Piezos thrive under pressure: mechanically activated ion channels in health and disease

Nature Reviews Molecular Cell Biology, Journal Year: 2017, Volume and Issue: 18(12), P. 771 - 783

Published: Oct. 4, 2017

Language: Английский

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Cationic Substitutions in Hydroxyapatite: Current Status of the Derived Biofunctional Effects and Their In Vitro Interrogation Methods

Materials, Journal Year: 2018, Volume and Issue: 11(11), P. 2081 - 2081

Published: Oct. 24, 2018

High-performance bioceramics are required for preventing failure and prolonging the life-time of bone grafting scaffolds osseous implants. The proper identification development materials with extended functionalities addressing socio-economic needs health problems constitute important critical steps at heart clinical research. Recent findings in realm ion-substituted hydroxyapatite (HA) could pave road towards significant developments biomedicine, an emphasis on a new generation orthopaedic dentistry applications, since such able to mimic structural, compositional mechanical properties mineral phase. In fact, fascinating ability HA crystalline lattice allow substitution calcium ions plethora cationic species has been widely explored recent period, consequent modifications its physical chemical features, as well functional vitro vivo biological performance. A comprehensive inventory progresses achieved so far is both opportune paramount importance, order not only gather summarize information, but also fellow researchers compare ease filter best solutions cation HA-based enable multi-functional biomedical designs. review surveys preparation synthesis methods, pinpoints all dopants, discloses full application range substituted HA. Special attention dedicated antimicrobial efficiency spectrum cytotoxic trade-off concentration values various cell lines, highlighting prophylactic routes prevention implant failure. Importantly, current tests (widely employed unveil performance materials), their interactions, critically assessed. Future perspectives discussed, series recommendations underlined.

Language: Английский

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Deconstructing cortical folding: genetic, cellular and mechanical determinants

Nature reviews. Neuroscience, Journal Year: 2019, Volume and Issue: 20(3), P. 161 - 176

Published: Jan. 4, 2019

Language: Английский

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Fluid Shear Stress Sensing by the Endothelial Layer

Frontiers in Physiology, Journal Year: 2020, Volume and Issue: 11

Published: July 24, 2020

Blood flow produces mechanical frictional forces, parallel to the blood flow, exerted on endothelial wall of vessel, so-called shear stress (WSS). WSS sensing is associated with several vascular pathologies, but it first all a physiological phenomenon. Endothelial cell sensitivity involved in developmental and processes such as angiogenesis morphogenesis, remodeling, tone. Local conditions determine characteristics WSS, i.e., intensity, direction, pulsatility, sensed by cells that, through their effect network, impact WSS. All these generate local-global retroactive loop that determines ability system ensure perfusion tissues. In order account for role set point theory has been proposed, according which acts locally vessel remodeling so maintained close value, local distant effects flow. The aim this article (1) review existing literature involvement behavior its short-term (vasoreactivity) long-term (vascular morphogenesis remodeling) functioning condition; (2) present various hypotheses about sensors analyze conceptual background representations, particular concept tensional prestress or biotensegrity; (3) relevance, explanatory value limitations theory, should be viewed dynamical, not algorithmic, processes, acting self-organized way. We conclude dynamic biotensegrity provide relevant framework analyse mechanisms possible shift towards pathological situations.

Language: Английский

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The softness of tumour-cell-derived microparticles regulates their drug-delivery efficiency

Nature Biomedical Engineering, Journal Year: 2019, Volume and Issue: 3(9), P. 729 - 740

Published: May 20, 2019

Language: Английский

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Mechanical tumor microenvironment and transduction: cytoskeleton mediates cancer cell invasion and metastasis

International Journal of Biological Sciences, Journal Year: 2020, Volume and Issue: 16(12), P. 2014 - 2028

Published: Jan. 1, 2020

Metastasis is a complicated, multistep process that responsible for over 90% of cancer-related death.Metastatic disease or the movement cancer cells from one site to another requires dramatic remodeling cytoskeleton.The regulation cell migration determined not only by biochemical factors in microenvironment but also biomechanical contextual information provided extracellular matrix (ECM).The responses cytoskeleton chemical signals are well characterized and understood.However, mechanisms response mechanical form externally applied force forces generated ECM still poorly understood.Furthermore, understanding way cellular mechanosensors interact with physical properties transmit activate cytoskeletal movements may help identify an effective strategy treatment cancer.Here, we will discuss role tumor during metastasis how remodel through mechanosensing transduction.

Language: Английский

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Microglial Piezo1 senses Aβ fibril stiffness to restrict Alzheimer’s disease

Neuron, Journal Year: 2022, Volume and Issue: 111(1), P. 15 - 29.e8

Published: Nov. 10, 2022

Language: Английский

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A systematic investigation of the effect of the fluid shear stress on Caco-2 cells towards the optimization of epithelial organ-on-chip models

Biomaterials, Journal Year: 2019, Volume and Issue: 225, P. 119521 - 119521

Published: Sept. 25, 2019

Language: Английский

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<p>Polycaprolactone: How a Well-Known and Futuristic Polymer Has Become an Innovative Collagen-Stimulator in Esthetics</p>

Clinical Cosmetic and Investigational Dermatology, Journal Year: 2020, Volume and Issue: Volume 13, P. 31 - 48

Published: Jan. 1, 2020

Abstract: Compared to other domains, tissue engineering and esthetics have dramatically expanded in recent years, leading both major biomedical advances futuristic perspectives. The two share a common approach based on biomaterials, especially polymers. This paper illustrates this with the example of polycaprolactone (PCL), polymer synthesized early 1930s, one its most applications, PCL-based collagen stimulator, filler used esthetics. PCL is biocompatible biodegradable. Its specific physicochemical mechanical properties, viscoelasticity ease shaping led production products various shapes durations dependent biodegradation kinetics. has been safely field for more than 70 from sutures organ replacement by 3D printing. stimulator composed microspheres suspended carboxymethyl-cellulose gel carrier providing immediate sustained volumizing effects when injected; morphology, biocompatibility embedded fibers produced all contribute creation unique scaffold effect. safety investigated clinical studies vigilance surveys. Recently published experts’ recommendations injection modalities techniques should help further optimize treatment outcome safety. also integrates reviews prevention management adverse events related dermal subdermal fillers including stimulator. In addition, terms efficacy safety, product benefits daily use worldwide continuous extensive fundamental research, it polymer. Forthcoming data investigations will reinforce knowledge procedures field. Keywords: esthetics, stimulators, fillers, Ellansé ® , polycaprolactone,

Language: Английский

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Biophysical regulation of macrophages in health and disease

Journal of Leukocyte Biology, Journal Year: 2019, Volume and Issue: 106(2), P. 283 - 299

Published: March 12, 2019

Abstract Macrophages perform critical functions for homeostasis and immune defense in tissues throughout the body. These innate cells are capable of recognizing clearing dead pathogens, orchestrating inflammatory healing processes that occur response to injury. In addition, macrophages involved progression many diseases including cardiovascular disease, fibrosis, cancer. Although it has long been known respond dynamically biochemical signals their microenvironment, role biophysical cues only recently emerged. Furthermore, involve also characterized by changes tissue environment. This review will discuss current knowledge about effects matrix stiffness, material topography, applied mechanical forces, on macrophage behavior. We describe molecules be important mechanotransduction, adhesion molecules, ion channels, as well nuclear mediators such transcription factors, scaffolding proteins, epigenetic regulators. Together, this illustrate a developing biology, speculate upon molecular targets may potentially exploited therapeutically treat disease.

Language: Английский

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