Exercise Capacity and Occupational Competence Sequelae in COVID-19 Survivors: A Longitudinal Study DOI

Vildan Fidanoglu,

Melda Sağlam, Serkan Pekçetin

et al.

Occupational Therapy In Health Care, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 17

Published: April 9, 2025

The Sars-Cov-2 infection disease (COVID-19) causes symptoms during both acute and post-COVID phases. This study assessed exercise capacity occupational competence of 20 hospitalized COVID-19 patients, at discharge three months later using the 6-Minute Step Test Occupational Self-Assessment. Significant differences were found in scores between (p < 0.05). However, these measurements not correlated > Although patients show improvement after discharge, some persisted, affecting their exercise, performance. Further research is needed to explore long-term outcomes beyond one year.

Language: Английский

Epidemiology, clinical presentation, pathophysiology, and management of long COVID: an update DOI

Sizhen Su,

Yi‐Miao Zhao, Na Zeng

et al.

Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 28(10), P. 4056 - 4069

Published: July 25, 2023

Language: Английский

Citations

62
Post-viral fatigue in COVID-19: A review of symptom assessment methods, mental, cognitive, and physical impairment DOI
Maria Cristine Campos, Tatyana Nery,

Ana Carolina Starke

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2022, Volume and Issue: 142, P. 104902 - 104902

Published: Oct. 3, 2022

Language: Английский

Citations

42
A systematic review of trials currently investigating therapeutic modalities for post-acute COVID-19 syndrome and registered on WHO International Clinical Trials Platform DOI Creative Commons
Nader A. Fawzy, Bader Abou Shaar,

Rand M. Taha

et al.

Clinical Microbiology and Infection, Journal Year: 2023, Volume and Issue: 29(5), P. 570 - 577

Published: Jan. 13, 2023

Language: Английский

Citations

37
The Effects of SARS-CoV-2 Infection on the Cognitive Functioning of Patients with Pre-Existing Dementia DOI Creative Commons
Souvik Dubey, Shambaditya Das, Ritwik Ghosh

et al.

Journal of Alzheimer s Disease Reports, Journal Year: 2023, Volume and Issue: 7(1), P. 119 - 128

Published: Feb. 2, 2023

Background: Cognitive postscripts of COVID-19, codenamed as ‘cognitive COVID’ or ‘brain fog,’ characterized by multidomain cognitive impairments, are now being reckoned the most devastating sequelae COVID-19. However, impact on already demented brain has not been studied. Objective: We aimed to assess functioning and neuroimaging following SARS-CoV-2 infection in patients with pre-existing dementia. Methods: Fourteen COVID-19 survivors dementia (four Alzheimer’s disease, five vascular dementia, three Parkinson’s disease two behavioral variant frontotemporal dementia) were recruited. All these had detailed evaluations within months before suffering from one year later. Results: Of 14 patients, ten required hospitalization. developed increased white matter hyperintensities that mimicked multiple sclerosis small vessel disease. There was a significant increase fatigue ( p = 0.001) depression 0.016) scores The mean Frontal Assessment Battery (p < Addenbrooke’s Examination also significantly worsened. Conclusion: rapid progression addition further impairments/deterioration abilities, new appearance lesion burden suggest previously compromised brains have little defense withstand insult (i.e., ‘second hit’ like infection/dysregulated immune response, inflammation). ‘Brain fog’ is an ambiguous terminology without specific attribution spectrum post-COVID-19 sequelae. propose codename, i.e. ‘FADE-IN MEMORY’ Fatigue, decreased Fluency, Attention deficit, Depression, Executive dysfunction, slowed INformation processing speed, subcortical MEMORY impairment).

Language: Английский

Citations

37
Long COVID: Clinical characteristics, proposed pathogenesis and potential therapeutic targets DOI Creative Commons
Grace Kenny, Liam Townsend, Stefano Savinelli

et al.

Frontiers in Molecular Biosciences, Journal Year: 2023, Volume and Issue: 10

Published: April 26, 2023

The emergence of persistent ill-health in the aftermath SARS-CoV-2 infection has presented significant challenges to patients, healthcare workers and researchers. Termed long COVID, or post-acute sequelae COVID-19 (PASC), symptoms this condition are highly variable span multiple body systems. underlying pathophysiology remains poorly understood, with no therapeutic agents proven be effective. This narrative review describes predominant clinical features phenotypes COVID alongside data supporting potential pathogenesis these including ongoing immune dysregulation, viral persistence, endotheliopathy, gastrointestinal microbiome disturbance, autoimmunity, dysautonomia. Finally, we describe current therapies under investigation, as well future options based on proposed research.

Language: Английский

Citations

36
Effect of Pulmonary Rehabilitation on Exercise Capacity, Dyspnea, Fatigue, and Peripheral Muscle Strength in Patients With Post-COVID-19 Syndrome: A Systematic Review and Meta-analysis DOI
Murilo Rezende Oliveira, Mariana Hoffman, Arwel W. Jones

et al.

Archives of Physical Medicine and Rehabilitation, Journal Year: 2024, Volume and Issue: 105(8), P. 1559 - 1570

Published: Feb. 3, 2024

Language: Английский

Citations

15
Psychological factors associated with Long COVID: a systematic review and meta-analysis DOI Creative Commons
Petra Engelmann, Max Reinke, Clara Stein

et al.

EClinicalMedicine, Journal Year: 2024, Volume and Issue: 74, P. 102756 - 102756

Published: July 27, 2024

Language: Английский

Citations

12
Interplay between Comorbidities and Long COVID: Challenges and Multidisciplinary Approaches DOI Creative Commons
Rasha Ashmawy, Esraa Abdellatif Hammouda, Yousra A. El‐Maradny

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(7), P. 835 - 835

Published: July 11, 2024

Long COVID, a name often given to the persistent symptoms following acute SARS-CoV-2 infection, poses multifaceted challenge for health. This review explores intrinsic relationship between comorbidities and autoimmune responses in shaping trajectory of long COVID. Autoantibodies have emerged as significant players COVID-19 pathophysiology, with implications disease severity progression. Studies show immune dysregulation persisting months after marked by activated innate cells high cytokine levels. The presence autoantibodies against various autoantigens suggests their potential comorbid factors Additionally, formation complexes may lead severe progression, highlighting urgency early detection intervention. Furthermore, COVID is highly linked cardiovascular complications neurological symptoms, posing challenges diagnosis management. Multidisciplinary approaches, including vaccination, tailored rehabilitation, pharmacological interventions, are used mitigating COVID’s burden. However, numerous persist, from evolving diagnostic criteria addressing psychosocial impact predicting outcomes. Leveraging AI-based applications holds promise enhancing patient management improving our understanding As research continues unfold, unravelling complexities remains paramount effective intervention care.

Language: Английский

Citations

11
Hyperbaric Oxygen Therapy Counters Oxidative Stress/Inflammation-Driven Symptoms in Long COVID-19 Patients: Preliminary Outcomes DOI Creative Commons
Simona Mrakic‐Sposta, Alessandra Vezzoli,

Giacomo Garetto

et al.

Metabolites, Journal Year: 2023, Volume and Issue: 13(10), P. 1032 - 1032

Published: Sept. 25, 2023

Long COVID-19 patients show systemic inflammation and persistent symptoms such as fatigue malaise, profoundly affecting their quality of life. Since improving oxygenation can oppose at multiple tissue levels, we hypothesized that hyperbaric oxygen therapy (HBOT) could arrest progression thus relieve COVID-19. We evaluated oxy-inflammation biomarkers in long subjects treated with HBOT monitored non-invasive methods. Five (two athletes three other comorbidities) were assigned to receive HBOT: 100% inspired O2 2.4 ATA a multiplace chamber for 90 min (three athletes: 15 × 5 days/wk 3 weeks; two affected by Idiopathic Sudden Sensorineural Hearing Loss: 30 6 one patient osteomyelitis: week weeks and, after 30-day break, followed second cycle 20 HBOT). Using saliva and/or urine samples, reactive species (ROS), antioxidant capacity, cytokines, lipids peroxidation, DNA damage, renal status assessed T1_pre (basal level) T2_pre level treatment), the results showed attenuated ROS production, lipid NO metabolites, biomarker especially post-treatment. Thus, may represent an alternative method treating COVID-19-induced long-lasting manifestations oxy-inflammation.

Language: Английский

Citations

22
Long-COVID syndrome: physical–mental interplay in the spotlight DOI Creative Commons

Carolin Thurner,

Andreas Stengel

Inflammopharmacology, Journal Year: 2023, Volume and Issue: 31(2), P. 559 - 564

Published: March 9, 2023

Patients suffering from Long-COVID syndrome experience a variety of different symptoms on physical, but also psychological and social level. Previous psychiatric conditions such as depression anxiety have been identified separate risk factors for developing syndrome. This suggests complex interplay physical mental rather than simple cause-effect relationship specific biological pathogenic process. The biopsychosocial model provides foundation understanding these interactions integrating them into broader perspective the patient disease instead individual symptoms, pointing towards need treatment options well level besides targets. leads to our conclusion, that should be underlying philosophy understanding, diagnosing treating patients syndrome, moving away strictly biomedical suspected by many patients, treaters media while reducing stigma still associated with suggestion physical-mental interplay.

Language: Английский

Citations

21