Exosomes in esophageal cancer: a promising frontier for liquid biopsy in diagnosis and therapeutic monitoring DOI Creative Commons

Ren Zihan,

Cao Jingsi,

Ding Lingwen

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 17, 2024

Esophageal cancer is a common and lethal digestive system malignancy, both treatment efficacy patient survival rates face significant challenges. In recent years, exosomes have emerged as crucial mediators of intercellular communication, demonstrating tremendous clinical potential, particularly in the diagnosis, treatment, prognostic evaluation esophageal cancer. These not only serve biomarkers for early diagnosis prognosis but also modulate tumor growth, metastasis, drug resistance by delivering bioactive molecules. Importantly, can act carriers cancer-related therapeutic agents, optimizing gene therapy strategies to enhance while reducing toxicity side effects. Despite facing challenges applications such purification, enrichment, standardization analytical methods, maintain broad prospects application with potential significantly improve outcomes quality life. This review focuses on innovative role cancer, exploring their value safety disease monitoring assessment response. Furthermore, this study outlines limitations transitioning exosome research from basic studies applications, well solutions future directions address these obstacles.

Language: Английский

Extracellular Vesicle Preparation and Analysis: A State‐of‐the‐Art Review DOI Creative Commons
Zesheng Wang, Xiaoyu Zhou, Qinglong Kong

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(30)

Published: June 14, 2024

Abstract In recent decades, research on Extracellular Vesicles (EVs) has gained prominence in the life sciences due to their critical roles both health and disease states, offering promising applications diagnosis, drug delivery, therapy. However, inherent heterogeneity complex origins pose significant challenges preparation, analysis, subsequent clinical application. This review is structured provide an overview of biogenesis, composition, various sources EVs, thereby laying groundwork for a detailed discussion contemporary techniques preparation analysis. Particular focus given state‐of‐the‐art technologies that employ microfluidic non‐microfluidic platforms EV processing. Furthermore, this discourse extends into innovative approaches incorporate artificial intelligence cutting‐edge electrochemical sensors, with particular emphasis single proposes current outlines prospective avenues future research. The objective motivate researchers innovate expand methods analysis fully unlocking biomedical potential.

Language: Английский

Citations

39
Dual-Aptamer Recognition of DNA Logic Gate Sensor-Based Specific Exosomal Proteins for Ovarian Cancer Diagnosis DOI

Mingzhu Zhao,

Qin Li, Yan Zhao

et al.

ACS Sensors, Journal Year: 2024, Volume and Issue: 9(5), P. 2540 - 2549

Published: April 18, 2024

Clinical diagnosis of ovarian cancer lacks high accuracy due to the weak selection specific biomarkers along with circumstance localization. Clustering analysis proteins transported on exosomes enables a more precise screening effective biomarkers. Herein, through bioinformatics and exosome proteomes, two coexpressed proteins, EpCAM CD24, specifically enriched, were identified, together development an as-derived dual-aptamer targeted exosome-based strategy for screening. In brief, DNA ternary polymer aptamers targeting CD24 was designed present logic gate reaction upon recognizing exosomes, triggering rolling circle amplification chemiluminescent signal. A dynamic detection range 6 orders magnitude achieved by quantifying exosomes. Moreover, clinical samples, this could accurately differentiate from healthy persons, other patients, enabling promising

Language: Английский

Citations

13
Innovative landscapes in intraperitoneal therapy of ovarian cancer DOI
K. Kumar,

M. S. Madhusoodanan,

Meghna Pangath

et al.

Drug Delivery and Translational Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Language: Английский

Citations

1
Advances in small extracellular vesicles: roles in the tumor microenvironment and epithelial ovarian cancer diagnosis and treatment DOI Creative Commons
Liang Peng,

Yi Lai,

Baodi Cao

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 11, 2025

Epithelial ovarian cancer (EOC), one of the most prevalent subtypes cancer, has a 5-year survival rate less than 30%, highlighting urgent need for novel diagnostic and therapeutic strategies. The tumor microenvironment (TME), critical regulator progression, includes various components, among which small extracellular vesicles (sEVs) serve as important molecular carriers, having gained attention significant contributors to biology. These vesicles, released by cells into space, are pivotal in pathogenesis EOC. In addition, sEVs show promise biomarkers agents treatment management this malignancy. This review explores recent advancements understanding within TME their potential applications diagnosis

Language: Английский

Citations

0
Biomarkers in high grade serous ovarian cancer DOI
Mark C. Bates, Bashir M. Mohamed, F. Park Lewis

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2024, Volume and Issue: unknown, P. 189224 - 189224

Published: Nov. 1, 2024

Language: Английский

Citations

3
Circular RNAs in gynecologic cancers: mechanisms and implications for chemotherapy resistance DOI Creative Commons
Meiying Qin, Chunmei Zhang, Li Yang

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: June 8, 2023

Chemotherapy resistance remains a major challenge in the treatment of gynecologic malignancies. Increasing evidence suggests that circular RNAs (circRNAs) play significant role conferring chemoresistance these cancers. In this review, we summarize current understanding mechanisms by which circRNAs regulate chemotherapy sensitivity and We also discuss potential clinical implications findings highlight areas for future research. CircRNAs are novel class RNA molecules characterized their unique structure, confers increased stability to degradation exonucleases. Recent studies have shown can act as miRNA sponges, sequestering miRNAs preventing them from binding target mRNAs. This lead upregulation genes involved drug pathways, ultimately resulting decreased chemotherapy. several specific examples been implicated cancers, including cervical cancer, ovarian endometrial cancer. applications circRNA-based biomarkers predicting response guiding decisions. Overall, review provides comprehensive overview state knowledge regarding By elucidating underlying sensitivity, work has important improving patient outcomes developing more effective therapeutic strategies challenging

Language: Английский

Citations

8
Role of Syndecans in Ovarian Cancer: New Diagnostic and Prognostic Biomarkers and Potential Therapeutic Targets DOI Open Access
Júlia Oto, Quang-Khoi Le, Sebastian Daniel Schäfer

et al.

Cancers, Journal Year: 2023, Volume and Issue: 15(12), P. 3125 - 3125

Published: June 9, 2023

Ovarian cancer (OC) is the eighth both in prevalence and mortality women represents deadliest female reproductive cancer. Due to generally vague symptoms, OC frequently diagnosed only at a late advanced stage, resulting high mortality. The tumor extracellular matrix cellular receptors play key role pathogenesis of progression. Syndecans are family four transmembrane heparan sulfate proteoglycans (PG), including syndecan-1, -2, -3, -4, which dysregulated myriad cancers, OC. Many clinicopathological studies suggest that these proteins promising diagnostic prognostic biomarkers for Furthermore, functions syndecan regulation processes make it an interesting pharmacological target anticancer therapies.

Language: Английский

Citations

6
Key developments and hotspots of exosomes in Alzheimer’s disease: a bibliometric study spanning 2003 to 2023 DOI Creative Commons
Siyu Liu, Daoying Geng

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: May 1, 2024

Background Alzheimer’s disease (AD) is a degenerative illness of the central nervous system that irreversible and characterized by gradual behavioral impairment cognitive dysfunction. Researches on exosomes in AD have gradually gained attention scholars recent years. However, literatures this research area do not yet comprehensive visualization analysis. The aim work to use bibliometrics identify knowledge constructs investigate frontiers hotspots related AD. Methods From January 2003 until June 2023, we searched Web Science Core Collection for literature We found 585 papers total. bibliometric study was completed using VOSviewer, R package “bibliometrix,” CiteSpace. analysis covered nations, institutions, authors, journals, keywords. Results Following 2019, articles increased significantly year year. vast majority publications came from China US. University California System, National Institutes Health, NIH Institute Aging US were primary institutions. Goetzl Edward J. frequently co-cited, while Kapogiannis Dimitrios most prolific author discipline with greatest number articles. Lee Mijung et al. been prominent last two years Journal Disease widely read publication, Alzheimers & Dementia had highest impact factor. Biological Chemistry, Proceedings Academy Sciences United States America, three journals more than 1,000 citations. emphasis field disease, exosomes, extracellular vesicles; since 2017, phrases pertaining role pathogenesis has annually. “Identification preclinical profile pathogenic proteins neurally derived blood exosomes: case–control study” reference citing power, indicating future steered direction field. Conclusion Using bibliometrics, compiled progress tendencies first time. This helps determine objectives paths study.

Language: Английский

Citations

2
Advances in lysosomal escape mechanisms for gynecological cancer nano-therapeutics DOI Creative Commons
Wei Heng,

Yingying Hao,

Jin Zhang

et al.

Journal of Pharmaceutical Analysis, Journal Year: 2024, Volume and Issue: 14(12), P. 101119 - 101119

Published: Oct. 16, 2024

Gynecological cancers present significant treatment challenges due to drug resistance and adverse side effects. This review explores advancements in lysosomal escape mechanisms, essential for enhancing nano-therapeutic efficacy. Strategies such as pH-sensitive linkers membrane fusion are examined, showcasing their potential improve therapeutic outcomes ovarian, cervical, uterine cancers. We delve into novel materials strategies developed bypass the barrier, including linkers, fusogenic lipids, nanoparticles (NPs) engineered endosomal disruption. Mechanisms proton sponge effect, where NPs induce osmotic swelling rupture of membrane, fusion, which facilitates release agents directly cytoplasm, explored detail. These innovations not only promise but also minimize effects, marking a step forward By providing comprehensive analysis current implications clinical applications, this sheds light on revolutionize gynecological cancer treatment, setting stage future research development vital area.

Language: Английский

Citations

2
Exosomes in esophageal cancer: a promising frontier for liquid biopsy in diagnosis and therapeutic monitoring DOI Creative Commons

Ren Zihan,

Cao Jingsi,

Ding Lingwen

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 17, 2024

Esophageal cancer is a common and lethal digestive system malignancy, both treatment efficacy patient survival rates face significant challenges. In recent years, exosomes have emerged as crucial mediators of intercellular communication, demonstrating tremendous clinical potential, particularly in the diagnosis, treatment, prognostic evaluation esophageal cancer. These not only serve biomarkers for early diagnosis prognosis but also modulate tumor growth, metastasis, drug resistance by delivering bioactive molecules. Importantly, can act carriers cancer-related therapeutic agents, optimizing gene therapy strategies to enhance while reducing toxicity side effects. Despite facing challenges applications such purification, enrichment, standardization analytical methods, maintain broad prospects application with potential significantly improve outcomes quality life. This review focuses on innovative role cancer, exploring their value safety disease monitoring assessment response. Furthermore, this study outlines limitations transitioning exosome research from basic studies applications, well solutions future directions address these obstacles.

Language: Английский

Citations

1