Materials Today Nano, Journal Year: 2023, Volume and Issue: 24, P. 100404 - 100404
Published: Aug. 31, 2023
Language: Английский
Acta Pharmaceutica Sinica B, Journal Year: 2023, Volume and Issue: 13(11), P. 4391 - 4416
Published: May 20, 2023
Owing to the inherent shortcomings of traditional therapeutic drugs in terms inadequate efficacy and toxicity clinical treatment, nanomedicine designs have received widespread attention with significantly improved reduced non-target side effects. Nanomedicines hold tremendous theranostic potential for treating, monitoring, diagnosing, controlling various diseases are attracting an unfathomable amount input research resources. Against backdrop exponentially growing number publications, it is imperative help audience get a panorama image activities field nanomedicines. Herein, this review elaborates on development trends nanomedicines, emerging nanocarriers, vivo fate safety their extensive applications. Moreover, challenges obstacles hindering translation nanomedicines also discussed. The elaboration aspects may enlighten readers set route future endeavors.
Language: Английский
Citations
86
ACS Nano, Journal Year: 2024, Volume and Issue: 18(6), P. 4683 - 4703
Published: Jan. 31, 2024
Organic fluorescent molecules with emission in the second near-infrared (NIR-II) biological window have aroused increasing investigation cancer phototheranostics. Among these studies, Benzobisthiadiazole (BBT), high electron affinity, is widely utilized as acceptor constructing donor–acceptor–donor (D-A-D) structured fluorophores intensive (NIR) absorption and NIR-II fluorescence. Until now, numerous BBT-based dyes been employed tumor phototheranostics due to their exceptional structure tunability, biocompatibility, photophysical properties. This review systematically overviews research progress of small molecular focuses on molecule design bioapplications. First, engineering strategies fine-tune properties high-performance are discussed detail. Then, applications optical imaging phototherapy highlighted. Finally, current challenges future prospects also summarized. believed significantly promote further BBT-derived for
Language: Английский
Citations
41
Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 516, P. 215986 - 215986
Published: June 2, 2024
Language: Английский
Citations
25
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(16)
Published: Jan. 4, 2024
Abstract Second near‐infrared (NIR‐II) bioimaging technology shows broad application prospects in the field of biomedical due to its significant superiority deep tissue penetration and high signal‐to‐background ratio. Among them, organic small molecule fluorophores have received progressively more consideration their low biotoxicity, biocompatibility, rapid clearance, good modification properties. As key acceptor core, 2, 1, 3‐benzothiadiazole (BTD) derivative plays an essential role construction donor‐acceptor‐donor type NIR‐II fluorophores. This mini‐review summarizes research development based on BTD derivatives bioimaging, focusing molecular design photophysical properties, introduces a part applications biological field. Furthermore, challenges BTD‐based future are discussed .
Language: Английский
Citations
21
Nano Letters, Journal Year: 2024, Volume and Issue: 24(5), P. 1792 - 1800
Published: Jan. 26, 2024
A comprehensive approach for the construction of NIR-I/NIR-II nanofluorophores with exceptional brightness and excellent chemo- photostability has been developed. This study first confirmed that amphiphilic molecules stronger hydrophobic moieties weaker hydrophilic are superior candidates constructing brighter nanofluorophores, which attributed to its higher efficiency in suppressing intramolecular charge transfer/aggregation-caused fluorescence quenching donor-acceptor-donor type fluorophores. The prepared nanofluorophore demonstrates a quantum yield exceeding 4.5% aqueous solution exhibits strong NIR-II tail emission up 1300 nm. performance enabled achievement high-resolution whole-body vessel imaging brain imaging, as well high-contrast lymphatic system
Language: Английский
Citations
18
Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(8)
Published: Nov. 12, 2023
Abstract Organic molecules with second near‐infrared (NIR‐II, 1000–1700 nm) emission have significant advantages over NIR‐I (600–900 dyes, and been widely used as phototheranostic agents (PTAs) fluorescent probes. However, the two biggest challenges for such reagents are improving photothermal conversion efficiency (PCE), simplifying tedious synthetic procedures. Herein, different from traditional NIR skeleton, first time, it develops novel dibenzofulvene‐based NIR‐II PTAs via D‐π‐A concept high PCEs through simple steps. The increased intramolecular charge transfer effect extended π‐conjugation effectively red‐shift their emissions to region. In addition, introduction of molecular rotors/vibrators formation π–π stacking prompt exhibit PCEs. Notably, FE‐IDMN nanoparticles (FE‐IDMN NPs) achieve an exciting PCE 82.6%, higher than most reported emission. NPs also possess good colloidal, pH, stabilities, well excellent photoacoustic response, which is further successfully applied fluorescence/photoacoustic/photothermal imaging‐guided therapy. This work provides a strategy constructing new low weight, emission, cancer
Language: Английский
Citations
31
Small, Journal Year: 2023, Volume and Issue: 19(14)
Published: Jan. 20, 2023
Abstract For a long time, optical imaging of the deep brain with high resolution has been challenge. Recently, advance in second near‐infrared (NIR‐II) bioimaging techniques and contrast agents, NIR‐II window attracted great attention to monitoring deeper biological or pathophysiological processes signal‐to‐noise ratio (SNR) spatiotemporal resolution. Assisted bioimaging, modulation structure function is promising be noninvasive more precise. Herein, this review, first advantage light from interaction between tissue elaborated. Then, several specific technologies are introduced, including fluorescence imaging, multiphoton photoacoustic imaging. Furthermore, corresponding agents summarized. Next, application various visualizing characteristics cerebrovascular network changes pathology signals will presented. After that, based on discussed, treatment glioblastoma, guidance cell transplantation, neuromodulation. In end, future perspectives that would help improve clinical translation proposed.
Language: Английский
Citations
30
Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)
Published: Sept. 28, 2023
One-pot synthesis of heterocyclic aromatics with good optical properties from phenolic β-O-4 lignin segments is high importance to meet value added biorefinery demands. However, executing this process remains a huge challenge due the incompatible reaction conditions depolymerization containing γ-OH functionalities and bioresource-based aggregation-induced emission luminogens (BioAIEgens) formation desired properties. In work, benzannulation reactions starting moieties 3-alkenylated indoles catalyzed by vanadium-based complexes have been successfully developed, affording wide range functionalized carbazoles up 92% yield. Experiments density functional theory calculations suggest that pathway involves selective cleavage double C-O bonds/Diels-Alder cycloaddition/dehydrogenative aromatization. Photophysical investigations show these carbazole products represent class BioAIEgens twisted intramolecular charge transfer. Distinctions behavior were revealed based on unique acceptor-donor-acceptor-type molecular conformations as well packings. This work features motifs renewable substrates, without need apply external oxidant/reductant systems. Here, we concise sustainable route AIE properties, building bridge between BioAIE materials.
Language: Английский
Citations
23
Chemical Science, Journal Year: 2024, Volume and Issue: 15(18), P. 6777 - 6788
Published: Jan. 1, 2024
Designing molecules with donor-acceptor-donor (D-A-D) architecture plays an important role in obtaining second near-infrared region (NIR-II, 1000-1700 nm) fluorescent dyes for biomedical applications; however, this always comes a challenge due to very limited electronic acceptors. On the other hand, endow NIR-II combined therapeutic applications, trivial molecular design is indispensable. Herein, we propose pyrazine-based planar acceptor strong electron affinity, which can be used develop dyes. By structurally attaching two classical triphenylamine donors it, basic D-A-D module, namely Py-NIR, generated. The planarity of crucial induce distinct emission peaking at ∼1100 nm. unique construction cause twisted and flexible conformation by repulsive effect between donors, essential aggregation-induced (AIE) property. tuned intramolecular motions D-A pair brought lead remarkable photothermal conversion efficiency 56.1% type I photosensitization favorable hydroxyl radical (OH˙) formation. Note that no additional measures are adopted design, providing ideal platform realize probes synergetic functions based on such acceptor. Besides, nanoparticles Py-NIR exhibit excellent fluorescence imaging towards orthotopic 4T1 breast tumors living mice high sensitivity contrast. Combined photoacoustic caused thermal effect, imaging-guided photoablation well performed. Our work has created new opportunity accelerating applications.
Language: Английский
Citations
13
Aggregate, Journal Year: 2024, Volume and Issue: 5(3)
Published: Feb. 22, 2024
Abstract Near‐infrared (NIR)‐II fluorescence imaging‐guided photothermal therapy (PTT) has attracted great research interest, and constructing donor‐acceptor (D‐A) electronic configurations become an established approach to lower bandgap realize NIR‐II emission. However, very few π‐conjugated phototheranostic agents can efficient guided PTT using a clinically safe laser power density, implying that sufficient performance is still desired. In addition the continuously refreshed conversion efficiency levels, strategies focus on enhancing light absorptivity have been rarely discussed endow new direction for PTT. Herein, dimerization π‐extension strategy raised synthesize dimers with A‐D‐A monomers. We observe (ε) of strengthened three times owing enhanced coupling effect as result π‐conjugation extension, thereby surpassing 2‐fold increase in chromophore numbers from monomer dimers. Thanks enhancement absorption, could generate much more heat than vivo treatments. Therefore, anti‐tumor outcome fulfilled by under low (0.3 W/cm 2 ). Moreover, extended structures favorable radiative excited state decay, thus exhibiting distinguishing improvement imaging compared monomer. Collectively, due improved absorptivity, gain superior brightness over recently reported material, which goes beyond double doses applications. All these results prove effective designing high‐performance materials.
Language: Английский
Citations
12