Advanced Healthcare Materials,
Journal Year:
2022,
Volume and Issue:
11(21)
Published: Aug. 9, 2022
NIR-II
fluorescence
imaging
(NIR-II
FI)
and
photothermal
therapy
(PTT)
have
received
broad
attentions
in
precise
tumor
diagnosis
effective
treatment
attributed
to
high-resolution
deep
tissue
imaging,
negligible
invasivity,
high-efficiency
treatment.
Although
many
fluorescent
molecules
been
designed
conducted
for
FI
PTT,
it
is
still
an
enormous
challenge
researchers
pioneer
some
rational
design
guidelines
improve
brightness.
Organic
D-A-type
molecules,
including
small
conjugated
polymers,
can
be
developed
brightness
due
their
tunable
easy
functionalized
chemical
structures,
allowing
tailored
photophysical
properties.
In
this
review,
approaches
the
development
strategies
of
D-A
type
polymers
enhancement
are
systemically
introduced.
Meanwhile,
applications
PTT
PTT-based
combination
(such
as
PDT,
chemotherapy,
or
gas
therapy)
assisted
by
FI-based
single
multiimaging
technologies
classified
represented
detail
well.
Finally,
current
issues
challenges
organic
FI-navigated
summarized
discussed,
which
gives
future
direction
PTT.
Biomedicine & Pharmacotherapy,
Journal Year:
2020,
Volume and Issue:
134, P. 111103 - 111103
Published: Dec. 16, 2020
Nanomedicines
offer
nanoscale
drug
delivery
system.
They
ways
of
promising
transportation,
and
address
the
issues
lack
targeting
permeability
traditional
drugs.
The
physical
chemical
properties
in
domain
nanomedicine
applications
vivo
have
not
been
sufficiently
delivered.
What's
more,
metabolic
nanomedicines
is
clear
enough.
Those
factors
which
mentioned
above
determine
that
many
yet
realized
clinical
application
due
to
their
safety
problems
efficacy.
For
example,
they
may
cause
immune
response
cytotoxicity,
as
well
ability
organs
vivo,
penetration
them
also
poor
efficacy
drugs
vivo.
In
this
review,
new
progresses
different
kinds
(including
gold
nanoparticles,
nanorobots,
black
phosphorus
brain
diseases,
gene
editing
immunotherapy
etc.)
anti-tumor,
antibacterial,
ocular
diseases
arteriosclerosis
recent
years
were
summarized.
Their
shortcomings
pointed
out,
methods
improve
biosafety
Advanced Materials,
Journal Year:
2021,
Volume and Issue:
33(16)
Published: March 18, 2021
Abstract
Tumor‐targeted
drug
delivery
by
nanomaterials
is
important
to
improve
tumor
therapy
efficacy
and
reduce
toxic
side
effects,
but
its
efficiency
quite
limited.
In
this
work,
a
new
type
of
MBene,
zirconium
boride
nanosheet
(ZBN),
as
versatile
nanoplatform
realize
near‐infrared
(NIR)‐controlled
intratumoral
retention
release
developed.
ZBN
exhibits
high
NIR‐photothermal
conversion
(76.8%),
surface
modification
with
hyaluronic
acid
(HA)
polyol−borate
esterfication
endows
ZBN‐HA
good
dispersion,
the
photopyrolysis
borate
ester
causes
HA
detachment
aggregation,
enabling
NIR‐controlled
achieve
accumulation.
By
virtue
esterfication,
polyol
chemotherapeutic
(doxorubicin,
DOX),
NO
prodrug
(β‐galactosyl‐diazeniumdiolate,
Gal‐NO)
can
be
efficiently
stably
conjugated
on
(1.21
g
DOX
or
0.57
Gal‐NO
per
gram
ZBN)
without
visible
leakage,
enables
responsiveness
controllability.
Combined
chemothermal/gasothermal
therapies
based
ZBN‐HA/DOX
ZBN‐HA/NO
nanomedicines
eradicate
primary
tumors
interdict
metastasis
changing
microenvironment
killing
cancer
cells
in
tumors.
The
developed
MBene
confirmed
capable
high‐efficacy
tumor‐targeted
controlled
release.
Advanced Healthcare Materials,
Journal Year:
2022,
Volume and Issue:
11(21)
Published: Aug. 9, 2022
NIR-II
fluorescence
imaging
(NIR-II
FI)
and
photothermal
therapy
(PTT)
have
received
broad
attentions
in
precise
tumor
diagnosis
effective
treatment
attributed
to
high-resolution
deep
tissue
imaging,
negligible
invasivity,
high-efficiency
treatment.
Although
many
fluorescent
molecules
been
designed
conducted
for
FI
PTT,
it
is
still
an
enormous
challenge
researchers
pioneer
some
rational
design
guidelines
improve
brightness.
Organic
D-A-type
molecules,
including
small
conjugated
polymers,
can
be
developed
brightness
due
their
tunable
easy
functionalized
chemical
structures,
allowing
tailored
photophysical
properties.
In
this
review,
approaches
the
development
strategies
of
D-A
type
polymers
enhancement
are
systemically
introduced.
Meanwhile,
applications
PTT
PTT-based
combination
(such
as
PDT,
chemotherapy,
or
gas
therapy)
assisted
by
FI-based
single
multiimaging
technologies
classified
represented
detail
well.
Finally,
current
issues
challenges
organic
FI-navigated
summarized
discussed,
which
gives
future
direction
PTT.
