The applied implications of epigenetics in anxiety, affective and stress-related disorders - A review and synthesis on psychosocial stress, psychotherapy and prevention DOI Creative Commons
Miriam A. Schiele, Michael G. Gottschalk, Katharina Domschke

et al.

Clinical Psychology Review, Journal Year: 2020, Volume and Issue: 77, P. 101830 - 101830

Published: Feb. 4, 2020

Mental disorders are highly complex and multifactorial in origin, comprising an elaborate interplay of genetic environmental factors. Epigenetic mechanisms such as DNA modifications (e.g. CpG methylation), histone acetylation) microRNAs function a translator between genes the environment. Indeed, influences exposure to stress shape epigenetic patterns, lifetime experiences continue alter genome throughout lifespan. Here, we summarize recently burgeoning body research regarding involvement aberrant signatures mediating increased vulnerability wide range mental disorders. We review current knowledge changes constitute useful markers predicting clinical response psychotherapeutic interventions, psychotherapy - potentially reverse risk patterns. Given first evidence pointing transgenerational transmission information, alterations arising from successful might be transferred future generations thus contribute prevention Findings integrated into multi-level framework highlighting challenges pertaining action implications research. Promising directions prediction, prevention, personalized treatment line with 'precision medicine' approach discussed.

Language: Английский

Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for mood disorders DOI
Gin S. Malhi,

Darryl Bassett,

Philip Boyce

et al.

Australian & New Zealand Journal of Psychiatry, Journal Year: 2015, Volume and Issue: 49(12), P. 1087 - 1206

Published: Dec. 1, 2015

Objectives: To provide guidance for the management of mood disorders, based on scientific evidence supplemented by expert clinical consensus and formulate recommendations to maximise salience utility. Methods: Articles information sourced from search engines including PubMed EMBASE, MEDLINE, PsycINFO Google Scholar were literature known disorders committee (MDC) (e.g., books, book chapters government reports) published depression bipolar disorder guidelines. Information was reviewed discussed members MDC findings then formulated into consensus-based guidance. The guidelines subjected rigorous successive consultation external review involving: advisors, public, key stakeholders, professional bodies specialist groups with interest in disorders. Results: Royal Australian New Zealand College Psychiatrists practice (Mood Disorders CPG) up-to-date advice regarding that is informed experience. Mood CPG intended use psychiatrists, psychologists, physicians others an mental health care. Conclusions: Disorder first Clinical Practice Guideline address both depressive It provides within evidence-based framework, consensus. Committee: Professor Gin Malhi (Chair), Darryl Bassett, Philip Boyce, Richard Bryant, Paul Fitzgerald, Dr Kristina Fritz, Malcolm Hopwood, Bill Lyndon, Roger Mulder, Greg Murray, Porter Associate Ajeet Singh. International advisors: Carlo Altamura, Francesco Colom, Mark George, Guy Goodwin, McIntyre, Ng, John O’Brien, Harold Sackeim, Jan Scott, Nobuhiro Sugiyama, Eduard Vieta, Lakshmi Yatham. Marie-Paule Austin, Michael Berk, Yulisha Byrow, Helen Christensen, Nick De Felice, A/Professor Seetal Dodd, Megan Galbally, Josh Geffen, Hazell, David Horgan, Felice Jacka, Gordon Johnson, Anthony Jorm, Jon-Paul Khoo, Jayashri Kulkarni, Cameron Lacey, Noeline Latt, Florence Levy, Andrew Lewis, Colleen Loo, Thomas Mayze, Linton Meagher, Mitchell, Daniel O’Connor, Tim Outhred, Rowe, Narelle Shadbolt, Martien Snellen, Tiller, Watkins, Raymond Wu.

Language: Английский

Citations

730

Intervention studies to foster resilience – A systematic review and proposal for a resilience framework in future intervention studies DOI Creative Commons
Andrea Chmitorz, Angela Kunzler,

Isabella Helmreich

et al.

Clinical Psychology Review, Journal Year: 2017, Volume and Issue: 59, P. 78 - 100

Published: Nov. 10, 2017

Psychological resilience refers to the phenomenon that many people are able adapt challenges of life and maintain mental health despite exposure adversity. This has stimulated research on training programs foster psychological resilience. We evaluated concepts, methods designs 43 randomized controlled trials published between 1979 2014 which assessed efficacy such propose standards for future intervention based recent developments in field. found current studies limited use properly assess interventions Major problems definitions as trait or a composite factors, unsuited assessment instruments, inappropriate study designs. To overcome these challenges, we 1) an outcome-oriented definition resilience, 2) change relation stressor load, 3) methodological suitable studies. Our proposals may contribute improved quality stimulate further progress this growing

Language: Английский

Citations

513

Low back pain DOI
Johan W.S. Vlaeyen, Christopher G. Maher, Katja Wiech

et al.

Nature Reviews Disease Primers, Journal Year: 2018, Volume and Issue: 4(1)

Published: Dec. 13, 2018

Language: Английский

Citations

358

Towards a Transversal Definition of Psychological Resilience: A Literature Review DOI Creative Commons
Antonella Sisto, Flavia Vicinanza, Laura Leondina Campanozzi

et al.

Medicina, Journal Year: 2019, Volume and Issue: 55(11), P. 745 - 745

Published: Nov. 16, 2019

Background and objectives: This paper addresses psychological resilience, a multidisciplinary theoretical construct with important practical implications for health sciences. Although many definitions have been proposed in several contexts, an essential understanding of the concept is still lacking up to now. negatively affects comparisons among research results makes objective measurement difficult. The aim this review identify shared elements defining resilience across literature examined order move toward conceptual unification term. Materials methods: A was performed using electronic databases ‘PubMed’ ‘PsycINFO’. Scientific studies written English between 2002 May 2019 were included according following key terms: ‘Psychological’, ‘resilience’, ‘definition’. Results: identifies five macro-categories that summarize what has reported recent concerning phenomenon. They serve as preliminary necessary step clarification construct. Conclusions: We propose definition ability maintain persistence one’s orientation towards existential purposes. It constitutes transversal attitude can be understood overcome difficulties experienced different areas life perseverance, well good awareness oneself own internal coherence by activating personal growth project. will contribute improving accuracy on topic suggesting future paths investigation aimed at deeply exploring issues surrounding promotion resources.

Language: Английский

Citations

321

Psychological interventions to foster resilience in healthcare professionals DOI
Angela Kunzler,

Isabella Helmreich,

Andrea Chmitorz

et al.

Cochrane library, Journal Year: 2020, Volume and Issue: 2020(7)

Published: July 5, 2020

Language: Английский

Citations

288

Etiology in psychiatry: embracing the reality of poly‐gene‐environmental causation of mental illness DOI Open Access
Rudolf Uher, Alyson Zwicker

World Psychiatry, Journal Year: 2017, Volume and Issue: 16(2), P. 121 - 129

Published: May 12, 2017

Intriguing findings on genetic and environmental causation suggest a need to reframe the etiology of mental disorders. Molecular genetics shows that thousands common rare variants contribute illness. Epidemiological studies have identified dozens exposures are associated with psychopathology. The effect environment is likely conditional factors, resulting in gene‐environment interactions. impact factors also depends previous exposures, environment‐environment Most known shared across multiple Schizophrenia, bipolar disorder major depressive disorder, particular, closely causally linked. Synthesis from twin studies, molecular epidemiological research suggests joint consideration has much greater explanatory power than separate or causation. Multi‐factorial interactions be generic mechanism involved majority cases illness, which only partially tapped by existing studies. Future may cut psychiatric disorders address poly‐causation considering measures life course specific focus first two decades life. Integrative analyses including can realize potential for discovering causal types mechanisms generate new preventive therapeutic tools.

Language: Английский

Citations

283

Resilience as a multimodal dynamic process DOI
Alexandra Stainton, Katharine Chisholm, Nathalie Kaiser

et al.

Early Intervention in Psychiatry, Journal Year: 2018, Volume and Issue: 13(4), P. 725 - 732

Published: Aug. 20, 2018

Aim Resilience is rapidly gaining momentum in mental health literature. It provides a new understanding of the highly variable trajectories illness, and has consistently been linked with improved outcomes. The present review aims to clarify definition resilience discuss directions for field. Methods After discussing resilience, this narrative synthesizes evidence that identifies specific protective factors involved process. This also addresses mechanisms underlie resilience. Results Recent literature clarified three core components which are presence an adversity or risk illness; influence supersede risk; finally, subsequently more positive outcome than expected. Now these largely agreed upon, field should move on addressing other topics. dynamic process by individuals utilize resources their benefit. can vary within one individual across time circumstance. refer good functional outcomes context diagnosable illness. While previous research focused psychological it essential conceptualized modalities. Conclusions towards development multimodal model Researchers now focus producing empirical clarifies process, aligning concepts growing, homogeneous base, then inform intervention strategies.

Language: Английский

Citations

224

A systematic review of attachment and psychosis: measurement, construct validity and outcomes DOI
Andrew Gumley, Heather Taylor, Matthias Schwannauer

et al.

Acta Psychiatrica Scandinavica, Journal Year: 2013, Volume and Issue: 129(4), P. 257 - 274

Published: July 3, 2013

This review sought to identify, summarise and critically evaluate studies that investigated attachment amongst individuals with psychosis.The following computerised databases searched were CINAHL<1980 December 2012; EMBASE<1980 Ovid MEDLINE (R)<1980 PsychINFO<1980 Google Scholar<1980 2012.We identified 22 papers describing 21 comprising 1453 participants, a mean age of 35.0 years (range 12-71 years), whom 68.4% (n=994) male. Of our sample, 1112 (76.5%) had diagnosis schizophrenia. We found small moderate associations between greater insecurity (as reflected in anxiety avoidance) poorer engagement services, more interpersonal problems, avoidant coping strategies, negative appraisals parenting experiences severe trauma. also modest positive symptoms affective symptom problems.Attachment theory may be useful as means understanding the developmental basis recovery adaptation context psychosis. However, further research representative samples their first episode using prospective designs is required.

Language: Английский

Citations

218

Defeat stress in rodents: From behavior to molecules DOI

Caroline Hammels,

Ehsan Pishva,

Jochen De Vry

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2015, Volume and Issue: 59, P. 111 - 140

Published: Oct. 25, 2015

Language: Английский

Citations

212

Population-based validation of a German version of the Brief Resilience Scale DOI Creative Commons
Andrea Chmitorz, Mario Wenzel, Rolf‐Dieter Stieglitz

et al.

PLoS ONE, Journal Year: 2018, Volume and Issue: 13(2), P. e0192761 - e0192761

Published: Feb. 13, 2018

Smith and colleagues developed the Brief Resilience Scale (BRS) to assess individual ability recover from stress despite significant adversity. This study aimed validate German version of BRS. We used data a population-based (sample 1: n = 1.481) representative 2: 1.128) sample participants general population (age ≥ 18) reliability validity. Confirmatory factor analyses (CFA) were conducted compare one- two-factorial models previous studies with method-factor model which especially accounts for wording items. Reliability was analyzed. Convergent validity measured by correlating BRS scores mental health measures, coping, social support, optimism. good (α .85, ω .85 both samples). The showed excellent fit χ2/df 7.544; RMSEA .07; CFI .99; SRMR .02; 1.166; .01; 1.00; .01) significantly better than one-factor (Δχ2(4) 172.71, p < .001) or two-factor (Δχ2(3) 31.16, .001). positively correlated well-being, optimism, coping strategies active positive reframing, acceptance, humor. It negatively somatic symptoms, anxiety insomnia, dysfunction, depression, religion, denial, venting, substance use, self-blame. To conclude, our results provide evidence adaptation as well unidimensional structure scale once method effects are accounted for.

Language: Английский

Citations

184