Evaluation of serum inhibin B and inhibin B/FSH ratio in the diagnosis of non-obstructive azoospermia and oligozoospermia DOI

Olaniru B. Olumide,

Adoga I. Godwin, Nkereuwem Sunday Etukudoh

et al.

Hormone Molecular Biology and Clinical Investigation, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 20, 2024

Abstract Objectives Infertility affects approximately 15 % of couples globally, with 50 cases male factor infertility. Precise assessment spermatogenesis is essential for evaluating Recent studies suggest serum inhibin B as a promising biomarker testicular function. This study aims to evaluate the diagnostic utility in predicting infertility, particularly focusing on its relationship sperm count. Methods A cross-sectional was conducted 80 adult men (mean age 31.4 ± 6.89 years) presenting infertility at gynecology and urology outpatient departments. Semen analysis performed following WHO (2010) guidelines, levels were quantified. The correlation between parameters assessed using Pearson’s test. Receiver operating characteristic (ROC) curve employed accuracy B/FSH ratio non-obstructive azoospermia (NOA) oligozoospermia. Results significant positive observed count (r=0.94, p<0.001). ROC demonstrated that had highest NOA oligozoospermia (AUC=0.986), sensitivity 100 specificity 91.67 %. Serum alone also showed high value (AUC=0.965 0.969 oligozoospermia). Conclusions reliable assessing spermatogenic provides superior oligozoospermia, offering valuable clinical diagnosis.

Language: Английский

European Association of Urology Guidelines on Male Sexual and Reproductive Health: 2025 Update on Male Infertility DOI
Suks Minhas, Luca Boeri, Paolo Capogrosso

et al.

European Urology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

2
Can We Predict the Outcome of Micro Testicular Sperm Extraction in Non-Obstructive Azoospermia From Preoperative Hormonal Profile, Testicular Volume, and Patients Health Factors: A Retrospective Cross-Sectional Study DOI Creative Commons
Mohammad Al-Zubi, Sawsan Al-khawaldeh,

Mos’ab Mallak

et al.

American Journal of Men s Health, Journal Year: 2025, Volume and Issue: 19(1)

Published: Jan. 1, 2025

Infertility is characterized by the inability to conceive even after engaging in regular unprotected sexual intercourse for a period of 12 months or longer. Azoospermia affects around 1% men. Approximately 60% men diagnosed with azoospermia will have non-obstructive (NOA). The main aim this study investigate potential relationship between preoperative hormonal profiles, testicular volume, and patient health factors microdissection sperm extraction (micro-TESE) outcomes individuals NOA. A retrospective analysis 152 patients who underwent micro-TESE operation NOA at our center from January 2020 December 2022 was conducted. Both groups were compared age, follicle-stimulating hormone (FSH), luteinizing (LH), total free testosterone, volume before operation, previous TESE, smoking, medical illnesses. considered significant when p value less than .05. enrolled study. Patients divided into two groups: first group, whom sperms identified during procedure, representing 72 (47.3%) patients, second group (52.7%) no found. Results reveal that testosterone level, TESE are significantly related positive surgical results ( < .05). Our findings suggest levels, smoking status, may affect micro-TESE.

Language: Английский

Citations

1
From biological marker to clinical application: the role of anti-Müllerian hormone (AMH) for delayed puberty and idiopathic non-obstructive azoospermia in males DOI Creative Commons

Zeng Yuanyuan,

Zhao Guicheng,

Yi Zheng

et al.

Endocrine Connections, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Anti-Müllerian hormone (AMH), a biomarker secreted by Sertoli cells in the testes, has emerged as critical indicator of male reproductive function with significant clinical application potential. AMH reflects cell activity and plays pivotal role across different stages gonadal function. Firstly, prepubertal males, levels are crucial for assessing testicular development progression puberty, delayed or insufficient secretion often being associated disorders like puberty. Secondly, reproductive-age serves an important evaluating spermatogenic capacity, particularly cases idiopathic non-obstructive azoospermia. In these patients, can help predict success sperm extraction, thereby influencing fertility treatment strategies. This review explores physiological mechanisms its diagnostic prognostic significance both puberty males. While shows great promise management hypogonadism, further research is needed to validate utility refine protocols optimizing patient outcomes.

Language: Английский

Citations

1
Role of Follicle-stimulating Hormone, Inhibin B, and Anti-Müllerian Hormone in Predicting Sperm Retrieval from Men with Nonobstructive Azoospermia Undergoing Microdissection Testicular Sperm Extraction: A Systematic Review and Meta-analysis DOI Creative Commons
Edoardo Pozzi, Christian Corsini, Federico Belladelli

et al.

European Urology Open Science, Journal Year: 2024, Volume and Issue: 65, P. 3 - 12

Published: May 27, 2024

No clear-cut markers for predicting positive sperm retrieval (+SR) at microdissection testicular extraction (mTESE) have been identified thus far. Our aim was to conduct a systematic review and meta-analysis evaluate the ability of follicle-stimulating hormone (FSH), inhibin B (InhB), anti-Müllerian (AMH) predict +SR in men with nonobstructive azoospermia (NOA) undergoing mTESE.

Language: Английский

Citations

5
Clinical factors impacting microdissection testicular sperm extraction success in hypogonadal men with nonobstructive azoospermia DOI Creative Commons
Sandro C. Esteves, Arnold Peter Paul Achermann, Ricardo Miyaoka

et al.

Fertility and Sterility, Journal Year: 2024, Volume and Issue: 122(4), P. 636 - 647

Published: June 22, 2024

To explore factors influencing microdissection testicular sperm extraction (micro-TESE) success in hypogonadal men with nonobstructive azoospermia (NOA).

Language: Английский

Citations

5
Prevalence and clinical implications of biochemical hypogonadism in patients with nonobstructive azoospermia undergoing infertility evaluation DOI Creative Commons
Arnold Peter Paul Achermann, Sandro C. Esteves

F&S Reports, Journal Year: 2023, Volume and Issue: 5(1), P. 14 - 22

Published: Nov. 17, 2023

To investigate the prevalence and clinical implications of biochemical hypogonadism in infertile men with nonobstructive azoospermia (NOA).

Language: Английский

Citations

9
Global Practice Patterns in the Evaluation of Non-Obstructive Azoospermia: Results of a World-Wide Survey and Expert Recommendations DOI Creative Commons
Rupin Shah, Amarnath Rambhatla, Widi Atmoko

et al.

The World Journal of Men s Health, Journal Year: 2024, Volume and Issue: 42(4), P. 727 - 727

Published: Jan. 1, 2024

ou non, émanant des établissements d'enseignement et de recherche français étrangers, laboratoires publics privés.

Citations

3
Contemporary Diagnostic Work-Up for Male Infertility: Emphasizing Comprehensive Baseline Assessment DOI Creative Commons
Edoardo Pozzi, Federico Belladelli, Christian Corsini

et al.

The World Journal of Men s Health, Journal Year: 2024, Volume and Issue: 42

Published: Jan. 1, 2024

Infertility is a prevalent issue affecting many couples during their reproductive years, with significant number facing challenges in conceiving despite regular unprotected intercourse. Male factor infertility (MFI) contributes significantly to these cases, proportion of men lacking an identifiable etiology. As such, thorough assessment MFI has become increasingly vital for personalized management. This position paper from the Andrology team at IRCCS Ospedale San Raffaele emphasizes comprehensive and individualized approach work-up, addressing evolving encountered clinical practice. Our involves diagnostic work-up identify underlying causes MFI, integrating insights extensive literature review our proprietary data. data demonstrates that allows us least one cause most infertile men. However, persist diagnosing less severe phenotypes unclear We discuss importance its implications developing rational therapeutic protocols. Lastly, this highlights necessity assessment, daily emphasizing tailored approaches try improve outcomes among seeking first medical help infertility.

Language: Английский

Citations

3
Predictors of Successful Testicular Sperm Extraction: A New Era for Men with Non-Obstructive Azoospermia DOI Creative Commons
Aris Kaltsas,

Sofoklis Stavros,

Zisis Kratiras

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(12), P. 2679 - 2679

Published: Nov. 25, 2024

Background/Objectives: Non-obstructive azoospermia (NOA) is a severe form of male infertility characterized by the absence sperm in ejaculate due to impaired spermatogenesis. Testicular extraction (TESE) combined with intracytoplasmic injection primary treatment, but success rates are unpredictable, causing significant emotional and financial burdens. Traditional clinical hormonal predictors have shown inconsistent reliability. This review aims evaluate current emerging non-invasive preoperative successful retrieval men NOA, highlighting promising biomarkers their potential applications. Methods: A comprehensive literature was conducted, examining studies on factors, imaging techniques, molecular biology biomarkers, genetic testing related TESE outcomes NOA patients. The role artificial intelligence machine learning enhancing predictive models also explored. Results: such as patient age, body mass index, duration, testicular volume, serum hormone levels (follicle-stimulating hormone, luteinizing inhibin B) limited value for success. Emerging biomarkers-including anti-Müllerian levels, B ratio, specific microRNAs, long non-coding RNAs, circular germ-cell-specific proteins like TEX101-show promise predicting retrieval. Advanced techniques high-frequency ultrasound functional magnetic resonance offer require further validation. Integrating algorithms may enhance accuracy. Conclusions: Predicting remains challenging using conventional parameters. improve validation through large-scale studies. Incorporating could refine accuracy, aiding decision-making improving counseling treatment strategies NOA.

Language: Английский

Citations

3
Preliminary Results of Microsurgical Sperm Retrieval in Azoospermic Patients: A Randomized Controlled Trial Comparing Operating Microscope vs. Surgical Loupes DOI Open Access
Mirko Preto, Luca Boeri, Lorenzo Cirigliano

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(3), P. 970 - 970

Published: Feb. 3, 2025

Objectives: To compare surgical outcomes and sperm retrieval rates (SRRs) between conventional microsurgical-assisted testicular extraction (m-TeSE—Group A) performed with loupes (l-TeSE—Group B) in adult males non-obstructive azoospermia (NOA). Methods: A multicentric prospective randomized trial (ethics committee no. 202/2022) accordance the CONSORT guidelines was conducted from March 2022 to April 2024. Adult NOA without genetic alterations who signed informed consent were enrolled. SRRs, intra- postoperative complications (according Clavien–Dindo classification), hormonal profile changes considered as during follow-up period. Results: total of 42 patients The median age 35 years (IQR: 33–49). preoperative FSH 16.5 mIU/mL 11.6–22.5) testosterone 4.6 (3.5–5.6). Overall, SRR 22.6%, retrieved 19 testes. Histopathological findings reported Sertoli cell-only syndrome (SCOS) 46.4% (39 cases), hypospermatogenesis 26.2%, germ cell arrest 26.2% patients. No intraoperative recorded. minimal (Clavien–Dindo grade I), but no significant differences recorded in-between two approaches. Considering operative time exploration alone, Group B seemed be faster than m-TeSE, a saving 8 min (p < 0.01). Conclusion: use safe comparable m-TeSE terms SRRs complication rates. L-TeSE offered reduction compared m-TeSE.

Language: Английский

Citations

0