D–A Type NIR‐II Organic Molecules: Strategies for the Enhancement Fluorescence Brightness and Applications in NIR‐II Fluorescence Imaging‐Navigated Photothermal Therapy DOI
Yan Chen, Shangyu Chen, Haoli Yu

et al.

Advanced Healthcare Materials, Journal Year: 2022, Volume and Issue: 11(21)

Published: Aug. 9, 2022

NIR-II fluorescence imaging (NIR-II FI) and photothermal therapy (PTT) have received broad attentions in precise tumor diagnosis effective treatment attributed to high-resolution deep tissue imaging, negligible invasivity, high-efficiency treatment. Although many fluorescent molecules been designed conducted for FI PTT, it is still an enormous challenge researchers pioneer some rational design guidelines improve brightness. Organic D-A-type molecules, including small conjugated polymers, can be developed brightness due their tunable easy functionalized chemical structures, allowing tailored photophysical properties. In this review, approaches the development strategies of D-A type polymers enhancement are systemically introduced. Meanwhile, applications PTT PTT-based combination (such as PDT, chemotherapy, or gas therapy) assisted by FI-based single multiimaging technologies classified represented detail well. Finally, current issues challenges organic FI-navigated summarized discussed, which gives future direction PTT.

Language: Английский

Advances of nanoparticles as drug delivery systems for disease diagnosis and treatment DOI
Rui Liu, Cong Luo, Zhiqing Pang

et al.

Chinese Chemical Letters, Journal Year: 2022, Volume and Issue: 34(2), P. 107518 - 107518

Published: May 14, 2022

Language: Английский

Citations

343
Homogeneous Carbon/Potassium‐Incorporation Strategy for Synthesizing Red Polymeric Carbon Nitride Capable of Near‐Infrared Photocatalytic H2 Production DOI
Yangsen Xu,

Mingjian Fan,

Wenjuan Yang

et al.

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(39)

Published: Aug. 8, 2021

Abstract The efficient utilization of near‐infrared (NIR) light for photocatalytic hydrogen generation is vitally important to both solar energy and medicine, but remains a challenge at present, owing the strict requirement semiconductor high NIR responsiveness, narrow bandgap, suitable redox potentials. Here, an NIR‐active carbon/potassium‐doped red polymeric carbon nitride (RPCN) achieved by using similar‐structure dopant as melamine (C 3 H 6 N ) precursor with solid KCl. homogeneous incorporation potassium remarkably narrows bandgap (1.7 eV) endows RPCN NIR‐photocatalytic activity 2 evolution from water rate 140 µmol h −1 g under irradiation (700 nm ≤ λ 780 nm), apparent quantum efficiency 0.84% 700 ± 10 (and 13% 500 nm). A proof‐of‐concept experiment on tumor‐bearing mouse model verifies being capable intratumoral simultaneous glutathione deprivation safe high‐efficacy drug‐free cancer therapy. results shed designing photocatalysts capture full spectrum energy, also pioneer new pathway develop therapy major diseases.

Language: Английский

Citations

212
Photocatalysis-mediated drug-free sustainable cancer therapy using nanocatalyst DOI Creative Commons
Bin Zhao,

Yingshuai Wang,

Xianxian Yao

et al.

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: March 1, 2021

Abstract Drug therapy unavoidably brings toxic side effects and drug content-limited therapeutic efficacy although many nanocarriers have been developed to improve them a certain extent. In this work, concept of drug-free therapeutics is proposed defined as methodology without the use traditional drugs, consumption agents during treatment but with inexhaustible capability maximize benefit treatment, Z-scheme SnS 1.68 -WO 2.41 nanocatalyst achieve near infrared (NIR)-photocatalytic generation oxidative holes hydrogen molecules for realizing combined hole/hydrogen by strategy. Without need any other agent assistance, oxidizes/consumes intratumoral over-expressed glutathione (GSH) simultaneously generates in lasting controllable way under NIR irradiation. Mechanistically, generated GSH inhibit cancer cell energy destroy redox balance, respectively, synergistically damage DNA induce tumor apoptosis. High biosafety tumors are achieved nanocatalyst. The catalysis-based strategy breaks pathway realize high low toxicity treatment.

Language: Английский

Citations

170
Gas therapy potentiates aggregation-induced emission luminogen-based photoimmunotherapy of poorly immunogenic tumors through cGAS-STING pathway activation DOI Creative Commons
Kaiyuan Wang, Yang Li, Xia Wang

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: May 23, 2023

The immunologically "cold" microenvironment of triple negative breast cancer results in resistance to current immunotherapy. Here, we reveal the immunoadjuvant property gas therapy with cyclic GMP-AMP synthase-stimulator interferon genes (cGAS-STING) pathway activation augment aggregation-induced emission (AIE)-active luminogen (AIEgen)-based photoimmunotherapy. A virus-mimicking hollow mesoporous tetrasulfide-doped organosilica is developed for co-encapsulation AIEgen and manganese carbonyl fabricate nanoadjuvant. As tetra-sulfide bonds are responsive intratumoral glutathione, nanoadjuvant achieves tumor-specific drug release, promotes photodynamic therapy, produces hydrogen sulfide (H2S). Upon near-infrared laser irradiation, AIEgen-mediated phototherapy triggers burst carbon monoxide (CO)/Mn2+. Both H2S CO can destroy mitochondrial integrity induce leakage DNA into cytoplasm, serving as immunoadjuvants activate cGAS-STING pathway. Meanwhile, Mn2+ sensitize cGAS STING-mediated type I production. Consequently, potentiates photoimmunotherapy poorly immunogenic tumors female mice.

Language: Английский

Citations

141
Nanoscale CaH2 materials for synergistic hydrogen-immune cancer therapy DOI Creative Commons
Fei Gong, Jiachen Xu, Bo Liu

et al.

Chem, Journal Year: 2021, Volume and Issue: 8(1), P. 268 - 286

Published: Dec. 13, 2021

Language: Английский

Citations

132
Recent advances on modulation of H2O2 in tumor microenvironment for enhanced cancer therapeutic efficacy DOI

Zhaoyou Chu,

Juan Yang, Zheng Wang

et al.

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 481, P. 215049 - 215049

Published: Feb. 9, 2023

Language: Английский

Citations

125
Multifunctional nanotheranostics for near infrared optical imaging-guided treatment of brain tumors DOI
Li Zhang, Yue Liu, Haiyan Huang

et al.

Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 190, P. 114536 - 114536

Published: Sept. 13, 2022

Language: Английский

Citations

108
Magnesium galvanic cells produce hydrogen and modulate the tumor microenvironment to inhibit cancer growth DOI Creative Commons
Nailin Yang, Fei Gong, Bo Liu

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: April 28, 2022

Abstract Hydrogen can be used as an anti-cancer treatment. However, the continuous generation of H 2 molecules within tumor is challenging. Magnesium (Mg) and its alloys have been extensively in clinic implantable metals. Here we develop, by decorating platinum on surface Mg rods, a Mg-based galvanic cell (MgG), which allows aqueous environment due to galvanic-cell-accelerated water etching Mg. By implanting MgG rods into tumor, generated induces mitochondrial dysfunction intracellular redox homeostasis destruction. Meanwhile, Mg(OH) residue neutralize acidic microenvironment (TME). Such with micro-galvanic structure enable hydrogen therapy inhibit growth tumors, including murine models, patient-derived xenografts (PDX), well VX tumors rabbits. Our research suggests that cells for based metals may safe effective cancer

Language: Английский

Citations

106
Bioresponsive nano-antibacterials for H 2 S-sensitized hyperthermia and immunomodulation against refractory implant–related infections DOI Creative Commons
Zheng Su, Lingtong Kong, Yong Dai

et al.

Science Advances, Journal Year: 2022, Volume and Issue: 8(14)

Published: April 8, 2022

There is an increasingly growing demand for nonantibiotic strategies to overcome drug resistance in bacterial biofilm infections. Here, a novel “gas-sensitized hyperthermia” strategy proposed appreciable bacteria killing by the smart design of metal-organic framework (MOF)–sealed Prussian blue–based nanocarrier (MSDG). Once microenvironment (BME) reached, acidity-activated MOF degradation allows release diallyl trisulfide and subsequent glutathione-responsive generation hydrogen sulfide (H 2 S) gas. Upon near-infrared irradiation, H S-sensitized hyperthermia arising from MSDG can efficiently eliminate biofilms through S-induced extracellular DNA damage heat-induced death. The generated S stimulate polarization macrophages toward M2 phenotype reshaping immune microenvironment. Subsequently, secretion abundant regeneration-related cytokines accelerates tissue regeneration reversing infection-induced pro-inflammatory environment implant-related infection model. Collectively, such BME-responsive nano-antibacterials achieve biofilm-specific thermal eradiation immunomodulatory remodeling, thus realizing renaissance precision treatment refractory implant–related

Language: Английский

Citations

82
Recent advances in near-infrared-II hollow nanoplatforms for photothermal-based cancer treatment DOI Creative Commons
Li Zhang, Gerile Oudeng,

Feiqiu Wen

et al.

Biomaterials Research, Journal Year: 2022, Volume and Issue: 26(1)

Published: Sept. 30, 2022

Near-infrared-II (NIR-II, 1000-1700 nm) light-triggered photothermal therapy (PTT) has been regarded as a promising candidate for cancer treatment, but PTT alone often fails to achieve satisfactory curative outcomes. Hollow nanoplatforms prove be attractive in the biomedical field owing merits including good biocompatibility, intrinsic physical-chemical nature and unique hollow structures, etc. On one hand, themselves can NIR-II agents (PTAs), cavities of which are able carry diverse therapeutic units realize multi-modal therapies. other PTAs capable decorating on surface combine with functions components encapsulated inside synergistic treatment. Notably, generally serve photoacoustic imaging (PAI) contrast (CAs), means such kind also expected multifunctional all-in-one nanotheranostics. In this review, recent advances single-modal PTT, dual-modal PTT/photodynamic (PDT), PTT/chemotherapy, PTT/catalytic PTT/gas well PTT/chemodynamic (CDT)/chemotherapy, PTT/chemo/gene PTT/PDT/CDT/starvation (ST)/immunotherapy summarized first time. Before these, typical synthetic strategies structures presented, lastly, potential challenges perspectives related these novel paradigms future research clinical translation discussed.

Language: Английский

Citations

79