Neurological side effects of SARS‐CoV‐2 vaccinations

Acta Neurologica Scandinavica, Journal Year: 2021, Volume and Issue: 145(1), P. 5 - 9

Published: Nov. 8, 2021

SARS-CoV-2 and adverse reactions to vaccinations show a tropism for neuronal structures tissues. This narrative review was conducted collect discuss published data about neurological side effects of vaccines in order discover type, frequency, treatment, outcome these effects. The most frequent are headache, Guillain-Barre syndrome (GBS), venous sinus thrombosis (VST), transverse myelitis. Other occur much lower frequency. Neurological with any the approved but VST particularly occurs after vaccination vector-based vaccines. Treatment is not at variance from similar conditions due other causes. worst associated VST, why it should be missed treated appropriately time. In conclusion, safety concerns against backed by an increasing number studies reporting them GBS, Healthcare professionals, neurologists involved management patients having undergone vaccinations, aware stay vigilant recognize early treat adequately.

Language: Английский

---

COVID-19, post-acute COVID-19 syndrome (PACS, “long COVID”) and post-COVID-19 vaccination syndrome (PCVS, “post-COVIDvac-syndrome”): Similarities and differences

Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 246, P. 154497 - 154497

Published: May 3, 2023

Worldwide there have been over 760 million confirmed coronavirus disease 2019 (COVID-19) cases, and 13 billion COVID-19 vaccine doses administered as of April 2023, according to the World Health Organization. An infection with severe acute respiratory syndrome 2 (SARS-CoV-2) can lead an disease, i.e. COVID-19, but also a post-acute (PACS, "long COVID"). Currently, side effects vaccines are increasingly being noted studied. Here, we summarise currently available indications discuss our conclusions that (i) these specific similarities differences PACS, (ii) new term should be used refer (post-COVID-19 vaccination syndrome, PCVS, colloquially "post-COVIDvac-syndrome"), (iii) is need distinguish between (ACVS) (PACVS) - in analogy PACS ("long Moreover, address mixed forms caused by natural SARS-CoV-2 vaccination. We explain why it important for medical diagnosis, care research use terms (PCVS, ACVS PACVS) order avoid confusion misinterpretation underlying causes enable optimal therapy. do not recommend "Post-Vac-Syndrome" imprecise. The article serves current problem "medical gaslighting" relation PCVS raising awareness among professionals supplying appropriate terminology disease.

Language: Английский

---

IgG4 Antibodies Induced by Repeated Vaccination May Generate Immune Tolerance to the SARS-CoV-2 Spike Protein

Vaccines, Journal Year: 2023, Volume and Issue: 11(5), P. 991 - 991

Published: May 17, 2023

Less than a year after the global emergence of coronavirus SARS-CoV-2, novel vaccine platform based on mRNA technology was introduced to market. Globally, around 13.38 billion COVID-19 doses diverse platforms have been administered. To date, 72.3% total population has injected at least once with vaccine. As immunity provided by these vaccines rapidly wanes, their ability prevent hospitalization and severe disease in individuals comorbidities recently questioned, increasing evidence shown that, as many other vaccines, they do not produce sterilizing immunity, allowing people suffer frequent re-infections. Additionally, recent investigations found abnormally high levels IgG4 who were administered two or more injections vaccines. HIV, Malaria, Pertussis also reported induce higher-than-normal synthesis. Overall, there are three critical factors determining class switch antibodies: excessive antigen concentration, repeated vaccination, type used. It suggested that an increase could protecting role preventing immune over-activation, similar occurring during successful allergen-specific immunotherapy inhibiting IgE-induced effects. However, emerging suggests detected vaccination may be protective mechanism; rather, it constitutes tolerance mechanism spike protein promote unopposed SARS-CoV2 infection replication suppressing natural antiviral responses. Increased synthesis due concentrations cause autoimmune diseases, cancer growth myocarditis susceptible individuals.

Language: Английский

---

A review of neurological side effects of COVID-19 vaccination

European journal of medical research, Journal Year: 2023, Volume and Issue: 28(1)

Published: Feb. 25, 2023

Following the COVID-19 virus epidemic, extensive, coordinated international research has led to rapid development of effective vaccines. Although vaccines are now considered best way achieve collective safety and control mortality, due critical situation, these have been issued emergency use licenses some their potential subsequence side effects overlooked. At same time, there many reports after getting a vaccine. According reports, vaccination can an adverse event, especially on nervous system. The most important common complications cerebrovascular disorders including cerebral venous sinus thrombosis, transient ischemic attack, intracerebral hemorrhage, stroke, demyelinating transverse myelitis, first manifestation MS, neuromyelitis optica. These often acute transient, but they be severe even fatal in few cases. Herein, we provided comprehensive review documents reporting neurological databases from 2020 2022 discussed possibly caused by vaccination.

Language: Английский

---

COVID-19 at a Glance: An Up-to-Date Overview on Variants, Drug Design and Therapies

Viruses, Journal Year: 2022, Volume and Issue: 14(3), P. 573 - 573

Published: March 10, 2022

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a member of the Coronavirus family which caused worldwide pandemic human illness coronavirus disease 2019 (COVID-19). Presumably emerging at end 2019, it poses severe threat to public health and safety, with high incidence transmission, predominately through aerosols and/or direct contact infected surfaces. In 2020, search for vaccines began, leading obtaining of, date, about twenty COVID-19 approved use in least one country. However, continues spread new genetic mutations variants have been discovered, requiring pharmacological treatments. The most common therapies are represented by antiviral antimalarial agents, antibiotics, immunomodulators, angiotensin II receptor blockers, bradykinin B2 antagonists corticosteroids. addition, nutraceuticals, vitamins D C, omega-3 fatty acids probiotics under study. Finally, drug repositioning, concerns investigation existing drugs therapeutic target indications, has widely proposed literature therapies. Considering importance this ongoing global emergency, review aims offer synthetic up-to-date overview regarding diagnoses, COVID-19, particular attention paid adopted

Language: Английский

---

Neurological Adverse Reactions to SARS-CoV-2 Vaccines

Clinical Psychopharmacology and Neuroscience, Journal Year: 2023, Volume and Issue: 21(2), P. 222 - 239

Published: April 29, 2023

SARS-CoV-2 vaccines are not free of side effects and most commonly affect the central or peripheral nervous system (CNS, PNS). This narrative review aims to summarise recent advances in nature, frequency, management, outcome neurological from vaccines. CNS disorders triggered by include headache, cerebro-vascular (venous sinus thrombosis [VST], ischemic stroke, intracerebral hemorrhage, subarachnoid bleeding, reversible, cerebral vasoconstriction syndrome, vasculitis, pituitary apoplexy, Susac syndrome), inflammatory diseases (encephalitis, meningitis, demyelinating disorders, transverse myelitis), epilepsy, a number other rarely reported conditions. PNS related neuropathy cranial nerves, mono-/polyradiculitis (Guillain-Barre syndrome [GBS]), Parsonage-Turner (plexitis), small fiber neuropathy, myasthenia, myositis/dermatomyositis, rhabdomyolysis, The common facial palsy, VST, GBS. underlying pathophysiology is poorly understood, but several speculations have been generated explain development CNS/PNS disease after vaccination. In conclusion, develop with any type vaccine diverse, can be serious even fatal, should taken seriously initiate early treatment improve avoid fatalities.

Language: Английский

---

Incidence and management of the main serious adverse events reported after COVID‐19 vaccination

Pharmacology Research & Perspectives, Journal Year: 2024, Volume and Issue: 12(3)

Published: June 1, 2024

Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2n first appeared in Wuhan, China 2019. Soon after, it was declared a pandemic World Health Organization. The health crisis imposed new virus and its rapid spread worldwide prompted fast development of vaccines. For time human history, two vaccines based on recombinant genetic material technology were approved for use. These mRNA applied massive immunization programs around world, followed other more traditional approaches. Even though all tested clinical trials prior to their general administration, serious adverse events, usually very low incidence, mostly identified after application millions doses. Establishing direct correlation (the cause-effect paradigm) between vaccination appearance effects has proven challenging. This review focuses main observed vaccination, including anaphylaxis, myocarditis, vaccine-induced thrombotic thrombocytopenia, Guillain-Barré syndrome, transverse myelitis reported context COVID-19 vaccination. We highlight symptoms, laboratory tests required an adequate diagnosis, briefly outline recommended treatments these effects. aim this work is increase awareness among healthcare personnel about events that may arise post-vaccination. Regardless ongoing discussion safety must be promptly treated effectively reduce risk complications.

Language: Английский

---

Recent Advances in Antiviral Activities of Triterpenoids

Pharmaceuticals, Journal Year: 2022, Volume and Issue: 15(10), P. 1169 - 1169

Published: Sept. 21, 2022

Triterpenoids, important secondary plant metabolites made up of six isoprene units, are found widely in higher plants and studied for their structural variety wide range bioactivities, including antiviral, antioxidant, anticancer, anti-inflammatory properties. Numerous studies have demonstrated that different triterpenoids the potential to behave as antiviral agents. The activities derivatives summarized this review, with examples oleanane, ursane, lupane, dammarane, lanostane, cycloartane triterpenoids. We concentrated on tetracyclic pentacyclic particular. Furthermore, particular viral types possible methods, such anti-human immunodeficiency virus (HIV), anti-influenza virus, anti-hepatitis presented article. This review gives an overview a discussion

Language: Английский

---

Emergence of Post COVID-19 Vaccine Autoimmune Diseases: A Single Center Study

Infection and Drug Resistance, Journal Year: 2023, Volume and Issue: Volume 16, P. 1263 - 1278

Published: March 1, 2023

Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) became a major concern since the announcement that it is pandemic in early 2020. Vaccine trials were started November 2020, and completed rapidly due to urgency get over infection. Side effects vaccines be reported. There minor side including site of injection pain heaviness constitutional symptoms like fever which are considered minor. One rare adverse events post vaccine new onset autoimmune diseases. Methods: Data obtained from one center eastern province Saudi Arabia (King Fahd Hospital University). All patient reported occurred study period March 2021 February 2022. We identified patients presenting with diseases exclusively presentations. Results: 31 cases immune-mediated disease: 18 females (58%); 13 males (42%). Only 4 them (13%) had an background before COVID-19 vaccination. The average time between vaccination new-onset disease was 7 days. Among all our study, (22.5%) vasculitis, IgA vasculitis 5 ANCA 6 neurological (19.3%), (12.9%) systemic lupus erythematosus (SLE), 3 (9.6%) presented inflammatory arthritis, Sjogren's (3.2%). Conclusion: Our unique as first include largest number (31 patients) onsets confirmed related Covid-19 vaccines. Keywords: disease, SARS CoV-2, vaccine,

Language: Английский

---

Review of adverse events associated with COVID-19 vaccines, highlighting their frequencies and reported cases

Journal of Taibah University Medical Sciences, Journal Year: 2023, Volume and Issue: 18(6), P. 1646 - 1661

Published: Sept. 5, 2023

This review examines the immunological and autoimmune adverse events associated with COVID-19 vaccines, highlighting their frequencies, reported cases, associations specific vaccine classes. The concept of vaccine-induced immune thrombotic thrombocytopenia is crucial in addressing skepticism. Understanding this helps healthcare professionals identify manage potential after vaccination. Despite rarity, cause concern anxiety among public. To maintain public trust vaccination programs, health agencies must actively monitor address these events, promptly disclose suspicious incidents, take measures to mitigate dangers, inform transparency accurate information. Continuing research surveillance are essential for understanding underlying mechanisms developing strategies minimize occurrence.

Language: Английский

---