Circadian rhythms in the pathogenesis of gastrointestinal diseases DOI Creative Commons
Pilar Codoñer‐Franch, Marie Gombert

World Journal of Gastroenterology, Journal Year: 2018, Volume and Issue: 24(38), P. 4297 - 4303

Published: Oct. 11, 2018

The etiology of digestive pathologies such as irritable bowel syndrome (IBS), inflammatory diseases (IBD) and cancer is not yet fully understood. In recent years, several studies have evidenced circadian variations in mechanisms involved health. situations disturbed rhythms (chronodisruption) where the central clock peripheral clocks receive incoherent signals, synchronicity lost producing implications for This lack coordination could alter tissue function cause long term damage to organs. Life habits sleep, physical exercise, social interaction, feeding times are determinants stability integrity rhythms. experimental clinical consistently that alteration associated with development mainly linked dismotility or changes microbiota composition. Likewise, it seems reasonable deep into importance chronodisruption a factor may participate IBS, IBD cancers. Moreover, life respecting should be promoted prevention these diseases. Further will allow us better understanding acting at molecular level, new therapeutic targets.

Language: Английский

Effect of Diet on the Gut Microbiota: Rethinking Intervention Duration DOI Open Access
Emily R. Leeming, Abigail Johnson, Tim D. Spector

et al.

Nutrients, Journal Year: 2019, Volume and Issue: 11(12), P. 2862 - 2862

Published: Nov. 22, 2019

The human gut is inhabited by trillions of microorganisms composing a dynamic ecosystem implicated in health and disease. composition the microbiota unique to each individual tends remain relatively stable throughout life, yet daily transient fluctuations are observed. Diet key modifiable factor influencing microbiota, indicating potential for therapeutic dietary strategies manipulate microbial diversity, composition, stability. While diet can induce shift these changes appear be temporary. Whether prolonged permanent alterations unknown, mainly due lack long-term interventions, or follow-ups short-term interventions. It possible that habitual diets have greater influence on than acute strategies. This review presents current knowledge around response interventions identifies major factors contribute diet. Overall, further research include microbiome measures required before clinical recommendations made modulation health.

Language: Английский

Citations

654

Arrhythmic Gut Microbiome Signatures Predict Risk of Type 2 Diabetes DOI Creative Commons
Sandra Reitmeier, Silke Kießling, Thomas Clavel

et al.

Cell Host & Microbe, Journal Year: 2020, Volume and Issue: 28(2), P. 258 - 272.e6

Published: July 2, 2020

Language: Английский

Citations

223

Metabolic and cardiovascular consequences of shift work: The role of circadian disruption and sleep disturbances DOI
Laura Kervezee, Anastasi Kosmadopoulos, Diane B. Boivin

et al.

European Journal of Neuroscience, Journal Year: 2018, Volume and Issue: 51(1), P. 396 - 412

Published: Oct. 25, 2018

Abstract Shift work, defined as work occurring outside typical daytime working hours, is associated with an increased risk of various non‐communicable diseases, including diabetes and cardiovascular disease. Disruption the internal circadian timing system concomitant sleep disturbances thought to play a critical role in development these health problems. Indeed, controlled laboratory studies have shown that short‐term misalignment restriction independently impair physiological processes, insulin sensitivity, energy expenditure, immune function, blood pressure cardiac modulation by autonomous nervous system. If allowed persist, acute effects may lead cardiometabolic diseases long term. Here, we discuss evidence for contributions disruption metabolic problems shift workers. Improving understanding mechanisms affected disturbance will contribute implementation strategies prevent or mitigate impact work.

Language: Английский

Citations

174

Timing of Breakfast, Lunch, and Dinner. Effects on Obesity and Metabolic Risk DOI Open Access

Jesús Lόpez-Mínguez,

Purificación Gómez-Abellán,

Marta Garaulet

et al.

Nutrients, Journal Year: 2019, Volume and Issue: 11(11), P. 2624 - 2624

Published: Nov. 1, 2019

(1) Background: Eating is fundamental to survival. Animals choose when eat depending on food availability. The timing of eating can synchronize different organs and tissues that are related digestion, absorption, or metabolism, such as the stomach, gut, liver, pancreas, adipose tissue. Studies performed in experimental animal models suggest intake a major external synchronizer peripheral clocks. Therefore, may be decisive fat accumulation mobilization affect effectiveness weight loss treatments. (2) Results: We will review multiple studies about three main meals day, breakfast, lunch dinner, its potential impact glucose tolerance, obesity-related factors. also delve into several mechanisms implicated obesogenic effect late. Conclusion: Unusual time produce disruption circadian system might lead unhealthy consequences.

Language: Английский

Citations

164

Food as a circadian time cue — evidence from human studies DOI
Philip Lewis, Henrik Oster, Horst‐Werner Korf

et al.

Nature Reviews Endocrinology, Journal Year: 2020, Volume and Issue: 16(4), P. 213 - 223

Published: Feb. 13, 2020

Language: Английский

Citations

152

Time of sample collection is critical for the replicability of microbiome analyses DOI
Celeste Allaband,

Amulya Lingaraju,

Stephany Flores Ramos

et al.

Nature Metabolism, Journal Year: 2024, Volume and Issue: 6(7), P. 1282 - 1293

Published: July 1, 2024

Language: Английский

Citations

23

Meal timing and its role in obesity and associated diseases DOI Creative Commons

Beeke Peters,

Janna Vahlhaus,

Olga Pivovarova‐Ramich

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: March 22, 2024

Meal timing emerges as a crucial factor influencing metabolic health that can be explained by the tight interaction between endogenous circadian clock and homeostasis. Mistimed food intake, such delayed or nighttime consumption, leads to desynchronization of internal is associated with an increased risk for obesity disturbances type 2 diabetes cardiovascular diseases. Conversely, meal aligned cellular rhythms optimize performance tissues organs. In this review, we provide overview effects discuss underlying mechanisms. Additionally, explore factors timing, including determinants chronotype genetics, well external influences like social factors, cultural aspects, work schedules. This review could contribute defining meal-timing-based recommendations public initiatives developing guidelines effective lifestyle modifications targeting prevention treatment Furthermore, it sheds light on must considered in design future intervention trials.

Language: Английский

Citations

17

Green Tea Liquid Consumption Alters the Human Intestinal and Oral Microbiome DOI Creative Commons
Xiaojie Yuan,

Yong Long,

Zhaohua Ji

et al.

Molecular Nutrition & Food Research, Journal Year: 2018, Volume and Issue: 62(12)

Published: May 11, 2018

GTPs (green tea polyphenols) exert anti-CRC (colorectal cancer) activity. The intestinal microbiota and colonization by bacteria of oral origin has been implicated in colorectal carcinogenesis. GT modulates the composition mouse gut harmonious with anticancer Therefore, effect green liquid (GTL) consumption on microbiome is investigated healthy volunteers (n = 12).

Language: Английский

Citations

126

Intersection of the Gut Microbiome and Circadian Rhythms in Metabolism DOI
Katya Frazier, Eugene B. Chang

Trends in Endocrinology and Metabolism, Journal Year: 2019, Volume and Issue: 31(1), P. 25 - 36

Published: Nov. 3, 2019

Language: Английский

Citations

126

Circadian Rhythms in the Pathogenesis and Treatment of Fatty Liver Disease DOI

Anand Saran,

Shravan Dave, Amir Zarrinpar

et al.

Gastroenterology, Journal Year: 2020, Volume and Issue: 158(7), P. 1948 - 1966.e1

Published: Feb. 13, 2020

Language: Английский

Citations

122