties all Zn-containing PLGA incorporation Sr/Zn-nHAp did not affect Sr/Zn-nHAp-PLGA 99.7% growth inhibition. MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) cell viability assay co-doping supported osteoblast proliferation no apparent cytotoxicity highest doping percentage found be for growth. conclusion, findings demonstrate potential enhanced cytocompatibility suitable candidate regeneration.
Language: Английский
Citations
17