Phytomedicine, Journal Year: 2024, Volume and Issue: 135, P. 156181 - 156181
Published: Oct. 28, 2024
Language: Английский
Life, Journal Year: 2024, Volume and Issue: 14(5), P. 559 - 559
Published: April 26, 2024
The gastrointestinal tract is home to trillions of diverse microorganisms collectively known as the gut microbiota, which play a pivotal role in breaking down undigested foods, such dietary fibers. Through fermentation these food components, short-chain fatty acids (SCFAs) acetate, propionate, and butyrate are produced, offering numerous health benefits host. production absorption SCFAs occur through various mechanisms within human intestine, contingent upon types fibers reaching specific engaged fermentation. Medical literature extensively documents supplementation SCFAs, particularly butyrate, treatment gastrointestinal, metabolic, cardiovascular, gut-brain-related disorders. This review seeks provide an overview dynamics involved gut. Additionally, it will focus on roles promoting metabolic health, well their current therapeutic implications.
Language: Английский
Citations
60
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 178, P. 117207 - 117207
Published: July 26, 2024
Language: Английский
Citations
25
Nature Reviews Neurology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 8, 2025
Language: Английский
Citations
3
Biomimetics, Journal Year: 2025, Volume and Issue: 10(2), P. 73 - 73
Published: Jan. 24, 2025
The gut microbiota is a complex and dynamic ecosystem that plays fundamental role in human health by regulating immunity, metabolism, the gut–brain axis. Beyond its critical physiological functions, it has emerged as rich source of inspiration for biomimetic innovations healthcare biotechnology. This review explores transformative potential microbiota-based biomimetics, focusing on key biological mechanisms such resilience, self-regulation, quorum sensing. These have inspired development innovative applications, including personalized probiotics, synbiotics, artificial microbiomes, bioinspired biosensors, bioremediation systems. Such technologies aim to emulate optimize intricate functions microbial ecosystems, addressing challenges environmental sustainability. integration advanced technologies, intelligence, bioengineering, multi-omics approaches, further accelerated biomimetics. tools enable precision therapies tailored individual profiles, enhance efficacy diagnostic systems, facilitate design environmentally sustainable solutions, waste-to-energy systems platforms. Emerging areas innovation, gut-on-chip models synthetic biology, offer unprecedented opportunities studying applying principles controlled environments. Despite these advancements, remain. replication complexity environments, ethical concerns regarding genetically engineered microorganisms, equitable access are hurdles must be addressed. underscores importance interdisciplinary collaboration public awareness overcoming barriers ensuring responsible solutions. By leveraging biomimetics represents promising frontier approach revolutionize therapeutic strategies, redefine tools, address global challenges, paving way more personalized, efficient, future medicine
Language: Английский
Citations
3
Protein & Cell, Journal Year: 2023, Volume and Issue: 14(10), P. 709 - 712
Published: May 23, 2023
With its critical role in human health and disease, the microbiome has transformed modern biology. Over past few years, research evolved rapidly, with microbiologists gradually shifting their focus from cataloging microorganisms to understanding functional roles how they interact host. Here, we present global trends summarize current work on published Protein & Cell. In closing, highlight some of major advancements research, including technical, practical, conceptual advancements, that aim enhance disease diagnosis, medicine development, personalized interventions
Language: Английский
Citations
27
Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 335, P. 122113 - 122113
Published: April 1, 2024
Language: Английский
Citations
15
MedComm, Journal Year: 2024, Volume and Issue: 5(8)
Published: July 20, 2024
Abstract Previous studies have shown a bidirectional communication between human gut microbiota and the brain, known as microbiota–gut–brain axis (MGBA). The MGBA influences host's nervous system development, emotional regulation, cognitive function through neurotransmitters, immune modulation, metabolic pathways. Factors like diet, lifestyle, genetics, environment shape composition together. Most research explored how regulates host physiology its potential in preventing treating neurological disorders. However, individual heterogeneity of microbiota, strains playing dominant role diseases, interactions these microbial metabolites with central/peripheral systems still need exploration. This review summarizes driving neurodevelopmental disorders (autism spectrum disorder attention deficit/hyperactivity disorder), neurodegenerative diseases (Alzheimer's Parkinson's disease), mood (anxiety depression) recent years discusses current clinical preclinical microbe‐based interventions, including dietary intervention, probiotics, prebiotics, fecal transplantation. It also puts forward insufficient on provides framework for further
Language: Английский
Citations
15
Nutrients, Journal Year: 2024, Volume and Issue: 16(7), P. 1086 - 1086
Published: April 7, 2024
Resveratrol (RES) has been reported to prevent hyperuricemia (HUA); however, its effect on intestinal uric acid metabolism remains unclear. This study evaluated the impact of RES in mice with HUA induced by a high-fat diet (HFD). Moreover, we revealed underlying mechanism through metagenomics, fecal microbiota transplantation (FMT), and 16S ribosomal RNA analysis. We demonstrated that reduced serum acid, creatinine, urea nitrogen, urinary protein levels, improved glomerular atrophy, unclear renal tubule structure, fibrosis, inflammation. The results also showed increased degradation. significantly changed flora composition HFD-fed enriching beneficial bacteria degrade reducing harmful promote inflammation, improving microbial function via upregulation purine metabolism. FMT further is essential for HUA, Lactobacillus may play key role this process. present alleviates HFD-induced injury regulating gut acid.
Language: Английский
Citations
13
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 177, P. 117031 - 117031
Published: June 25, 2024
An expanding body of research indicates a correlation between the gut microbiota and various diseases. Metabolites produced by act as mediators host, interacting with multiple systems in human to regulate physiological or pathological functions. However, further investigation is still required elucidate underlying mechanisms. One such metabolite involved choline metabolism microbes trimethylamine (TMA), which can traverse intestinal epithelial barrier enter bloodstream, ultimately reaching liver where it undergoes oxidation catalyzed flavin-containing monooxygenase 3 (FMO3) form N-oxide (TMAO). While some TMAO eliminated through renal excretion, remaining amounts circulate leading systemic inflammation, endoplasmic reticulum (ER) stress, mitochondrial disruption normal functions humans. As representative microbial originating from gut, has significant potential both biomarker for monitoring disease occurrence progression tailoring personalized treatment strategies patients. This review provides an extensive overview sources its blood, well impact on several major Additionally, we explore latest areas related along future directions.
Language: Английский
Citations
12
Neuroscience, Journal Year: 2025, Volume and Issue: 567, P. 172 - 181
Published: Jan. 8, 2025
Language: Английский
Citations
1