Exploring the Mechanistic Interplay between Gut Microbiota and Precocious Puberty: A Narrative Review

Microorganisms, Journal Year: 2024, Volume and Issue: 12(2), P. 323 - 323

Published: Feb. 4, 2024

The gut microbiota has been implicated in the context of sexual maturation during puberty, with discernible differences its composition before and after this critical developmental stage. Notably, there a global rise prevalence precocious puberty recent years, particularly among girls, where approximately 90% central cases lack clearly identifiable cause. While link between observed, precise causality underlying mechanisms remain elusive. This narrative review aims to systematically elucidate potential that underlie intricate relationship puberty. Potential avenues exploration include investigating impact on endocrine function, regulation hormones, such as gonadotropin-releasing hormone (GnRH), luteinizing (LH), follicle-stimulating (FSH). Additionally, will delve into interplay microbiome, metabolism, obesity, considering known association obesity also explore how microbiome's involvement nutrient metabolism could Finally, attention is given microbiota's ability produce neurotransmitters neuroactive compounds, potentially influencing nervous system components involved regulating By exploring these mechanisms, seeks identify unexplored targets emerging directions understanding role microbiome relation ultimate goal provide valuable insights for development non-invasive diagnostic methods innovative therapeutic strategies future, specific probiotic therapy.

Language: Английский

---

Early puberty: a review on its role as a risk factor for metabolic and mental disorders

Frontiers in Pediatrics, Journal Year: 2024, Volume and Issue: 12

Published: Sept. 12, 2024

Accumulating evidence indicates that there is a trend of early puberty onset in humans. The timing has raised concerns due to its association with significant negative health outcomes. However, overall impact and potential risk remain uncertain. In this study, we conducted comprehensive review existing epidemiological studies gain insights into the long-term adverse effects associated puberty. Our objective was provide consolidated summary these outcomes at population level by considering encompass various indicators all, been identified as factor for metabolic diseases, such obesity, diabetes, cardiovascular diseases (CVD). Children who experience are more likely have higher body mass index (BMI) during adulthood, increasing their obesity. Early also found be an independent diabetes mellitus, including gestational mellitus (GDM) type 2 (T2DM), earlier menarche girls voice breaking boys prevalence T2DM. Furthermore, suggests may contribute elevated CVD, conditions like coronary heart disease (CHD), stroke, angina, hypertension. addition, adolescents puberty, particularly girls, suffer from mental problems, behavioral dysfunction depression. Notably, on than boys. Further research should consider underlying mechanisms preventive measures.

Language: Английский

---

The Role of Pediatric Nutrition as a Modifiable Risk Factor for Precocious Puberty

Life, Journal Year: 2021, Volume and Issue: 11(12), P. 1353 - 1353

Published: Dec. 7, 2021

Puberty is a critical phase of growth and development characterized by complex process regulated the neuroendocrine system. Precocious puberty (PP) defined as appearance physical hormonal signs pubertal at an earlier age than considered normal. The timing has important public health, clinical, social implications. In fact, it crucial in psychological can impact future health. Nutritional status one most factors modulating development. This narrative review presents overview on role nutritional determinants sexual maturation, focusing early-life childhood nutrition. As reported, breast milk seems to have protective against early onset, mainly due its positive influence infant rate overweight prevention. energy imbalance, macro/micronutrient food content, dietary patterns may modulate premature activation hypothalamic-pituitary-gonadal axis, inducing precocious puberty. An increase knowledge mechanism whereby nutrients will be useful providing adequate recommendations prevent PP related complications.

Language: Английский

---

Gut microbiota and its derived SCFAs regulate the HPGA to reverse obesity-induced precocious puberty in female rats

Frontiers in Endocrinology, Journal Year: 2022, Volume and Issue: 13

Published: Dec. 9, 2022

The intestinal microbiota and its derived short-chain fatty acids (SCFAs) can reverse obesity obesity-related metabolic diseases, but whether it has an effect on complicated by precocious puberty potential mechanism need to be further understood. purpose of this study was investigate the gut obesity-induced rats their regulatory mechanisms. We constructed using a high-fat diet (HFD) had notable similarity caused due overeating in children. then added acetate, propionate, butyrate or mixture HFD, investigated SCFAs hypothalamic-pituitary-gonadal axis (HPGA) with puberty. found that early first estrous cycle, increased hypothalamic mRNA expression Kiss1, GPR54 GnRH, gonadal maturation. Meanwhile, imbalance main production decreased colon. addition HFD could significantly rats, reduce GnRH release from hypothalamus delay development through Kiss1–GPR54–PKC–ERK1/2 pathway. Our findings suggest microbiota-derived are promising therapeutic means for prevention provide new strategies clinical value.

Language: Английский

---

The therapeutic role and potential mechanism of EGCG in obesity-related precocious puberty as determined by integrated metabolomics and network pharmacology

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: June 2, 2023

Objective (-)-Epigallocatechin-3-gallate (EGCG) has preventive effects on obesity-related precocious puberty, but its underlying mechanism remains unclear. The aim of this study was to integrate metabolomics and network pharmacology reveal the EGCG in prevention puberty. Materials methods A high-performance liquid chromatography-electrospray ionization ion-trap tandem mass spectrometry (LC-ESI-MS/MS) used analyze impact serum associated metabolic pathways a randomized controlled trial. Twelve weeks capsules were given obese girls trail. Additionally, targets preventing puberty predicted using pharmacology. Finally, elucidated through integrated Results Serum screened 234 endogenous differential metabolites, identified total 153 common targets. These metabolites mainly enrichment involving endocrine-related (estrogen signaling pathway, insulin resistance, secretion), signal transduction (PI3K-Akt, MAPK, Jak-STAT pathways). indicated that AKT1, EGFR, ESR1, STAT3, IGF1, MAPK1 may be key for Conclusion contribute such as multiple pathways, including estrogen, PI3K-Akt, pathways. This provided theoretical foundation future research.

Language: Английский

---

Research on Body Composition and Lifestyle Behaviors During Pubertal Development in 6–12-Year-Old Children with Obesity

Healthcare, Journal Year: 2025, Volume and Issue: 13(6), P. 607 - 607

Published: March 11, 2025

Objective: The objective of this study was to investigate the pubertal development in school-age children with obesity and explore body composition lifestyle behaviors influencing its onset. Method: We enrolled 217 children, aged 6–12 years, who visited Pediatrics Department at Beijing Jishuitan Hospital, Capital Medical University. All participants underwent a series examinations. These assessments included analysis, measurement blood glucose fasting insulin levels, evaluation secondary sexual characteristics. Statistical analysis conducted using R4.0.3 software. Results: Of 152 male participants, 83 (54.6%) were adolescent-undeveloped group, 69 (45.4%) adolescent-developed group. 119 female students, 30 (25.2%) 89 (74.8%) In comparative those adolescent group exhibited significantly higher values for age, height, weight, mass index (BMI), BMI-z score, fat, muscle mass, fat-free index, waist/hip ratio compared (p < 0.05). Additionally, resistance also statistical significance observed. BMI emerged as an independent factor affecting girls Among boys consumption sugary drinks fried food than undeveloped moderate-intensity exercise lower, girls, reported longer daily sitting times intakes foods these differences being statistically significant positively correlated identified Conclusions: A high (BMI) intake both genders are strong predictors early puberty children.

Language: Английский

---

Global secular trends in timing of puberty

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

---

Research summary, possible mechanisms and perspectives of gut microbiota changes causing precocious puberty

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: April 25, 2025

The increasing global incidence of precocious puberty, linked to environmental, metabolic, and genetic factors, necessitates innovative therapies beyond gonadotropin-releasing hormone (GnRH) analogs. Accumulating evidence implicates gut microbiota dysbiosis as a pivotal regulator pubertal timing via interactions with metabolism (e.g., estrogen reactivation β-glucuronidase), neuroendocrine pathways (nitric oxide signaling), immune-inflammatory responses. This review delineates taxonomic alterations in central puberty (CPP) obesity-related subtypes, including Streptococcus enrichment Alistipes depletion, alongside functional shifts microbial metabolite production. Mechanistic insights highlight microbiota-driven modulation the hypothalamic-pituitary-gonadal (HPG) axis, leptin/insulin dynamics, epigenetic regulation. Emerging interventions-probiotics, fecal transplantation (FMT), dietary modifications-demonstrate efficacy preclinical models early clinical studies for delaying onset restoring hormonal balance. Translational efforts validate these strategies are critical addressing psychosocial challenges posed by positioning novel therapeutic frontier pediatric endocrinology.

Language: Английский

---

The connection between epigenetics and gut microbiota‐current perspective

Cell Biochemistry and Function, Journal Year: 2024, Volume and Issue: 42(2)

Published: Jan. 30, 2024

Abstract Both the epigenetic changes and gut microbiota (GM) have attracted a growing interest in establishing effective diagnostics potential therapeutic strategies for number of diseases. These disorders include metabolic, central nervous system‐related diseases, autoimmune, gastrointestinal infections (GI). Despite studies, there is no extensive review that connects epigenetics modifications GM as biomarkers could confer treatment options. To this end, hopes to give detailed information on connecting GM. An updated connection between factors influence diseases are given. In addition, showed some associations maternal offspring health. Finally, limitations concept prospects into new emerging discipline were also looked into. Although elucidated diet response health with respect modifications, still exist various newly discipline. addition integrating complementary multi‐omics data, longitudinal sampling will aid identification functional mechanisms may serve targets. gave perspective harnessing disease diagnostics, prevention options through

Language: Английский

---

Integrated analysis of proteomics and metabolomics in girls with central precocious puberty

Frontiers in Endocrinology, Journal Year: 2022, Volume and Issue: 13

Published: July 28, 2022

Background Central precocious puberty (CPP) is a multifactorial and complex condition. Traditional studies focusing on single indicator cannot always elucidate this panoramic condition but these may be revealed by using omics techniques. Objective Proteomics metabolomics analysis of girls with CPP were compared to normal controls the potential biomarkers pathways involved explored. Methods Serum proteins metabolites from those LC-MS/MS. Multivariate univariate statistical used identify differentially expressed (DEPs) (DEMs). Functional annotation pathway enrichment performed GO KEGG databases, candidate markers screened. Finally, bioinformatic was integrate results proteomics find key differential proteins, CPP. Results 134 DEPs identified in 71 up- 63 down-regulated, respectively. Up-regulated enriched mainly extracellular matrix, cell adhesion cellular protein metabolic processes, platelet degranulation skeletal system development. The down-regulated immune response. Candidate including MMP9, TIMP1, SPP1, CDC42, POSTN, COL1A1, COL6A1, COL2A1 BMP1, found that related pubertal 103 DEMs identified, 42 up-regulated 61 which lipid taurine pathways. KGML network showed phosphocholine (16:1(9Z)/16:1(9Z)) arachidonic acid, glycerophospholipid, linoleic acid α-linolenic metabolism it as biomarker Conclusions Our study first analyze serum we some well for Lipid are provide direction further explore molecular mechanisms pathogenesis

Language: Английский

---