Radioimmunotherapy: a game-changer for advanced non-small cell lung cancer DOI Creative Commons

Huichan Xue,

Yunshang Chen,

Yun Zhou

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 6, 2024

Lung cancer, particularly non-small cell lung cancer (NSCLC), remains a leading cause of cancer-related deaths, with conventional treatments offering limited effectiveness in advanced stages, due to distant metastases and treatment resistance. Recent advancements immunotherapy, specifically immune checkpoint inhibitors (ICIs), have shown promise, but their efficacy as standalone therapies are often insufficient. This has led increased interest combining ICIs radiotherapy, known radioimmunotherapy (iRT), enhance outcomes. review explores the mechanisms that underlie synergy between radiotherapy immunotherapy. Radiotherapy can induce "abscopal effect", eliciting systemic responses reduce tumor burdens outside treated area. It also increases expression major histocompatibility complex class I (MHC-I) on cells, improving recognition. Furthermore, modify microenvironment by inducing metabolic reprogramming bolster anti-tumor immunity. We discuss strategies for optimizing iRT, including considerations radiation doses, fractionation schedules, site selection, which significantly influence enhancing MHC-I or promoting T-cell infiltration. Clinical evidence supports iRT NSCLC other cancers, though challenges standardizing protocols managing side effects persist. Overall, presents promising approach Ongoing research into its refinement may reshape clinical practice, more effective personalized options patients cancer. Further studies essential validate these findings optimize therapeutic protocols.

Language: Английский

Senescent fibroblast facilitates re-epithelization and collagen deposition in radiation-induced skin injury through IL-33-mediated macrophage polarization DOI Creative Commons
Yan Chen, Le Ma, Zhuo Cheng

et al.

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Feb. 18, 2024

Abstract Background The need for radiotherapy among the elderly rises with increasing life expectancy and a corresponding increase of cancer patients. Radiation-induced skin injury is one most frequent adverse effects in patients, severely limiting their quality. Re-epithelialization collagen deposition have essential roles recovery injuries induced by high doses ionizing radiation. At same time, radiation-induced senescent cells accumulate irradiated tissues. However, mechanisms on re-epithelialization not been fully elucidated. Results Here, we identified role population expressing p16 promoting injury. Targeted ablation + or treatment Senolytics resulted disruption structure retardation epidermal coverage. By analyzing publicly available single-cell sequencing dataset, fibroblasts as major contributor to promotion cells. Notably, our analysis transcriptome data highlighted IL-33 key senescence-associated secretory phenotype produced fibroblasts. Neutralizing significantly impedes healing process. Finally, found that effect was partly due modulation macrophage polarization. Conclusions In conclusion, suggested accumulated sites participated wound mainly secreting IL-33. This secretion regulated local immune microenvironment polarization, thus emphasizing importance precise regulation phased manner. Graphical

Language: Английский

Citations

9
Advancements in engineered exosomes for wound repair: current research and future perspectives DOI Creative Commons

Hailian Ye,

Feng Wang, Guangchao Xu

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2023, Volume and Issue: 11

Published: Nov. 14, 2023

Wound healing is a complex and prolonged process that remains significant challenge in clinical practice. Exosomes, type of nanoscale extracellular vesicles naturally secreted by cells, are endowed with numerous advantageous attributes, including superior biocompatibility, minimal toxicity, non-specific immunogenicity. These properties render them an exceptionally promising candidate for bioengineering applications. Recent advances have illustrated the potential exosome therapy promoting tissue repair. To further augment their therapeutic efficacy, concept engineered exosomes has been proposed. designed functionally modifiable tailored on attributes natural exosomes. This comprehensive review delineates various strategies engineering, placing specific emphasis studies exploring application precision wound healing. Furthermore, this sheds light integrating biomaterials to enhance delivery effectiveness. The insights presented herein provide novel perspectives lay robust foundation forthcoming research realm cutaneous repair therapies.

Language: Английский

Citations

16
Unraveling links between aging, circadian rhythm and cancer: Insights from evidence-based analysis. DOI
Dechao Feng,

Yuhan Xiao,

Jie Wang

et al.

PubMed, Journal Year: 2024, Volume and Issue: 36(3), P. 341 - 350

Published: June 30, 2024

Aging and circadian rhythms have been connected for decades, but their molecular interaction has remained unknown, especially cancers. In this situation, we summarized the current research actuality problems in field using bibliometric analysis. Publications PubMed Web of Science databases were retrieved. Overall, there is a rising trend publication volume regarding aging cancer. Researchers from USA, Germany, Italy, China England greater studies than others. Top three institutions are University California System, UDICE-French Research Universities Texas System. Current hotspots include oxidative stress, breast cancer, melatonin, cell cycle, calorie restriction, prostate cancer NF-KB. conclusion, results generated by analysis indicate that many approaches involve complex interactions between rhythm These established emerging directions guide our exploration regulatory mechanisms provide reference developing new avenues.

Language: Английский

Citations

5
Out of this World: Wound Healing on Earth and in Space DOI
Nathan C. Balukoff,

Garrett Houk,

Tammy Gonzalez

et al.

Journal of Investigative Dermatology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Targeting the NLRP3 in macrophages contributes to senescence cell clearance in radiation-induced skin injury DOI Creative Commons
Gaoyu Liu, Yan Chen, Shijie Dai

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 18, 2025

The persistent accumulation of senescence cells is one the characteristics radiation-induced skin injury (RISI), leading to fibrosis and impaired healing. However, reasons why these are resistant clearance remain unclear. mouse RISI model was established using an X-ray generator, a shield used cover all areas except right leg or back for protecting surrounding tissue. ScRNA sequencing, immunohistochemistry, immunofluorescence, qPCR, western blot, primary cell co-culture system fluorescence microsphere phagocytosis assay were performed functional mechanistic investigations. dynamic changes levels multiple immune during evaluated, we found that macrophages could remove from dermis, ability gradually strengthens over time. sequencing revealed with high capacity exhibited increased NOD-like receptor family pyrin domain-containing 3 (NLRP3) expression compared those low capacity. Inhibition conditional knockout Nlrp3 in led dysfunction Further studies interleukin-33 secreted by inhibited NLRP3 their phagocytize cells, especially early stages after radiation. In addition, Nocardia rubra wall skeleton (Nr-CWS), approved immunomodulator, activate macrophage expression, reduce burden, accelerate healing RISI. This study underscored as critical intervention target immunosurveillance emphasized Nr-CWS potential therapeutic agent accelerating

Language: Английский

Citations

0
Ruthenium Nanozyme@Magnesium silicate nanosheets encapsuled in microneedle patches promote repair of radiation‐induced skin defects by remodeling pathological environment DOI Creative Commons

Zhongyi Sun,

Haibo Liu, Lanying Li

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: March 31, 2025

Abstract Radiotherapy induced skin defect (RISD) is a severe radiotherapy complication with persistent oxidative stress and recurrent excessive reactive oxygen species (ROS), impeding normal tissue repair processes. Nevertheless, the lack of standardized animal model severely hinders progress related research work. We develop novel strategy for repairing RISD microenvironment, which combines initial ROS clearance, subsequent inhibition production proliferation cell pathways/functions. As proof concept, composite microneedle (MN) patch comprising γ‐polyglutamic acid as base ruthenium (Ru) clusters modified magnesium silicate nanosheets (MSR NSs) enzyme‐like component prepared. The Ru have excellent scavenging ability help activate peroxisome proliferators activated receptor signaling pathway confirmed by sequencing analysis while degraded under physiological conditions to release ions ions, enhancing proliferation, migration, angiogenesis ability. radiation established evaluate efficacy our MSR@MN in comparison γPGA‐MSR ointment commercial product Orgotein. results show that effectively improves pathological microenvironment abnormal accumulation, reduces inflammatory response promotes mature remodeling.

Language: Английский

Citations

0
A Multifunctional Parathyroid Hormone-related Supramolecular Peptide-loaded Dual Network Hydrogel for Radiation-induced Wound Repair DOI Creative Commons
Mengyue Zhu, Guang Shi, Renxin Chen

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101807 - 101807

Published: April 1, 2025

Language: Английский

Citations

0
New insights into the role of cellular senescence and chronic wounds DOI Creative Commons
Huiqing Yang, Xin Zhang, Xue Bo

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 4, 2024

Chronic or non-healing wounds, such as diabetic foot ulcers (DFUs), venous leg (VLUs), pressure (PUs) and wounds in the elderly etc., impose significant biological, social, financial burdens on patients their families. Despite ongoing efforts, effective treatments for these remain elusive, costing United States over US$25 billion annually. The wound healing process is notably slower elderly, partly due to cellular senescence, which plays a complex role repair. High glucose levels, reactive oxygen species, persistent inflammation are key factors that induce contributing chronic failure. This suggests senescence may not only drive age-related phenotypes pathology but also be mediator of decreased capacity trauma review analyzes four aspects: characteristics senescence; cytotoxic stressors related signaling pathways; relationship between typical wounds; current future treatment strategies. In theory, anti-aging therapy influence healing. However, underlying molecular mechanism well understood. summarizes contribute better understanding mechanisms

Language: Английский

Citations

3
Copper homeostasis and cuproptosis in radiation-induced injury DOI Open Access
Daoming Zhang, Yuan Li,

Jinghui Pan

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 178, P. 117150 - 117150

Published: July 23, 2024

Radiation therapy for cancer treatment brings about a series of radiation injuries to normal tissues. In recent years, the discovery copper-regulated cell death, cuproptosis, novel form programmed has attracted widespread attention and exploration in various biological functions pathological mechanisms copper metabolism cuproptosis. Understanding its role process injury may open up new avenues directions biology oncology, thereby improving tumor response mitigating adverse reactions radiotherapy. This review provides an overview metabolism, characteristics their potential regulatory injury.

Language: Английский

Citations

2
Features of apoptotic and proliferative processes in experimental infected radiation-induced skin ulcer under conditions of photodynamic therapy and the use of platelet-rich plasma DOI

Olena S. Pushkar,

Mykhailo S. Myroshnychenko, O. М. Koliada

et al.

Polski Merkuriusz Lekarski, Journal Year: 2024, Volume and Issue: 52(1), P. 54 - 59

Published: Jan. 1, 2024

Aim: The purpose of the study was to identify features apoptotic and proliferative processes in experimental Staphylococcus aureus-infected radiation skin ulcer under conditions photodynamic therapy use platelet-rich plasma. Materials Methods: An conducted on 95 six-month-old male rats WAG population, which were divided into three groups. Group 1 included 25 animals that simulated a thigh area with subsequent application its surface 7th day after irradiation 0.2 ml suspension aureus (ATCC 25923) reference strain (0.5 million microbial cells/cm2). 2 ulcer, subjected infection. 3 45 ulcers, which, infection, received first half day, second periphery wound defect injected material for underlying soft tissues from exposure. Histological, immunohistochemical, morphometric statistical methods used. Results: In cases simultaneous plasma, compared alone, ofapoptosis proliferation more balanced, active, shift proliferative-apoptotic ratio towards met needs regenerative process. From 10th 22nd experiment these increased, indicated active healing processes, that, during survey microscopy manifested by complete filling cavity granulation connective presence an epithelial layer regenerate. 45th experiment, decrease rate regeneration recorded, as evidenced intensity processes. latter sufficient, led restoration original structure skin. Conclusions: Photodynamic combination plasma balancedly activates predominance lumen leads

Language: Английский

Citations

1