Projection-Based Clustering through Self-Organization and Swarm Intelligence

Springer eBooks, Journal Year: 2018, Volume and Issue: unknown

Published: Jan. 1, 2018

Language: Английский

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Implications of nanotechnology for the treatment of Dry Eye Disease: Recent advances

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125355 - 125355

Published: Feb. 1, 2025

Language: Английский

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Global distribution of antimicrobial resistance genes in aquaculture

One Health Advances, Journal Year: 2025, Volume and Issue: 3(1)

Published: March 31, 2025

Abstract Aquaculture has rapidly developed into one of the most fast-expanding food industries, providing an essential source protein for humanity worldwide. The rapid growth aquaculture industry is closely associated with crucial role antimicrobials in prevention and treatment animal diseases. Nevertheless, irrational utilization gives rise to emergence pathogen resistance, which poses a potential threat human health environmental sustainability. This issue garnered considerable attention from international organizations escalated global public crisis that requires urgent intervention. paper undertakes review sources antimicrobial resistance aquaculture, drawing on data Microbial Browser Identification Genetic Genomic Elements (MicroBIGG-E) related literature. characteristics distribution patterns drug genes pathogenic bacteria diseased aquatic animals food-borne contaminated products were elaborated detail. resistant not solely attributable but rather social activities. Diverse tetracyclines, aminoglycosides, β-lactams, quinolones, sulfonamides, amphenicols coexist foodborne pathogens might contribute multidrug aquaculture. also evaluates risks respect health, safety, ecological balance. Government entities, research institutions, private companies are adopting proactive measures initiating specific strategies alleviate dissemination thereby enhancing as well

Language: Английский

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An exploratory study of host polymorphisms in genes that clinically characterize breast cancer tumors and pretreatment cognitive performance in breast cancer survivors

Breast Cancer Targets and Therapy, Journal Year: 2017, Volume and Issue: Volume 9, P. 95 - 110

Published: March 1, 2017

Inspired by the hypothesis that heterogeneity in biology of breast cancers at cellular level may account for cognitive dysfunction symptom variability survivors, current study explored relationships between host single-nucleotide polymorphisms (SNPs) 25 cancer-related candidate genes (AURKA, BAG1, BCL2, BIRC5, CCNB1, CD68, CENPA, CMC2, CTSL2, DIAPH3, ERBB2, ESR1, GRB7, GSTM1, MELK, MKI67, MMP11, MYBL2, NDC80, ORC6, PGR, RACGAP1, RFC4, RRM2, and SCUBE2), identified from clinically relevant prognostic multigene-expression profiles cancer, pretreatment performance.The sample (n=220) was comprised 138 postmenopausal women newly diagnosed with early stage cancer 82 age- education-matched healthy controls without cancer. Cognitive performance assessed after primary surgery but prior to initiation adjuvant chemotherapy and/or hormonal therapy using a comprehensive battery neuropsychological tests encompassing eight function composite domains: attention, concentration, executive function, mental flexibility, psychomotor speed, verbal memory, visual working memory. In total, 131 SNPs were included analysis. Standard robust multiple linear regression modeling used examine each domain presence or absence one more minor alleles SNP. Genetic risk/protection scores (GRSs) calculated evaluate collective effect possession risk/protective alleles.With exception significant (P<0.05) SNP main future prescribed treatment group interactions observed every gene least SNPs. All GRSs found be significantly (P<0.001) associated respective score.Associations computed support hypothesis, warrant further investigations identify biomarkers dysfunction.

Language: Английский

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The 2025 Nucleic Acids Research database issue and the online molecular biology database collection

Nucleic Acids Research, Journal Year: 2024, Volume and Issue: 53(D1), P. D1 - D9

Published: Dec. 10, 2024

The 2025 Nucleic Acids Research database issue contains 185 papers spanning biology and related areas. Seventy three new databases are covered, while resources previously described in the account for 101 update articles. Databases most recently published elsewhere a further 11 papers. acid include EXPRESSO multi-omics of 3D genome structure (this issue's chosen Breakthrough Resource Article) NAIRDB Fourier transform infrared data. New protein predictions human isoforms at ASpdb viral proteins BFVD. UniProt, Pfam InterPro have all provided updates: metabolism signalling covered by descriptions STRING, KEGG CAZy, updated microbe-oriented Enterobase, VFDB PHI-base. Biomedical research is supported, among others, ClinVar, PubChem DrugMAP. Genomics-related Ensembl, UCSC Genome Browser dbSNP. plant cover Solanaceae (SolR) Asteraceae (AMIR) families an from NCBI Taxonomy also features. Database Issue freely available on website (https://academic.oup.com/nar). At NAR online Molecular Biology Collection (http://www.oxfordjournals.org/nar/database/c/), 932 entries been reviewed last year, 74 added 226 discontinued URLs eliminated bringing current total to 2236 databases.

Language: Английский

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Research Article Genomic regions and genes associated with carcass quality in Nelore cattle

Genetics and Molecular Research, Journal Year: 2019, Volume and Issue: 18(1)

Published: Jan. 1, 2019

Many studies have explored variability to select cattle with high genetic potential for economic interest traits.Genetic is a powerful tool improve production indexes in cattle, as it also associated variations meat and carcass quality traits.We made Genome-Wide Association Study of beef Bos indicus origin, particular Nelore animals, identify regions genes quality, by examining phenotypic genotypic data from 909 animals.Several were observed above 1% the portion explained variance explained: hot weight, LRGUK, TRIM24, SVOPL, TEX37, CA10, OXSR1; ribeye area, TWIST2, SFXN1, CMYA5, CPQ MRS2; backfat thickness, OR2S2, 5S_rRNA, LOC100299372, LOC523083, LOC532403, LOC613441, SNORA69 ITGA9; marbling, EMCN, LNX1, EIF5, SNORA28 DSC3.The various genomic small effects show complexity these phenotypes that they do not depend only on few determine their variations.

Language: Английский

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Environmental metabolomics characterization of modern stromatolites and annotation of ibhayipeptolides

Published: April 17, 2024

Lithified layers of complex microbial mats known as microbialites are ubiquitous in the fossil record, and modern forms increasingly identified globally. A key challenge to developing an understanding microbialite formation environmental role is how investigate diverse communities situ. We selected living, layered (stromatolites) a peritidal environment near Schoenmakerskop, Eastern Cape, South Africa conduct spatial survey mapping composition small molecule production from samples. Substrate core samples were collected nine sampling stations ranging upper point freshwater inflow lower marine interface where tidal overtopping takes place. cores provided material for parallel analyses community diversity by 16S rRNA gene amplicon sequencing metabolomics using LC–MS2. Species metabolite diversities correlated, prominent specialized metabolites targeted preliminary characterization. new series cyclic hexadepsipeptides, named ibhayipeptolides, was most abundant substrate submerged microbialites. These results demonstrate detection identification mass-limited contribute knowledge about chemistry biology, which facilitates future studies function biosynthesis.

Language: Английский

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RDBridge: a knowledge graph of rare diseases based on large-scale text mining

Bioinformatics, Journal Year: 2023, Volume and Issue: 39(7)

Published: July 1, 2023

Abstract Motivation Despite low prevalence, rare diseases affect 300 million people worldwide. Research on pathogenesis and drug development lags due to limited commercial potential, insufficient epidemiological data, a dearth of publications. The unique characteristics diseases, including annotated intricate processes for extracting pertinent entity relationships, difficulties in standardizing represent challenges text mining. Results We developed disease data acquisition framework using mining knowledge graphs constructed the most comprehensive graph date, Rare Disease Bridge (RDBridge). RDBridge offers search functions genes, potential drugs, pathways, literature, medical imaging that will support mechanistic research, development, diagnosis, treatment diseases. Availability implementation is freely available at http://rdb.lifesynther.com/.

Language: Английский

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Novel Mobile Integrons and Strain-Specific Integrase Genes within <em>Shewanella</em> spp. Unveil Multiple Lateral Genetic Transfer Events within the Genus

Published: April 19, 2022

Shewanella spp. are gram-negative bacteria that thrive in aquatic niches and also cause infectious diseases as opportunistic pathogens. Chromosomal integrons (CI) mobile (MI) were previously described some isolates. Here, we evaluated the occurrence of integrase genes, integron systems their genetic surroundings genus. We identified 22 gene types, 17 which newly described, different species, evidencing multiple gain loss events. Phylogenetic analysis showed most them strain-specific, except for algae, seem to have co-evolve within host typical CIs. Noteworthy, co-existence up 5 well wide dissemination Alteromonadales, Vibronales, Chromatiales, Oceanospirillales Enterobacterales was observed. Identification novel MIs suggests lateral transfer may occurred resembling behavior class 1 integrons. The constant emergence determinants associated antimicrobial resistance worldwide, concomitantly with strains capable harbor several types be an alarming threat recruitment cassettes genus Shewanella, its evolution towards multidrug resistance.

Language: Английский

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Plugin for concept-assisted search and navigation on PUBMED

2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), Journal Year: 2015, Volume and Issue: unknown, P. 1712 - 1714

Published: Nov. 1, 2015

Introduction: Search of MEDLINE using the PUBMED interface still remains a preferred approach for many scientists, even in presence alternatives. While provides rich querying, it does not provide deep analysis query results to refine queries and build hypotheses. To an improved search experience PubMed, we have developed Firefox browser plugin called "TPX plus" that enables concept-assisted navigation database while remaining PubMed website. Some features include identification highlighting biomedical concept types like genes, processes, diseases etc. page; link-outs dictionary sources identified terms; Concept Explorer view ranked automatically concepts as well use them filtering/refining search; deriving related statistical concept-associations network; bookmarking managing articles, storing notes sharing comments on articles. Implementation: The core is written JavaScript uses Web 2.0 technologies such jQuery, AJAXlJSON XUL handling manipulating content web pages within domain. 'TPX plus' DOM structure PubMed's a) building input Annotation server by extracting appropriate title, abstract text ID from elements b) presenting top based their relevance under explorer c) highlight each result article interface. Conclusion: Its three-pronged nature relying basic indexing engine, enhancing performing customized offline on-the-fly most importantly being available allowing user-interface makes this ideal assistant scientists.

Language: Английский

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