Food Frontiers,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 22, 2025
ABSTRACT
The
One
Health
approach
emphasizes
the
interconnectedness
of
human,
animal,
and
environmental
health,
recognizing
that
health
each
is
interdependent
influenced
by
shared
ecosystems.
Nutrition
research
plays
a
critical
role
in
improving
outcomes
across
these
domains,
with
implications
for
sustainability
food
security.
Organ‐on‐chip
(OoC)
technologies
have
emerged
as
innovative
tools
replicating
key
organ
functions,
supporting
disease
modeling,
drug
discovery,
personalized
medicine.
They
also
hold
promise
alternatives
to
traditional
animal
models.
This
systematic
review
examines
potential
OoC
within
framework
nutrition
research,
focusing
on
(1)
their
ability
replicate
human
(2)
applications
safety
ecotoxicology,
(3)
use
studying
components’
effects.
Challenges
future
directions
adoption
are
discussed.
Although
fully
complexity
vivo
physiology
remains
challenge,
OoCs
offer
promising
platform
simulate
functions
interactions.
These
systems
significant
advancing
assessments,
impacts
addressing
systems.
such
standardization,
scalability,
accessibility,
biases
toward
models
remain.
Despite
hurdles,
current
advancements
underscore
versatility
OoCs,
positioning
them
valuable
driving
innovation
feed
safety,
ecotoxicology.
With
continued
progress,
poised
make
contributions
goals
framework.
Allergy,
Journal Year:
2024,
Volume and Issue:
79(11), P. 2912 - 2923
Published: July 16, 2024
Exposure
to
toxic
substances,
introduced
into
our
daily
lives
during
industrialization
and
modernization,
can
disrupt
the
epithelial
barriers
in
skin,
respiratory,
gastrointestinal
systems,
leading
microbial
dysbiosis
inflammation.
Athletes
physically
active
individuals
are
at
increased
risk
of
exposure
agents
that
damage
microbiome,
their
extreme
physical
exercise
exerts
stress
on
many
organs,
resulting
tissue
Epithelial
barrier-damaging
substances
include
surfactants
enzymes
cleaning
products,
laundry
dishwasher
detergents,
chlorine
swimming
pools,
microplastics,
air
pollutants
such
as
ozone,
particulate
matter,
diesel
exhaust.
Athletes'
high-calorie
diet
often
relies
processed
foods
may
contain
food
emulsifiers
other
additives
cause
barrier
dysfunction
dysbiosis.
The
type
material
used
sport
equipment
clothing
extensive
increase
inflammatory
effects.
Excessive
travel-related
stress,
sleep
disturbances
different
microbe
represent
additional
factors.
Here,
we
review
detrimental
impact
microbiome;
bring
a
new
perspective
factors
affecting
health
performance
athletes
individuals.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(20), P. 3494 - 3494
Published: Oct. 15, 2024
Our
objective
was
to
review
published
studies
of
the
intestinal
barrier
and
permeability,
deleterious
effects
dietary
components
(particularly
fat),
impact
altered
permeability
in
disease
models
human
diseases,
role
microbiome
epigenomics
control
function,
opportunities
restore
normal
function
with
interventions
products
microbiota.
Medicina,
Journal Year:
2025,
Volume and Issue:
61(2), P. 192 - 192
Published: Jan. 22, 2025
The
purpose
of
this
article
is
to
present
selected
food
additives
as
disruptors
normal
intestinal
homeostasis
with
a
potential
impact
on
the
development
metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD).
A
comprehensive
literature
search
was
conducted
in
three
major
electronic
databases:
PubMed,
ScienceDirect,
and
Google
Scholar.
MASLD
prevalent
condition
that
closely
related
global
rise
obesity.
Its
pathogenesis
multifactorial,
genetic,
environmental,
factors
playing
key
role.
“multiple-hit”
hypothesis
suggests
Western-style
diet,
rich
ultra-processed
foods,
saturated
fats,
additives,
combined
low
physical
activity,
contributes
obesity,
which
promotes
lipid
accumulation
liver.
Recent
studies
underscore
role
impaired
MASLD.
Food
including
preservatives,
emulsifiers,
sweeteners,
affect
gut
health
function.
Selected
preservatives
inhibit
pathogenic
microorganisms
but
disrupt
microbiota,
leading
changes
permeability
dysfunction.
Some
emulsifiers
thickeners
can
cause
inflammation
alter
microbiome,
contributing
steatosis.
Furthermore,
use
sweeteners
such
sucralose
aspartame
has
been
linked
metabolism
microbial
composition,
turn
disorders.
Journal of Food Science,
Journal Year:
2025,
Volume and Issue:
90(2)
Published: Feb. 1, 2025
Abstract
Modern
diets
are
increasingly
dominated
by
ultra‐processed
foods,
a
shift
driven
urbanization
and
lifestyle
changes.
Among
these,
meat
products
(UPMPs)
particularly
popular
due
to
their
appealing
flavor
texture.
However,
emerging
evidence
highlights
potential
health
risks
associated
with
UPMPs.
Although
rich
in
high‐quality
proteins,
the
processing
methods
used
UPMPs
can
affect
protein
digestibility.
Moderate
techniques,
such
as
sous‐vide
cooking,
fermentation,
enzymatic
tenderization,
enhance
digestion
nutrient
absorption,
whereas
excessive
may
lead
aggregation
cross‐linking,
reducing
Additionally,
overuse
of
additives
thermal
key
concerns
UPMP
production,
leading
formation
potentially
harmful
substances,
including
acrylamide,
heterocyclic
amines,
polycyclic
aromatic
hydrocarbons,
advanced
glycation
end
products.
This
review
examines
how
different
techniques
influence
digestibility
UPMPs,
elucidates
pathways
through
which
substances
generated,
assesses
impact
on
gut
health,
focus
microbiota
colon.
Our
synthesis
current
research
indicates
that
consumption
contributes
dysbiosis,
compromises
barrier,
increases
risk
colorectal
cancer,
though
dose‐dependent
effects
require
further
clarification.
Future
should
parameters
moderate
processing,
explore
natural
alternatives
additives,
examine
dose–response
relationship
between
risks,
evaluate
individual
factors,
genetics
metabolism,
impacts
Allergy Asthma and Immunology Research,
Journal Year:
2023,
Volume and Issue:
15(6), P. 705 - 705
Published: Jan. 1, 2023
Allergic
diseases
are
a
major
public
health
problem
with
increasing
prevalence.These
immune-mediated
characterized
by
defective
epithelial
barriers,
which
explained
the
barrier
theory
and
continuously
emerging
evidence.Environmental
exposures
(exposome)
including
global
warming,
changes
loss
of
biodiversity,
pollution,
pathogens,
allergens
mites,
laundry
dishwasher
detergents,
surfactants,
shampoos,
body
cleaners
household
cleaners,
microplastics,
nanoparticles,
toothpaste,
enzymes
emulsifiers
in
processed
foods,
dietary
habits
responsible
for
mucosal
skin
disruption.Exposure
to
barrier-damaging
agents
causes
cell
injury
damage,
colonization
opportunistic
commensal
bacteria,
decreased
microbiota
diversity,
bacterial
translocation,
allergic
sensitization,
inflammation
periepithelial
area.Here,
we
review
scientific
evidence
on
environmental
components
that
impact
barriers
microbiome
composition
their
influence
asthma
diseases.We
also
discuss
historical
overview
evolution
hygiene
hypothesis
theoretical
evidence.
Nutrients,
Journal Year:
2023,
Volume and Issue:
16(1), P. 92 - 92
Published: Dec. 27, 2023
Food
allergy
(FA)
is
a
growing
public
health
concern,
with
an
increasing
prevalence
in
Western
countries.
Increasing
evidence
suggests
that
the
balance
of
human
gut
microbiota
and
integrity
our
intestinal
barrier
may
play
roles
development
FA.
Environmental
factors,
including
industrialization
consumption
highly
processed
food,
can
contribute
to
altering
barrier,
susceptibility
allergic
sensitization.
Compositional
functional
alterations
microbiome
have
also
been
associated
In
addition,
increased
permeability
allows
translocation
allergenic
molecules,
triggering
Th2
immune
responses.
Preclinical
clinical
studies
highlighted
potential
probiotics,
prebiotics,
postbiotics
prevention
treatment
FA
through
enhancing
function
promoting
restoration
healthy
microbiota.
Finally,
fecal
transplantation
(FMT)
now
being
explored
as
promising
therapeutic
strategy
prevent
both
experimental
studies.
this
review
article,
we
aim
explore
complex
interplay
between
FA,
well
depict
strategies.
Allergy,
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 13, 2024
Abstract
Background
and
Objective
The
updated
World
Health
Organization
(WHO)
air
quality
guideline
recommends
an
annual
mean
concentration
of
fine
particulate
matter
(PM2.5)
not
exceeding
5
or
15
μg/m
3
in
the
short‐term
(24
h)
for
no
more
than
3–4
days
annually.
However,
90%
global
population
is
currently
exposed
to
daily
concentrations
surpassing
these
limits,
especially
during
extreme
weather
conditions
due
transboundary
dust
transport
influenced
by
climate
change.
Herein,
effect
respirable
<PM2.5
inorganic
silica
particle
exposures
on
epithelial
barrier
integrity
was
simultaneously
evaluated
within
biomimetic
microfluidic
platform‐based
airway
(AEB)‐on‐a‐chip
human
bronchoscopic
ex
vivo
tissue
models,
comparatively.
Methods
Silica
particles
at
average
size
1
μm,
referred
as
<PM2.5,
dose‐dependently
tested
MTT
LDH
analyses.
elicited
dose
800
μg/mL
applied
cells
(Calu‐3)
seeded
membrane
air–liquid
interface
AEB‐on‐a‐chip
platform,
which
operated
under
static
dynamic
bronchoscopy
bronchial
slices
72
h.
For
both
healthy
groups
were
comparatively
investigated.
Computational
fluid
dynamics
simulations
performed
assess
shear
stress
profiles
different
flow
conditions.
Qualitative
quantitative
analyses
carried
out
evaluate
resilience
via
cell
survivability,
morphology,
integrity,
permeability,
inflammation.
Results
In
exposure
PM2.5
disrupted
AEB
increasing
decreasing
adhesion‐barrier
markers
such
ZO‐1
,
Vinculin
ACE2
CD31
impaired
viability
increased
expression
levels
proinflammatory
markers;
IFNs
IL‐6
IL‐1s
TNF‐α
CD68
CD80
Inos
mostly
Besides,
decreased
viability,
β‐catenin
E‐cadherin
also
response
with
elevated
IL‐1
α,
IFN‐Ɣ
markers,
observed
after
tissue.
Conclusion
duration
that
can
be
natural
events
aligns
our
model
(0–800
h).
At
this
level
exposure,
demonstrated
platform
emulating
forces
body
biopsy
slices.
Lung‐on‐a‐chip
models
will
serve
reliable
context.
