Bisphenol Analogues Other Than BPA: Environmental Occurrence, Human Exposure, and Toxicity—A Review

Environmental Science & Technology, Journal Year: 2016, Volume and Issue: 50(11), P. 5438 - 5453

Published: May 4, 2016

Numerous studies have investigated the environmental occurrence, human exposure, and toxicity of bisphenol A (BPA). Following stringent regulations on production usage BPA, several analogues been produced as a replacement for BPA in various applications. The present review outlines current state knowledge occurrence (other than BPA) environment, consumer products foodstuffs, exposure biomonitoring, toxicity. Whereas was still major analogue found most monitoring studies, BPF BPS were also frequently detected. Elevated concentrations BPAF, BPF, (i.e., similar to or greater that reported abiotic environment urine from some regions. Many exhibit endocrine disrupting effects, cytotoxicity, genotoxicity, reproductive toxicity, dioxin-like neurotoxicity laboratory studies. BPB, shown estrogenic and/or antiandrogenic activities even BPA. Knowledge gaps research needs identified, which include elucidation occurrences, persistence, fate BPA), sources pathways effects systems mammary gland, mechanisms coexposure multiple analogues, metabolic products, impact modification

Language: Английский

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Bisphenol S and F: A Systematic Review and Comparison of the Hormonal Activity of Bisphenol A Substitutes

Environmental Health Perspectives, Journal Year: 2015, Volume and Issue: 123(7), P. 643 - 650

Published: March 16, 2015

Increasing concern over bisphenol A (BPA) as an endocrine-disrupting chemical and its possible effects on human health have prompted the removal of BPA from consumer products, often labeled "BPA-free." Some replacements, however, are also bisphenols may similar physiological in organisms. Bisphenol S (BPS) F (BPF) two such substitutes.This review was carried out to evaluate endocrine activities substitutes BPS BPF. Further, we compared hormonal potency BPF that BPA.We conducted a systematic based Office Health Assessment Translation (OHAT) protocol.We identified body literature date, consisting 32 studies (25 vitro only, 7 vivo). The majority these examined found their be same order magnitude action (estrogenic, antiestrogenic, androgenic, antiandrogenic) vivo. has potencies estradiol membrane-mediated pathways, which important for cellular actions proliferation, differentiation, death. showed other vivo, altered organ weights, reproductive end points, enzyme expression.Based current literature, hormonally active BPA, they effects.Rochester JR, Bolden AL. 2015. F: comparison activity substitutes.

Language: Английский

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Overview of known plastic packaging-associated chemicals and their hazards

The Science of The Total Environment, Journal Year: 2018, Volume and Issue: 651, P. 3253 - 3268

Published: Oct. 3, 2018

Global plastics production has reached 380 million metric tons in 2015, with around 40% used for packaging. Plastic packaging is diverse and made of multiple polymers numerous additives, along other components, such as adhesives or coatings. Further, can contain residues from substances during manufacturing, solvents, non-intentionally added (NIAS), impurities, oligomers, degradation products. To characterize risks chemicals potentially released use, disposal, and/or recycling packaging, comprehensive information on all involved needed. Here, we present a database Chemicals associated Packaging (CPPdb), which includes manufacturing final articles. The CPPdb lists 906 likely plastic 3377 that are possibly associated. Of the 63 rank highest human health hazards 68 environmental according to harmonized hazard classifications assigned by European Agency within Classification, Labeling (CLP) regulation implementing United Nations' Globally Harmonized System (GHS). 7 classified Union persistent, bioaccumulative, toxic (PBT), very bioaccumulative (vPvB), 15 endocrine disrupting (EDC). Thirty-four also recognized EDC potential recent report Nations Environment Programme. identified hazardous monomers, intermediates, surfactants, plasticizers, stabilizers, biocides, flame retardants, accelerators, colorants, among functions. Our work was challenged lack transparency incompleteness publicly available both use toxicity substances. most here should be assessed detail candidates substitution.

Language: Английский

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A new chapter in the bisphenol A story: bisphenol S and bisphenol F are not safe alternatives to this compound

Fertility and Sterility, Journal Year: 2014, Volume and Issue: 103(1), P. 11 - 21

Published: Dec. 2, 2014

Bisphenol A (BPA) is a widely studied typical endocrine-disrupting chemical, and one of the major new issues safe replacement this commonly used compound. S (BPS) bisphenol F (BPF) are already or planned to be as BPA alternatives. With use culture system that we developed (fetal testis assay [FeTA]), previously showed 10 nmol/L reduces basal testosterone secretion human fetal explants susceptibility at least 100-fold lower in rat mouse testes. Here, show addition LH FeTA considerably enhances minimum effective concentration but not Then, using without (the experimental conditions which testes most sensitive BPA), found that, for BPA, BPS BPF sufficient decrease by with often nonmonotonic dose-response curves. In testes, curves were mostly monotonic concentrations 1,000 100 BPS. Finally, 10,000 BPS, reduced Insl3 expression cultured This first report describing adverse effects on physiologic function humans rodents.

Language: Английский

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Low-dose exposure to bisphenol A and replacement bisphenol S induces precocious hypothalamic neurogenesis in embryonic zebrafish

Proceedings of the National Academy of Sciences, Journal Year: 2015, Volume and Issue: 112(5), P. 1475 - 1480

Published: Jan. 12, 2015

Bisphenol A (BPA), a ubiquitous endocrine disruptor that is present in many household products, has been linked to obesity, cancer, and, most relevant here, childhood neurological disorders such as anxiety and hyperactivity. However, how BPA exposure translates into these neurodevelopmental remains poorly understood. Here, we used zebrafish link mechanistically disease etiology. Strikingly, treatment of embryonic with very low-dose (0.0068 μM, 1,000-fold lower than the accepted human daily exposure) bisphenol S (BPS), common analog BPA-free resulted 180% 240% increases, respectively, neuronal birth (neurogenesis) within hypothalamus, highly conserved brain region involved Furthermore, restricted BPA/BPS specifically during neurogenic window caused later hyperactive behaviors larvae. Unexpectedly, show BPA-mediated precocious neurogenesis concomitant behavioral phenotype were not dependent on predicted estrogen receptors but relied androgen receptor-mediated up-regulation aromatase. Although epidemiological results are still emerging, an association between high maternal urinary gestation hyperactivity other disturbances child suggested. Our studies here provide mechanistic support period indeed may be vulnerability uncovers previously unexplored avenues research disruptors might perturb early development. our products necessarily safer removal all bisphenols from consumer merchandise.

Language: Английский

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Exposure to Bisphenol A, Bisphenol F, and Bisphenol S in U.S. Adults and Children: The National Health and Nutrition Examination Survey 2013–2014

ACS Omega, Journal Year: 2018, Volume and Issue: 3(6), P. 6523 - 6532

Published: June 18, 2018

Bisphenol F (BPF) and bisphenol S (BPS) are replacing A (BPA) in the manufacturing of products containing polycarbonates epoxy resins. Data on current human exposure levels these substitutes needed to aid assessment their health risks. This study analyzed urinary adults (N = 1808) children 868) participating National Health Nutrition Examination Survey (NHANES) 2013–2014 investigated demographic lifestyle factors associated with bisphenols. BPA, BPS, BPF were detected 95.7, 89.4, 66.5% randomly selected urine samples as part NHANES 2013–2014, respectively. Median BPA U.S. adult higher (1.24 μg/L) than BPS (0.35 0.37 μg/L, respectively). For children, median also (1.25 (0.32 0.29 The limits detection for BPF, 0.2, 0.1 Urinary showed associations gender, race/ethnicity, family income, physical activity, smoking, and/or alcohol intake that depended specific bisphenol. results this indicate general population is almost ubiquitous. Because exposures differ across population, further studies environmental, consumer, affecting warranted.

Language: Английский

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Occurrence of bisphenol S in the environment and implications for human exposure: A short review

The Science of The Total Environment, Journal Year: 2017, Volume and Issue: 615, P. 87 - 98

Published: Oct. 17, 2017

Language: Английский

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Occurrence, toxicity and ecological risk of Bisphenol A analogues in aquatic environment – A review

Ecotoxicology and Environmental Safety, Journal Year: 2020, Volume and Issue: 208, P. 111481 - 111481

Published: Oct. 23, 2020

Bisphenol analogues (BPs) have been widely applied to industry as the substitutes for bisphenol A (BPA), which detected frequently in surface water, sediment, sewage and sludge. The presence of BPs natural environment could pose risks aquatic ecosystem human health. This study outlined occurrence, toxicity manifested their potential ecological risk throughout world. As BPA was losing its dominance, while were occupying a large part, especially S (BPS), F (BPF) AF (BPAF). In some heavily polluted areas, concentration reached µg/L environment, effluent plants higher than that water. content sludge sediment more aqueous phase. All other BPS P (BPP) had moderate toxicity. current data supports exposure may adverse effects on dysfunction endocrine system such thyroid hormone concentration, enzyme activity, even cell dysfunction, gene damage chromosomal abnormalities. According quotient (RQ), BPF shows highest China, Japan South Korea, followed by BPS. occurrence bisphenols neurotoxicity organisms merit further investigation.

Language: Английский

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Bifidobacterium species associated with breastfeeding produce aromatic lactic acids in the infant gut

Nature Microbiology, Journal Year: 2021, Volume and Issue: 6(11), P. 1367 - 1382

Published: Oct. 21, 2021

Abstract Breastfeeding profoundly shapes the infant gut microbiota, which is critical for early life immune development, and microbiota can impact host physiology in various ways, such as through production of metabolites. However, few breastmilk-dependent microbial metabolites mediating host–microbiota interactions are currently known. Here, we demonstrate that breastmilk-promoted Bifidobacterium species convert aromatic amino acids (tryptophan, phenylalanine tyrosine) into their respective lactic (indolelactic acid, phenyllactic acid 4-hydroxyphenyllactic acid) via a previously unrecognized lactate dehydrogenase (ALDH). The ability to derivatives was confirmed using monocolonized mice. Longitudinal profiling faecal composition metabolome Danish infants ( n = 25), from birth until 6 months age, showed concentrations correlated positively with abundance human milk oligosaccharide-degrading containing ALDH, including longum , B. breve bifidum . We further -derived indolelactic associated capacity these samples activate vitro aryl hydrocarbon receptor (AhR), important controlling intestinal homoeostasis responses. Finally, show modulates ex vivo responses CD4 + T cells monocytes dose-dependent manner by acting an agonist both AhR hydroxycarboxylic 3 (HCA ). Our findings reveal produce suggest may function life.

Language: Английский

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Effects of bisphenol A and its analogs on reproductive health: A mini review

Reproductive Toxicology, Journal Year: 2018, Volume and Issue: 79, P. 96 - 123

Published: June 18, 2018

Language: Английский

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