Intestinal Barrier Dysfunction and Microbial Translocation in Patients with First-Diagnosed Atrial Fibrillation DOI Creative Commons

Leon Blöbaum,

Marco Witkowski,

Max Wegner

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(1), P. 176 - 176

Published: Jan. 10, 2023

According to the leaky gut concept, microbial products (e.g., lipopolysaccharide, LPS) enter circulation and mediate pro-inflammatory immunological responses. Higher plasma LPS levels have been reported in patients with various cardiovascular diseases, but not specifically during early atrial fibrillation (AF).We studied data blood samples from presenting first-diagnosed AF (FDAF) (n = 80) 20 controls.Circulating biomarkers that are suggestive of mucosal inflammation (zonulin, adhesion molecule MAdCAM-1) intestinal epithelium damage (intestinal fatty acid binding protein, IFABP) were increased FDAF when compared chronic diseases without AF. Surrogate markers permeability (LPS, CD14, LPS-binding gut-derived LPS-neutralising IgA antibodies, EndoCAbs) detected A reduced ratio IgG/IgM EndoCAbs titres indicated endotoxaemia. Collagen turnover biomarkers, which corresponded values, suggested an association low-grade endotoxaemia adverse structural remodelling. The concentrations higher who experienced a major event.Intestinal barrier dysfunction translocation accompany FDAF. Improving might be potential therapeutic approach reducing disease progression complications

Language: Английский

Epidemiology and modifiable risk factors for atrial fibrillation DOI
Adrian D. Elliott, Melissa E. Middeldorp,

Isabelle C. Van Gelder

et al.

Nature Reviews Cardiology, Journal Year: 2023, Volume and Issue: 20(6), P. 404 - 417

Published: Jan. 4, 2023

Language: Английский

Citations

195
Inflammatory signalling in atrial cardiomyocytes: a novel unifying principle in atrial fibrillation pathophysiology DOI Open Access
Dobromir Dobrev, Jordi Heijman, Roddy Hiram

et al.

Nature Reviews Cardiology, Journal Year: 2022, Volume and Issue: 20(3), P. 145 - 167

Published: Sept. 15, 2022

Language: Английский

Citations

151
Inflammasome Signaling in Atrial Fibrillation DOI Creative Commons
Amir Ajoolabady, Stanley Nattel, Gregory Y.H. Lip

et al.

Journal of the American College of Cardiology, Journal Year: 2022, Volume and Issue: 79(23), P. 2349 - 2366

Published: June 1, 2022

Language: Английский

Citations

76
Gut microbiome and risk of ischaemic stroke: a comprehensive Mendelian randomization study DOI

Changjiang Meng,

Peizhi Deng,

Rujia Miao

et al.

European Journal of Preventive Cardiology, Journal Year: 2023, Volume and Issue: 30(7), P. 613 - 620

Published: Feb. 16, 2023

Abstract Aims Increasing evidence implicates the microbiome as a susceptibility factor for ischaemic stroke (IS). Interpretation of this is difficult, composition influenced by various factors and might affect differently in IS subtypes. We aim to determine if specific gut causally associated with subtypes suggest potential approaches prevention. Methods results conducted two-sample Mendelian randomization (MR) analysis test causal relationship between For exposure data, we extracted genetic variants 194 bacterial traits from MiBioGen consortium (n = 18 340). outcomes, selected three including cardioembolic (CES, n 410 484), small vessel (SVS, 198 048), large artery (LAS, 048). Additionally, performed sequence sensitivity analyses validate preliminary MR results. There were four, three, four bacteria showing an increased risk LAS, SVS, CES, respectively, there five, six, five leading decreasing respectively. Amongst these, genus_Intestinimonas showed negative associations LAS [odds ratio (OR) 0.77, 95% confidence interval (CI) (0.61–0.98)] SVS (0.85, 0.73–0.98). The genus_LachnospiraceaeNK4A136group was genetically decreased both (0.81, 0.66–0.99) CES (0.75, 0.60–0.94). Conclusion study revealed effect abundance features on Notably, displayed significant protection against more than one subtype, further suggesting applications targeted probiotics

Language: Английский

Citations

54
Atrial Cardiomyopathy Revisited - Evolution of a Concept. A Clinical Consensus Statement of the European Heart Rhythm Association (EHRA) of the ESC, the Heart Rhythm Society (HRS), the Asian Pacific Heart Rhythm Association (APHRS), and the Latin American Heart Rhythm Society (LAHRS) DOI Creative Commons
Andreas Goette, Domenico Corradi, Dobromir Dobrev

et al.

EP Europace, Journal Year: 2024, Volume and Issue: 26(9)

Published: July 30, 2024

Abstract Aims The concept of “atrial cardiomyopathy” (AtCM) had been percolating through the literature since its first mention in 1972. Since then, publications using term were sporadic until decision was made to convene an expert working group with representation from four multinational arrhythmia organizations prepare a consensus document on atrial cardiomyopathy 2016 (EHRA/HRS/APHRS/SOLAECE cardiomyopathies: definition, characterization, and clinical implication). Subsequently, AtCM have increased progressively. Methods results present elaborates further implement simple staging system (AtCM stages 1–3) by integrating biomarkers, geometry, electrophysiological changes. However, proposed needs validation. Importantly, it is clearly stated that presence might serve as substrate for development fibrillation (AF) AF may accelerates substantially, but per se be viewed separate entity. Conclusion Thus, serves statement European Heart Rhythm Association (EHRA) ESC, Society (HRS), Asian Pacific (APHRS), Latin American (LAHRS) contribute evolution concept.

Language: Английский

Citations

41
The individual response to antibiotics and diet — insights into gut microbial resilience and host metabolism DOI
Lars M. M. Vliex, John Penders, Arjen Nauta

et al.

Nature Reviews Endocrinology, Journal Year: 2024, Volume and Issue: 20(7), P. 387 - 398

Published: March 14, 2024

Language: Английский

Citations

17
The role of the gut microbiota in health and cardiovascular diseases DOI Creative Commons
Lu Wang, Shiqi Wang, Qing Zhang

et al.

Molecular Biomedicine, Journal Year: 2022, Volume and Issue: 3(1)

Published: Oct. 11, 2022

Abstract The gut microbiota is critical to human health, such as digesting nutrients, forming the intestinal epithelial barrier, regulating immune function, producing vitamins and hormones, metabolites interact with host. Meanwhile, increasing evidence indicates that has a strong correlation occurrence, progression treatment of cardiovascular diseases (CVDs). In patients CVDs corresponding risk factors, composition ratio have significant differences compared their healthy counterparts. Therefore, dysbiosis, microbiota-generated metabolites, related signaling pathway may serve explanations for some mechanisms about occurrence development CVDs. Several studies also demonstrated many traditional latest therapeutic treatments are associated its generated pathways. Given information, we summarized advances in current research regarding effect on main CVDs, highlighted roles several introduced promising microbiota. this review mainly focuses exploring role potential which eventually provide better solutions well prevention

Language: Английский

Citations

67
Gut microbiome and atrial fibrillation—results from a large population-based study DOI Creative Commons
Joonatan Palmu, Christin S. Börschel,

Alfredo Ortega‐Alonso

et al.

EBioMedicine, Journal Year: 2023, Volume and Issue: 91, P. 104583 - 104583

Published: April 27, 2023

Atrial fibrillation (AF) is an important heart rhythm disorder in aging populations. The gut microbiome composition has been previously related to cardiovascular disease risk factors. Whether the microbial profile also associated with of AF remains unknown.We examined associations prevalent and incident microbiota FINRISK 2002 study, a random population sample 6763 individuals. We replicated our findings independent case-control cohort 138 individuals Hamburg, Germany.Multivariable-adjusted regression models revealed that (N = 116) was nine genera. Incident 539) over median follow-up 15 years eight genera false discovery rate (FDR)-corrected P < 0.05. Both were Enorma Bifidobacterium (FDR-corrected 0.001). not significantly bacterial diversity measures. Seventy-five percent top (Enorma, Paraprevotella, Odoribacter, Collinsella, Barnesiella, Alistipes) Cox analyses showed consistent direction shifted abundance used for replication.Our establish basis use profiles prediction. However, extensive research still warranted before sequencing can be prevention targeted treatment AF.This study funded by European Research Council, German Ministry Education, Academy Finland, Finnish Medical Foundation, Foundation Cardiovascular Research, Emil Aaltonen Paavo Nurmi Foundation.

Language: Английский

Citations

38
Gut microbiota and microbiota-derived metabolites in cardiovascular diseases DOI Creative Commons
Xiaofeng Chen, Hua Zhang, Sichong Ren

et al.

Chinese Medical Journal, Journal Year: 2023, Volume and Issue: 136(19), P. 2269 - 2284

Published: July 5, 2023

Abstract Cardiovascular diseases, including heart failure, coronary artery disease, atherosclerosis, aneurysm, thrombosis, and hypertension, are a great economic burden threat to human health the major cause of death worldwide. Recently, researchers have begun appreciate role microbial ecosystems within body in contributing metabolic cardiovascular disorders. Accumulating evidence has demonstrated that gut microbiota is closely associated with occurrence development diseases. The functions as an endocrine organ secretes bioactive metabolites participate maintenance homeostasis, their dysfunction can directly influence progression disease. This review summarizes current literature demonstrating We also highlight mechanism by which well-documented microbiota-derived metabolites, especially trimethylamine N-oxide, short-chain fatty acids, phenylacetylglutamine, promote or inhibit pathogenesis discuss therapeutic potential altering improve prevent

Language: Английский

Citations

33
The epithelial barrier theory and its associated diseases DOI Creative Commons
Na Sun, İsmail Öğülür, Yasutaka Mitamura

et al.

Allergy, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 7, 2024

Abstract The prevalence of many chronic noncommunicable diseases has been steadily rising over the past six decades. During this time, 350,000 new chemical substances have introduced to lives humans. In recent years, epithelial barrier theory came light explaining growing and exacerbations these worldwide. It attributes their onset a functionally impaired triggered by toxicity exposed substances, associated with microbial dysbiosis, immune system activation, inflammation. Diseases encompassed share common features such as an increased after 1960s or 2000s that cannot (solely) be accounted for emergence improved diagnostic methods. Other traits include defects, dysbiosis loss commensals colonization opportunistic pathogens, circulating inflammatory cells cytokines. addition, practically unrelated fulfill criteria started emerge multimorbidities during last Here, we provide comprehensive overview discuss evidence similarities epidemiology, genetic susceptibility, dysfunction, tissue

Language: Английский

Citations

13