Critical Reviews in Food Science and Nutrition,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 28
Published: March 7, 2025
(Poly)phenols
in
plant-based
foods
contribute
to
the
prevention
of
non-communicable
diseases,
yet
defining
their
optimal
intake
remains
challenging.
Biomarkers
provide
a
more
objective
alternative
self-reported
dietary
assessments,
but
validation
is
essential.
This
review
systematically
summarizes
and
critically
evaluates
validated
(poly)phenol
biomarkers
inform
future
research.
A
systematic
search
three
databases
identified
studies
published
from
1995
January
2025
that
quantified
biofluids
using
analytical
methods
provided
evidence
specificity
dose-response.
Biomarker
validity
was
assessed
based
on
plausibility/specificity,
dose-response,
time-response,
robustness,
reliability,
stability,
performance,
reproducibility.
Five
multi-metabolite
panels
were
across
eight
studies:
genistein
+
daidzein
or
sum
isoflavone
aglycones
metabolites
(isoflavone
intake),
hydroxytyrosol
its
phase
II
(hydroxytyrosol
structurally
related
(-)-epicatechin
(SREM)
((-)-epicatechin
5-(3',4'-dihydroxyphenyl)-γ-valerolactone
(PgVLM)
(flavan-3-ol
intake).
The
most
extensively
biomarkers,
SREM
PgVLM
24-h
urine,
met
five
criteria.
However,
challenges
remain,
including
limited
specificity,
short
half-lives,
inter-individual
variability,
lack
authentic
chemical
standards.
Further
research
needed
enhance
biomarker
for
precise
assessment
epidemiological
studies.
Food Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown, P. 144266 - 144266
Published: April 1, 2025
The
present
study
aimed
to
evaluate
the
effect
of
inclusion
in
lamb
diet
hazelnut
skin
(H
diet),
extruded
linseed
(L
or
a
combination
thereof
(HL
diet)
on
oxidative
stability
cooked
and
vitro
digested
meat
compared
basal
(C
diet).
A
significant
decrease
46.1
%
40.9
lipid
hydroperoxides
was
attended
after
digestion
from
L
H
diets
with
respect
C
diet.
Moreover,
HL
most
effective
decreasing
TBA-RS
value
intestinal
(23.3
Five
different
phenolic-
four
tocopherol-derived
metabolites
were
identified
whose
amount
greater
supplemented
diets.
Furthermore,
resulted
higher
endogenous
antioxidants
(carnosine
reduced
glutathione)
raw
meat.
Food & Function,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
There
is
an
increasing
body
of
evidence
indicating
that
phenolic
compounds
derived
from
microbiota-mediated
breakdown
dietary
(poly)phenolics
in
the
colon
are
at
least
partially
responsible
for
beneficial
effects
a
plant-based
diet.
Food & Function,
Journal Year:
2024,
Volume and Issue:
15(15), P. 7812 - 7827
Published: Jan. 1, 2024
Circulating
metabolites
resulting
from
colonic
metabolism
of
dietary
(poly)phenols
are
highly
abundant
in
the
bloodstream,
though
still
marginally
explored,
particularly
concerning
their
brain
accessibility.
Our
goal
is
to
disclose
(poly)phenol
metabolites'
blood-brain
barrier
(BBB)
transport,
vivo
and
vitro,
as
well
role
at
BBB
level.
For
three
selected
metabolites,
benzene-1,2-diol-3-sulfate/benzene-1,3-diol-2-sulfate
(pyrogallol-sulfate
-
Pyr-sulf),
benzene-1,3-diol-6-sulfate
(phloroglucinol-sulfate
Phlo-sulf),
phenol-3-sulfate
(resorcinol-sulfate
Res-sulf),
transport
was
assessed
human
microvascular
endothelial
cells
(HBMEC).
Their
potential
modulating
vitro
properties
circulating
concentrations
also
studied.
Metabolites'
fate
towards
brain,
liver,
kidney,
urine,
blood
disclosed
Wistar
rats
upon
injection.
Transport
kinetics
HBMEC
highlighted
different
permeability
rates,
where
Pyr-sulf
emerged
most
permeable
metabolite.
potent
regarding
improvement,
namely
increased
beta(β)-catenin
membrane
expression
reduction
zonula
occludens-1
gaps.
Whereas
no
differences
were
observed
for
transferrin,
caveolin-1
Res-sulf
treatments
found.
capable
gene
protein
some
solute
carrier
transporters.
Notably,
each
injected
exhibited
a
unique
tissue
distribution
vivo,
with
remarkable
ability
almost
immediately
reach
brain.
Frontiers in Nutrition,
Journal Year:
2023,
Volume and Issue:
9
Published: Jan. 9, 2023
This
investigation
determined
if
4-weeks
ingestion
of
nutrient-dense
almonds
mitigated
post-exercise
inflammation
and
muscle
soreness
damage.An
acute
90-min
eccentric
exercise
(90-EE)
was
used
to
induce
damage
in
64
non-obese
adults
not
engaging
regular
resistance
training
(ages
30-65
years,
BMI
<
30
kg/m2).
Using
a
parallel
group
design,
participants
were
randomized
almond
(AL)
(57
g/d)
or
cereal
bar
(CB)
(calorie
matched)
treatment
groups
for
4-week
period
prior
the
90-EE
(17
exercises).
Blood
24-h
urine
samples
collected
before
after
supplementation,
with
additional
blood
immediately
post-90-EE,
then
daily
during
4
days
recovery.
Changes
plasma
oxylipins,
urinary
gut-derived
phenolics,
cytokines,
biomarkers,
mood
states,
performance
assessed.The
protocol
induced
significant
damage,
delayed
onset
(DOMS),
inflammation,
reduced
strength
power
performance,
disturbance.
Interaction
effects
(2
×
7
time
points)
supported
that
AL
vs.
CB
associated
fatigue
tension
(p
=
0.051,
0.033,
respectively)
higher
levels
leg-back
0.029).
No
differences
found
post-90-EE
increases
DOMS
six
cytokines.
lower
serum
creatine
kinase
immediately-
1-day
0.034
0.013,
respectively).
The
bout
increased
13
oxylipins.
revealed
significantly
12,13-DiHOME
0.001)
9,10-DiHOME
0.001).
Urine
seven
phenolics
including
5-(3',4'-dihydroxyphenyl)-γ-valerolactone
inversely
related
changes
(r
-0.029,
p
0.021).These
data
support
some
positive
intake
improving
state,
retaining
strength,
decreasing
increasing
generation
phenolic
metabolites,
altering
oxylipin
DiHOME
response
unaccustomed
untrained
adults.
elevated
metabolic
outcomes
bouts.
International Journal of Food Sciences and Nutrition,
Journal Year:
2023,
Volume and Issue:
74(4), P. 532 - 543
Published: May 19, 2023
Phenolic
catabolites
excreted
by
fasting
subjects
with
a
functioning
colon
and
ileostomists
on
low
(poly)phenol
diet
have
been
investigated.
Urine
was
collected
over
12
h
period
after
adherence
to
for
36
h.
UHPLC-HR-MS
quantified
77
phenolics.
Some
were
present
in
the
urine
of
both
groups
similar
trace
amounts
others
higher
participants
indicating
involvement
microbiota.
Most
sub-
or
low-µmol
amounts,
but
hippuric
acid
dominated
accounting
average
60%
total
volunteer
categories
significant
production
from
sources
other
than
non-nutrient
dietary
(poly)phenols.
The
potential
origins
phenolics
associated
diet,
include
endogenous
catecholamines,
surplus
tyrosine
phenylalanine,
washout
derived
pre-study
intakes
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(13), P. 3045 - 3045
Published: July 5, 2023
A
mechanistic
understanding
of
the
effects
dietary
treatment
in
irritable
bowel
syndrome
(IBS)
is
lacking.
Our
aim
was
therefore
to
investigate
how
fermentable
oligo-
di-,
monosaccharides,
and
polyols
(FODMAPs)
gluten
affected
gut
microbiota
circulating
metabolite
profiles,
as
well
potential
links
between
microbiota,
metabolites,
IBS
symptoms.
We
used
data
from
a
double-blind,
randomized,
crossover
study
with
week-long
provocations
FODMAPs,
gluten,
placebo
participants
IBS.
To
on
fecal
plasma
short-chain
fatty
acids,
untargeted
metabolome,
symptoms,
we
Random
Forest,
linear
mixed
model
Spearman
correlation
analysis.
FODMAPs
increased
saccharolytic
bacteria,
phenolic-derived
3-indolepropionate,
decreased
isobutyrate
bile
acids.
Gluten
isovalerate
altered
carnitine
derivatives,
CoA,
acids
plasma.
For
modest
correlations
were
observed
metabolites
previously
associated
improved
metabolic
health,
reduced
inflammation.
Correlations
molecular
symptoms
weak.
but
not
composition
correlated
only
weak
associations
Thus,
minor
effect
must
be
weighed
against
related
positive
health
factors.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(15), P. 12265 - 12265
Published: July 31, 2023
Several
studies
have
suggested
that
a
phenolic-rich
diet
may
be
protective
against
colon
cancer.
Most
phenolic
compounds
are
not
absorbed
in
the
small
intestine
and
reach
where
they
metabolized
by
gut
microbiota
simple
acids.
In
this
study,
anti-proliferative
activity
of
quercetins,
chlorogenic
acids,
their
metabolites
mixtures
parent
compounds/metabolites
was
assessed
using
two
cancer
cell
lines
(Caco-2
SW480)
at
physiologically
relevant
concentrations.
Chlorogenic
quercetin
metabolite
3-(3′,4′-dihydroxyphenyl)acetic
acid
exerted
remarkable
Caco-2,
whereas
derivatives
were
most
active
SW480.
Tested
arrested
cycle
S
phase
both
lines.
The
compounds/metabolites,
which
mimic
human
metabotypes
slowly
or
rapidly
metabolize
compounds,
similarly
inhibited
growth.
SW480
cells
more
extensively
than
stable.
These
results
suggest
dietary
exert
an
effect
can
further
sustained
metabolites.
Therefore,
metabolism
paramount
importance
explaining
foods
